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Items: 24

1.

Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors.

Lanman BA, Allen JR, Allen JG, Amegadzie AK, Ashton KS, Booker SK, Chen JJ, Chen N, Frohn MJ, Goodman G, Kopecky DJ, Liu L, Lopez P, Low JD, Ma V, Minatti AE, Nguyen TT, Nishimura N, Pickrell AJ, Reed AB, Shin Y, Siegmund AC, Tamayo NA, Tegley CM, Walton MC, Wang HL, Wurz RP, Xue M, Yang KC, Achanta P, Bartberger MD, Canon J, Hollis LS, McCarter JD, Mohr C, Rex K, Saiki AY, San Miguel T, Volak LP, Wang KH, Whittington DA, Zech SG, Lipford JR, Cee VJ.

J Med Chem. 2020 Jan 9;63(1):52-65. doi: 10.1021/acs.jmedchem.9b01180. Epub 2019 Dec 24.

PMID:
31820981
2.

Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C.

Shin Y, Jeong JW, Wurz RP, Achanta P, Arvedson T, Bartberger MD, Campuzano IDG, Fucini R, Hansen SK, Ingersoll J, Iwig JS, Lipford JR, Ma V, Kopecky DJ, McCarter J, San Miguel T, Mohr C, Sabet S, Saiki AY, Sawayama A, Sethofer S, Tegley CM, Volak LP, Yang K, Lanman BA, Erlanson DA, Cee VJ.

ACS Med Chem Lett. 2019 Aug 20;10(9):1302-1308. doi: 10.1021/acsmedchemlett.9b00258. eCollection 2019 Sep 12.

PMID:
31531201
3.

Bystander programs addressing sexual violence on college campuses: A reply to Mindthoff, Stephens, and Madhivanan.

Jouriles EN PhD, Krauss Ba A, Vu Ma NL, Banyard PhD VL, McDonald PhD R, Rosenfield PhD D.

J Am Coll Health. 2020 Jan;68(1):39-40. doi: 10.1080/07448481.2018.1515764. Epub 2019 Jan 7. No abstract available.

PMID:
30614772
4.

Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine.

Horne DB, Biswas K, Brown J, Bartberger MD, Clarine J, Davis CD, Gore VK, Harried S, Horner M, Kaller MR, Lehto SG, Liu Q, Ma VV, Monenschein H, Nguyen TT, Yuan CC, Youngblood BD, Zhang M, Zhong W, Allen JR, Chen JJ, Gavva NR.

J Med Chem. 2018 Sep 27;61(18):8186-8201. doi: 10.1021/acs.jmedchem.8b00518. Epub 2018 Sep 10.

PMID:
30148953
5.
6.

Anterior commissural white matter fiber abnormalities in first-episode psychosis: a tractography study.

Kikinis Z, Fitzsimmons J, Dunn C, Vu MA, Makris N, Bouix S, Goldstein JM, Mesholam-Gately RI, Petryshen T, Del Re EC, Wojcik J, Seidman LJ, Kubicki M.

Schizophr Res. 2015 Mar;162(1-3):29-34. doi: 10.1016/j.schres.2015.01.037. Epub 2015 Feb 7.

7.

Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer's disease.

Chen JJ, Liu Q, Yuan C, Gore V, Lopez P, Ma V, Amegadzie A, Qian W, Judd TC, Minatti AE, Brown J, Cheng Y, Xue M, Zhong W, Dineen TA, Epstein O, Human J, Kreiman C, Marx I, Weiss MM, Hitchcock SA, Powers TS, Chen K, Wen PH, Whittington DA, Cheng AC, Bartberger MD, Hickman D, Werner JA, Vargas HM, Everds NE, Vonderfecht SL, Dunn RT 2nd, Wood S, Fremeau RT Jr, White RD, Patel VF.

Bioorg Med Chem Lett. 2015 Feb 15;25(4):767-74. doi: 10.1016/j.bmcl.2014.12.092. Epub 2015 Jan 8.

PMID:
25613679
8.

Optimization of potency and pharmacokinetic properties of tetrahydroisoquinoline transient receptor potential melastatin 8 (TRPM8) antagonists.

Horne DB, Tamayo NA, Bartberger MD, Bo Y, Clarine J, Davis CD, Gore VK, Kaller MR, Lehto SG, Ma VV, Nishimura N, Nguyen TT, Tang P, Wang W, Youngblood BD, Zhang M, Gavva NR, Monenschein H, Norman MH.

J Med Chem. 2014 Apr 10;57(7):2989-3004. doi: 10.1021/jm401955h. Epub 2014 Mar 19.

PMID:
24597733
9.

Abnormalities in myelination of the superior cerebellar peduncle in patients with schizophrenia and deficits in movement sequencing.

Hüttlova J, Kikinis Z, Kerkovsky M, Bouix S, Vu MA, Makris N, Shenton M, Kasparek T.

Cerebellum. 2014 Aug;13(4):415-24. doi: 10.1007/s12311-014-0550-y.

PMID:
24550129
10.

Working memory in schizotypal personality disorder: fMRI activation and deactivation differences.

Vu MA, Thermenos HW, Terry DP, Wolfe DJ, Voglmaier MM, Niznikiewicz MA, McCarley RW, Seidman LJ, Dickey CC.

Schizophr Res. 2013 Dec;151(1-3):113-23. doi: 10.1016/j.schres.2013.09.013. Epub 2013 Oct 23.

PMID:
24161536
11.

Age-related changes in prefrontal and hippocampal contributions to relational encoding.

Addis DR, Giovanello KS, Vu MA, Schacter DL.

Neuroimage. 2014 Jan 1;84:19-26. doi: 10.1016/j.neuroimage.2013.08.033. Epub 2013 Aug 27.

12.

White matter microstructure in individuals at clinical high risk of psychosis: a whole-brain diffusion tensor imaging study.

von Hohenberg CC, Pasternak O, Kubicki M, Ballinger T, Vu MA, Swisher T, Green K, Giwerc M, Dahlben B, Goldstein JM, Woo TU, Petryshen TL, Mesholam-Gately RI, Woodberry KA, Thermenos HW, Mulert C, McCarley RW, Seidman LJ, Shenton ME.

Schizophr Bull. 2014 Jul;40(4):895-903. doi: 10.1093/schbul/sbt079. Epub 2013 Jun 4.

13.

Prosodic abnormalities in schizotypal personality disorder.

Dickey CC, Vu MA, Voglmaier MM, Niznikiewicz MA, McCarley RW, Panych LP.

Schizophr Res. 2012 Dec;142(1-3):20-30. doi: 10.1016/j.schres.2012.09.006. Epub 2012 Oct 12.

14.

A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury.

Shenton ME, Hamoda HM, Schneiderman JS, Bouix S, Pasternak O, Rathi Y, Vu MA, Purohit MP, Helmer K, Koerte I, Lin AP, Westin CF, Kikinis R, Kubicki M, Stern RA, Zafonte R.

Brain Imaging Behav. 2012 Jun;6(2):137-92. doi: 10.1007/s11682-012-9156-5. Review.

15.

Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists.

Tamayo NA, Bo Y, Gore V, Ma V, Nishimura N, Tang P, Deng H, Klionsky L, Lehto SG, Wang W, Youngblood B, Chen J, Correll TL, Bartberger MD, Gavva NR, Norman MH.

J Med Chem. 2012 Feb 23;55(4):1593-611. doi: 10.1021/jm2013634. Epub 2012 Feb 13.

PMID:
22329507
16.

Structure-activity relationship (SAR) investigations of tetrahydroquinolines as BKCa agonists.

Gore VK, Ma VV, Yin R, Ligutti J, Immke D, Doherty EM, Norman MH.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3573-8. doi: 10.1016/j.bmcl.2010.04.125. Epub 2010 May 20.

PMID:
20493696
17.

Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress.

Hains AB, Vu MA, Maciejewski PK, van Dyck CH, Gottron M, Arnsten AF.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17957-62. doi: 10.1073/pnas.0908563106. Epub 2009 Sep 11.

18.

Constructive episodic simulation of the future and the past: distinct subsystems of a core brain network mediate imagining and remembering.

Addis DR, Pan L, Vu MA, Laiser N, Schacter DL.

Neuropsychologia. 2009 Sep;47(11):2222-38. doi: 10.1016/j.neuropsychologia.2008.10.026. Epub 2008 Nov 11.

PMID:
19041331
19.

Blockade of IP3-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memory.

Brennan AR, Dolinsky B, Vu MA, Stanley M, Yeckel MF, Arnsten AF.

Learn Mem. 2008 Feb 19;15(3):93-6. doi: 10.1101/lm.767408. Print 2008 Mar.

20.

Structure-activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists.

Gore VK, Ma VV, Tamir R, Gavva NR, Treanor JJ, Norman MH.

Bioorg Med Chem Lett. 2007 Nov 1;17(21):5825-30. Epub 2007 Aug 25.

PMID:
17851073
21.

Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties.

Wang HL, Katon J, Balan C, Bannon AW, Bernard C, Doherty EM, Dominguez C, Gavva NR, Gore V, Ma V, Nishimura N, Surapaneni S, Tang P, Tamir R, Thiel O, Treanor JJ, Norman MH.

J Med Chem. 2007 Jul 26;50(15):3528-39. Epub 2007 Jun 22.

PMID:
17585751
22.

Solid-phase synthesis and structure-activity relationships of novel biarylethers as melanin-concentrating hormone receptor-1 antagonists.

Ma V, Bannon AW, Baumgartner J, Hale C, Hsieh F, Hulme C, Rorrer K, Salon J, van Staden C, Tempest P.

Bioorg Med Chem Lett. 2006 Oct 1;16(19):5066-72. Epub 2006 Aug 1.

PMID:
16887348
23.

Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles.

Ognyanov VI, Balan C, Bannon AW, Bo Y, Dominguez C, Fotsch C, Gore VK, Klionsky L, Ma VV, Qian YX, Tamir R, Wang X, Xi N, Xu S, Zhu D, Gavva NR, Treanor JJ, Norman MH.

J Med Chem. 2006 Jun 15;49(12):3719-42.

PMID:
16759115
24.

Angiographic and clinical outcomes after rescue coronary stenting.

Dauerman HL, Prpic R, Andreou C, Vu MA, Popma JJ.

Catheter Cardiovasc Interv. 2000 Jul;50(3):269-75.

PMID:
10878620

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