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Items: 1 to 50 of 69

1.

Four-jointed knock-out delays renal failure in an ADPKD model with kidney injury.

Formica C, Happé H, Veraar KA, Vortkamp A, Scharpfenecker M, McNeill H, Peters DJ.

J Pathol. 2019 Apr 30. doi: 10.1002/path.5286. [Epub ahead of print]

PMID:
31038742
2.

A newly discovered stem cell that keeps bones growing.

Wuelling M, Vortkamp A.

Nature. 2019 Mar;567(7747):178-179. doi: 10.1038/d41586-019-00527-w. No abstract available.

PMID:
30850738
3.

Signaling systems affecting the severity of multiple osteochondromas.

Piombo V, Jochmann K, Hoffmann D, Wuelling M, Vortkamp A.

Bone. 2018 Jun;111:71-81. doi: 10.1016/j.bone.2018.03.010. Epub 2018 Mar 13.

4.

Regulation of Calvarial Osteogenesis by Concomitant De-repression of GLI3 and Activation of IHH Targets.

Veistinen LK, Mustonen T, Hasan MR, Takatalo M, Kobayashi Y, Kesper DA, Vortkamp A, Rice DP.

Front Physiol. 2017 Dec 19;8:1036. doi: 10.3389/fphys.2017.01036. eCollection 2017.

5.

Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion.

Hu Y, Kim JH, He K, Wan Q, Kim J, Flach M, Kirchhausen T, Vortkamp A, Winau F.

J Exp Med. 2016 Nov 14;213(12):2759-2772. Epub 2016 Oct 24.

6.

Involvement of Ca2+ Activated Cl- Channel Ano6 in Platelet Activation and Apoptosis.

Liu G, Liu G, Chen H, Borst O, Gawaz M, Vortkamp A, Schreiber R, Kunzelmann K, Lang F.

Cell Physiol Biochem. 2015;37(5):1934-44. doi: 10.1159/000438554. Epub 2015 Nov 20.

7.

[Hypertrophic chondrocytes: Programmed cell death or stem cell reservoir?].

Severmann AC, Vortkamp A.

Z Rheumatol. 2015 Dec;74(10):898-901. doi: 10.1007/s00393-013-1293-8. Review. German.

PMID:
26555549
8.

Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage.

Mattheij NJ, Braun A, van Kruchten R, Castoldi E, Pircher J, Baaten CC, Wülling M, Kuijpers MJ, Köhler R, Poole AW, Schreiber R, Vortkamp A, Collins PW, Nieswandt B, Kunzelmann K, Cosemans JM, Heemskerk JW.

FASEB J. 2016 Feb;30(2):727-37. doi: 10.1096/fj.15-280446. Epub 2015 Oct 19.

PMID:
26481309
9.

[OVERLOAD of joints and its role in osteoarthritis. Towards understanding and preventing progression of primary osteoarthritis].

Willie BM, Pap T, Perka C, Schmidt CO, Eckstein F, Arampatzis A, Hege HC, Madry H, Vortkamp A, Duda GN.

Z Rheumatol. 2015 Sep;74(7):618-21. doi: 10.1007/s00393-015-1649-3. German. No abstract available.

PMID:
26334971
10.

OVERLOAD of joints and its role in osteoarthritis : Towards understanding and preventing progression of primary osteoarthritis. English version.

Willie BM, Pap T, Perka C, Schmidt CO, Eckstein F, Arampatzis A, Hege HC, Madry H, Vortkamp A, Duda GN.

Z Rheumatol. 2017 Mar;76(Suppl 1):1-4. doi: 10.1007/s00393-014-1561-2. No abstract available.

PMID:
26224533
11.

Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones.

Dierker T, Bachvarova V, Krause Y, Li JP, Kjellén L, Seidler DG, Vortkamp A.

Matrix Biol. 2016 Jan;49:82-92. doi: 10.1016/j.matbio.2015.06.004. Epub 2015 Jun 24.

PMID:
26116392
12.

Sweet on Hedgehogs: regulatory roles of heparan sulfate proteoglycans in Hedgehog-dependent cell proliferation and differentiation.

Bandari S, Exner S, Ortmann C, Bachvarova V, Vortkamp A, Grobe K.

Curr Protein Pept Sci. 2015;16(1):66-76. Review.

PMID:
25692848
13.

Anoctamin-6 controls bone mineralization by activating the calcium transporter NCX1.

Ousingsawat J, Wanitchakool P, Schreiber R, Wuelling M, Vortkamp A, Kunzelmann K.

J Biol Chem. 2015 Mar 6;290(10):6270-80. doi: 10.1074/jbc.M114.602979. Epub 2015 Jan 14.

14.

Gene expression profiling reveals similarities between the spatial architectures of postnatal articular and growth plate cartilage.

Chau M, Lui JC, Landman EB, Späth SS, Vortkamp A, Baron J, Nilsson O.

PLoS One. 2014 Jul 28;9(7):e103061. doi: 10.1371/journal.pone.0103061. eCollection 2014.

15.

Signaling domain of Sonic Hedgehog as cannibalistic calcium-regulated zinc-peptidase.

Rebollido-Rios R, Bandari S, Wilms C, Jakuschev S, Vortkamp A, Grobe K, Hoffmann D.

PLoS Comput Biol. 2014 Jul 17;10(7):e1003707. doi: 10.1371/journal.pcbi.1003707. eCollection 2014 Jul.

16.

Inactivation of patched1 in murine chondrocytes causes spinal fusion without inflammation.

Dittmann K, Wuelling M, Uhmann A, Dullin C, Hahn H, Schweyer S, Vortkamp A, Wienands J.

Arthritis Rheumatol. 2014 Apr;66(4):831-40. doi: 10.1002/art.38325.

17.

Reprint of: Heparan sulfate as a regulator of endochondral ossification and osteochondroma development.

Jochmann K, Bachvarova V, Vortkamp A.

Matrix Biol. 2014 Apr;35:239-47. doi: 10.1016/j.matbio.2014.04.001. Epub 2014 Apr 12.

18.

Cartilage explant cultures.

Wuelling M, Vortkamp A.

Methods Mol Biol. 2014;1130:89-97. doi: 10.1007/978-1-62703-989-5_7.

PMID:
24482167
19.

Heparan sulfate as a regulator of endochondral ossification and osteochondroma development.

Jochmann K, Bachvarova V, Vortkamp A.

Matrix Biol. 2014 Feb;34:55-63. doi: 10.1016/j.matbio.2013.11.003. Epub 2013 Dec 24. Review.

20.

The multi zinc-finger protein Trps1 acts as a regulator of histone deacetylation during mitosis.

Wuelling M, Pasdziernik M, Moll CN, Thiesen AM, Schneider S, Johannes C, Vortkamp A.

Cell Cycle. 2013 Jul 15;12(14):2219-32. doi: 10.4161/cc.25267.

21.

Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues.

Ehlen HW, Chinenkova M, Moser M, Munter HM, Krause Y, Gross S, Brachvogel B, Wuelling M, Kornak U, Vortkamp A.

J Bone Miner Res. 2013 Feb;28(2):246-59. doi: 10.1002/jbmr.1751.

22.

Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice.

Gross S, Krause Y, Wuelling M, Vortkamp A.

PLoS One. 2012;7(8):e43553. doi: 10.1371/journal.pone.0043553. Epub 2012 Aug 20.

23.

Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone.

Galli GG, Honnens de Lichtenberg K, Carrara M, Hans W, Wuelling M, Mentz B, Multhaupt HA, Fog CK, Jensen KT, Rappsilber J, Vortkamp A, Coulton L, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Calogero RA, Couchman JR, Lund AH.

PLoS Genet. 2012;8(5):e1002711. doi: 10.1371/journal.pgen.1002711. Epub 2012 May 10.

24.

Loss-of-Function of Gli3 in Mice Causes Abnormal Frontal Bone Morphology and Premature Synostosis of the Interfrontal Suture.

Veistinen L, Takatalo M, Tanimoto Y, Kesper DA, Vortkamp A, Rice DP.

Front Physiol. 2012 May 3;3:121. doi: 10.3389/fphys.2012.00121. eCollection 2012.

25.

Sonic hedgehog signaling during adrenal development.

Laufer E, Kesper D, Vortkamp A, King P.

Mol Cell Endocrinol. 2012 Mar 31;351(1):19-27. doi: 10.1016/j.mce.2011.10.002. Epub 2011 Oct 13. Review.

26.

Chondrocyte proliferation and differentiation.

Wuelling M, Vortkamp A.

Endocr Dev. 2011;21:1-11. doi: 10.1159/000328081. Epub 2011 Aug 22. Review.

PMID:
21865749
27.

BMP signaling balances proliferation and differentiation of muscle satellite cell descendants.

Friedrichs M, Wirsdöerfer F, Flohé SB, Schneider S, Wuelling M, Vortkamp A.

BMC Cell Biol. 2011 Jun 6;12:26. doi: 10.1186/1471-2121-12-26.

29.

Expression patterns of sulfatase genes in the developing mouse embryo.

Ratzka A, Mundlos S, Vortkamp A.

Dev Dyn. 2010 Jun;239(6):1779-88. doi: 10.1002/dvdy.22294.

30.

The resorption of nanocrystalline calcium phosphates by osteoclast-like cells.

Detsch R, Hagmeyer D, Neumann M, Schaefer S, Vortkamp A, Wuelling M, Ziegler G, Epple M.

Acta Biomater. 2010 Aug;6(8):3223-33. doi: 10.1016/j.actbio.2010.03.003. Epub 2010 Mar 4.

PMID:
20206720
31.

A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes.

Jones KB, Piombo V, Searby C, Kurriger G, Yang B, Grabellus F, Roughley PJ, Morcuende JA, Buckwalter JA, Capecchi MR, Vortkamp A, Sheffield VC.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2054-9. doi: 10.1073/pnas.0910875107. Epub 2009 Dec 22.

32.

Transcriptional networks controlling chondrocyte proliferation and differentiation during endochondral ossification.

Wuelling M, Vortkamp A.

Pediatr Nephrol. 2010 Apr;25(4):625-31. doi: 10.1007/s00467-009-1368-6. Epub 2009 Dec 1. Review.

PMID:
19949815
33.

Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60.

Schirling C, Heseding C, Heise F, Kesper D, Klebes A, Klein-Hitpass L, Vortkamp A, Hoffmann D, Saumweber H, Ehrenhofer-Murray AE.

Chromosoma. 2010 Feb;119(1):99-113. doi: 10.1007/s00412-009-0247-z. Epub 2009 Dec 1.

PMID:
19949809
34.

Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3.

Wuelling M, Kaiser FJ, Buelens LA, Braunholz D, Shivdasani RA, Depping R, Vortkamp A.

Dev Biol. 2009 Apr 1;328(1):40-53. doi: 10.1016/j.ydbio.2009.01.012. Epub 2009 Jan 14.

35.

Tricho-rhino-phalangeal syndrome with supernumerary teeth.

Kantaputra P, Miletich I, Lüdecke HJ, Suzuki EY, Praphanphoj V, Shivdasani R, Wuelling M, Vortkamp A, Napierala D, Sharpe PT.

J Dent Res. 2008 Nov;87(11):1027-31.

PMID:
18946009
36.

Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development.

Ratzka A, Kalus I, Moser M, Dierks T, Mundlos S, Vortkamp A.

Dev Dyn. 2008 Feb;237(2):339-53. doi: 10.1002/dvdy.21423.

37.

The rodent Four-jointed ortholog Fjx1 regulates dendrite extension.

Probst B, Rock R, Gessler M, Vortkamp A, Püschel AW.

Dev Biol. 2007 Dec 1;312(1):461-70. Epub 2007 Oct 4.

38.

Follistatin antagonizes transforming growth factor-beta3-induced epithelial-mesenchymal transition in vitro: implications for murine palatal development supported by microarray analysis.

Nogai H, Rosowski M, Grün J, Rietz A, Debus N, Schmidt G, Lauster C, Janitz M, Vortkamp A, Lauster R.

Differentiation. 2008 Apr;76(4):404-16. Epub 2007 Nov 20.

PMID:
18028449
39.

Ucma--A novel secreted factor represents a highly specific marker for distal chondrocytes.

Tagariello A, Luther J, Streiter M, Didt-Koziel L, Wuelling M, Surmann-Schmitt C, Stock M, Adam N, Vortkamp A, Winterpacht A.

Matrix Biol. 2008 Jan;27(1):3-11. Epub 2007 Jul 13.

PMID:
17707622
40.

Hedgehog signaling in skeletal development.

Ehlen HW, Buelens LA, Vortkamp A.

Birth Defects Res C Embryo Today. 2006 Sep;78(3):267-79. Review.

PMID:
17061262
41.

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation.

Koziel L, Wuelling M, Schneider S, Vortkamp A.

Development. 2005 Dec;132(23):5249-60.

42.

Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification.

Minina E, Schneider S, Rosowski M, Lauster R, Vortkamp A.

Gene Expr Patterns. 2005 Dec;6(1):102-9. Epub 2005 Jun 15.

PMID:
15963767
43.

Targeted expression of SHH affects chondrocyte differentiation, growth plate organization, and Sox9 expression.

Tavella S, Biticchi R, Schito A, Minina E, Di Martino D, Pagano A, Vortkamp A, Horton WA, Cancedda R, Garofalo S.

J Bone Miner Res. 2004 Oct;19(10):1678-88. Epub 2004 Jul 12.

44.

Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification.

Koziel L, Kunath M, Kelly OG, Vortkamp A.

Dev Cell. 2004 Jun;6(6):801-13.

45.

Essential role for ADAM19 in cardiovascular morphogenesis.

Zhou HM, Weskamp G, Chesneau V, Sahin U, Vortkamp A, Horiuchi K, Chiusaroli R, Hahn R, Wilkes D, Fisher P, Baron R, Manova K, Basson CT, Hempstead B, Blobel CP.

Mol Cell Biol. 2004 Jan;24(1):96-104.

46.

Expression of Trps1 during mouse embryonic development.

Kunath M, Lüdecke HJ, Vortkamp A.

Mech Dev. 2002 Dec;119 Suppl 1:S117-20.

47.

Expression of Trps1 during mouse embryonic development.

Kunath M, Lüdecke HJ, Vortkamp A.

Gene Expr Patterns. 2002 Nov;2(1-2):119-22.

PMID:
12617849
48.

Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation.

Minina E, Kreschel C, Naski MC, Ornitz DM, Vortkamp A.

Dev Cell. 2002 Sep;3(3):439-49.

49.

Role of Runx genes in chondrocyte differentiation.

Stricker S, Fundele R, Vortkamp A, Mundlos S.

Dev Biol. 2002 May 1;245(1):95-108.

50.

BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation.

Minina E, Wenzel HM, Kreschel C, Karp S, Gaffield W, McMahon AP, Vortkamp A.

Development. 2001 Nov;128(22):4523-34.

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