Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 77

1.

Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK cell effector function in patients with mantle cell lymphoma.

Flinsenberg TWH, Tromedjo CC, Hu N, Liu Y, Guo Y, Thia KYT, Noori T, Song X, Aw Yeang HX, Tantalo DG, Handunnetti S, Seymour JF, Roberts AW, Ritchie D, Koldej R, Neeson PJ, Wang L, Trapani JA, Tam CS, Voskoboinik I.

Haematologica. 2019 Jun 6. pii: haematol.2019.220590. doi: 10.3324/haematol.2019.220590. [Epub ahead of print]

2.

Antagonism of IAPs Enhances CAR T-cell Efficacy.

Michie J, Beavis PA, Freeman AJ, Vervoort SJ, Ramsbottom KM, Narasimhan V, Lelliott EJ, Lalaoui N, Ramsay RG, Johnstone RW, Silke J, Darcy PK, Voskoboinik I, Kearney CJ, Oliaro J.

Cancer Immunol Res. 2019 Feb;7(2):183-192. doi: 10.1158/2326-6066.CIR-18-0428. Epub 2019 Jan 16.

PMID:
30651288
3.

Tumor immune evasion arises through loss of TNF sensitivity.

Kearney CJ, Vervoort SJ, Hogg SJ, Ramsbottom KM, Freeman AJ, Lalaoui N, Pijpers L, Michie J, Brown KK, Knight DA, Sutton V, Beavis PA, Voskoboinik I, Darcy PK, Silke J, Trapani JA, Johnstone RW, Oliaro J.

Sci Immunol. 2018 May 18;3(23). pii: eaar3451. doi: 10.1126/sciimmunol.aar3451.

PMID:
29776993
4.

Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing.

Lopez JA, Noori T, Minson A, Li Jovanoska L, Thia K, Hildebrand MS, Akhlaghi H, Darcy PK, Kershaw MH, Brown NJ, Grigg A, Trapani JA, Voskoboinik I.

Front Immunol. 2018 Mar 15;9:529. doi: 10.3389/fimmu.2018.00529. eCollection 2018.

5.

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.

Brennan AJ, Law RHP, Conroy PJ, Noori T, Lukoyanova N, Saibil H, Yagita H, Ciccone A, Verschoor S, Whisstock JC, Trapani JA, Voskoboinik I.

Cell Death Differ. 2018 Aug;25(8):1517-1529. doi: 10.1038/s41418-018-0057-z. Epub 2018 Feb 7.

PMID:
29416110
6.

Neonatal Cytomegalovirus Palatal Ulceration and Bocavirus Pneumonitis Associated With a Defect of Lymphocyte Cytotoxicity Caused by Mutations in UNC13D.

Gray PE, Shadur B, Russell S, Mitchell R, Gallagher K, Thia K, Palasanthiran P, Voskoboinik I.

J Pediatric Infect Dis Soc. 2019 Mar 28;8(1):73-76. doi: 10.1093/jpids/pix112.

PMID:
29415165
7.

Adaptive reprogramming of NK cells in X-linked lymphoproliferative syndrome.

Opat S, Hearps AC, Thia K, Yuen A, Rogers B, Chachage M, Moore G, Shortt J, Ryland G, Blombery P, Schwarer AP, Noori T, Trapani JA, Jaworowski A, Voskoboinik I.

Blood. 2018 Feb 8;131(6):699-702. doi: 10.1182/blood-2017-08-803668. Epub 2017 Dec 12. No abstract available.

8.

Late-Onset Non-HLH Presentations of Growth Arrest, Inflammatory Arachnoiditis, and Severe Infectious Mononucleosis, in Siblings with Hypomorphic Defects in UNC13D.

Gray PE, Shadur B, Russell S, Mitchell R, Buckley M, Gallagher K, Andrews I, Thia K, Trapani JA, Kirk EP, Voskoboinik I.

Front Immunol. 2017 Aug 9;8:944. doi: 10.3389/fimmu.2017.00944. eCollection 2017.

9.

Cytolytic DNA vaccine encoding lytic perforin augments the maturation of- and antigen presentation by- dendritic cells in a time-dependent manner.

Wijesundara DK, Yu W, Quah BJC, Eldi P, Hayball JD, Diener KR, Voskoboinik I, Gowans EJ, Grubor-Bauk B.

Sci Rep. 2017 Aug 17;7(1):8530. doi: 10.1038/s41598-017-08063-1.

10.

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.

Burr ML, Sparbier CE, Chan YC, Williamson JC, Woods K, Beavis PA, Lam EYN, Henderson MA, Bell CC, Stolzenburg S, Gilan O, Bloor S, Noori T, Morgens DW, Bassik MC, Neeson PJ, Behren A, Darcy PK, Dawson SJ, Voskoboinik I, Trapani JA, Cebon J, Lehner PJ, Dawson MA.

Nature. 2017 Sep 7;549(7670):101-105. doi: 10.1038/nature23643. Epub 2017 Aug 16.

11.

Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation.

House IG, House CM, Brennan AJ, Gilan O, Dawson MA, Whisstock JC, Law RH, Trapani JA, Voskoboinik I.

EMBO Rep. 2017 Oct;18(10):1775-1785. doi: 10.15252/embr.201744351. Epub 2017 Aug 14.

12.

Perforin-A key (shaped) weapon in the immunological arsenal.

Spicer BA, Conroy PJ, Law RHP, Voskoboinik I, Whisstock JC.

Semin Cell Dev Biol. 2017 Dec;72:117-123. doi: 10.1016/j.semcdb.2017.07.033. Epub 2017 Jul 27. Review.

PMID:
28757431
13.

Real-time visualization of perforin nanopore assembly.

Leung C, Hodel AW, Brennan AJ, Lukoyanova N, Tran S, House CM, Kondos SC, Whisstock JC, Dunstone MA, Trapani JA, Voskoboinik I, Saibil HR, Hoogenboom BW.

Nat Nanotechnol. 2017 May;12(5):467-473. doi: 10.1038/nnano.2016.303. Epub 2017 Feb 6.

PMID:
28166206
14.

Loss of DNAM-1 ligand expression by acute myeloid leukemia cells renders them resistant to NK cell killing.

Kearney CJ, Ramsbottom KM, Voskoboinik I, Darcy PK, Oliaro J.

Oncoimmunology. 2016 Jun 27;5(8):e1196308. doi: 10.1080/2162402X.2016.1196308. eCollection 2016 Aug.

15.

Missense mutations in the perforin (PRF1) gene as a cause of hereditary cancer predisposition.

Chaudhry MS, Gilmour KC, House IG, Layton M, Panoskaltsis N, Sohal M, Trapani JA, Voskoboinik I.

Oncoimmunology. 2016 Jun 2;5(7):e1179415. doi: 10.1080/2162402X.2016.1179415. eCollection 2016 Jul.

16.

Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity.

Sutton VR, Brennan AJ, Ellis S, Danne J, Thia K, Jenkins MR, Voskoboinik I, Pejler G, Johnstone RW, Andrews DM, Trapani JA.

FEBS J. 2016 Mar;283(5):947-61. doi: 10.1111/febs.13649. Epub 2016 Jan 22.

17.

Perforin-dependent cytotoxicity: 'Kiss of death' or prolonged embrace with darker elocation-idnseque11es?

Trapani JA, Voskoboinik I, Jenkins MR.

Oncoimmunology. 2015 Apr 14;4(9):e1036215. eCollection 2015 Sep.

18.

Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.

Yagi H, Conroy PJ, Leung EW, Law RH, Trapani JA, Voskoboinik I, Whisstock JC, Norton RS.

J Biol Chem. 2015 Oct 16;290(42):25213-26. doi: 10.1074/jbc.M115.668384. Epub 2015 Aug 25.

19.

Intradermal delivery of DNA encoding HCV NS3 and perforin elicits robust cell-mediated immunity in mice and pigs.

Grubor-Bauk B, Yu W, Wijesundara D, Gummow J, Garrod T, Brennan AJ, Voskoboinik I, Gowans EJ.

Gene Ther. 2016 Jan;23(1):26-37. doi: 10.1038/gt.2015.86. Epub 2015 Oct 1.

PMID:
26262584
20.

B cell-derived circulating granzyme B is a feature of acute infectious mononucleosis.

Hagn M, Panikkar A, Smith C, Balfour HH Jr, Khanna R, Voskoboinik I, Trapani JA.

Clin Transl Immunology. 2015 Jun 26;4(6):e38. doi: 10.1038/cti.2015.10. eCollection 2015 Jun.

21.

A Multiantigenic DNA Vaccine That Induces Broad Hepatitis C Virus-Specific T-Cell Responses in Mice.

Gummow J, Li Y, Yu W, Garrod T, Wijesundara D, Brennan AJ, Mullick R, Voskoboinik I, Grubor-Bauk B, Gowans EJ.

J Virol. 2015 Aug;89(15):7991-8002. doi: 10.1128/JVI.00803-15. Epub 2015 May 27.

22.

Perforin and granzymes: function, dysfunction and human pathology.

Voskoboinik I, Whisstock JC, Trapani JA.

Nat Rev Immunol. 2015 Jun;15(6):388-400. Review.

PMID:
25998963
23.

Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals.

House IG, Thia K, Brennan AJ, Tothill R, Dobrovic A, Yeh WZ, Saffery R, Chatterton Z, Trapani JA, Voskoboinik I.

Immunol Cell Biol. 2015 Jul;93(6):575-80. doi: 10.1038/icb.2015.1. Epub 2015 Mar 17.

PMID:
25776844
24.

Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time.

Jenkins MR, Rudd-Schmidt JA, Lopez JA, Ramsbottom KM, Mannering SI, Andrews DM, Voskoboinik I, Trapani JA.

J Exp Med. 2015 Mar 9;212(3):307-17. doi: 10.1084/jem.20140964. Epub 2015 Mar 2.

25.

Conformational changes during pore formation by the perforin-related protein pleurotolysin.

Lukoyanova N, Kondos SC, Farabella I, Law RH, Reboul CF, Caradoc-Davies TT, Spicer BA, Kleifeld O, Traore DA, Ekkel SM, Voskoboinik I, Trapani JA, Hatfaludi T, Oliver K, Hotze EM, Tweten RK, Whisstock JC, Topf M, Saibil HR, Dunstone MA.

PLoS Biol. 2015 Feb 5;13(2):e1002049. doi: 10.1371/journal.pbio.1002049. eCollection 2015 Feb.

26.

A method for detecting intracellular perforin in mouse lymphocytes.

Brennan AJ, House IG, Oliaro J, Ramsbottom KM, Hagn M, Yagita H, Trapani JA, Voskoboinik I.

J Immunol. 2014 Dec 1;193(11):5744-50. doi: 10.4049/jimmunol.1402207. Epub 2014 Oct 27.

27.

Familial haemophagocytic lymphohistiocytosis: Australian experience and perspectives.

Voskoboinik I, Thia K, Trapani JA.

Intern Med J. 2014 Aug;44(8):826-7. doi: 10.1111/imj.12493. No abstract available.

PMID:
25081055
28.

Perforinopathy: a spectrum of human immune disease caused by defective perforin delivery or function.

Voskoboinik I, Trapani JA.

Front Immunol. 2013 Dec 12;4:441. doi: 10.3389/fimmu.2013.00441. Review.

29.

Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin.

Spicer JA, Lena G, Lyons DM, Huttunen KM, Miller CK, O'Connor PD, Bull M, Helsby N, Jamieson SM, Denny WA, Ciccone A, Browne KA, Lopez JA, Rudd-Schmidt J, Voskoboinik I, Trapani JA.

J Med Chem. 2013 Dec 12;56(23):9542-55. doi: 10.1021/jm401604x. Epub 2013 Nov 19.

30.

Defining the interaction of perforin with calcium and the phospholipid membrane.

Traore DA, Brennan AJ, Law RH, Dogovski C, Perugini MA, Lukoyanova N, Leung EW, Norton RS, Lopez JA, Browne KA, Yagita H, Lloyd GJ, Ciccone A, Verschoor S, Trapani JA, Whisstock JC, Voskoboinik I.

Biochem J. 2013 Dec 15;456(3):323-35. doi: 10.1042/BJ20130999.

PMID:
24070258
31.

Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse.

Lopez JA, Jenkins MR, Rudd-Schmidt JA, Brennan AJ, Danne JC, Mannering SI, Trapani JA, Voskoboinik I.

J Immunol. 2013 Sep 1;191(5):2328-34. doi: 10.4049/jimmunol.1301205. Epub 2013 Jul 24.

32.

Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis.

Susanto O, Stewart SE, Voskoboinik I, Brasacchio D, Hagn M, Ellis S, Asquith S, Sedelies KA, Bird PI, Waterhouse NJ, Trapani JA.

Cell Death Differ. 2013 Sep;20(9):1183-93. doi: 10.1038/cdd.2013.59. Epub 2013 Jun 7.

33.

Human perforin mutations and susceptibility to multiple primary cancers.

Trapani JA, Thia KY, Andrews M, Davis ID, Gedye C, Parente P, Svobodova S, Chia J, Browne K, Campbell IG, Phillips WA, Voskoboinik I, Cebon JS.

Oncoimmunology. 2013 Apr 1;2(4):e24185.

34.

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack.

Lopez JA, Susanto O, Jenkins MR, Lukoyanova N, Sutton VR, Law RH, Johnston A, Bird CH, Bird PI, Whisstock JC, Trapani JA, Saibil HR, Voskoboinik I.

Blood. 2013 Apr 4;121(14):2659-68. doi: 10.1182/blood-2012-07-446146. Epub 2013 Feb 1.

35.

Surprisingly variable "dangers, toils, and snares" faced by humans and mice.

Trapani JA, Voskoboinik I.

Blood. 2013 Jan 24;121(4):568-70. doi: 10.1182/blood-2012-11-468652. No abstract available.

36.

Deciphering the syntax of cytotoxic lymphocyte degranulation.

Lopez JA, Voskoboinik I.

Eur J Immunol. 2013 Jan;43(1):46-9. doi: 10.1002/eji.201243221.

37.

Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death.

Lopez JA, Brennan AJ, Whisstock JC, Voskoboinik I, Trapani JA.

Trends Immunol. 2012 Aug;33(8):406-12. doi: 10.1016/j.it.2012.04.001. Epub 2012 May 18. Review.

PMID:
22608996
38.

Fatal immune dysregulation due to a gain of glycosylation mutation in lymphocyte perforin.

Chia J, Thia K, Brennan AJ, Little M, Williams B, Lopez JA, Trapani JA, Voskoboinik I.

Blood. 2012 Feb 16;119(7):1713-6. doi: 10.1182/blood-2011-08-374355. Epub 2011 Dec 20.

39.

Molecular study of the perforin gene in familial hematological malignancies.

El Abed R, Bourdon V, Voskoboinik I, Omri H, Youssef YB, Laatiri MA, Huiart L, Eisinger F, Rabayrol L, Frenay M, Gesta P, Demange L, Dreyfus H, Bonadona V, Dugast C, Zattara H, Faivre L, Zaier M, Jemni SY, Noguchi T, Sobol H, Soua Z.

Hered Cancer Clin Pract. 2011 Sep 21;9(1):9. doi: 10.1186/1897-4287-9-9.

40.

Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes.

Brennan AJ, Chia J, Browne KA, Ciccone A, Ellis S, Lopez JA, Susanto O, Verschoor S, Yagita H, Whisstock JC, Trapani JA, Voskoboinik I.

Immunity. 2011 Jun 24;34(6):879-92. doi: 10.1016/j.immuni.2011.04.007. Epub 2011 Jun 9.

41.

The structural basis for membrane binding and pore formation by lymphocyte perforin.

Law RH, Lukoyanova N, Voskoboinik I, Caradoc-Davies TT, Baran K, Dunstone MA, D'Angelo ME, Orlova EV, Coulibaly F, Verschoor S, Browne KA, Ciccone A, Kuiper MJ, Bird PI, Trapani JA, Saibil HR, Whisstock JC.

Nature. 2010 Nov 18;468(7322):447-51. doi: 10.1038/nature09518. Epub 2010 Oct 31.

PMID:
21037563
42.

The structure and function of mammalian membrane-attack complex/perforin-like proteins.

Kondos SC, Hatfaludi T, Voskoboinik I, Trapani JA, Law RH, Whisstock JC, Dunstone MA.

Tissue Antigens. 2010 Nov;76(5):341-51. doi: 10.1111/j.1399-0039.2010.01566.x. Epub 2010 Sep 22. Review.

PMID:
20860583
43.

Perforin: structure, function, and role in human immunopathology.

Voskoboinik I, Dunstone MA, Baran K, Whisstock JC, Trapani JA.

Immunol Rev. 2010 May;235(1):35-54. doi: 10.1111/j.0105-2896.2010.00896.x. Review.

PMID:
20536554
44.

Perforin deficiency and susceptibility to cancer.

Brennan AJ, Chia J, Trapani JA, Voskoboinik I.

Cell Death Differ. 2010 Apr;17(4):607-15. doi: 10.1038/cdd.2009.212. Epub 2010 Jan 15. Review.

45.

The battlefield of perforin/granzyme cell death pathways.

Hoves S, Trapani JA, Voskoboinik I.

J Leukoc Biol. 2010 Feb;87(2):237-43. doi: 10.1189/jlb.0909608. Epub 2009 Nov 13. Review.

PMID:
19915166
46.

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer.

Chia J, Yeo KP, Whisstock JC, Dunstone MA, Trapani JA, Voskoboinik I.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9809-14. doi: 10.1073/pnas.0903815106. Epub 2009 Jun 1.

47.

The molecular basis for perforin oligomerization and transmembrane pore assembly.

Baran K, Dunstone M, Chia J, Ciccone A, Browne KA, Clarke CJ, Lukoyanova N, Saibil H, Whisstock JC, Voskoboinik I, Trapani JA.

Immunity. 2009 May;30(5):684-95. doi: 10.1016/j.immuni.2009.03.016. Epub 2009 May 14.

48.

The MACPF/CDC family of pore-forming toxins.

Rosado CJ, Kondos S, Bull TE, Kuiper MJ, Law RH, Buckle AM, Voskoboinik I, Bird PI, Trapani JA, Whisstock JC, Dunstone MA.

Cell Microbiol. 2008 Sep;10(9):1765-74. doi: 10.1111/j.1462-5822.2008.01191.x. Epub 2008 Jun 28. Review.

49.

Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules.

Sutton VR, Waterhouse NJ, Baran K, Browne K, Voskoboinik I, Trapani JA.

Methods. 2008 Mar;44(3):241-9. doi: 10.1016/j.ymeth.2007.11.011. Review.

PMID:
18314055
50.

A common fold mediates vertebrate defense and bacterial attack.

Rosado CJ, Buckle AM, Law RH, Butcher RE, Kan WT, Bird CH, Ung K, Browne KA, Baran K, Bashtannyk-Puhalovich TA, Faux NG, Wong W, Porter CJ, Pike RN, Ellisdon AM, Pearce MC, Bottomley SP, Emsley J, Smith AI, Rossjohn J, Hartland EL, Voskoboinik I, Trapani JA, Bird PI, Dunstone MA, Whisstock JC.

Science. 2007 Sep 14;317(5844):1548-51. Epub 2007 Aug 23.

Supplemental Content

Loading ...
Support Center