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Items: 1 to 50 of 90

1.

Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation.

Zhang J, Webster JD, Dugger DL, Goncharov T, Roose-Girma M, Hung J, Kwon YC, Vucic D, Newton K, Dixit VM.

Cell Rep. 2019 May 28;27(9):2679-2689.e3. doi: 10.1016/j.celrep.2019.04.111.

2.

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases.

Patel S, Webster JD, Varfolomeev E, Kwon YC, Cheng JH, Zhang J, Dugger DL, Wickliffe KE, Maltzman A, Sujatha-Bhaskar S, Bir Kohli P, Ramaswamy S, Deshmukh G, Liederer BM, Fong R, Hamilton G, Lupardus P, Caplazi P, Lee WP, van Lookeren Campagne M, Johnson A, McKenzie BS, Junttila MR, Newton K, Vucic D.

Cell Death Differ. 2019 May 17. doi: 10.1038/s41418-019-0347-0. [Epub ahead of print]

PMID:
31101885
3.

Potent and selective inhibitors of receptor-interacting protein kinase 1 that lack an aromatic back pocket group.

Hamilton GL, Chen H, Deshmukh G, Eigenbrot C, Fong R, Johnson A, Kohli PB, Lupardus PJ, Liederer BM, Ramaswamy S, Wang H, Wang J, Xu Z, Zhu Y, Vucic D, Patel S.

Bioorg Med Chem Lett. 2019 Jun 15;29(12):1497-1501. doi: 10.1016/j.bmcl.2019.04.014. Epub 2019 Apr 11.

PMID:
31000154
4.

RADIOACTIVITY OF SOIL IN THE REGION OF THE TOWN OF NIŠ, SERBIA.

Manić V, Manić G, Radojković B, Vučić D, Nikezić D, Krstić D.

Radiat Prot Dosimetry. 2019 Mar 27. pii: ncz034. doi: 10.1093/rpd/ncz034. [Epub ahead of print]

PMID:
30916765
5.

OTULIN limits cell death and inflammation by deubiquitinating LUBAC.

Heger K, Wickliffe KE, Ndoja A, Zhang J, Murthy A, Dugger DL, Maltzman A, de Sousa E Melo F, Hung J, Zeng Y, Verschueren E, Kirkpatrick DS, Vucic D, Lee WP, Roose-Girma M, Newman RJ, Warming S, Hsiao YC, Kőműves LG, Webster JD, Newton K, Dixit VM.

Nature. 2018 Jul;559(7712):120-124. doi: 10.1038/s41586-018-0256-2. Epub 2018 Jun 27.

PMID:
29950720
6.

XIAP at the crossroads of cell death and inflammation.

Vucic D.

Oncotarget. 2018 Jun 8;9(44):27319-27320. doi: 10.18632/oncotarget.25363. eCollection 2018 Jun 8. No abstract available.

7.

Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling.

Goncharov T, Hedayati S, Mulvihill MM, Izrael-Tomasevic A, Zobel K, Jeet S, Fedorova AV, Eidenschenk C, deVoss J, Yu K, Shaw AS, Kirkpatrick DS, Fairbrother WJ, Deshayes K, Vucic D.

Mol Cell. 2018 Feb 15;69(4):551-565.e7. doi: 10.1016/j.molcel.2018.01.016.

8.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

9.

Diverse ubiquitin linkages regulate RIP kinases-mediated inflammatory and cell death signaling.

Witt A, Vucic D.

Cell Death Differ. 2017 Jul;24(7):1160-1171. doi: 10.1038/cdd.2017.33. Epub 2017 May 5. Review.

10.

The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation.

Senger K, Pham VC, Varfolomeev E, Hackney JA, Corzo CA, Collier J, Lau VWC, Huang Z, Hamidzhadeh K, Caplazi P, Peng I, Setiadi AF, Francis R, Paler-Martinez A, Kwon YC, Ramirez-Carrozzi V, Sun Y, Grigg PW, Roose-Girma M, Jeet S, Barck KH, Pham A, Ota N, Ha C, Stinson J, Guillory J, Tam L, Modrusan Z, Emson C, McKenzie BS, Townsend MJ, Carano RAD, Warming S, Vucic D, DeVoss J, Lee WP, Lill JR, Zarrin AA.

Sci Signal. 2017 Apr 18;10(475). pii: eaah4273. doi: 10.1126/scisignal.aah4273.

PMID:
28420753
11.

Intracellular regulation of TNF activity in health and disease.

Varfolomeev E, Vucic D.

Cytokine. 2018 Jan;101:26-32. doi: 10.1016/j.cyto.2016.08.035. Epub 2016 Sep 9. Review.

PMID:
27623350
12.

Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death.

de Almagro MC, Goncharov T, Izrael-Tomasevic A, Duttler S, Kist M, Varfolomeev E, Wu X, Lee WP, Murray J, Webster JD, Yu K, Kirkpatrick DS, Newton K, Vucic D.

Cell Death Differ. 2017 Jan;24(1):26-37. doi: 10.1038/cdd.2016.78. Epub 2016 Aug 12.

13.

Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers.

Lueck SC, Russ AC, Botzenhardt U, Schlenk RF, Zobel K, Deshayes K, Vucic D, Döhner H, Döhner K, Fulda S, Bullinger L.

Oncotarget. 2016 Aug 2;7(31):49539-49551. doi: 10.18632/oncotarget.10390.

14.

Targeting Cell Death Pathways for Therapeutic Intervention in Kidney Diseases.

Garg JP, Vucic D.

Semin Nephrol. 2016 May;36(3):153-61. doi: 10.1016/j.semnephrol.2016.03.003. Review.

PMID:
27339381
15.

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury.

Newton K, Dugger DL, Maltzman A, Greve JM, Hedehus M, Martin-McNulty B, Carano RA, Cao TC, van Bruggen N, Bernstein L, Lee WP, Wu X, DeVoss J, Zhang J, Jeet S, Peng I, McKenzie BS, Roose-Girma M, Caplazi P, Diehl L, Webster JD, Vucic D.

Cell Death Differ. 2016 Sep 1;23(9):1565-76. doi: 10.1038/cdd.2016.46. Epub 2016 May 13.

16.

Transfer factors of natural radionuclides and (137)Cs from soil to plants used in traditional medicine in central Serbia.

Djelic G, Krstic D, Stajic JM, Milenkovic B, Topuzovic M, Nikezic D, Vucic D, Zeremski T, Stankovic M, Kostic D.

J Environ Radioact. 2016 Jul;158-159:81-8. doi: 10.1016/j.jenvrad.2016.03.028. Epub 2016 Apr 12.

PMID:
27082759
17.

Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination.

de Almagro MC, Goncharov T, Newton K, Vucic D.

Cell Death Dis. 2015 Jun 25;6:e1800. doi: 10.1038/cddis.2015.158.

18.

Identification of RIP1 as a critical mediator of Smac mimetic-mediated sensitization of glioblastoma cells for Drozitumab-induced apoptosis.

Cristofanon S, Abhari BA, Krueger M, Tchoghandjian A, Momma S, Calaminus C, Vucic D, Pichler BJ, Fulda S.

Cell Death Dis. 2015 Apr 16;6:e1724. doi: 10.1038/cddis.2014.592.

19.

Immunoaffinity enrichment coupled to quantitative mass spectrometry reveals ubiquitin-mediated signaling events.

Yu K, Phu L, Varfolomeev E, Bustos D, Vucic D, Kirkpatrick DS.

J Mol Biol. 2015 Jun 5;427(11):2121-34. doi: 10.1016/j.jmb.2015.03.018. Epub 2015 Apr 8.

PMID:
25861760
20.

Roles of c-IAP proteins in TNF receptor family activation of NF-κB signaling.

Varfolomeev E, Goncharov T, Vucic D.

Methods Mol Biol. 2015;1280:269-82. doi: 10.1007/978-1-4939-2422-6_15.

PMID:
25736754
21.

Necroptosis: Pathway diversity and characteristics.

de Almagro MC, Vucic D.

Semin Cell Dev Biol. 2015 Mar;39:56-62. doi: 10.1016/j.semcdb.2015.02.002. Epub 2015 Feb 13. Review.

PMID:
25683283
22.

In vitro activity of heather [Calluna vulgaris (L.) Hull] extracts on selected urinary tract pathogens.

Vučić DM, Petković MR, Rodić-Grabovac BB, Stefanović OD, Vasić SM, Comić LR.

Bosn J Basic Med Sci. 2014 Nov 15;14(4):234-8. doi: 10.17305/bjbms.2014.4.40.

23.

Ubiquitination profiling identifies sensitivity factors for IAP antagonist treatment.

Varfolomeev E, Izrael-Tomasevic A, Yu K, Bustos D, Goncharov T, Belmont LD, Masselot A, Bakalarski CE, Kirkpatrick DS, Vucic D.

Biochem J. 2015 Feb 15;466(1):45-54. doi: 10.1042/BJ20141195.

PMID:
25423073
24.

Ubiquitination in disease pathogenesis and treatment.

Popovic D, Vucic D, Dikic I.

Nat Med. 2014 Nov;20(11):1242-53. doi: 10.1038/nm.3739. Epub 2014 Nov 6. Review.

PMID:
25375928
25.

IAP family of cell death and signaling regulators.

Silke J, Vucic D.

Methods Enzymol. 2014;545:35-65. doi: 10.1016/B978-0-12-801430-1.00002-0. Review.

PMID:
25065885
26.

Dose assessment from domestic building materials used in housing sector in Serbia.

Petrović M, Vučić D, Karamarković J.

Radiat Prot Dosimetry. 2014 Nov;162(1-2):2-5. doi: 10.1093/rpd/ncu206. Epub 2014 Jul 4.

PMID:
24996919
27.

Ubiquitin in inflammation: the right linkage makes all the difference.

Corn JE, Vucic D.

Nat Struct Mol Biol. 2014 Apr;21(4):297-300. doi: 10.1038/nsmb.2808. Review. No abstract available.

PMID:
24699077
28.

Predictors of fitness status on success in Taekwondo.

Cular D, Krstulović S, Katić R, Primorac D, Vucić D.

Coll Antropol. 2013 Dec;37(4):1267-74.

PMID:
24611344
29.

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis.

Newton K, Dugger DL, Wickliffe KE, Kapoor N, de Almagro MC, Vucic D, Komuves L, Ferrando RE, French DM, Webster J, Roose-Girma M, Warming S, Dixit VM.

Science. 2014 Mar 21;343(6177):1357-60. doi: 10.1126/science.1249361. Epub 2014 Feb 20.

PMID:
24557836
30.

The Role of Ubiquitination in TWEAK-Stimulated Signaling.

Vucic D.

Front Immunol. 2013 Dec 19;4:472. doi: 10.3389/fimmu.2013.00472.

31.

Phenolic content, antibacterial and antioxidant activities of Erica herbacea L.

Vucić DM, Petković MR, Rodić-Grabovac BB, Stefanović OD, Vasić SM, Comić LR.

Acta Pol Pharm. 2013 Nov-Dec;70(6):1021-6.

32.

Motor determinants of fighting efficacy in Croatian youth karateka.

Katić R, Jukić J, Cavala M, Vucić D, Blazević S.

Coll Antropol. 2013 May;37 Suppl 2:1-8.

PMID:
23914482
33.

A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism.

Pribluda A, Elyada E, Wiener Z, Hamza H, Goldstein RE, Biton M, Burstain I, Morgenstern Y, Brachya G, Billauer H, Biton S, Snir-Alkalay I, Vucic D, Schlereth K, Mernberger M, Stiewe T, Oren M, Alitalo K, Pikarsky E, Ben-Neriah Y.

Cancer Cell. 2013 Aug 12;24(2):242-56. doi: 10.1016/j.ccr.2013.06.005. Epub 2013 Jul 25. Erratum in: Cancer Cell. 2015 Jun 8;27(6):877-8.

34.

OTUB1 modulates c-IAP1 stability to regulate signalling pathways.

Goncharov T, Niessen K, de Almagro MC, Izrael-Tomasevic A, Fedorova AV, Varfolomeev E, Arnott D, Deshayes K, Kirkpatrick DS, Vucic D.

EMBO J. 2013 Apr 17;32(8):1103-14. doi: 10.1038/emboj.2013.62. Epub 2013 Mar 22.

35.

Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production.

Kearney CJ, Sheridan C, Cullen SP, Tynan GA, Logue SE, Afonina IS, Vucic D, Lavelle EC, Martin SJ.

J Biol Chem. 2013 Feb 15;288(7):4878-90. doi: 10.1074/jbc.M112.422410. Epub 2012 Dec 28.

36.
37.

Characterization of ML-IAP protein stability and physiological role in vivo.

Varfolomeev E, Moradi E, Dynek JN, Zha J, Fedorova AV, Deshayes K, Fairbrother WJ, Newton K, Le Couter J, Vucic D.

Biochem J. 2012 Nov 1;447(3):427-36. doi: 10.1042/BJ20121103.

PMID:
22853455
38.

Duane type I retraction syndrome associated with Wyburn-Mason syndrome.

Vucic D, Kalezic T, Kostic A, Stojkovic M, Risimic D, Stankovic B.

Ophthalmic Genet. 2013 Mar-Jun;34(1-2):61-4. doi: 10.3109/13816810.2012.695422. Epub 2012 Jun 14.

PMID:
22697299
39.

Protease activity of MALT1: a mystery unravelled.

Kirchhofer D, Vucic D.

Biochem J. 2012 Jun 1;444(2):e3-5. doi: 10.1042/BJ20120414. Review.

PMID:
22574776
40.

Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner.

Wagner L, Marschall V, Karl S, Cristofanon S, Zobel K, Deshayes K, Vucic D, Debatin KM, Fulda S.

Oncogene. 2013 Feb 21;32(8):988-97. doi: 10.1038/onc.2012.108. Epub 2012 Apr 2.

PMID:
22469979
41.

Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors.

Varfolomeev E, Goncharov T, Maecker H, Zobel K, Kömüves LG, Deshayes K, Vucic D.

Sci Signal. 2012 Mar 20;5(216):ra22. doi: 10.1126/scisignal.2001878.

42.

Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).

Flygare JA, Beresini M, Budha N, Chan H, Chan IT, Cheeti S, Cohen F, Deshayes K, Doerner K, Eckhardt SG, Elliott LO, Feng B, Franklin MC, Reisner SF, Gazzard L, Halladay J, Hymowitz SG, La H, LoRusso P, Maurer B, Murray L, Plise E, Quan C, Stephan JP, Young SG, Tom J, Tsui V, Um J, Varfolomeev E, Vucic D, Wagner AJ, Wallweber HJ, Wang L, Ware J, Wen Z, Wong H, Wong JM, Wong M, Wong S, Yu R, Zobel K, Fairbrother WJ.

J Med Chem. 2012 May 10;55(9):4101-13. doi: 10.1021/jm300060k. Epub 2012 Mar 28.

43.

Targeting IAP proteins for therapeutic intervention in cancer.

Fulda S, Vucic D.

Nat Rev Drug Discov. 2012 Feb 1;11(2):109-24. doi: 10.1038/nrd3627. Review. Erratum in: Nat Rev Drug Discov. 2012 Apr;11(4):331.

PMID:
22293567
44.

Requirement of nuclear factor κB for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis.

Stadel D, Cristofanon S, Abhari BA, Deshayes K, Zobel K, Vucic D, Debatin KM, Fulda S.

Neoplasia. 2011 Dec;13(12):1162-70.

45.

Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis.

Laukens B, Jennewein C, Schenk B, Vanlangenakker N, Schier A, Cristofanon S, Zobel K, Deshayes K, Vucic D, Jeremias I, Bertrand MJ, Vandenabeele P, Fulda S.

Neoplasia. 2011 Oct;13(10):971-9.

46.

Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination.

Dueber EC, Schoeffler AJ, Lingel A, Elliott JM, Fedorova AV, Giannetti AM, Zobel K, Maurer B, Varfolomeev E, Wu P, Wallweber HJ, Hymowitz SG, Deshayes K, Vucic D, Fairbrother WJ.

Science. 2011 Oct 21;334(6054):376-80. doi: 10.1126/science.1207862.

47.

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death.

Vucic D, Dixit VM, Wertz IE.

Nat Rev Mol Cell Biol. 2011 Jun 23;12(7):439-52. doi: 10.1038/nrm3143. Review.

PMID:
21697901
48.

Inhibitor of apoptosis proteins: fascinating biology leads to attractive tumor therapeutic targets.

Varfolomeev E, Vucic D.

Future Oncol. 2011 May;7(5):633-48. doi: 10.2217/fon.11.40. Review.

PMID:
21568679
49.

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells.

Ong CC, Jubb AM, Haverty PM, Zhou W, Tran V, Truong T, Turley H, O'Brien T, Vucic D, Harris AL, Belvin M, Friedman LS, Blackwood EM, Koeppen H, Hoeflich KP.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7177-82. doi: 10.1073/pnas.1103350108. Epub 2011 Apr 11.

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