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Items: 48


The Laboratory Features of Congenital Hypothyroidism and Approach to Therapy.

Weiner A, Oberfield S, Vuguin P.

Neoreviews. 2020 Jan;21(1):e37-e44. doi: 10.1542/neo.21-1-e37.


N-Acetylcysteine Resolves Placental Inflammatory-Vasculopathic Changes in Mice Consuming a High-Fat Diet.

Williams L, Burgos ES, Vuguin PM, Manuel CR, Pekson R, Munnangi S, Reznik SE, Charron MJ.

Am J Pathol. 2019 Nov;189(11):2246-2257. doi: 10.1016/j.ajpath.2019.07.010. Epub 2019 Aug 17.


Glucagon: The Name Says It All, or Not!

Dean ED, Vuguin PM, Charron MJ.

Endocrinology. 2019 May 1;160(5):1359-1361. doi: 10.1210/en.2019-00251. No abstract available.


In Utero Exposure to a High-Fat Diet Programs Hepatic Hypermethylation and Gene Dysregulation and Development of Metabolic Syndrome in Male Mice.

Seki Y, Suzuki M, Guo X, Glenn AS, Vuguin PM, Fiallo A, Du Q, Ko YA, Yu Y, Susztak K, Zheng D, Greally JM, Katz EB, Charron MJ.

Endocrinology. 2017 Sep 1;158(9):2860-2872. doi: 10.1210/en.2017-00334.


Alterations in Glucose Effectiveness and Insulin Dynamics: Polycystic Ovary Syndrome or Body Mass Index.

Vuguin P, Sopher AB, Roumimper H, Chin V, Silfen M, McMahon DJ, Fennoy I, Oberfield SE.

Horm Res Paediatr. 2017;87(6):359-367. doi: 10.1159/000471804. Epub 2017 May 5.


Prevalence and Determinants of True Thyroid Dysfunction Among Pediatric Referrals for Abnormal Thyroid Function Tests.

Lahoti A, Klein J, Schumaker T, Vuguin P, Frank G.

Glob Pediatr Health. 2016 May 5;3:2333794X16646701. doi: 10.1177/2333794X16646701. eCollection 2016.


Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist.

Damond N, Thorel F, Moyers JS, Charron MJ, Vuguin PM, Powers AC, Herrera PL.

Elife. 2016 Apr 19;5. pii: e13828. doi: 10.7554/eLife.13828.


Polycystic Ovarian Syndrome.

Klein J, Craven M, Vuguin PM.

Adolesc Med State Art Rev. 2015 Aug;26(2):326-42. Review. No abstract available.


Lack of glucagon receptor signaling and its implications beyond glucose homeostasis.

Charron MJ, Vuguin PM.

J Endocrinol. 2015 Mar;224(3):R123-30. doi: 10.1530/JOE-14-0614. Epub 2015 Jan 7. Review.


Cushing syndrome.

Klein J, Vuguin P, Hyman S.

Pediatr Rev. 2014 Sep;35(9):405-7. doi: 10.1542/pir.35-9-405. No abstract available.


Critical periods of increased fetal vulnerability to a maternal high fat diet.

Plata Mdel M, Williams L, Seki Y, Hartil K, Kaur H, Lin CL, Fiallo A, Glenn AS, Katz EB, Fuloria M, Charron MJ, Vuguin PM.

Reprod Biol Endocrinol. 2014 Aug 18;12:80. doi: 10.1186/1477-7827-12-80.


Effects of genetics and in utero diet on murine pancreatic development.

Lin CL, Williams L, Seki Y, Kaur H, Hartil K, Fiallo A, Glenn AS, Katz EB, Charron MJ, Vuguin PM.

J Endocrinol. 2014 Aug;222(2):217-27. doi: 10.1530/JOE-14-0114. Epub 2014 Jun 3.


In utero exposure to a maternal high-fat diet alters the epigenetic histone code in a murine model.

Suter MA, Ma J, Vuguin PM, Hartil K, Fiallo A, Harris RA, Charron MJ, Aagaard KM.

Am J Obstet Gynecol. 2014 May;210(5):463.e1-463.e11. doi: 10.1016/j.ajog.2014.01.045.


Animal models of in utero exposure to a high fat diet: a review.

Williams L, Seki Y, Vuguin PM, Charron MJ.

Biochim Biophys Acta. 2014 Mar;1842(3):507-519. doi: 10.1016/j.bbadis.2013.07.006. Epub 2013 Jul 18. Review.


High-fat intake during pregnancy and lactation exacerbates high-fat diet-induced complications in male offspring in mice.

Kruse M, Seki Y, Vuguin PM, Du XQ, Fiallo A, Glenn AS, Singer S, Breuhahn K, Katz EB, Charron MJ.

Endocrinology. 2013 Oct;154(10):3565-76. doi: 10.1210/en.2012-1877. Epub 2013 Jul 16.


Shared effects of genetic and intrauterine and perinatal environment on the development of metabolic syndrome.

Vuguin PM, Hartil K, Kruse M, Kaur H, Lin CL, Fiallo A, Glenn AS, Patel A, Williams L, Seki Y, Katz EB, Charron MJ.

PLoS One. 2013 May 17;8(5):e63021. doi: 10.1371/journal.pone.0063021. Print 2013.


Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for a circulating α-cell growth factor.

Longuet C, Robledo AM, Dean ED, Dai C, Ali S, McGuinness I, de Chavez V, Vuguin PM, Charron MJ, Powers AC, Drucker DJ.

Diabetes. 2013 Apr;62(4):1196-205. doi: 10.2337/db11-1605. Epub 2012 Nov 16.


Determinants of pancreatic islet development in mice and men: a focus on the role of transcription factors.

Lin CL, Vuguin PM.

Horm Res Paediatr. 2012;77(4):205-13. doi: 10.1159/000337219. Epub 2012 Apr 5. Review.


Minireview: Epigenetic programming of diabetes and obesity: animal models.

Seki Y, Williams L, Vuguin PM, Charron MJ.

Endocrinology. 2012 Mar;153(3):1031-8. doi: 10.1210/en.2011-1805. Epub 2012 Jan 17. Review.


Hypoglycemia, hyperglucagonemia, and fetoplacental defects in glucagon receptor knockout mice: a role for glucagon action in pregnancy maintenance.

Ouhilal S, Vuguin P, Cui L, Du XQ, Gelling RW, Reznik SE, Russell R, Parlow AF, Karpovsky C, Santoro N, Charron MJ.

Am J Physiol Endocrinol Metab. 2012 Mar 1;302(5):E522-31. doi: 10.1152/ajpendo.00420.2011. Epub 2011 Dec 13.


Novel insight into glucagon receptor action: lessons from knockout and transgenic mouse models.

Vuguin PM, Charron MJ.

Diabetes Obes Metab. 2011 Oct;13 Suppl 1:144-50. doi: 10.1111/j.1463-1326.2011.01447.x. Review.


Neonatal exendin-4 treatment reduces oxidative stress and prevents hepatic insulin resistance in intrauterine growth-retarded rats.

Raab EL, Vuguin PM, Stoffers DA, Simmons RA.

Am J Physiol Regul Integr Comp Physiol. 2009 Dec;297(6):R1785-94. doi: 10.1152/ajpregu.00519.2009. Epub 2009 Oct 21.


Pancreatic beta-cell overexpression of the glucagon receptor gene results in enhanced beta-cell function and mass.

Gelling RW, Vuguin PM, Du XQ, Cui L, Rømer J, Pederson RA, Leiser M, Sørensen H, Holst JJ, Fledelius C, Johansen PB, Fleischer N, McIntosh CH, Nishimura E, Charron MJ.

Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E695-707. doi: 10.1152/ajpendo.00082.2009. Epub 2009 Jul 14.


Maternal substrate utilization programs the development of the metabolic syndrome in male mice exposed to high fat in utero.

Hartil K, Vuguin PM, Kruse M, Schmuel E, Fiallo A, Vargas C, Warner MJ, Durand JL, Jelicks LA, Charron MJ.

Pediatr Res. 2009 Oct;66(4):368-73. doi: 10.1203/PDR.0b013e3181b33375.


Relationship between adiponectin and ambulatory blood pressure in obese adolescents.

Shatat IF, Freeman KD, Vuguin PM, Dimartino-Nardi JR, Flynn JT.

Pediatr Res. 2009 Jun;65(6):691-5. doi: 10.1203/PDR.0b013e31819ea776.


Current approaches to the diagnosis and treatment of polycystic ovarian syndrome in youth.

Harwood K, Vuguin P, DiMartino-Nardi J.

Horm Res. 2007;68(5):209-17. Epub 2007 Apr 5. Review.


Nestin expression in pancreatic endocrine and exocrine cells of mice lacking glucagon signaling.

Kedees MH, Guz Y, Vuguin PM, Vargas C, Cui L, Steiner DF, Charron MJ, Teitelman G.

Dev Dyn. 2007 Apr;236(4):1126-33.


Animal models for small for gestational age and fetal programming of adult disease.

Vuguin PM.

Horm Res. 2007;68(3):113-23. Epub 2007 Mar 9. Review.


Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo.

Kim HS, Ali O, Shim M, Lee KW, Vuguin P, Muzumdar R, Barzilai N, Cohen P.

Pediatr Res. 2007 Feb;61(2):159-64.


Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action.

Muzumdar RH, Ma X, Fishman S, Yang X, Atzmon G, Vuguin P, Einstein FH, Hwang D, Cohen P, Barzilai N.

Diabetes. 2006 Oct;55(10):2788-96.


Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation.

Vuguin PM, Kedees MH, Cui L, Guz Y, Gelling RW, Nejathaim M, Charron MJ, Teitelman G.

Endocrinology. 2006 Sep;147(9):3995-4006. Epub 2006 Apr 20.


Prediction models for insulin resistance in girls with premature adrenarche. The premature adrenarche insulin resistance score: PAIR score.

Vuguin P, Grinstein G, Freeman K, Saenger P, DiMartino Nardi J.

Horm Res. 2006;65(4):185-91. Epub 2006 Mar 17.


Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation.

Vuguin P, Raab E, Liu B, Barzilai N, Simmons R.

Diabetes. 2004 Oct;53(10):2617-22.


Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action.

Muzumdar R, Ma X, Atzmon G, Vuguin P, Yang X, Barzilai N.

Diabetes. 2004 Feb;53(2):441-6.


Presentation and 5-year follow-up of type 2 diabetes mellitus in African-American and Caribbean-Hispanic adolescents.

Grinstein G, Muzumdar R, Aponte L, Vuguin P, Saenger P, DiMartino-Nardi J.

Horm Res. 2003;60(3):121-6.


Assessing insulin resistance: application of a fasting glucose to insulin ratio in growth hormone-treated children.

Burgert TS, Vuguin PM, DiMartino-Nardi J, Attie KM, Saenger P.

Horm Res. 2002;57(1-2):37-42.


Fasting glucose insulin ratio: a useful measure of insulin resistance in girls with premature adrenarche.

Vuguin P, Saenger P, Dimartino-Nardi J.

J Clin Endocrinol Metab. 2001 Oct;86(10):4618-21.


Food deprivation limits insulin secretory capacity in postpubertal rats.

Vuguin P, Ma X, Yang X, Surana M, Liu B, Barzilai N.

Pediatr Res. 2001 Apr;49(4):468-73.


Aging does not contribute to the decline in insulin action on storage of muscle glycogen in rats.

Gupta G, She L, Ma XH, Yang XM, Hu M, Cases JA, Vuguin P, Rossetti L, Barzilai N.

Am J Physiol Regul Integr Comp Physiol. 2000 Jan;278(1):R111-7.


Discordant effects of glucosamine on insulin-stimulated glucose metabolism and phosphatidylinositol 3-kinase activity.

Hawkins M, Hu M, Yu J, Eder H, Vuguin P, She L, Barzilai N, Leiser M, Backer JM, Rossetti L.

J Biol Chem. 1999 Oct 29;274(44):31312-9.


Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action.

Barzilai N, She L, Liu L, Wang J, Hu M, Vuguin P, Rossetti L.

Am J Physiol. 1999 Aug;277(2):E291-8. doi: 10.1152/ajpendo.1999.277.2.E291.


Deletion of the pseudoautosomal region in a male with a unique Y;13 translocation and short stature.

Shanske A, Ellison J, Vuguin P, Dowling P, Wasserman E, Heinrich J, Saenger P.

Am J Med Genet. 1999 Jan 1;82(1):34-9.


Surgical removal of visceral fat reverses hepatic insulin resistance.

Barzilai N, She L, Liu BQ, Vuguin P, Cohen P, Wang J, Rossetti L.

Diabetes. 1999 Jan;48(1):94-8.


Leptin selectively decreases visceral adiposity and enhances insulin action.

Barzilai N, Wang J, Massilon D, Vuguin P, Hawkins M, Rossetti L.

J Clin Invest. 1997 Dec 15;100(12):3105-10.


Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action.

Rossetti L, Massillon D, Barzilai N, Vuguin P, Chen W, Hawkins M, Wu J, Wang J.

J Biol Chem. 1997 Oct 31;272(44):27758-63.

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