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Items: 1 to 50 of 72

1.

Apnea Associated with Brainstem Seizures in Cacna1a S218L Mice Is Caused by Medullary Spreading Depolarization.

Jansen NA, Schenke M, Voskuyl RA, Thijs RD, van den Maagdenberg AMJM, Tolner EA.

J Neurosci. 2019 Nov 27;39(48):9633-9644. doi: 10.1523/JNEUROSCI.1713-19.2019. Epub 2019 Oct 18.

PMID:
31628185
2.

Brainstem spreading depolarization and cortical dynamics during fatal seizures in Cacna1a S218L mice.

Loonen ICM, Jansen NA, Cain SM, Schenke M, Voskuyl RA, Yung AC, Bohnet B, Kozlowski P, Thijs RD, Ferrari MD, Snutch TP, van den Maagdenberg AMJM, Tolner EA.

Brain. 2019 Feb 1;142(2):412-425. doi: 10.1093/brain/awy325.

PMID:
30649209
3.

Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([18F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression.

Verbeek J, Eriksson J, Syvänen S, Huisman M, Schuit RC, Molthoff CFM, Voskuyl RA, de Lange EC, Lammertsma AA, Windhorst AD.

EJNMMI Radiopharm Chem. 2018 Sep 21;3:11. doi: 10.1186/s41181-018-0046-z. eCollection 2018 Dec.

4.

P-glycoprotein protein expression versus functionality at the blood-brain barrier using immunohistochemistry, microdialysis and mathematical modeling.

De Lange ECM, Vd Berg DJ, Bellanti F, Voskuyl RA, Syvänen S.

Eur J Pharm Sci. 2018 Nov 1;124:61-70. doi: 10.1016/j.ejps.2018.08.022. Epub 2018 Aug 23.

5.

Biomarkers in epilepsy-A modelling perspective.

van Dijkman SC, Voskuyl RA, de Lange EC.

Eur J Pharm Sci. 2017 Nov 15;109S:S47-S52. doi: 10.1016/j.ejps.2017.05.035. Epub 2017 May 17. Review.

6.

Parametric Methods for Dynamic 11C-Phenytoin PET Studies.

Mansor S, Yaqub M, Boellaard R, Froklage FE, de Vries A, Bakker ED, Voskuyl RA, Eriksson J, Schwarte LA, Verbeek J, Windhorst AD, Lammertsma AA.

J Nucl Med. 2017 Mar;58(3):479-483. doi: 10.2967/jnumed.116.178707. Epub 2016 Sep 22.

7.

Multi-omics profile of the mouse dentate gyrus after kainic acid-induced status epilepticus.

Schouten M, Bielefeld P, Fratantoni SA, Hubens CJ, Piersma SR, Pham TV, Voskuyl RA, Lucassen PJ, Jimenez CR, Fitzsimons CP.

Sci Data. 2016 Aug 16;3:160068. doi: 10.1038/sdata.2016.68.

8.

Optogenetic induction of cortical spreading depression in anesthetized and freely behaving mice.

Houben T, Loonen IC, Baca SM, Schenke M, Meijer JH, Ferrari MD, Terwindt GM, Voskuyl RA, Charles A, van den Maagdenberg AM, Tolner EA.

J Cereb Blood Flow Metab. 2017 May;37(5):1641-1655. doi: 10.1177/0271678X16645113. Epub 2016 Jan 1.

9.

Altered GABAA receptor density and unaltered blood-brain barrier [11C]flumazenil transport in drug-resistant epilepsy patients with mesial temporal sclerosis.

Froklage FE, Postnov A, Yaqub MM, Bakker E, Boellaard R, Hendrikse NH, Comans EF, Schuit RC, Schober P, Velis DN, Zwemmer J, Heimans JJ, Lammertsma AA, Voskuyl RA, Reijneveld JC.

J Cereb Blood Flow Metab. 2017 Jan;37(1):97-105. Epub 2015 Nov 19.

10.

MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells.

Schouten M, Fratantoni SA, Hubens CJ, Piersma SR, Pham TV, Bielefeld P, Voskuyl RA, Lucassen PJ, Jimenez CR, Fitzsimons CP.

Sci Rep. 2015 Jul 24;5:12448. doi: 10.1038/srep12448.

11.

Quantification of Dynamic 11C-Phenytoin PET Studies.

Mansor S, Boellaard R, Froklage FE, Bakker ED, Yaqub M, Voskuyl RA, Schwarte LA, Verbeek J, Windhorst AD, Lammertsma A.

J Nucl Med. 2015 Sep;56(9):1372-7. doi: 10.2967/jnumed.115.158055. Epub 2015 Jul 1.

12.

Kainate-induced epileptogenesis alters circular hole board learning strategy but not the performance of C57BL/6J mice.

Hubens CJ, Kaptein PS, ter Horst JP, Voskuyl RA, Schenk GJ.

Epilepsy Behav. 2014 Dec;41:127-35. doi: 10.1016/j.yebeh.2014.09.038. Epub 2014 Oct 20.

PMID:
25461204
13.

(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model.

Bogdanović RM, Syvänen S, Michler C, Russmann V, Eriksson J, Windhorst AD, Lammertsma AA, de Lange EC, Voskuyl RA, Potschka H.

Neuropharmacology. 2014 Oct;85:104-12. doi: 10.1016/j.neuropharm.2014.05.002. Epub 2014 May 28.

PMID:
24880085
14.

[11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsiveness.

Syvänen S, Russmann V, Verbeek J, Eriksson J, Labots M, Zellinger C, Seeger N, Schuit R, Rongen M, van Kooij R, Windhorst AD, Lammertsma AA, de Lange EC, Voskuyl RA, Koepp M, Potschka H.

Nucl Med Biol. 2013 Aug;40(6):764-75. doi: 10.1016/j.nucmedbio.2013.05.008. Epub 2013 Jul 1.

PMID:
23827307
15.

Altered GABAA receptor density and unaltered blood-brain barrier transport in a kainate model of epilepsy: an in vivo study using 11C-flumazenil and PET.

Syvänen S, Labots M, Tagawa Y, Eriksson J, Windhorst AD, Lammertsma AA, de Lange EC, Voskuyl RA.

J Nucl Med. 2012 Dec;53(12):1974-83. doi: 10.2967/jnumed.112.104588. Epub 2012 Nov 9.

16.

Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood-brain barriers studied with (R)-[11C]verapamil positron emission tomography.

Müllauer J, Kuntner C, Bauer M, Bankstahl JP, Müller M, Voskuyl RA, Langer O, Syvänen S.

EJNMMI Res. 2012 Oct 16;2(1):58. doi: 10.1186/2191-219X-2-58.

17.

[11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats.

Verbeek J, Eriksson J, Syvänen S, Labots M, de Lange EC, Voskuyl RA, Mooijer MP, Rongen M, Lammertsma AA, Windhorst AD.

EJNMMI Res. 2012 Jul 2;2(1):36. doi: 10.1186/2191-219X-2-36.

18.

[11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein.

Froklage FE, Syvänen S, Hendrikse NH, Huisman MC, Molthoff CF, Tagawa Y, Reijneveld JC, Heimans JJ, Lammertsma AA, Eriksson J, de Lange EC, Voskuyl RA.

EJNMMI Res. 2012 Mar 28;2:12. doi: 10.1186/2191-219X-2-12.

19.

Alteration in P-glycoprotein functionality affects intrabrain distribution of quinidine more than brain entry-a study in rats subjected to status epilepticus by kainate.

Syvänen S, Schenke M, van den Berg DJ, Voskuyl RA, de Lange EC.

AAPS J. 2012 Mar;14(1):87-96. doi: 10.1208/s12248-011-9318-1. Epub 2012 Jan 4.

20.

Simultaneous in vivo measurements of receptor density and affinity using [11C]flumazenil and positron emission tomography: comparison of full saturation and steady state methods.

Syvänen S, de Lange EC, Tagawa Y, Schenke M, Molthoff CF, Windhorst AD, Lammertsma AA, Voskuyl RA.

Neuroimage. 2011 Aug 1;57(3):928-37. doi: 10.1016/j.neuroimage.2011.05.022. Epub 2011 May 14.

PMID:
21609773
21.

(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus.

Syvänen S, Luurtsema G, Molthoff CF, Windhorst AD, Huisman MC, Lammertsma AA, Voskuyl RA, de Lange EC.

BMC Med Imaging. 2011 Jan 3;11:1. doi: 10.1186/1471-2342-11-1.

22.

Pharmacokinetics of clindamycin in pregnant women in the peripartum period.

Muller AE, Mouton JW, Oostvogel PM, Dörr PJ, Voskuyl RA, DeJongh J, Steegers EA, Danhof M.

Antimicrob Agents Chemother. 2010 May;54(5):2175-81. doi: 10.1128/AAC.01017-09. Epub 2010 Feb 22.

23.

Pharmacokinetics of amoxicillin in maternal, umbilical cord, and neonatal sera.

Muller AE, Oostvogel PM, DeJongh J, Mouton JW, Steegers EA, Dörr PJ, Danhof M, Voskuyl RA.

Antimicrob Agents Chemother. 2009 Apr;53(4):1574-80. doi: 10.1128/AAC.00119-08. Epub 2009 Jan 21.

24.

The influence of labour on the pharmacokinetics of intravenously administered amoxicillin in pregnant women.

Muller AE, Dörr PJ, Mouton JW, De Jongh J, Oostvogel PM, Steegers EA, Voskuyl RA, Danhof M.

Br J Clin Pharmacol. 2008 Dec;66(6):866-74. doi: 10.1111/j.1365-2125.2008.03292.x.

25.

Impact of efflux transporters and of seizures on the pharmacokinetics of oxcarbazepine metabolite in the rat brain.

Clinckers R, Smolders I, Michotte Y, Ebinger G, Danhof M, Voskuyl RA, Della Pasqua O.

Br J Pharmacol. 2008 Dec;155(7):1127-38. doi: 10.1038/bjp.2008.366. Epub 2008 Oct 6.

26.

Changes in GABAA receptor properties in amygdala kindled animals: in vivo studies using [11C]flumazenil and positron emission tomography.

Liefaard LC, Ploeger BA, Molthoff CF, de Jong HW, Dijkstra J, van der Weerd L, Lammertsma AA, Danhof M, Voskuyl RA.

Epilepsia. 2009 Jan;50(1):88-98. doi: 10.1111/j.1528-1167.2008.01763.x. Epub 2008 Aug 25.

27.

Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research.

Danhof M, de Lange EC, Della Pasqua OE, Ploeger BA, Voskuyl RA.

Trends Pharmacol Sci. 2008 Apr;29(4):186-91. doi: 10.1016/j.tips.2008.01.007. Epub 2008 Mar 18. Review.

PMID:
18353445
28.

Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes.

Muller AE, DeJongh J, Oostvogel PM, Voskuyl RA, Dörr PJ, Danhof M, Mouton JW.

Am J Obstet Gynecol. 2008 Jan;198(1):108.e1-6. Epub 2007 Dec 3.

PMID:
18061131
29.

Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy.

Liefaard LC, Gunput RA, Danhof M, Voskuyl RA.

Epilepsia. 2007 Jul;48(7):1378-87. Epub 2007 Apr 18.

30.

Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats.

van Vliet EA, van Schaik R, Edelbroek PM, Voskuyl RA, Redeker S, Aronica E, Wadman WJ, Gorter JA.

J Pharmacol Exp Ther. 2007 Jul;322(1):141-7. Epub 2007 Mar 28.

PMID:
17392402
31.

Synergistic combinations of anticonvulsant agents: what is the evidence from animal experiments?

Jonker DM, Voskuyl RA, Danhof M.

Epilepsia. 2007 Mar;48(3):412-34. Review.

32.

Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis.

Danhof M, de Jongh J, De Lange EC, Della Pasqua O, Ploeger BA, Voskuyl RA.

Annu Rev Pharmacol Toxicol. 2007;47:357-400. Review.

PMID:
17067280
33.

Population pharmacokinetic analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography.

Liefaard LC, Ploeger BA, Molthoff CF, Boellaard R, Lammertsma AA, Danhof M, Voskuyl RA.

Mol Imaging Biol. 2005 Nov-Dec;7(6):411-21.

PMID:
16328648
34.

Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo.

Jonker DM, Visser SA, van der Graaf PH, Voskuyl RA, Danhof M.

Pharmacol Ther. 2005 Apr;106(1):1-18. Epub 2004 Dec 23. Review.

PMID:
15781119
35.

Experimental studies on antiarrhythmic and antiseizure effects of polyunsaturated fatty acids in excitable tissues.

Leaf A, Kang JX, Xiao YF, Billman GE, Voskuyl RA.

J Nutr Biochem. 1999 Aug;10(8):440-8.

PMID:
15539321
36.
37.

Anticonvulsant drugs differentially suppress individual ictal signs: a pharmacokinetic/pharmacodynamic analysis in the cortical stimulation model in the rat.

Jonker DM, van de Mheen C, Eilers PH, Kruk MR, Voskuyl RA, Danhof M.

Behav Neurosci. 2003 Oct;117(5):1076-85.

PMID:
14570556
38.

Pharmacodynamic analysis of the interaction between tiagabine and midazolam with an allosteric model that incorporates signal transduction.

Jonker DM, Vermeij DA, Edelbroek PM, Voskuyl RA, Piotrovsky VK, Danhof M.

Epilepsia. 2003 Mar;44(3):329-38.

39.

Is marine fat anti-epileptogenic?

Voskuyl RA.

Nutr Health. 2002;16(1):51-3. No abstract available.

PMID:
12083414
40.
41.
42.

Pharmacokinetic-pharmacodynamic correlation of lamotrigine, flunarizine, loreclezole, CGP40116 and CGP39551 in the cortical stimulation model.

Della Paschoa OE, Hoogerkamp A, Edelbroek PM, Voskuyl RA, Danhof M.

Epilepsy Res. 2000 Jun;40(1):41-52.

PMID:
10771257
43.

Application of a combined "effect compartment/indirect response model" to the central nervous system effects of tiagabine in the rat.

Cleton A, de Greef HJ, Edelbroek PM, Voskuyl RA, Danhof M.

J Pharmacokinet Biopharm. 1999 Jun;27(3):301-23.

PMID:
10728492
44.
45.

The antiarrhythmic and anticonvulsant effects of dietary N-3 fatty acids.

Leaf A, Kang JX, Xiao YF, Billman GE, Voskuyl RA.

J Membr Biol. 1999 Nov 1;172(1):1-11. Review.

PMID:
10552009
46.

Functional and electrophysiologic effects of polyunsaturated fatty acids on exictable tissues: heart and brain.

Leaf A, Kang JX, Xiao YF, Billman GE, Voskuyl RA.

Prostaglandins Leukot Essent Fatty Acids. 1999 May-Jun;60(5-6):307-12. Review.

PMID:
10471113
47.

Rate of change of blood concentrations is a major determinant of the pharmacodynamics of midazolam in rats.

Cleton A, Mazee D, Voskuyl RA, Danhof M.

Br J Pharmacol. 1999 May;127(1):227-35.

48.

Modelling of the pharmacodynamic interaction between phenytoin and sodium valproate.

Della Paschoa OE, Voskuyl RA, Danhof M.

Br J Pharmacol. 1998 Dec;125(7):1610-6.

49.

Pharmacodynamic interaction between phenytoin and sodium valproate changes seizure thresholds and pattern.

Della Paschoa OE, Kruk MR, Hamstra R, Voskuyl RA, Danhof M.

Br J Pharmacol. 1998 Nov;125(5):997-1004.

50.

Effects of repeated seizure induction on seizure activity, post-ictal and interictal behavior.

Della Paschoa OE, Kruk MR, Voskuyl RA, Danhof M.

Brain Res. 1998 Dec 14;814(1-2):199-208.

PMID:
9838114

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