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Identification and Validation of a Biomarker Signature in Patients With Resectable Pancreatic Cancer via Genome-Wide Screening for Functional Genetic Variants.

Dimitrakopoulos C, Vrugt B, Flury R, Schraml P, Knippschild U, Wild P, Hoerstrup S, Henne-Bruns D, Wuerl P, Graf R, Breitenstein S, Bond G, Beerenwinkel N, Grochola LF.

JAMA Surg. 2019 Apr 3:e190484. doi: 10.1001/jamasurg.2019.0484. [Epub ahead of print]


Visualisation of interstitial lung disease by molecular imaging of integrin αvβ3 and somatostatin receptor 2.

Schniering J, Benešová M, Brunner M, Haller S, Cohrs S, Frauenfelder T, Vrugt B, Feghali-Bostwick CA, Schibli R, Distler O, Mueller C, Maurer B.

Ann Rheum Dis. 2019 Feb;78(2):218-227. doi: 10.1136/annrheumdis-2018-214322. Epub 2018 Nov 17. Erratum in: Ann Rheum Dis. 2019 Jun;78(6):e60.


Liver Allograft Failure After Nivolumab Treatment-A Case Report With Systematic Literature Research.

Gassmann D, Weiler S, Mertens JC, Reiner CS, Vrugt B, Nägeli M, Mangana J, Müllhaupt B, Jenni F, Misselwitz B.

Transplant Direct. 2018 Jul 20;4(8):e376. doi: 10.1097/TXD.0000000000000814. eCollection 2018 Aug.


Preoperative Evaluation of Pancreatic Fibrosis and Lipomatosis: Correlation of Magnetic Resonance Findings With Histology Using Magnetization Transfer Imaging and Multigradient Echo Magnetic Resonance Imaging.

Schawkat K, Eshmuminov D, Lenggenhager D, Endhardt K, Vrugt B, Boss A, Petrowsky H, Clavien PA, Reiner CS.

Invest Radiol. 2018 Dec;53(12):720-727. doi: 10.1097/RLI.0000000000000496.


Computer-Based Intensity Measurement Assists Pathologists in Scoring Phosphatase and Tensin Homolog Immunohistochemistry - Clinical Associations in NSCLC Patients of the European Thoracic Oncology Platform Lungscape Cohort.

Rulle U, Tsourti Z, Casanova R, Deml KF, Verbeken E, Thunnissen E, Warth A, Cheney R, Sejda A, Speel EJ, Madsen LB, Nonaka D, Navarro A, Sansano I, Marchetti A, Finn SP, Monkhorst K, Kerr KM, Haberecker M, Wu C, Zygoura P, Kammler R, Geiger T, Gendreau S, Schulze K, Vrugt B, Wild P, Moch H, Weder W, Ciftlik AT, Dafni U, Peters S, Bubendorf L, Stahel RA, Soltermann A.

J Thorac Oncol. 2018 Dec;13(12):1851-1863. doi: 10.1016/j.jtho.2018.08.2034. Epub 2018 Sep 18.


Gemcitabine Synergizes with Immune Checkpoint Inhibitors and Overcomes Resistance in a Preclinical Model and Mesothelioma Patients.

Tallón de Lara P, Cecconi V, Hiltbrunner S, Yagita H, Friess M, Bode B, Opitz I, Vrugt B, Weder W, Stolzmann P, Felley-Bosco E, Stahel RA, Tischler V, Britschgi C, Soldini D, van den Broek M, Curioni-Fontecedro A.

Clin Cancer Res. 2018 Dec 15;24(24):6345-6354. doi: 10.1158/1078-0432.CCR-18-1231. Epub 2018 Aug 28.


Absence of calretinin protein expression in malignant mesotheliomas from asbestos-exposed NF2+/- mice and mouse mesothelioma cell lines from various mouse strains.

Blum W, Henzi T, Châtel-Soulet HE, Pecze L, Rodriguez JW, Vrugt B, Schwaller B.

Biomark Res. 2018 Jun 6;6:19. doi: 10.1186/s40364-018-0132-0. eCollection 2018.


Heterogeneity in Malignant Pleural Mesothelioma.

Oehl K, Vrugt B, Opitz I, Meerang M.

Int J Mol Sci. 2018 May 30;19(6). pii: E1603. doi: 10.3390/ijms19061603. Review.


Urokinase application for hemothorax in pulmonary mucormycosis.

Hodel L, Inci I, Schanz U, Vrugt B, Weder W, Hillinger S.

J Thorac Dis. 2018 Mar;10(3):E175-E178. doi: 10.21037/jtd.2018.03.01.


MRI and PET-CT Failed to Differentiate Between Hepatic Malignancy and Brucelloma.

Schreiber PW, Schmid A, Fagagnini S, Kröger A, Vrugt B, Reiner CS, Boggian K, Schiesser M, Müllhaupt B, Günthard HF.

Open Forum Infect Dis. 2018 Mar 8;5(4):ofy052. doi: 10.1093/ofid/ofy052. eCollection 2018 Apr.


Targeted next-generation-sequencing for reliable detection of targetable rearrangements in lung adenocarcinoma-a single center retrospective study.

Velizheva NP, Rechsteiner MP, Valtcheva N, Freiberger SN, Wong CE, Vrugt B, Zhong Q, Wagner U, Moch H, Hillinger S, Schmitt-Opitz I, Soltermann A, Wild PJ, Tischler V.

Pathol Res Pract. 2018 Apr;214(4):572-578. doi: 10.1016/j.prp.2018.02.001. Epub 2018 Feb 16.


Live-Cell Mesothelioma Biobank to Explore Mechanisms of Tumor Progression.

Oehl K, Kresoja-Rakic J, Opitz I, Vrugt B, Weder W, Stahel R, Wild P, Felley-Bosco E.

Front Oncol. 2018 Feb 23;8:40. doi: 10.3389/fonc.2018.00040. eCollection 2018.


How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations.

Rehrauer H, Wu L, Blum W, Pecze L, Henzi T, Serre-Beinier V, Aquino C, Vrugt B, de Perrot M, Schwaller B, Felley-Bosco E.

Oncogene. 2018 May;37(20):2645-2659. doi: 10.1038/s41388-018-0153-z. Epub 2018 Mar 6.


Nuclear grade and necrosis predict prognosis in malignant epithelioid pleural mesothelioma: a multi-institutional study.

Rosen LE, Karrison T, Ananthanarayanan V, Gallan AJ, Adusumilli PS, Alchami FS, Attanoos R, Brcic L, Butnor KJ, Galateau-Sallé F, Hiroshima K, Kadota K, Klampatsa A, Stang NL, Lindenmann J, Litzky LA, Marchevsky A, Medeiros F, Montero MA, Moore DA, Nabeshima K, Pavlisko EN, Roggli VL, Sauter JL, Sharma A, Sheaff M, Travis WD, Vigneswaran WT, Vrugt B, Walts AE, Tjota MY, Krausz T, Husain AN.

Mod Pathol. 2018 Apr;31(4):598-606. doi: 10.1038/modpathol.2017.170. Epub 2018 Jan 12.


Acute pulmonary embolism and multiple pulmonary nodules mimicking metastatic disease.

Brüstle K, Zachariassen K, Vrugt B, Frauenfelder T, Weder W, Franzen D.

Thorax. 2018 Feb;73(2):193-194. doi: 10.1136/thoraxjnl-2017-210435. Epub 2017 Aug 31. No abstract available.


Erratum to: Establishment of immortalized murine mesothelial cells and a novel mesothelioma cell line.

Blum W, Pecze L, Felley-Bosco E, Worthmüller-Rodriguez J, Wu L, Vrugt B, de Perrot M, Schwaller B.

In Vitro Cell Dev Biol Anim. 2017 Oct;53(9):853. doi: 10.1007/s11626-017-0194-6. No abstract available.


Sarcoidosis as a rare cause for symmetrical giant bullous disease.

Jungraithmayr W, Leggeri E, Weder W, Vrugt B.

BMC Pulm Med. 2017 May 30;17(1):88. doi: 10.1186/s12890-017-0429-z.


Development of Allograft Cancer after Lung Transplantation: A Case Report.

Schwarz EI, Vrugt B, Huber LC, Murer C, Schuurmans MM, Inci I, Benden C.

Ann Thorac Cardiovasc Surg. 2017 Aug 20;23(4):196-199. doi: 10.5761/ Epub 2017 Mar 29.


Morphoproteomic Characterization of Lung Squamous Cell Carcinoma Fragmentation, a Histological Marker of Increased Tumor Invasiveness.

Casanova R, Xia D, Rulle U, Nanni P, Grossmann J, Vrugt B, Wettstein R, Ballester-Ripoll R, Astolfo A, Weder W, Moch H, Stampanoni M, Beck AH, Soltermann A.

Cancer Res. 2017 May 15;77(10):2585-2593. doi: 10.1158/0008-5472.CAN-16-2363. Epub 2017 Mar 31. Erratum in: Cancer Res. 2018 Feb 1;78(3):841.


Placental transmogrification of the lung presenting as progressive symptomatic bullous emphysema.

Brüstle K, Lema S, Komminoth P, Weder W, Vrugt B, Jungraithmayr W.

Thorax. 2017 Mar;72(3):284-285. doi: 10.1136/thoraxjnl-2016-208914. Epub 2016 Sep 8. No abstract available.


Low Merlin expression and high Survivin labeling index are indicators for poor prognosis in patients with malignant pleural mesothelioma.

Meerang M, Bérard K, Friess M, Bitanihirwe BK, Soltermann A, Vrugt B, Felley-Bosco E, Bueno R, Richards WG, Seifert B, Stahel R, Weder W, Opitz I.

Mol Oncol. 2016 Oct;10(8):1255-65. doi: 10.1016/j.molonc.2016.06.005. Epub 2016 Jun 25.


CD44 SNPrs187115: A Novel Biomarker Signature that Predicts Survival in Resectable Pancreatic Ductal Adenocarcinoma.

Stracquadanio G, Vrugt B, Flury R, Schraml P, Würl P, Müller TH, Knippschild U, Henne-Bruns D, Breitenstein S, Clavien PA, Graf R, Bond GL, Grochola LF.

Clin Cancer Res. 2016 Dec 15;22(24):6069-6077. Epub 2016 Jun 9.


Reactive Pulmonary Capillary Hemangiomatosis and Pulmonary Veno-Occlusive Disease in a Patient with Repaired Scimitar Syndrome.

Güttinger E, Vrugt B, Speich R, Ulrich S, Schwitz F, Arrigo M, Huber LC.

Case Rep Cardiol. 2016;2016:9384126. doi: 10.1155/2016/9384126. Epub 2016 Mar 16.


Antagonizing the Hedgehog Pathway with Vismodegib Impairs Malignant Pleural Mesothelioma Growth In Vivo by Affecting Stroma.

Meerang M, Bérard K, Felley-Bosco E, Lauk O, Vrugt B, Boss A, Kenkel D, Broggini-Tenzer A, Stahel RA, Arni S, Weder W, Opitz I.

Mol Cancer Ther. 2016 May;15(5):1095-105. doi: 10.1158/1535-7163.MCT-15-0583. Epub 2016 Feb 2.


Variable Pringle Maneuvers and Effect on Intestinal Epithelium in Rats. A Pilot Experimental Study in Rats.

Dimitroulis D, Moris D, Pikoulis E, Spartalis E, Kontadakis G, Vrugt B, Valsami S, Kouraklis G.

PLoS One. 2015 Oct 23;10(10):e0140707. doi: 10.1371/journal.pone.0140707. eCollection 2015.


Expression of the Stem Cell Factor Nestin in Malignant Pleural Mesothelioma Is Associated with Poor Prognosis.

Thies S, Friess M, Frischknecht L, Korol D, Felley-Bosco E, Stahel R, Vrugt B, Weder W, Opitz I, Soltermann A.

PLoS One. 2015 Sep 30;10(9):e0139312. doi: 10.1371/journal.pone.0139312. eCollection 2015.


Old dilemma: asthma with irreversible airway obstruction or COPD.

Fattahi F, Vonk JM, Bulkmans N, Fleischeuer R, Gouw A, Grünberg K, Mauad T, Popper H, Felipe-Silva A, Vrugt B, Wright JL, Yang HM, Kocks JW, Hylkema MN, Postma DS, Timens W, Ten Hacken NH.

Virchows Arch. 2015 Nov;467(5):583-93. doi: 10.1007/s00428-015-1824-6. Epub 2015 Sep 14.


Establishment of immortalized murine mesothelial cells and a novel mesothelioma cell line.

Blum W, Pecze L, Felley-Bosco E, Worthmüller-Rodriguez J, Wu L, Vrugt B, de Perrot M, Schwaller B.

In Vitro Cell Dev Biol Anim. 2015 Aug;51(7):714-21. doi: 10.1007/s11626-015-9885-z. Epub 2015 Apr 15. Erratum in: In Vitro Cell Dev Biol Anim. 2017 Aug 24;:.


Endoscopic resection of a diverticulum-arisen colonic adenoma using a full-thickness resection device.

Valli PV, Kaufmann M, Vrugt B, Bauerfeind P.

Gastroenterology. 2014 Nov;147(5):969-71. doi: 10.1053/j.gastro.2014.07.053. Epub 2014 Aug 2. No abstract available.


Middle ear adenoma: case report and discussion.

Isenring D, Pezier TF, Vrugt B, Huber AM.

Case Rep Otolaryngol. 2014;2014:342125. doi: 10.1155/2014/342125. Epub 2014 Jun 22.


GAS5 long non-coding RNA in malignant pleural mesothelioma.

Renganathan A, Kresoja-Rakic J, Echeverry N, Ziltener G, Vrugt B, Opitz I, Stahel RA, Felley-Bosco E.

Mol Cancer. 2014 May 23;13:119. doi: 10.1186/1476-4598-13-119.


Integrated ¹⁸F-FDG PET/perfusion CT for the monitoring of neoadjuvant chemoradiotherapy in rectal carcinoma: correlation with histopathology.

Fischer MA, Vrugt B, Alkadhi H, Hahnloser D, Hany TF, Veit-Haibach P.

Eur J Nucl Med Mol Imaging. 2014 Aug;41(8):1563-73. doi: 10.1007/s00259-014-2752-4. Epub 2014 Apr 24.


Inflammatory cytokines in pulmonary hypertension.

Groth A, Vrugt B, Brock M, Speich R, Ulrich S, Huber LC.

Respir Res. 2014 Apr 16;15:47. doi: 10.1186/1465-9921-15-47. Review.


Correlation of immunohistochemical staining p63 and TTF-1 with EGFR and K-ras mutational spectrum and diagnostic reproducibility in non small cell lung carcinoma.

Thunnissen E, Boers E, Heideman DA, Grünberg K, Kuik DJ, Noorduin A, van Oosterhout M, Pronk D, Seldenrijk C, Sietsma H, Smit EF, van Suylen R, von der Thusen J, Vrugt B, Wiersma A, Witte BI, den Bakker M.

Virchows Arch. 2012 Dec;461(6):629-38. doi: 10.1007/s00428-012-1324-x. Epub 2012 Oct 12.


Small cell carcinoma of the lung and large cell neuroendocrine carcinoma interobserver variability.

den Bakker MA, Willemsen S, Grünberg K, Noorduijn LA, van Oosterhout MF, van Suylen RJ, Timens W, Vrugt B, Wiersma-van Tilburg A, Thunnissen FB.

Histopathology. 2010 Feb;56(3):356-63. doi: 10.1111/j.1365-2559.2010.03486.x.


[Gout as an unusual cause of pelvic pain].

van den Berge M, Vrugt B, Holt C, Smit CJ, Hoogenberg K.

Ned Tijdschr Geneeskd. 2006 Jan 21;150(3):151-4. Dutch.


Growth factor-induced contraction of human bronchial smooth muscle is Rho-kinase-dependent.

Gosens R, Schaafsma D, Grootte Bromhaar MM, Vrugt B, Zaagsma J, Meurs H, Nelemans SA.

Eur J Pharmacol. 2004 Jun 21;494(1):73-6.


A 71-yr-old male with increasing dyspnoea, cough and an intrathoracic mass.

Seebus E, Vrugt B, de Jong RS, Aalbers R.

Eur Respir J. 2003 Dec;22(6):1042-5. No abstract available.


The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma.

Hamilton LM, Torres-Lozano C, Puddicombe SM, Richter A, Kimber I, Dearman RJ, Vrugt B, Aalbers R, Holgate ST, Djukanović R, Wilson SJ, Davies DE.

Clin Exp Allergy. 2003 Feb;33(2):233-40.


Increased expression of p21(waf) cyclin-dependent kinase inhibitor in asthmatic bronchial epithelium.

Puddicombe SM, Torres-Lozano C, Richter A, Bucchieri F, Lordan JL, Howarth PH, Vrugt B, Albers R, Djukanovic R, Holgate ST, Wilson SJ, Davies DE.

Am J Respir Cell Mol Biol. 2003 Jan;28(1):61-8.


A 49-year-old woman with well-differentiated fetal adenocarcinoma.

Politiek MJ, Vrugt B, Aalbers R.

Neth J Med. 2001 Apr;58(4):177-80.


Bronchial angiogenesis in severe glucocorticoid-dependent asthma.

Vrugt B, Wilson S, Bron A, Holgate ST, Djukanovic R, Aalbers R.

Eur Respir J. 2000 Jun;15(6):1014-21.


Mucosal inflammation in severe glucocorticoid-dependent asthma.

Vrugt B, Wilson S, Underwood J, Bron A, de Bruyn R, Bradding P, Holgate ST, Djukanovic R, Aalbers R.

Eur Respir J. 1999 Jun;13(6):1245-52.


Effects of high dose intravenous immunoglobulin in two severe corticosteroid insensitive asthmatic patients.

Vrugt B, Wilson S, van Velzen E, Bron A, Shute JK, Holgate ST, Djukanovic R, Aalbers R.

Thorax. 1997 Jul;52(7):662-4.


Free and complexed interleukin-8 in blood and bronchial mucosa in asthma.

Shute JK, Vrugt B, Lindley IJ, Holgate ST, Bron A, Aalbers R, Djukanović R.

Am J Respir Crit Care Med. 1997 Jun;155(6):1877-83.


New insights into the pathogenesis of severe corticosteroid-dependent asthma.

Vrugt B, Djukanović R, Bron A, Aalbers R.

J Allergy Clin Immunol. 1996 Nov;98(5 Pt 2):S22-6; discussion S33-40. Review.


Determinants of asthma severity.

Djukanović R, Howarth P, Vrugt B, Wilson S, Semper A, Bradding P, Aalbers R, Holgate S.

Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):389. No abstract available.


Inflammation and bronchial hyperresponsiveness in allergic asthma and chronic obstructive pulmonary disease.

Vrugt B, Aalbers R.

Respir Med. 1993 Aug;87 Suppl B:3-7. Review. No abstract available.


Dynamics of eosinophil infiltration in the bronchial mucosa before and after the late asthmatic reaction.

Aalbers R, de Monchy JG, Kauffman HF, Smith M, Hoekstra Y, Vrugt B, Timens W.

Eur Respir J. 1993 Jun;6(6):840-7.


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