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2011 1
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VSTM2L contributes to anoikis resistance and acts as a novel biomarker for metastasis and clinical outcome in ovarian cancer.
Li Y, Zhang J, Cai Y, Liu H, Yang W, Xu Y, Huang M. Li Y, et al. Biochem Biophys Res Commun. 2023 May 28;658:107-115. doi: 10.1016/j.bbrc.2023.03.073. Epub 2023 Apr 1. Biochem Biophys Res Commun. 2023. PMID: 37030064
Mechanistically, GSEA highlighted that epithelial-mesenchymal transition (EMT)-related pathways was positively associated with VSTM2L expression. Consistently, the validation based on the VSTM2L silence suggested the involvement of VSTM2L in EMT-related TGF-b …
Mechanistically, GSEA highlighted that epithelial-mesenchymal transition (EMT)-related pathways was positively associated with VSTM2L …
High Expression of VSTM2L Induced Resistance to Chemoradiotherapy in Rectal Cancer through Downstream IL-4 Signaling.
Liu H, Zhang Z, Zhen P, Zhou M. Liu H, et al. J Immunol Res. 2021 Jan 8;2021:6657012. doi: 10.1155/2021/6657012. eCollection 2021. J Immunol Res. 2021. PMID: 33506057 Free PMC article.
High expression of VSTM2L was significantly associated with tumor regression after pCRT (P = 0.030). Moreover, high expression of VSTM2L reduced gamma-H2AX expression in rectal cancer patient-derived organoids treated with CRT. ...
High expression of VSTM2L was significantly associated with tumor regression after pCRT (P = 0.030). Moreover, high expression of …
VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin.
Rossini L, Hashimoto Y, Suzuki H, Kurita M, Gianfriddo M, Scali C, Roncarati R, Franceschini D, Pollio G, Trabalzini L, Terstappen GC, Matsuoka M, Caricasole A. Rossini L, et al. FASEB J. 2011 Jun;25(6):1983-2000. doi: 10.1096/fj.10-163535. Epub 2011 Mar 10. FASEB J. 2011. PMID: 21393573
When tested in HN neuroprotection bioassays, VSTM2L acts as a strong antagonist of HN neuroprotective activity. In summary, VSTM2L is the first example of a secreted antagonist of HN and may play a role in the modulation of HN biological functions....
When tested in HN neuroprotection bioassays, VSTM2L acts as a strong antagonist of HN neuroprotective activity. In summary, VSTM2L …
VSTM2L is a promising therapeutic target and a prognostic soluble-biomarker in cholangiocarcinoma.
Lee J, Sim W, Lee J, Kim JH. Lee J, et al. BMB Rep. 2024 Apr 23:6090. Online ahead of print. BMB Rep. 2024. PMID: 38649146 Free article.
The aim of the present study is to provide a rational background for silencing the V-set and transmembrane domain containing 2 like (VSTM2L) in consort with recognising soluble VSTM2L against cholangiocarcinoma. ...In silico analysis showed that VSTM2L affect …
The aim of the present study is to provide a rational background for silencing the V-set and transmembrane domain containing 2 like (VSTM …
Pan-Cancer Analysis Reveals the Multidimensional Expression and Prognostic and Immunologic Roles of VSTM2L in Cancer.
Zhang S, Xiong H, Yang J, Yuan X. Zhang S, et al. Front Mol Biosci. 2022 Jan 27;8:792154. doi: 10.3389/fmolb.2021.792154. eCollection 2021. Front Mol Biosci. 2022. PMID: 35155565 Free PMC article.
In conclusion, VSTM2L has prognostic value in various cancers and can predict both poor (STAD) and good (KIRP) outcomes. The relationship between VSTM2L expression and immune markers suggests a role in modulating the TIME....
In conclusion, VSTM2L has prognostic value in various cancers and can predict both poor (STAD) and good (KIRP) outcomes. The relation …
Genome-wide analysis identified novel susceptible genes of restless legs syndrome in migraineurs.
Jiang YJ, Fann CS, Fuh JL, Chung MY, Huang HY, Chu KC, Wang YF, Hsu CL, Kao LS, Chen SP, Wang SJ. Jiang YJ, et al. J Headache Pain. 2022 Mar 29;23(1):39. doi: 10.1186/s10194-022-01409-9. J Headache Pain. 2022. PMID: 35350973 Free PMC article.
Transcriptional CRISPR/dCas9 knockdown and transient CRISPR/Cas9 knockout of vstm2l and ccdc141 replicated the findings observed in translationally knocked-down morphants. CONCLUSIONS: Our GWAS and functional analysis suggest VSTM2L and CCDC141 are highly relevant t …
Transcriptional CRISPR/dCas9 knockdown and transient CRISPR/Cas9 knockout of vstm2l and ccdc141 replicated the findings observed in t …
A genome-wide association study for varicose veins.
Lee ML, Liang C, Chuang CH, Lee PS, Chen TH, Sun S, Liao KW, Huang HD. Lee ML, et al. Phlebology. 2022 May;37(4):267-278. doi: 10.1177/02683555211069248. Epub 2022 Jan 31. Phlebology. 2022. PMID: 35099328
RESULTS: After comparison of genetic information of ninety-six patients to that of healthy controls, two significant single nucleotide polymorphisms (SNPs) were identified. One was in DPYSL2 gene, and the other was in VSTM2L gene. A further comparison between C2-3 patient …
RESULTS: After comparison of genetic information of ninety-six patients to that of healthy controls, two significant single nucleotide polym …
The Molecular Structure and Role of Humanin in Neural and Skeletal Diseases, and in Tissue Regeneration.
Zhu S, Hu X, Bennett S, Xu J, Mai Y. Zhu S, et al. Front Cell Dev Biol. 2022 Mar 16;10:823354. doi: 10.3389/fcell.2022.823354. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35372353 Free PMC article. Review.
Additionally, it interacts with CNTFR-alpha/gp130/WSX-1 trimeric receptors to induce JAK2/STA3 signalling cascades. HN also binds soluble extracellular proteins such as VSTM2L and IGFBP3 to modulate cytoprotection. It is reported that HN plays a role in neuronal disorders …
Additionally, it interacts with CNTFR-alpha/gp130/WSX-1 trimeric receptors to induce JAK2/STA3 signalling cascades. HN also binds soluble ex …
The Value of the Stemness Index in Ovarian Cancer Prognosis.
Yuan H, Yu Q, Pang J, Chen Y, Sheng M, Tang W. Yuan H, et al. Genes (Basel). 2022 May 31;13(6):993. doi: 10.3390/genes13060993. Genes (Basel). 2022. PMID: 35741755 Free PMC article.
Among these genes, the expression levels of nine, including SFRP2, MFAP4, CCDC80, COL16A1, DUSP1, VSTM2L, TGFBI, PXDN, and GAS1, were increased in the high-risk group. ...
Among these genes, the expression levels of nine, including SFRP2, MFAP4, CCDC80, COL16A1, DUSP1, VSTM2L, TGFBI, PXDN, and GAS1, were …
Identification of Tumor Antigens and Immune Subtypes of High-grade Serous Ovarian Cancer for mRNA Vaccine Development.
Wu Y, Li Z, Lin H, Wang H. Wu Y, et al. J Cancer. 2023 Aug 28;14(14):2655-2669. doi: 10.7150/jca.87184. eCollection 2023. J Cancer. 2023. PMID: 37779866 Free PMC article.
Based on transcription data from The Cancer Genome Atlas (TCGA), we identified four tumour-specific antigens for vaccine production: ARPC1B, ELF3, VSTM2L, and IL27RA. In addition to being associated with HGSC patient prognosis, the expression of these antigens was positive …
Based on transcription data from The Cancer Genome Atlas (TCGA), we identified four tumour-specific antigens for vaccine production: ARPC1B, …
14 results