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Protein kinase B controls Mycobacterium tuberculosis growth via phosphorylation of the transcriptional regulator Lsr2 at threonine 112.

Alqaseer K, Turapov O, Barthe P, Jagatia H, De Visch A, Roumestand C, Wegrzyn M, Bartek IL, Voskuil MI, O'Hare HM, Ajuh P, Bottrill AR, Witney AA, Cohen-Gonsaud M, Waddell SJ, Mukamolova GV.

Mol Microbiol. 2019 Dec;112(6):1847-1862. doi: 10.1111/mmi.14398. Epub 2019 Oct 10.


Antibiotic Lethality and Membrane Bioenergetics.

Voskuil MI, Covey CR, Walter ND.

Adv Microb Physiol. 2018;73:77-122. doi: 10.1016/bs.ampbs.2018.06.002. Epub 2018 Jul 20.


Anaerobic Mycobacterium tuberculosis Cell Death Stems from Intracellular Acidification Mitigated by the DosR Regulon.

Reichlen MJ, Leistikow RL, Scobey MS, Born SEM, Voskuil MI.

J Bacteriol. 2017 Oct 31;199(23). pii: e00320-17. doi: 10.1128/JB.00320-17. Print 2017 Dec 1.


Antibiotic Bactericidal Activity Is Countered by Maintaining pH Homeostasis in Mycobacterium smegmatis.

Bartek IL, Reichlen MJ, Honaker RW, Leistikow RL, Clambey ET, Scobey MS, Hinds AB, Born SE, Covey CR, Schurr MJ, Lenaerts AJ, Voskuil MI.

mSphere. 2016 Aug 24;1(4). pii: e00176-16. doi: 10.1128/mSphere.00176-16. eCollection 2016 Jul-Aug.


Mycobacterium tuberculosis Phosphate Uptake System Component PstA2 Is Not Required for Gene Regulation or Virulence.

Tischler AD, Leistikow RL, Ramakrishnan P, Voskuil MI, McKinney JD.

PLoS One. 2016 Aug 24;11(8):e0161467. doi: 10.1371/journal.pone.0161467. eCollection 2016.


Sputum is a surrogate for bronchoalveolar lavage for monitoring Mycobacterium tuberculosis transcriptional profiles in TB patients.

Garcia BJ, Loxton AG, Dolganov GM, Van TT, Davis JL, de Jong BC, Voskuil MI, Leach SM, Schoolnik GK, Walzl G, Strong M, Walter ND.

Tuberculosis (Edinb). 2016 Sep;100:89-94. doi: 10.1016/ Epub 2016 Jul 25.


Adaptation of Mycobacterium tuberculosis to Impaired Host Immunity in HIV-Infected Patients.

Walter ND, de Jong BC, Garcia BJ, Dolganov GM, Worodria W, Byanyima P, Musisi E, Huang L, Chan ED, Van TT, Antonio M, Ayorinde A, Kato-Maeda M, Nahid P, Leung AM, Yen A, Fingerlin TE, Kechris K, Strong M, Voskuil MI, Davis JL, Schoolnik GK.

J Infect Dis. 2016 Oct 15;214(8):1205-11. doi: 10.1093/infdis/jiw364. Epub 2016 Aug 17. Erratum in: J Infect Dis. 2017 Feb 1;215(3):495.


Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice.

Irwin SM, Prideaux B, Lyon ER, Zimmerman MD, Brooks EJ, Schrupp CA, Chen C, Reichlen MJ, Asay BC, Voskuil MI, Nuermberger EL, Andries K, Lyons MA, Dartois V, Lenaerts AJ.

ACS Infect Dis. 2016 Apr 8;2(4):251-267. Epub 2016 Feb 24.


Toward Resolving the Paradox of the Critical Role of the DosR Regulon in Mycobacterium tuberculosis Persistence and Active Disease.

Voskuil MI, Schlesinger LS.

Am J Respir Crit Care Med. 2015 May 15;191(10):1103-5. doi: 10.1164/rccm.201503-0424ED. No abstract available.


In vitro models that utilize hypoxia to induce non-replicating persistence in Mycobacteria.

Sohaskey CD, Voskuil MI.

Methods Mol Biol. 2015;1285:201-13. doi: 10.1007/978-1-4939-2450-9_11.


Transcriptional Adaptation of Drug-tolerant Mycobacterium tuberculosis During Treatment of Human Tuberculosis.

Walter ND, Dolganov GM, Garcia BJ, Worodria W, Andama A, Musisi E, Ayakaka I, Van TT, Voskuil MI, de Jong BC, Davidson RM, Fingerlin TE, Kechris K, Palmer C, Nahid P, Daley CL, Geraci M, Huang L, Cattamanchi A, Strong M, Schoolnik GK, Davis JL.

J Infect Dis. 2015 Sep 15;212(6):990-8. doi: 10.1093/infdis/jiv149. Epub 2015 Mar 11.


A Burkholderia pseudomallei colony variant necessary for gastric colonization.

Austin CR, Goodyear AW, Bartek IL, Stewart A, Sutherland MD, Silva EB, Zweifel A, Vitko NP, Tuanyok A, Highnam G, Mittelman D, Keim P, Schweizer HP, Vázquez-Torres A, Dow SW, Voskuil MI.

mBio. 2015 Feb 3;6(1). pii: e02462-14. doi: 10.1128/mBio.02462-14.


Nitric oxide from IFNγ-primed macrophages modulates the antimicrobial activity of β-lactams against the intracellular pathogens Burkholderia pseudomallei and Nontyphoidal Salmonella.

Jones-Carson J, Zweifel AE, Tapscott T, Austin C, Brown JM, Jones KL, Voskuil MI, Vázquez-Torres A.

PLoS Negl Trop Dis. 2014 Aug 14;8(8):e3079. doi: 10.1371/journal.pntd.0003079. eCollection 2014 Aug.


Mycobacterium tuberculosis Lsr2 is a global transcriptional regulator required for adaptation to changing oxygen levels and virulence.

Bartek IL, Woolhiser LK, Baughn AD, Basaraba RJ, Jacobs WR Jr, Lenaerts AJ, Voskuil MI.

mBio. 2014 Jun 3;5(3):e01106-14. doi: 10.1128/mBio.01106-14.


Limited activity of clofazimine as a single drug in a mouse model of tuberculosis exhibiting caseous necrotic granulomas.

Irwin SM, Gruppo V, Brooks E, Gilliland J, Scherman M, Reichlen MJ, Leistikow R, Kramnik I, Nuermberger EL, Voskuil MI, Lenaerts AJ.

Antimicrob Agents Chemother. 2014 Jul;58(7):4026-34. doi: 10.1128/AAC.02565-14. Epub 2014 May 5.


Mycobacterium tuberculosis cholesterol catabolism requires a new class of acyl coenzyme A dehydrogenase.

Voskuil MI.

J Bacteriol. 2013 Oct;195(19):4319-21. doi: 10.1128/JB.00867-13. Epub 2013 Jul 26. No abstract available.


Mycobacterium tuberculosis requires phosphate-responsive gene regulation to resist host immunity.

Tischler AD, Leistikow RL, Kirksey MA, Voskuil MI, McKinney JD.

Infect Immun. 2013 Jan;81(1):317-28. doi: 10.1128/IAI.01136-12. Epub 2012 Nov 6.


The oxidation-sensing regulator (MosR) is a new redox-dependent transcription factor in Mycobacterium tuberculosis.

Brugarolas P, Movahedzadeh F, Wang Y, Zhang N, Bartek IL, Gao YN, Voskuil MI, Franzblau SG, He C.

J Biol Chem. 2012 Nov 2;287(45):37703-12. doi: 10.1074/jbc.M112.388611. Epub 2012 Sep 18.


Nitric oxide-dependent killing of aerobic, anaerobic and persistent Burkholderia pseudomallei.

Jones-Carson J, Laughlin JR, Stewart AL, Voskuil MI, Vázquez-Torres A.

Nitric Oxide. 2012 Jun 30;27(1):25-31. doi: 10.1016/j.niox.2012.04.001. Epub 2012 Apr 10.


The response of mycobacterium tuberculosis to reactive oxygen and nitrogen species.

Voskuil MI, Bartek IL, Visconti K, Schoolnik GK.

Front Microbiol. 2011 May 13;2:105. doi: 10.3389/fmicb.2011.00105. eCollection 2011.


Adaptation and antibiotic tolerance of anaerobic Burkholderia pseudomallei.

Hamad MA, Austin CR, Stewart AL, Higgins M, Vázquez-Torres A, Voskuil MI.

Antimicrob Agents Chemother. 2011 Jul;55(7):3313-23. doi: 10.1128/AAC.00953-10. Epub 2011 May 2.


DosS responds to a reduced electron transport system to induce the Mycobacterium tuberculosis DosR regulon.

Honaker RW, Dhiman RK, Narayanasamy P, Crick DC, Voskuil MI.

J Bacteriol. 2010 Dec;192(24):6447-55. doi: 10.1128/JB.00978-10. Epub 2010 Oct 15.


Anti-tuberculosis activity of α-helical antimicrobial peptides: de novo designed L- and D-enantiomers versus L- and D-LL-37.

Jiang Z, Higgins MP, Whitehurst J, Kisich KO, Voskuil MI, Hodges RS.

Protein Pept Lett. 2011 Mar;18(3):241-52.


Multiple M. tuberculosis phenotypes in mouse and guinea pig lung tissue revealed by a dual-staining approach.

Ryan GJ, Hoff DR, Driver ER, Voskuil MI, Gonzalez-Juarrero M, Basaraba RJ, Crick DC, Spencer JS, Lenaerts AJ.

PLoS One. 2010 Jun 14;5(6):e11108. doi: 10.1371/journal.pone.0011108.


Implantable cardiac defibrillator pocket infection due to a previously undescribed Cupriavidus species.

Christensen JB, Vitko NP, Voskuil MI, Castillo-Mancilla JR.

J Clin Microbiol. 2010 Jul;48(7):2623-5. doi: 10.1128/JCM.00507-10. Epub 2010 Apr 28.


The Mycobacterium tuberculosis DosR regulon assists in metabolic homeostasis and enables rapid recovery from nonrespiring dormancy.

Leistikow RL, Morton RA, Bartek IL, Frimpong I, Wagner K, Voskuil MI.

J Bacteriol. 2010 Mar;192(6):1662-70. doi: 10.1128/JB.00926-09. Epub 2009 Dec 18.


Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response.

Singh A, Crossman DK, Mai D, Guidry L, Voskuil MI, Renfrow MB, Steyn AJ.

PLoS Pathog. 2009 Aug;5(8):e1000545. doi: 10.1371/journal.ppat.1000545. Epub 2009 Aug 14.


The Mycobacterium tuberculosis sigma factor sigmaB is required for full response to cell envelope stress and hypoxia in vitro, but it is dispensable for in vivo growth.

Fontán PA, Voskuil MI, Gomez M, Tan D, Pardini M, Manganelli R, Fattorini L, Schoolnik GK, Smith I.

J Bacteriol. 2009 Sep;191(18):5628-33. doi: 10.1128/JB.00510-09. Epub 2009 Jul 10.


The DosR regulon of M. tuberculosis and antibacterial tolerance.

Bartek IL, Rutherford R, Gruppo V, Morton RA, Morris RP, Klein MR, Visconti KC, Ryan GJ, Schoolnik GK, Lenaerts A, Voskuil MI.

Tuberculosis (Edinb). 2009 Jul;89(4):310-6. doi: 10.1016/ Epub 2009 Jul 3.


Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy.

Honaker RW, Leistikow RL, Bartek IL, Voskuil MI.

Infect Immun. 2009 Aug;77(8):3258-63. doi: 10.1128/IAI.01449-08. Epub 2009 Jun 1.


An allelic exchange system for compliant genetic manipulation of the select agents Burkholderia pseudomallei and Burkholderia mallei.

Hamad MA, Zajdowicz SL, Holmes RK, Voskuil MI.

Gene. 2009 Feb 1;430(1-2):123-31. doi: 10.1016/j.gene.2008.10.011. Epub 2008 Oct 28.


Inactivation of [Fe-S] metalloproteins mediates nitric oxide-dependent killing of Burkholderia mallei.

Jones-Carson J, Laughlin J, Hamad MA, Stewart AL, Voskuil MI, Vázquez-Torres A.

PLoS One. 2008 Apr 9;3(4):e1976. doi: 10.1371/journal.pone.0001976.


Mycobacterium bovis BCG vaccine strains lack narK2 and narX induction and exhibit altered phenotypes during dormancy.

Honaker RW, Stewart A, Schittone S, Izzo A, Klein MR, Voskuil MI.

Infect Immun. 2008 Jun;76(6):2587-93. doi: 10.1128/IAI.01235-07. Epub 2008 Mar 24.


A predicted operon map for Mycobacterium tuberculosis.

Roback P, Beard J, Baumann D, Gille C, Henry K, Krohn S, Wiste H, Voskuil MI, Rainville C, Rutherford R.

Nucleic Acids Res. 2007;35(15):5085-95. Epub 2007 Jul 25.


Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination.

Lin MY, Geluk A, Smith SG, Stewart AL, Friggen AH, Franken KL, Verduyn MJ, van Meijgaarden KE, Voskuil MI, Dockrell HM, Huygen K, Ottenhoff TH, Klein MR.

Infect Immun. 2007 Jul;75(7):3523-30. Epub 2007 May 14.


Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis.

Leyten EM, Lin MY, Franken KL, Friggen AH, Prins C, van Meijgaarden KE, Voskuil MI, Weldingh K, Andersen P, Schoolnik GK, Arend SM, Ottenhoff TH, Klein MR.

Microbes Infect. 2006 Jul;8(8):2052-60. Epub 2006 Jun 13.


Regulation of the Mycobacterium tuberculosis PE/PPE genes.

Voskuil MI, Schnappinger D, Rutherford R, Liu Y, Schoolnik GK.

Tuberculosis (Edinb). 2004;84(3-4):256-62.


Mycobacterium tuberculosis gene expression during adaptation to stationary phase and low-oxygen dormancy.

Voskuil MI, Visconti KC, Schoolnik GK.

Tuberculosis (Edinb). 2004;84(3-4):218-27.


Mycobacterium tuberculosis gene expression during environmental conditions associated with latency.

Voskuil MI.

Tuberculosis (Edinb). 2004;84(3-4):138-43. Review. No abstract available.


Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program.

Voskuil MI, Schnappinger D, Visconti KC, Harrell MI, Dolganov GM, Sherman DR, Schoolnik GK.

J Exp Med. 2003 Sep 1;198(5):705-13.


Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment.

Schnappinger D, Ehrt S, Voskuil MI, Liu Y, Mangan JA, Monahan IM, Dolganov G, Efron B, Butcher PD, Nathan C, Schoolnik GK.

J Exp Med. 2003 Sep 1;198(5):693-704.


Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis.

Park HD, Guinn KM, Harrell MI, Liao R, Voskuil MI, Tompa M, Schoolnik GK, Sherman DR.

Mol Microbiol. 2003 May;48(3):833-43.


The TRTGn motif stabilizes the transcription initiation open complex.

Voskuil MI, Chambliss GH.

J Mol Biol. 2002 Sep 20;322(3):521-32.


Role of the extracytoplasmic-function sigma factor sigma(H) in Mycobacterium tuberculosis global gene expression.

Manganelli R, Voskuil MI, Schoolnik GK, Dubnau E, Gomez M, Smith I.

Mol Microbiol. 2002 Jul;45(2):365-74.


The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages.

Manganelli R, Voskuil MI, Schoolnik GK, Smith I.

Mol Microbiol. 2001 Jul;41(2):423-37.


Whole genome DNA microarray expression analysis of biofilm development by Vibrio cholerae O1 E1 Tor.

Schoolnik GK, Voskuil MI, Schnappinger D, Yildiz FH, Meibom K, Dolganov NA, Wilson MA, Chong KH.

Methods Enzymol. 2001;336:3-18. No abstract available.


NADP, corepressor for the Bacillus catabolite control protein CcpA.

Kim JH, Voskuil MI, Chambliss GH.

Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9590-5.


The -16 region of Bacillus subtilis and other gram-positive bacterial promoters.

Voskuil MI, Chambliss GH.

Nucleic Acids Res. 1998 Aug 1;26(15):3584-90.


Significance of HPr in catabolite repression of alpha-amylase.

Voskuil MI, Chambliss GH.

J Bacteriol. 1996 Dec;178(23):7014-5.

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