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Items: 1 to 50 of 64

1.

Pro-inflammatory macrophages promote multiple myeloma resistance to bortezomib therapy.

Beyar-Katz O, Magidey K, Reiner-Benaim A, Barak N, Avivi I, Cohen Y, Timaner M, Avraham S, Hayun M, Lavi N, Bersudsky M, Voronov E, Apte RN, Shaked Y.

Mol Cancer Res. 2019 Aug 13. pii: molcanres.0487.2019. doi: 10.1158/1541-7786.MCR-19-0487. [Epub ahead of print]

PMID:
31409628
2.

Interleukin-1α as an intracellular alarmin in cancer biology.

Voronov E, Dinarello CA, Apte RN.

Semin Immunol. 2018 Aug;38:3-14. doi: 10.1016/j.smim.2018.10.006. Epub 2018 Oct 26. Review. No abstract available.

PMID:
30554608
3.

Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation.

Kaplanov I, Carmi Y, Kornetsky R, Shemesh A, Shurin GV, Shurin MR, Dinarello CA, Voronov E, Apte RN.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1361-1369. doi: 10.1073/pnas.1812266115. Epub 2018 Dec 13.

4.

Interleukin 1α-Deficient Mice Have an Altered Gut Microbiota Leading to Protection from Dextran Sodium Sulfate-Induced Colitis.

Nunberg M, Werbner N, Neuman H, Bersudsky M, Braiman A, Ben-Shoshan M, Ben Izhak M, Louzoun Y, Apte RN, Voronov E, Koren O.

mSystems. 2018 May 8;3(3). pii: e00213-17. doi: 10.1128/mSystems.00213-17. eCollection 2018 May-Jun.

5.

Targeting the Tumor Microenvironment by Intervention in Interleukin-1 Biology.

Voronov E, Apte RN.

Curr Pharm Des. 2017;23(32):4893-4905. doi: 10.2174/1381612823666170613080919. Review.

PMID:
28606052
6.

Immunotherapeutic approaches of IL-1 neutralization in the tumor microenvironment.

Apte RN, Voronov E.

J Leukoc Biol. 2017 Aug;102(2):293-306. doi: 10.1189/jlb.3MR1216-523R. Epub 2017 May 18. Review.

PMID:
28522598
7.

Alarmins: Feel the Stress.

Rider P, Voronov E, Dinarello CA, Apte RN, Cohen I.

J Immunol. 2017 Feb 15;198(4):1395-1402. doi: 10.4049/jimmunol.1601342. Review.

8.

Cancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid.

Pesakhov S, Nachliely M, Barvish Z, Aqaqe N, Schwartzman B, Voronov E, Sharoni Y, Studzinski GP, Fishman D, Danilenko M.

Oncotarget. 2016 May 31;7(22):31847-61. doi: 10.18632/oncotarget.7240.

9.

Preface.

Voronov E, Apte RN.

Cancer Microenviron. 2015 Dec;8(3):123-4. doi: 10.1007/s12307-015-0178-6. No abstract available.

10.

IL-1 in Colon Inflammation, Colon Carcinogenesis and Invasiveness of Colon Cancer.

Voronov E, Apte RN.

Cancer Microenviron. 2015 Dec;8(3):187-200. doi: 10.1007/s12307-015-0177-7. Epub 2015 Dec 19.

11.

Inhibition of primary and metastatic tumors in mice by E-selectin-targeted polymer-drug conjugates.

Shamay Y, Raviv L, Golan M, Voronov E, Apte RN, David A.

J Control Release. 2015 Nov 10;217:102-12. doi: 10.1016/j.jconrel.2015.08.029. Epub 2015 Aug 18.

PMID:
26297207
12.

Blocking IL1β Pathway Following Paclitaxel Chemotherapy Slightly Inhibits Primary Tumor Growth but Promotes Spontaneous Metastasis.

Voloshin T, Alishekevitz D, Kaneti L, Miller V, Isakov E, Kaplanov I, Voronov E, Fremder E, Benhar M, Machluf M, Apte RN, Shaked Y.

Mol Cancer Ther. 2015 Jun;14(6):1385-94. doi: 10.1158/1535-7163.MCT-14-0969. Epub 2015 Apr 17.

13.

Knockdown of interleukin-1α does not attenuate LPS-induced production of interleukin-1β in mouse macrophages.

Almog T, Kandel-Kfir M, Shaish A, Dissen M, Shlomai G, Voronov E, Apte RN, Harats D, Kamari Y.

Cytokine. 2015 May;73(1):138-43. doi: 10.1016/j.cyto.2015.01.029. Epub 2015 Mar 6.

PMID:
25748836
14.

Amplified lipid rafts of malignant cells constitute a target for inhibition of aberrantly active NFAT and melanoma tumor growth by the aminobisphosphonate zoledronic acid.

Levin-Gromiko U, Koshelev V, Kushnir P, Fedida-Metula S, Voronov E, Fishman D.

Carcinogenesis. 2014 Nov;35(11):2555-66. doi: 10.1093/carcin/bgu178. Epub 2014 Aug 20.

PMID:
25142972
15.

Multifunctional activity of a small tellurium redox immunomodulator compound, AS101, on dextran sodium sulfate-induced murine colitis.

Halpert G, Eitan T, Voronov E, Apte RN, Rath-Wolfson L, Albeck M, Kalechman Y, Sredni B.

J Biol Chem. 2014 Jun 13;289(24):17215-27. doi: 10.1074/jbc.M113.536664. Epub 2014 Apr 24.

16.

The role IL-1 in tumor-mediated angiogenesis.

Voronov E, Carmi Y, Apte RN.

Front Physiol. 2014 Mar 28;5:114. doi: 10.3389/fphys.2014.00114. eCollection 2014. Review.

17.

Critical role for IL-1β in DNA damage-induced mucositis.

Kanarek N, Grivennikov SI, Leshets M, Lasry A, Alkalay I, Horwitz E, Shaul YD, Stachler M, Voronov E, Apte RN, Pagano M, Pikarsky E, Karin M, Ghosh S, Ben-Neriah Y.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E702-11. doi: 10.1073/pnas.1322691111. Epub 2014 Jan 27.

18.

Interleukin-1α.

Rider P, Carmi Y, Voronov E, Apte RN.

Semin Immunol. 2013 Dec 15;25(6):430-8. doi: 10.1016/j.smim.2013.10.005. Epub 2013 Nov 1. Review.

PMID:
24183701
19.

Unique Versus Redundant Functions of IL-1α and IL-1β in the Tumor Microenvironment.

Voronov E, Dotan S, Krelin Y, Song X, Elkabets M, Carmi Y, Rider P, Idan Cohen, Romzova M, Kaplanov I, Apte RN.

Front Immunol. 2013 Jul 8;4:177. doi: 10.3389/fimmu.2013.00177. eCollection 2013.

20.

Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice.

Bersudsky M, Luski L, Fishman D, White RM, Ziv-Sokolovskaya N, Dotan S, Rider P, Kaplanov I, Aychek T, Dinarello CA, Apte RN, Voronov E.

Gut. 2014 Apr;63(4):598-609. doi: 10.1136/gutjnl-2012-303329. Epub 2013 Jun 21.

PMID:
23793223
21.

Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions.

Fejer G, Wegner MD, Györy I, Cohen I, Engelhard P, Voronov E, Manke T, Ruzsics Z, Dölken L, Prazeres da Costa O, Branzk N, Huber M, Prasse A, Schneider R, Apte RN, Galanos C, Freudenberg MA.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2191-8. doi: 10.1073/pnas.1302877110. Epub 2013 May 24.

22.

The role of IL-1β in the early tumor cell-induced angiogenic response.

Carmi Y, Dotan S, Rider P, Kaplanov I, White MR, Baron R, Abutbul S, Huszar M, Dinarello CA, Apte RN, Voronov E.

J Immunol. 2013 Apr 1;190(7):3500-9. doi: 10.4049/jimmunol.1202769. Epub 2013 Mar 8.

23.

Interleukin-1β regulates fat-liver crosstalk in obesity by auto-paracrine modulation of adipose tissue inflammation and expandability.

Nov O, Shapiro H, Ovadia H, Tarnovscki T, Dvir I, Shemesh E, Kovsan J, Shelef I, Carmi Y, Voronov E, Apte RN, Lewis E, Haim Y, Konrad D, Bashan N, Rudich A.

PLoS One. 2013;8(1):e53626. doi: 10.1371/journal.pone.0053626. Epub 2013 Jan 16.

24.

The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells.

Rider P, Kaplanov I, Romzova M, Bernardis L, Braiman A, Voronov E, Apte RN.

Front Immunol. 2012 Sep 14;3:290. doi: 10.3389/fimmu.2012.00290. eCollection 2012.

25.

Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow.

Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E, Brenner DA, Apte RN, Jung S, Lapidot T.

Nat Immunol. 2012 Nov;13(11):1072-82. doi: 10.1038/ni.2408. Epub 2012 Sep 16.

PMID:
22983360
26.

Lipid rafts couple store-operated Ca2+ entry to constitutive activation of PKB/Akt in a Ca2+/calmodulin-, Src- and PP2A-mediated pathway and promote melanoma tumor growth.

Fedida-Metula S, Feldman B, Koshelev V, Levin-Gromiko U, Voronov E, Fishman D.

Carcinogenesis. 2012 Apr;33(4):740-50. doi: 10.1093/carcin/bgs021. Epub 2012 Jan 27.

PMID:
22287561
27.

IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation.

Rider P, Carmi Y, Guttman O, Braiman A, Cohen I, Voronov E, White MR, Dinarello CA, Apte RN.

J Immunol. 2011 Nov 1;187(9):4835-43. doi: 10.4049/jimmunol.1102048. Epub 2011 Sep 19.

28.

Lack of interleukin-1α or interleukin-1β inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice.

Kamari Y, Shaish A, Vax E, Shemesh S, Kandel-Kfir M, Arbel Y, Olteanu S, Barshack I, Dotan S, Voronov E, Dinarello CA, Apte RN, Harats D.

J Hepatol. 2011 Nov;55(5):1086-94. doi: 10.1016/j.jhep.2011.01.048. Epub 2011 Feb 24.

29.

Microenvironment-derived IL-1 and IL-17 interact in the control of lung metastasis.

Carmi Y, Rinott G, Dotan S, Elkabets M, Rider P, Voronov E, Apte RN.

J Immunol. 2011 Mar 15;186(6):3462-71. doi: 10.4049/jimmunol.1002901. Epub 2011 Feb 7.

30.

Reduced atherosclerosis and inflammatory cytokines in apolipoprotein-E-deficient mice lacking bone marrow-derived interleukin-1α.

Kamari Y, Shaish A, Shemesh S, Vax E, Grosskopf I, Dotan S, White M, Voronov E, Dinarello CA, Apte RN, Harats D.

Biochem Biophys Res Commun. 2011 Feb 11;405(2):197-203. doi: 10.1016/j.bbrc.2011.01.008. Epub 2011 Jan 8.

PMID:
21219852
31.

Sialylation of 3-methylcholanthrene-induced fibrosarcoma determines antitumor immune responses during immunoediting.

Cohen M, Elkabets M, Perlmutter M, Porgador A, Voronov E, Apte RN, Lichtenstein RG.

J Immunol. 2010 Nov 15;185(10):5869-78. doi: 10.4049/jimmunol.1001635. Epub 2010 Oct 18.

32.

IL-1-induced inflammation promotes development of leishmaniasis in susceptible BALB/c mice.

Voronov E, Dotan S, Gayvoronsky L, White RM, Cohen I, Krelin Y, Benchetrit F, Elkabets M, Huszar M, El-On J, Apte RN.

Int Immunol. 2010 Apr;22(4):245-57. doi: 10.1093/intimm/dxq006. Epub 2010 Feb 24.

PMID:
20181656
33.

Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation.

Cohen I, Rider P, Carmi Y, Braiman A, Dotan S, White MR, Voronov E, Martin MU, Dinarello CA, Apte RN.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2574-9. doi: 10.1073/pnas.0915018107. Epub 2010 Jan 25.

34.

Effects of IL-1 molecules on growth patterns of 3-MCA-induced cell lines: an interplay between immunogenicity and invasive potential.

Voronov E, Reich E, Dotan S, Dransh P, Cohen I, Huszar M, Fogel M, Kleinman HK, White RM, Apte RN.

J Immunotoxicol. 2010 Mar;7(1):27-38. doi: 10.3109/15476910903405528.

PMID:
20001788
35.

The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis.

Carmi Y, Voronov E, Dotan S, Lahat N, Rahat MA, Fogel M, Huszar M, White MR, Dinarello CA, Apte RN.

J Immunol. 2009 Oct 1;183(7):4705-14. doi: 10.4049/jimmunol.0901511. Epub 2009 Sep 14.

36.

Host-derived interleukin-1alpha is important in determining the immunogenicity of 3-methylcholantrene tumor cells.

Elkabets M, Krelin Y, Dotan S, Cerwenka A, Porgador A, Lichtenstein RG, White MR, Zoller M, Iwakura Y, Dinarello CA, Voronov E, Apte RN.

J Immunol. 2009 Apr 15;182(8):4874-81. doi: 10.4049/jimmunol.0803916.

37.

Contribution of IL-1 to resistance to Streptococcus pneumoniae infection.

Kafka D, Ling E, Feldman G, Benharroch D, Voronov E, Givon-Lavi N, Iwakura Y, Dagan R, Apte RN, Mizrachi-Nebenzahl Y.

Int Immunol. 2008 Sep;20(9):1139-46. doi: 10.1093/intimm/dxn071. Epub 2008 Jul 1.

PMID:
18596024
38.

Tumorigenicity of IL-1alpha- and IL-1beta-deficient fibrosarcoma cells.

Nazarenko I, Marhaba R, Reich E, Voronov E, Vitacolonna M, Hildebrand D, Elter E, Rajasagi M, Apte RN, Zöller M.

Neoplasia. 2008 Jun;10(6):549-62.

39.

Opposing effects of fibrosarcoma cell-derived IL-1 alpha and IL-1 beta on immune response induction.

Marhaba R, Nazarenko I, Knöfler D, Reich E, Voronov E, Vitacolonna M, Hildebrand D, Elter E, Apte RN, Zöller M.

Int J Cancer. 2008 Jul 1;123(1):134-45. doi: 10.1002/ijc.23503.

40.

Is interleukin-1 a good or bad 'guy' in tumor immunobiology and immunotherapy?

Apte RN, Voronov E.

Immunol Rev. 2008 Apr;222:222-41. doi: 10.1111/j.1600-065X.2008.00615.x. Review.

PMID:
18364005
41.

Sustained delivery of IL-1 Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases.

Lavi G, Voronov E, Dinarello CA, Apte RN, Cohen S.

J Control Release. 2007 Nov 6;123(2):123-30. Epub 2007 Aug 7.

PMID:
17900737
42.

Role of IL-1-mediated inflammation in tumor angiogenesis.

Voronov E, Carmi Y, Apte RN.

Adv Exp Med Biol. 2007;601:265-70. Review.

PMID:
17713014
43.

Interleukin-1beta-driven inflammation promotes the development and invasiveness of chemical carcinogen-induced tumors.

Krelin Y, Voronov E, Dotan S, Elkabets M, Reich E, Fogel M, Huszar M, Iwakura Y, Segal S, Dinarello CA, Apte RN.

Cancer Res. 2007 Feb 1;67(3):1062-71.

44.

Differential role and tissue specificity of interleukin-1alpha gene expression in atherogenesis and lipid metabolism.

Kamari Y, Werman-Venkert R, Shaish A, Werman A, Harari A, Gonen A, Voronov E, Grosskopf I, Sharabi Y, Grossman E, Iwakura Y, Dinarello CA, Apte RN, Harats D.

Atherosclerosis. 2007 Nov;195(1):31-8. Epub 2006 Dec 14.

PMID:
17173923
45.

The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions.

Apte RN, Dotan S, Elkabets M, White MR, Reich E, Carmi Y, Song X, Dvozkin T, Krelin Y, Voronov E.

Cancer Metastasis Rev. 2006 Sep;25(3):387-408. Review.

PMID:
17043764
46.

IL-1 beta-deficient mice are resistant to induction of experimental SLE.

Voronov E, Dayan M, Zinger H, Gayvoronsky L, Lin JP, Iwakura Y, Apte RN, Mozes E.

Eur Cytokine Netw. 2006 Jun;17(2):109-16.

47.

Immune phenomena involved in the in vivo regression of fibrosarcoma cells expressing cell-associated IL-1alpha.

Dvorkin T, Song X, Argov S, White RM, Zoller M, Segal S, Dinarello CA, Voronov E, Apte RN.

J Leukoc Biol. 2006 Jul;80(1):96-106. Epub 2006 May 17.

PMID:
16707560
48.

Effects of micro-environment- and malignant cell-derived interleukin-1 in carcinogenesis, tumour invasiveness and tumour-host interactions.

Apte RN, Krelin Y, Song X, Dotan S, Recih E, Elkabets M, Carmi Y, Dvorkin T, White RM, Gayvoronsky L, Segal S, Voronov E.

Eur J Cancer. 2006 Apr;42(6):751-9. Epub 2006 Mar 10. Review.

PMID:
16530403
49.

CD11b+/Gr-1+ immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1beta-secreting cells.

Song X, Krelin Y, Dvorkin T, Bjorkdahl O, Segal S, Dinarello CA, Voronov E, Apte RN.

J Immunol. 2005 Dec 15;175(12):8200-8.

50.

The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription.

Werman A, Werman-Venkert R, White R, Lee JK, Werman B, Krelin Y, Voronov E, Dinarello CA, Apte RN.

Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2434-9.

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