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Inhaled nebulized glatiramer acetate against Gram-negative bacteria is not associated with adverse pulmonary reactions in healthy, young adult female pigs.

Skovdal SM, Christiansen SH, Johansen KS, Viborg O, Bruun NH, Jensen-Fangel S, Holm IE, Vorup-Jensen T, Petersen E.

PLoS One. 2019 Oct 10;14(10):e0223647. doi: 10.1371/journal.pone.0223647. eCollection 2019.


Efficient data acquisition with three-channel centerpieces in sedimentation velocity.

Juul-Madsen K, Zhao H, Vorup-Jensen T, Schuck P.

Anal Biochem. 2019 Dec 1;586:113414. doi: 10.1016/j.ab.2019.113414. Epub 2019 Sep 4.


Editorial: The Role of Complement in Health and Disease.

Cedzyński M, Thielens NM, Mollnes TE, Vorup-Jensen T.

Front Immunol. 2019 Aug 7;10:1869. doi: 10.3389/fimmu.2019.01869. eCollection 2019. No abstract available.


Structural Immunology of Complement Receptors 3 and 4.

Vorup-Jensen T, Jensen RK.

Front Immunol. 2018 Nov 26;9:2716. doi: 10.3389/fimmu.2018.02716. eCollection 2018. Review.


Correction: Decreased monocyte shedding of the migration inhibitor soluble CD18 in alcoholic hepatitis.

Støy S, Sandahl TD, Hansen AL, Deleuran B, Vorup-Jensen T, Vilstrup H, Kragstrup TW.

Clin Transl Gastroenterol. 2018 Jul 24;9(7):171. doi: 10.1038/s41424-018-0041-4.


Decreased monocyte shedding of the migration inhibitor soluble CD18 in alcoholic hepatitis.

Støy S, Sandahl TD, Hansen AL, Deleuran B, Vorup-Jensen T, Vilstrup H, Kragstrup TW.

Clin Transl Gastroenterol. 2018 Jun 15;9(6):160. doi: 10.1038/s41424-018-0022-7. Erratum in: Clin Transl Gastroenterol. 2018 Jul 24;9(7):171.


The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria.

Christiansen SH, Murphy RA, Juul-Madsen K, Fredborg M, Hvam ML, Axelgaard E, Skovdal SM, Meyer RL, Sørensen UBS, Möller A, Nyengaard JR, Nørskov-Lauritsen N, Wang M, Gadjeva M, Howard KA, Davies JC, Petersen E, Vorup-Jensen T.

Sci Rep. 2017 Nov 15;7(1):15653. doi: 10.1038/s41598-017-15969-3.


Altered levels of soluble CD18 may associate immune mechanisms with outcome in sepsis.

Kragstrup TW, Juul-Madsen K, Christiansen SH, Zhang X, Krog J, Vorup-Jensen T, Kjaergaard AG.

Clin Exp Immunol. 2017 Nov;190(2):258-267. doi: 10.1111/cei.13016. Epub 2017 Aug 7.


Insight on the impacts of free amino acids and their metabolites on the immune system from a perspective of inborn errors of amino acid metabolism.

Pakula MM, Maier TJ, Vorup-Jensen T.

Expert Opin Ther Targets. 2017 Jun;21(6):611-626. doi: 10.1080/14728222.2017.1323879. Epub 2017 May 9. Review.


Targets and Mechanisms in Prevention of Parkinson's Disease through Immunomodulatory Treatments.

von Euler Chelpin M, Vorup-Jensen T.

Scand J Immunol. 2017 May;85(5):321-330. doi: 10.1111/sji.12542. Review.


The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage.

Christiansen SH, Zhang X, Juul-Madsen K, Hvam ML, Vad BS, Behrens MA, Thygesen IL, Jalilian B, Pedersen JS, Howard KA, Otzen DE, Vorup-Jensen T.

Biochim Biophys Acta Biomembr. 2017 Mar;1859(3):425-437. doi: 10.1016/j.bbamem.2017.01.001. Epub 2017 Jan 5.


Impact of Microbiota on Resistance to Ocular Pseudomonas aeruginosa-Induced Keratitis.

Kugadas A, Christiansen SH, Sankaranarayanan S, Surana NK, Gauguet S, Kunz R, Fichorova R, Vorup-Jensen T, Gadjeva M.

PLoS Pathog. 2016 Sep 22;12(9):e1005855. doi: 10.1371/journal.ppat.1005855. eCollection 2016 Sep.


Structural Basis for Simvastatin Competitive Antagonism of Complement Receptor 3.

Jensen MR, Bajic G, Zhang X, Laustsen AK, Koldsø H, Skeby KK, Schiøtt B, Andersen GR, Vorup-Jensen T.

J Biol Chem. 2016 Aug 12;291(33):16963-76. doi: 10.1074/jbc.M116.732222. Epub 2016 Jun 23.


In silico and in vivo analysis of Toxoplasma gondii epitopes by correlating survival data with peptide-MHC-I binding affinities.

Huang SY, Jensen MR, Rosenberg CA, Zhu XQ, Petersen E, Vorup-Jensen T.

Int J Infect Dis. 2016 Jul;48:14-9. doi: 10.1016/j.ijid.2016.04.014. Epub 2016 Apr 22.


The interleukin-20 receptor axis in early rheumatoid arthritis: novel links between disease-associated autoantibodies and radiographic progression.

Kragstrup TW, Greisen SR, Nielsen MA, Rhodes C, Stengaard-Pedersen K, Hetland ML, Hørslev-Petersen K, Junker P, Østergaard M, Hvid M, Vorup-Jensen T, Robinson WH, Sokolove J, Deleuran B.

Arthritis Res Ther. 2016 Mar 11;18:61. doi: 10.1186/s13075-016-0964-7.


The cationic peptide LL-37 binds Mac-1 (CD11b/CD18) with a low dissociation rate and promotes phagocytosis.

Zhang X, Bajic G, Andersen GR, Christiansen SH, Vorup-Jensen T.

Biochim Biophys Acta. 2016 May;1864(5):471-8. doi: 10.1016/j.bbapap.2016.02.013. Epub 2016 Feb 11.


Changes in Soluble CD18 in Murine Autoimmune Arthritis and Rheumatoid Arthritis Reflect Disease Establishment and Treatment Response.

Kragstrup TW, Jalilian B, Keller KK, Zhang X, Laustsen JK, Stengaard-Pedersen K, Hetland ML, Hørslev-Petersen K, Junker P, Østergaard M, Hauge EM, Hvid M, Vorup-Jensen T, Deleuran B.

PLoS One. 2016 Feb 5;11(2):e0148486. doi: 10.1371/journal.pone.0148486. eCollection 2016.


Interleukin 20 regulates dendritic cell migration and expression of co-stimulatory molecules.

Bech R, Jalilian B, Agger R, Iversen L, Erlandsen M, Otkjaer K, Johansen C, Paludan SR, Rosenberg CA, Kragballe K, Vorup-Jensen T.

Mol Cell Ther. 2016 Jan 26;4:1. doi: 10.1186/s40591-016-0046-x. eCollection 2016.


Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?

Roos J, Grösch S, Werz O, Schröder P, Ziegler S, Fulda S, Paulus P, Urbschat A, Kühn B, Maucher I, Fettel J, Vorup-Jensen T, Piesche M, Matrone C, Steinhilber D, Parnham MJ, Maier TJ.

Pharmacol Ther. 2016 Jan;157:43-64. doi: 10.1016/j.pharmthera.2015.11.001. Epub 2015 Nov 6. Review.


Immunogenicity of twenty peptides representing epitopes of the hepatitis B core and surface antigens by IFN-γ response in chronic and resolved HBV.

Brinck-Jensen NS, Vorup-Jensen T, Leutscher PD, Erikstrup C, Petersen E.

BMC Immunol. 2015 Nov 2;16:65. doi: 10.1186/s12865-015-0127-7.


Multiple low-affinity interactions support binding of human osteopontin to integrin αXβ2.

Kläning E, Christensen B, Bajic G, Hoffmann SV, Jones NC, Callesen MM, Andersen GR, Sørensen ES, Vorup-Jensen T.

Biochim Biophys Acta. 2015 Aug;1854(8):930-8. doi: 10.1016/j.bbapap.2015.03.008. Epub 2015 Apr 1.


Effect of Polarization on Airway Epithelial Conditioning of Monocyte-Derived Dendritic Cells.

Papazian D, Chhoden T, Arge M, Vorup-Jensen T, Nielsen CH, Lund K, Würtzen PA, Hansen S.

Am J Respir Cell Mol Biol. 2015 Sep;53(3):368-77. doi: 10.1165/rcmb.2014-0183OC.


Osteopontin binds multiple calcium ions with high affinity and independently of phosphorylation status.

Kläning E, Christensen B, Sørensen ES, Vorup-Jensen T, Jensen JK.

Bone. 2014 Sep;66:90-5. doi: 10.1016/j.bone.2014.05.020. Epub 2014 Jun 10.


Sialic acid residues are essential for cell lysis mediated by leukotoxin from Aggregatibacter actinomycetemcomitans.

Munksgaard PS, Skals M, Reinholdt J, Poulsen K, Jensen MR, Yang C, Leipziger J, Vorup-Jensen T, Praetorius HA.

Infect Immun. 2014 Jun;82(6):2219-28. doi: 10.1128/IAI.01647-14. Epub 2014 Mar 18.


Interleukin 20 protein locates to distinct mononuclear cells in psoriatic skin.

Bech R, Otkjaer K, Birkelund S, Vorup-Jensen T, Agger R, Johansen C, Iversen L, Kragballe K, Rømer J.

Exp Dermatol. 2014 May;23(5):349-52. doi: 10.1111/exd.12371.


Reply to Shin and Bayry on "An age-related decline of CD62L and vaccine response: a role of microRNA 92a?".

Vorup-Jensen T, Rosenberg C, Petersen E.

Hum Vaccin Immunother. 2014;10(5):1406-7. doi: 10.4161/hv.27843. Epub 2014 Feb 11.


Decreased plasma levels of soluble CD18 link leukocyte infiltration with disease activity in spondyloarthritis.

Kragstrup TW, Jalilian B, Hvid M, Kjærgaard A, Østgård R, Schiøttz-Christensen B, Jurik AG, Robinson WH, Vorup-Jensen T, Deleuran B.

Arthritis Res Ther. 2014 Feb 4;16(1):R42. doi: 10.1186/ar4471.


Accumulation of nano-sized particles in a murine model of angiogenesis.

Wittenborn TR, Larsen EK, Nielsen T, Rydtoft LM, Hansen L, Nygaard JV, Vorup-Jensen T, Kjems J, Horsman MR, Nielsen NC.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):470-6. doi: 10.1016/j.bbrc.2013.11.127. Epub 2013 Dec 7.


Detection of soluble CR3 (CD11b/CD18) by time-resolved immunofluorometry.

Nielsen GK, Vorup-Jensen T.

Methods Mol Biol. 2014;1100:355-64. doi: 10.1007/978-1-62703-724-2_30.


Challenges and opportunities in fractionation of recombinant human mannan-binding lectin.

Vorup-Jensen T.

Methods Mol Biol. 2014;1100:109-21. doi: 10.1007/978-1-62703-724-2_9.


Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3.

Bajic G, Yatime L, Sim RB, Vorup-Jensen T, Andersen GR.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16426-31. doi: 10.1073/pnas.1311261110. Epub 2013 Sep 24.


Age is an important determinant in humoral and T cell responses to immunization with hepatitis B surface antigen.

Rosenberg C, Bovin NV, Bram LV, Flyvbjerg E, Erlandsen M, Vorup-Jensen T, Petersen E.

Hum Vaccin Immunother. 2013 Jul;9(7):1466-76. doi: 10.4161/hv.24480. Epub 2013 Apr 9.


Properties and prospects of adjuvants in influenza vaccination - messy precipitates or blessed opportunities?

Jalilian B, Christiansen SH, Einarsson HB, Pirozyan MR, Petersen E, Vorup-Jensen T.

Mol Cell Ther. 2013 Nov 6;1:2. doi: 10.1186/2052-8426-1-2. eCollection 2013. Review.


Monodisperse and LPS-free Aggregatibacter actinomycetemcomitans leukotoxin: interactions with human β2 integrins and erythrocytes.

Reinholdt J, Poulsen K, Brinkmann CR, Hoffmann SV, Stapulionis R, Enghild JJ, Jensen UB, Boesen T, Vorup-Jensen T.

Biochim Biophys Acta. 2013 Feb;1834(2):546-58. doi: 10.1016/j.bbapap.2012.12.004. Epub 2012 Dec 9.


Glatiramer acetate in treatment of multiple sclerosis: a toolbox of random co-polymers for targeting inflammatory mechanisms of both the innate and adaptive immune system?

Jalilian B, Einarsson HB, Vorup-Jensen T.

Int J Mol Sci. 2012 Nov 9;13(11):14579-605. doi: 10.3390/ijms131114579. Review.


Nanotoxicity and the importance of being earnest.

Vorup-Jensen T, Peer D.

Adv Drug Deliv Rev. 2012 Dec;64(15):1661-2. doi: 10.1016/j.addr.2012.09.002. Epub 2012 Sep 8. No abstract available.


Leukotoxin from Aggregatibacter actinomycetemcomitans causes shrinkage and P2X receptor-dependent lysis of human erythrocytes.

Munksgaard PS, Vorup-Jensen T, Reinholdt J, Söderström CM, Poulsen K, Leipziger J, Praetorius HA, Skals M.

Cell Microbiol. 2012 Dec;14(12):1904-20. doi: 10.1111/cmi.12021. Epub 2012 Sep 25.


On the roles of polyvalent binding in immune recognition: perspectives in the nanoscience of immunology and the immune response to nanomedicines.

Vorup-Jensen T.

Adv Drug Deliv Rev. 2012 Dec;64(15):1759-81. doi: 10.1016/j.addr.2012.06.003. Epub 2012 Jun 15. Review.


The role of nanometer-scaled ligand patterns in polyvalent binding by large mannan-binding lectin oligomers.

Gjelstrup LC, Kaspersen JD, Behrens MA, Pedersen JS, Thiel S, Kingshott P, Oliveira CL, Thielens NM, Vorup-Jensen T.

J Immunol. 2012 Feb 1;188(3):1292-306. doi: 10.4049/jimmunol.1103012. Epub 2012 Jan 4.


Ultrahigh-field DCE-MRI of angiogenesis in a novel angiogenesis mouse model.

Wittenborn T, Nielsen T, Nygaard JV, Larsen EK, Thim T, Rydtoft LM, Vorup-Jensen T, Kjems J, Nielsen NC, Horsman MR, Falk E.

J Magn Reson Imaging. 2012 Mar;35(3):703-10. doi: 10.1002/jmri.22855. Epub 2011 Oct 26.


Surface plasmon resonance biosensing in studies of the binding between β₂ integrin I domains and their ligands.

Vorup-Jensen T.

Methods Mol Biol. 2012;757:55-71. doi: 10.1007/978-1-61779-166-6_5.


The role of higher-order protein structure in supporting binding by heteroclitic monoclonal antibodies: the monoclonal antibody KIM185 to CD18 also binds C4-binding protein.

Gjelstrup LC, Andersen SH, Petersen SV, Enghild JJ, Blom AM, Vorup-Jensen T, Thiel S.

Mol Immunol. 2011 Oct;49(1-2):38-47. doi: 10.1016/j.molimm.2011.07.018.


Protein ultrastructure and the nanoscience of complement activation.

Vorup-Jensen T, Boesen T.

Adv Drug Deliv Rev. 2011 Sep 16;63(12):1008-19. doi: 10.1016/j.addr.2011.05.023. Epub 2011 Jun 12. Review.


The effect of IgG levels on the number of natural killer cells and their Fc receptors in chronic inflammatory demyelinating polyradiculoneuropathy.

Bohn AB, Nederby L, Harbo T, Skovbo A, Vorup-Jensen T, Krog J, Jakobsen J, Hokland ME.

Eur J Neurol. 2011 Jun;18(6):919-24. doi: 10.1111/j.1468-1331.2010.03333.x. Epub 2011 Jan 11.


Shedding of large functionally active CD11/CD18 Integrin complexes from leukocyte membranes during synovial inflammation distinguishes three types of arthritis through differential epitope exposure.

Gjelstrup LC, Boesen T, Kragstrup TW, Jørgensen A, Klein NJ, Thiel S, Deleuran BW, Vorup-Jensen T.

J Immunol. 2010 Oct 1;185(7):4154-68. doi: 10.4049/jimmunol.1000952. Epub 2010 Sep 8.


Curvature of synthetic and natural surfaces is an important target feature in classical pathway complement activation.

Pedersen MB, Zhou X, Larsen EK, Sørensen US, Kjems J, Nygaard JV, Nyengaard JR, Meyer RL, Boesen T, Vorup-Jensen T.

J Immunol. 2010 Feb 15;184(4):1931-45. doi: 10.4049/jimmunol.0902214. Epub 2010 Jan 6.


Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors.

Larsen EK, Nielsen T, Wittenborn T, Birkedal H, Vorup-Jensen T, Jakobsen MH, Ostergaard L, Horsman MR, Besenbacher F, Howard KA, Kjems J.

ACS Nano. 2009 Jul 28;3(7):1947-51. doi: 10.1021/nn900330m. Epub 2009 Jul 2.


Osteopontin enhances phagocytosis through a novel osteopontin receptor, the alphaXbeta2 integrin.

Schack L, Stapulionis R, Christensen B, Kofod-Olsen E, Skov Sørensen UB, Vorup-Jensen T, Sørensen ES, Höllsberg P.

J Immunol. 2009 Jun 1;182(11):6943-50. doi: 10.4049/jimmunol.0900065.

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