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Items: 1 to 50 of 67

1.

Targeted Drug and Metabolite Imaging: Desorption Electrospray Ionization Combined with Triple Quadrupole Mass Spectrometry.

Lamont L, Eijkel GB, Jones EA, Flinders B, Ellis SR, Porta Siegel T, Heeren RMA, Vreeken RJ.

Anal Chem. 2018 Nov 6. doi: 10.1021/acs.analchem.8b03857. [Epub ahead of print]

PMID:
30346139
2.

Cross-Species Molecular Imaging of Bile Salts and Lipids in Liver: Identification of Molecular Structural Markers in Health and Disease.

Flinders B, Huizing LRS, van Heerden M, Cuyckens F, Neumann UP, van der Laan LJW, Olde Damink SWM, Heeren RMA, Schaap FG, Vreeken RJ.

Anal Chem. 2018 Oct 16;90(20):11835-11846. doi: 10.1021/acs.analchem.8b01378. Epub 2018 Oct 4.

3.

Ionisation efficiencies can be predicted in complicated biological matrices: A proof of concept.

Liigand P, Liigand J, Cuyckens F, Vreeken RJ, Kruve A.

Anal Chim Acta. 2018 Nov 22;1032:68-74. doi: 10.1016/j.aca.2018.05.072. Epub 2018 May 31.

PMID:
30143223
4.

Mass spectrometric recommendations for Quan/Qual analysis using liquid-chromatography coupled to quadrupole time-of-flight mass spectrometry.

Dubbelman AC, Cuyckens F, Dillen L, Gross G, Vreeken RJ, Hankemeier T.

Anal Chim Acta. 2018 Aug 22;1020:62-75. doi: 10.1016/j.aca.2018.02.055. Epub 2018 Mar 3.

5.

Deregulation of secondary metabolism in a histone deacetylase mutant of Penicillium chrysogenum.

Guzman-Chavez F, Salo O, Samol M, Ries M, Kuipers J, Bovenberg RAL, Vreeken RJ, Driessen AJM.

Microbiologyopen. 2018 Oct;7(5):e00598. doi: 10.1002/mbo3.598. Epub 2018 Mar 24.

6.

Development and application of a UHPLC-MS/MS metabolomics based comprehensive systemic and tissue-specific screening method for inflammatory, oxidative and nitrosative stress.

Schoeman JC, Harms AC, van Weeghel M, Berger R, Vreeken RJ, Hankemeier T.

Anal Bioanal Chem. 2018 Apr;410(10):2551-2568. doi: 10.1007/s00216-018-0912-2. Epub 2018 Mar 2.

7.

Potent peptidic fusion inhibitors of influenza virus.

Kadam RU, Juraszek J, Brandenburg B, Buyck C, Schepens WBG, Kesteleyn B, Stoops B, Vreeken RJ, Vermond J, Goutier W, Tang C, Vogels R, Friesen RHE, Goudsmit J, van Dongen MJP, Wilson IA.

Science. 2017 Oct 27;358(6362):496-502. doi: 10.1126/science.aan0516. Epub 2017 Sep 28.

8.

High sensitivity and selectivity in quantitative analysis of drugs in biological samples using 4-column multidimensional micro-UHPLC-MS enabling enhanced sample loading capacity.

de Vries R, Vereyken L, François I, Dillen L, Vreeken RJ, Cuyckens F.

Anal Chim Acta. 2017 Oct 9;989:104-111. doi: 10.1016/j.aca.2017.07.067. Epub 2017 Aug 4.

PMID:
28915936
9.

Fetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants.

Schoeman JC, Moutloatse GP, Harms AC, Vreeken RJ, Scherpbier HJ, Van Leeuwen L, Kuijpers TW, Reinecke CJ, Berger R, Hankemeier T, Bunders MJ.

J Infect Dis. 2017 Aug 15;216(4):436-446. doi: 10.1093/infdis/jix291.

10.

Endometriosis is associated with aberrant metabolite profiles in plasma.

Letsiou S, Peterse DP, Fassbender A, Hendriks MM, van den Broek NJ, Berger R, O DF, Vanhie A, Vodolazkaia A, Van Langendonckt A, Donnez J, Harms AC, Vreeken RJ, Groothuis PG, Dolmans MM, Brenkman AB, D'Hooghe TM.

Fertil Steril. 2017 Mar;107(3):699-706.e6. doi: 10.1016/j.fertnstert.2016.12.032.

PMID:
28259259
11.

Metabolomics profiling of the free and total oxidised lipids in urine by LC-MS/MS: application in patients with rheumatoid arthritis.

Fu J, Schoeman JC, Harms AC, van Wietmarschen HA, Vreeken RJ, Berger R, Cuppen BV, Lafeber FP, van der Greef J, Hankemeier T.

Anal Bioanal Chem. 2016 Sep;408(23):6307-19. doi: 10.1007/s00216-016-9742-2. Epub 2016 Jul 12.

12.

Metabolic characterization of the natural progression of chronic hepatitis B.

Schoeman JC, Hou J, Harms AC, Vreeken RJ, Berger R, Hankemeier T, Boonstra A.

Genome Med. 2016 Jun 10;8(1):64. doi: 10.1186/s13073-016-0318-8.

13.

Serum-Based Oxylipins Are Associated with Outcomes in Primary Prevention Implantable Cardioverter Defibrillator Patients.

Zhang Y, Guallar E, Blasco-Colmenares E, Harms AC, Vreeken RJ, Hankemeier T, Tomaselli GF, Cheng A.

PLoS One. 2016 Jun 9;11(6):e0157035. doi: 10.1371/journal.pone.0157035. eCollection 2016.

14.

Identification of a Polyketide Synthase Involved in Sorbicillin Biosynthesis by Penicillium chrysogenum.

Salo O, Guzmán-Chávez F, Ries MI, Lankhorst PP, Bovenberg RAL, Vreeken RJ, Driessen AJM.

Appl Environ Microbiol. 2016 Jun 13;82(13):3971-3978. doi: 10.1128/AEM.00350-16. Print 2016 Jul 1.

15.

Enhanced performance for the analysis of prostaglandins and thromboxanes by liquid chromatography-tandem mass spectrometry using a new atmospheric pressure ionization source.

Lubin A, Geerinckx S, Bajic S, Cabooter D, Augustijns P, Cuyckens F, Vreeken RJ.

J Chromatogr A. 2016 Apr 1;1440:260-265. doi: 10.1016/j.chroma.2016.02.055. Epub 2016 Feb 22.

PMID:
26948759
16.

Collagen Induced Arthritis in DBA/1J Mice Associates with Oxylipin Changes in Plasma.

He M, van Wijk E, Berger R, Wang M, Strassburg K, Schoeman JC, Vreeken RJ, van Wietmarschen H, Harms AC, Kobayashi M, Hankemeier T, van der Greef J.

Mediators Inflamm. 2015;2015:543541. doi: 10.1155/2015/543541. Epub 2015 Oct 29.

17.

Genomic mutational analysis of the impact of the classical strain improvement program on β-lactam producing Penicillium chrysogenum.

Salo OV, Ries M, Medema MH, Lankhorst PP, Vreeken RJ, Bovenberg RA, Driessen AJ.

BMC Genomics. 2015 Nov 14;16:937. doi: 10.1186/s12864-015-2154-4.

18.

First-Trimester Serum Acylcarnitine Levels to Predict Preeclampsia: A Metabolomics Approach.

Koster MP, Vreeken RJ, Harms AC, Dane AD, Kuc S, Schielen PC, Hankemeier T, Berger R, Visser GH, Pennings JL.

Dis Markers. 2015;2015:857108. doi: 10.1155/2015/857108. Epub 2015 Jun 4.

19.

Matrix Effect Compensation in Small-Molecule Profiling for an LC-TOF Platform Using Multicomponent Postcolumn Infusion.

González O, van Vliet M, Damen CW, van der Kloet FM, Vreeken RJ, Hankemeier T.

Anal Chem. 2015 Jun 16;87(12):5921-9. doi: 10.1021/ac504268y. Epub 2015 May 27.

PMID:
25965142
20.

Modulation of stratum corneum lipid composition and organization of human skin equivalents by specific medium supplements.

Thakoersing VS, van Smeden J, Boiten WA, Gooris GS, Mulder AA, Vreeken RJ, El Ghalbzouri A, Bouwstra JA.

Exp Dermatol. 2015 Sep;24(9):669-74. doi: 10.1111/exd.12740. Epub 2015 Jul 14.

PMID:
25939986
21.

A mutasynthesis approach with a Penicillium chrysogenum ΔroqA strain yields new roquefortine D analogues.

Ouchaou K, Maire F, Salo O, Ali H, Hankemeier T, van der Marel GA, Filippov DV, Bovenberg RA, Vreeken RJ, Driessen AJ, Overkleeft HS.

Chembiochem. 2015 Apr 13;16(6):915-23. doi: 10.1002/cbic.201402686. Epub 2015 Mar 12.

PMID:
25766600
22.

Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity.

Dubbelman AC, Cuyckens F, Dillen L, Gross G, Hankemeier T, Vreeken RJ.

J Chromatogr A. 2014 Dec 29;1374:122-133. doi: 10.1016/j.chroma.2014.11.037. Epub 2014 Nov 20.

PMID:
25435462
23.

Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen.

Ordas A, Raterink RJ, Cunningham F, Jansen HJ, Wiweger MI, Jong-Raadsen S, Bos S, Bates RH, Barros D, Meijer AH, Vreeken RJ, Ballell-Pages L, Dirks RP, Hankemeier T, Spaink HP.

Antimicrob Agents Chemother. 2015 Feb;59(2):753-62. doi: 10.1128/AAC.03588-14. Epub 2014 Nov 10.

24.

Gas pressure assisted microliquid-liquid extraction coupled online to direct infusion mass spectrometry: a new automated screening platform for bioanalysis.

Raterink RJ, Witkam Y, Vreeken RJ, Ramautar R, Hankemeier T.

Anal Chem. 2014 Oct 21;86(20):10323-30. doi: 10.1021/ac502582f. Epub 2014 Oct 2.

PMID:
25243401
25.

Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry.

Ahonen L, Maire FB, Savolainen M, Kopra J, Vreeken RJ, Hankemeier T, Myöhänen T, Kylli P, Kostiainen R.

J Chromatogr A. 2014 Oct 17;1364:214-22. doi: 10.1016/j.chroma.2014.08.088. Epub 2014 Sep 2.

PMID:
25204266
26.

Metabolic phenotyping reveals a lipid mediator response to ionizing radiation.

Laiakis EC, Strassburg K, Bogumil R, Lai S, Vreeken RJ, Hankemeier T, Langridge J, Plumb RS, Fornace AJ Jr, Astarita G.

J Proteome Res. 2014 Sep 5;13(9):4143-54. doi: 10.1021/pr5005295. Epub 2014 Aug 15.

27.

Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability.

Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sànchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R.

CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3:e125. doi: 10.1038/psp.2014.22.

28.

Enhanced lipid isomer separation in human plasma using reversed-phase UPLC with ion-mobility/high-resolution MS detection.

Damen CW, Isaac G, Langridge J, Hankemeier T, Vreeken RJ.

J Lipid Res. 2014 Aug;55(8):1772-83. doi: 10.1194/jlr.D047795. Epub 2014 Jun 2.

29.

A non-canonical NRPS is involved in the synthesis of fungisporin and related hydrophobic cyclic tetrapeptides in Penicillium chrysogenum.

Ali H, Ries MI, Lankhorst PP, van der Hoeven RA, Schouten OL, Noga M, Hankemeier T, van Peij NN, Bovenberg RA, Vreeken RJ, Driessen AJ.

PLoS One. 2014 Jun 2;9(6):e98212. doi: 10.1371/journal.pone.0098212. eCollection 2014.

30.

Metabolomics profiling for identification of novel potential markers in early prediction of preeclampsia.

Kuc S, Koster MP, Pennings JL, Hankemeier T, Berger R, Harms AC, Dane AD, Schielen PC, Visser GH, Vreeken RJ.

PLoS One. 2014 May 29;9(5):e98540. doi: 10.1371/journal.pone.0098540. eCollection 2014. Erratum in: PLoS One. 2014;9(8):e106358.

31.

A protective lipidomic biosignature associated with a balanced omega-6/omega-3 ratio in fat-1 transgenic mice.

Astarita G, McKenzie JH, Wang B, Strassburg K, Doneanu A, Johnson J, Baker A, Hankemeier T, Murphy J, Vreeken RJ, Langridge J, Kang JX.

PLoS One. 2014 Apr 23;9(4):e96221. doi: 10.1371/journal.pone.0096221. eCollection 2014.

32.

Integrating metabolomics profiling measurements across multiple biobanks.

Dane AD, Hendriks MM, Reijmers TH, Harms AC, Troost J, Vreeken RJ, Boomsma DI, van Duijn CM, Slagboom EP, Hankemeier T.

Anal Chem. 2014 May 6;86(9):4110-4. doi: 10.1021/ac404191a. Epub 2014 Apr 16.

PMID:
24650176
33.

The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients.

van Smeden J, Janssens M, Kaye EC, Caspers PJ, Lavrijsen AP, Vreeken RJ, Bouwstra JA.

Exp Dermatol. 2014 Jan;23(1):45-52. doi: 10.1111/exd.12293.

PMID:
24299153
34.

Intercellular skin barrier lipid composition and organization in Netherton syndrome patients.

van Smeden J, Janssens M, Boiten WA, van Drongelen V, Furio L, Vreeken RJ, Hovnanian A, Bouwstra JA.

J Invest Dermatol. 2014 May;134(5):1238-1245. doi: 10.1038/jid.2013.517. Epub 2013 Nov 29.

35.

Novel key metabolites reveal further branching of the roquefortine/meleagrin biosynthetic pathway.

Ries MI, Ali H, Lankhorst PP, Hankemeier T, Bovenberg RA, Driessen AJ, Vreeken RJ.

J Biol Chem. 2013 Dec 27;288(52):37289-95. doi: 10.1074/jbc.M113.512665. Epub 2013 Nov 13.

36.

Postprandial fatty acid specific changes in circulating oxylipins in lean and obese men after high-fat challenge tests.

Strassburg K, Esser D, Vreeken RJ, Hankemeier T, Müller M, van Duynhoven J, van Golde J, van Dijk SJ, Afman LA, Jacobs DM.

Mol Nutr Food Res. 2014 Mar;58(3):591-600. doi: 10.1002/mnfr.201300321. Epub 2013 Oct 14.

PMID:
24127338
37.

Combined LC/MS-platform for analysis of all major stratum corneum lipids, and the profiling of skin substitutes.

van Smeden J, Boiten WA, Hankemeier T, Rissmann R, Bouwstra JA, Vreeken RJ.

Biochim Biophys Acta. 2014 Jan;1841(1):70-9. doi: 10.1016/j.bbalip.2013.10.002. Epub 2013 Oct 11.

PMID:
24120918
38.

A branched biosynthetic pathway is involved in production of roquefortine and related compounds in Penicillium chrysogenum.

Ali H, Ries MI, Nijland JG, Lankhorst PP, Hankemeier T, Bovenberg RA, Vreeken RJ, Driessen AJ.

PLoS One. 2013 Jun 12;8(6):e65328. doi: 10.1371/journal.pone.0065328. Print 2013.

39.

Three-phase electroextraction: a new (online) sample purification and enrichment method for bioanalysis.

Raterink RJ, Lindenburg PW, Vreeken RJ, Hankemeier T.

Anal Chem. 2013 Aug 20;85(16):7762-8. doi: 10.1021/ac4010716. Epub 2013 Jun 13.

PMID:
23724849
40.

Skin barrier dysfunction in non-lesional atopic eczema: the role of stratum corneum lipids.

van Smeden J, Janssens M, Lavrijsen AP, Kezic S, Vreeken RJ, Bouwstra JA.

Eur J Dermatol. 2013 Apr 9. [Epub ahead of print] No abstract available.

PMID:
23567090
41.

Plasma oxylipin profiling identifies polyunsaturated vicinal diols as responsive to arachidonic acid and docosahexaenoic acid intake in growing piglets.

Bruins MJ, Dane AD, Strassburg K, Vreeken RJ, Newman JW, Salem N Jr, Tyburczy C, Brenna JT.

J Lipid Res. 2013 Jun;54(6):1598-607. doi: 10.1194/jlr.M034918. Epub 2013 Mar 29.

42.

Lipidomics of familial longevity.

Gonzalez-Covarrubias V, Beekman M, Uh HW, Dane A, Troost J, Paliukhovich I, van der Kloet FM, Houwing-Duistermaat J, Vreeken RJ, Hankemeier T, Slagboom EP.

Aging Cell. 2013 Jun;12(3):426-34. doi: 10.1111/acel.12064. Epub 2013 Apr 2.

43.

Gender-dependent associations of metabolite profiles and body fat distribution in a healthy population with central obesity: towards metabolomics diagnostics.

Szymańska E, Bouwman J, Strassburg K, Vervoort J, Kangas AJ, Soininen P, Ala-Korpela M, Westerhuis J, van Duynhoven JP, Mela DJ, Macdonald IA, Vreeken RJ, Smilde AK, Jacobs DM.

OMICS. 2012 Dec;16(12):652-67. doi: 10.1089/omi.2012.0062.

PMID:
23215804
44.

A lipidomic analysis approach to evaluate the response to cholesterol-lowering food intake.

Szymańska E, van Dorsten FA, Troost J, Paliukhovich I, van Velzen EJ, Hendriks MM, Trautwein EA, van Duynhoven JP, Vreeken RJ, Smilde AK.

Metabolomics. 2012 Oct;8(5):894-906. Epub 2011 Dec 7.

45.

Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients.

Janssens M, van Smeden J, Gooris GS, Bras W, Portale G, Caspers PJ, Vreeken RJ, Hankemeier T, Kezic S, Wolterbeek R, Lavrijsen AP, Bouwstra JA.

J Lipid Res. 2012 Dec;53(12):2755-66. doi: 10.1194/jlr.P030338. Epub 2012 Sep 28.

46.

Fragmentation trees for the structural characterisation of metabolites.

Kasper PT, Rojas-Chertó M, Mistrik R, Reijmers T, Hankemeier T, Vreeken RJ.

Rapid Commun Mass Spectrom. 2012 Oct 15;26(19):2275-86. doi: 10.1002/rcm.6340.

47.

Increased presence of monounsaturated fatty acids in the stratum corneum of human skin equivalents.

Thakoersing VS, van Smeden J, Mulder AA, Vreeken RJ, El Ghalbzouri A, Bouwstra JA.

J Invest Dermatol. 2013 Jan;133(1):59-67. doi: 10.1038/jid.2012.262. Epub 2012 Aug 16.

48.

Quantitative profiling of oxylipins through comprehensive LC-MS/MS analysis: application in cardiac surgery.

Strassburg K, Huijbrechts AM, Kortekaas KA, Lindeman JH, Pedersen TL, Dane A, Berger R, Brenkman A, Hankemeier T, van Duynhoven J, Kalkhoven E, Newman JW, Vreeken RJ.

Anal Bioanal Chem. 2012 Sep;404(5):1413-26. doi: 10.1007/s00216-012-6226-x. Epub 2012 Jul 20.

49.

Metabolomics of cerebrospinal fluid reveals changes in the central nervous system metabolism in a rat model of multiple sclerosis.

Noga MJ, Dane A, Shi S, Attali A, van Aken H, Suidgeest E, Tuinstra T, Muilwijk B, Coulier L, Luider T, Reijmers TH, Vreeken RJ, Hankemeier T.

Metabolomics. 2012 Apr;8(2):253-263. Epub 2011 Apr 16.

50.

An efficient hydrophilic interaction liquid chromatography separation of 7 phospholipid classes based on a diol column.

Zhu C, Dane A, Spijksma G, Wang M, van der Greef J, Luo G, Hankemeier T, Vreeken RJ.

J Chromatogr A. 2012 Jan 13;1220:26-34. doi: 10.1016/j.chroma.2011.11.034. Epub 2011 Nov 25.

PMID:
22169191

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