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Biomarkers of cell-mediated immunity to bovine tuberculosis.

Palmer MV, Thacker TC, Rabideau MM, Jones GJ, Kanipe C, Vordermeier HM, Ray Waters W.

Vet Immunol Immunopathol. 2019 Nov 30;220:109988. doi: 10.1016/j.vetimm.2019.109988. [Epub ahead of print]


Potential of the dual IFN-γ/IL-2 fluorescence-immunospot assay to distinguish different stages in bovine tuberculosis.

Steinbach S, Vordermeier HM, Jones GJ.

Vet Immunol Immunopathol. 2019 Nov;217:109930. doi: 10.1016/j.vetimm.2019.109930. Epub 2019 Aug 13.


A defined antigen skin test for the diagnosis of bovine tuberculosis.

Srinivasan S, Jones G, Veerasami M, Steinbach S, Holder T, Zewude A, Fromsa A, Ameni G, Easterling L, Bakker D, Juleff N, Gifford G, Hewinson RG, Vordermeier HM, Kapur V.

Sci Adv. 2019 Jul 17;5(7):eaax4899. doi: 10.1126/sciadv.aax4899. eCollection 2019 Jul.


The Humoral Immune Response to BCG Vaccination.

Tanner R, Villarreal-Ramos B, Vordermeier HM, McShane H.

Front Immunol. 2019 Jun 11;10:1317. doi: 10.3389/fimmu.2019.01317. eCollection 2019. Review.


Transposon libraries identify novel Mycobacterium bovis BCG genes involved in the dynamic interactions required for BCG to persist during in vivo passage in cattle.

Mendum TA, Chandran A, Williams K, Vordermeier HM, Villarreal-Ramos B, Wu H, Singh A, Smith AA, Butler RE, Prasad A, Bharti N, Banerjee R, Kasibhatla SM, Bhatt A, Stewart GR, McFadden J.

BMC Genomics. 2019 May 28;20(1):431. doi: 10.1186/s12864-019-5791-1.


Efficacy and Safety of BCG Vaccine for Control of Tuberculosis in Domestic Livestock and Wildlife.

Buddle BM, Vordermeier HM, Chambers MA, de Klerk-Lorist LM.

Front Vet Sci. 2018 Oct 26;5:259. doi: 10.3389/fvets.2018.00259. eCollection 2018. Review.


The expression of Indoleamine 2, 3-dioxygenase (IDO) is reduced in granulomas from BCG vaccinated cattle compared to granulomas from unvaccinated controls after experimental challenge with Mycobacterium bovis.

Garcia-Jimenez WL, Villarreal-Ramos B, Grainger D, Hewisnon RG, Vordermeier HM, Salguero FJ.

Vet Immunol Immunopathol. 2018 Sep;203:52-56. doi: 10.1016/j.vetimm.2018.08.002. Epub 2018 Aug 13.


Ag85A-specific CD4+ T cell lines derived after boosting BCG-vaccinated cattle with Ad5-85A possess both mycobacterial growth inhibition and anti-inflammatory properties.

Metcalfe HJ, Biffar L, Steinbach S, Guzman E, Connelley T, Morrison I, Vordermeier HM, Villarreal-Ramos B.

Vaccine. 2018 May 11;36(20):2850-2854. doi: 10.1016/j.vaccine.2018.03.068. Epub 2018 Apr 11.


Methodology and preliminary results of a systematic literature review of ante-mortem and post-mortem diagnostic tests for bovine tuberculosis.

Downs SH, Parry JE, Upton PA, Broughan JM, Goodchild AV, Nuñez-Garcia J, Greiner M, Abernethy DA, Cameron AR, Cook AJ, de la Rua-Domenech R, Gunn J, Pritchard E, Rhodes S, Rolfe S, Sharp M, Vordermeier HM, Watson E, Welsh M, Whelan AO, Woolliams JA, More SJ, Clifton-Hadley RS.

Prev Vet Med. 2018 May 1;153:117-126. doi: 10.1016/j.prevetmed.2017.11.004. Epub 2017 Nov 9. Review.


Identification of Novel Antigens Recognized by Serum Antibodies in Bovine Tuberculosis.

Lyashchenko KP, Grandison A, Keskinen K, Sikar-Gang A, Lambotte P, Esfandiari J, Ireton GC, Vallur A, Reed SG, Jones G, Vordermeier HM, Stabel JR, Thacker TC, Palmer MV, Waters WR.

Clin Vaccine Immunol. 2017 Dec 5;24(12). pii: e00259-17. doi: 10.1128/CVI.00259-17. Print 2017 Dec.


Potential for rapid antibody detection to identify tuberculous cattle with non-reactive tuberculin skin test results.

Waters WR, Vordermeier HM, Rhodes S, Khatri B, Palmer MV, Maggioli MF, Thacker TC, Nelson JT, Thomsen BV, Robbe-Austerman S, Bravo Garcia DM, Schoenbaum MA, Camacho MS, Ray JS, Esfandiari J, Lambotte P, Greenwald R, Grandison A, Sikar-Gang A, Lyashchenko KP.

BMC Vet Res. 2017 Jun 7;13(1):164. doi: 10.1186/s12917-017-1085-5.


Meta-analyses of the sensitivity and specificity of ante-mortem and post-mortem diagnostic tests for bovine tuberculosis in the UK and Ireland.

Nuñez-Garcia J, Downs SH, Parry JE, Abernethy DA, Broughan JM, Cameron AR, Cook AJ, de la Rua-Domenech R, Goodchild AV, Gunn J, More SJ, Rhodes S, Rolfe S, Sharp M, Upton PA, Vordermeier HM, Watson E, Welsh M, Whelan AO, Woolliams JA, Clifton-Hadley RS, Greiner M.

Prev Vet Med. 2018 May 1;153:94-107. doi: 10.1016/j.prevetmed.2017.02.017. Epub 2017 Mar 6.


Tuberculin Skin Testing Boosts Interferon Gamma Responses to DIVA Reagents in Mycobacterium bovis-Infected Cattle.

Jones GJ, Coad M, Khatri B, Bezos J, Parlane NA, Buddle BM, Villarreal-Ramos B, Hewinson RG, Vordermeier HM.

Clin Vaccine Immunol. 2017 May 5;24(5). pii: e00551-16. doi: 10.1128/CVI.00551-16. Print 2017 May.


Vaccination of calves with Mycobacterium bovis Bacillus Calmette-Guerin reduces the frequency and severity of lesions of bovine tuberculosis under a natural transmission setting in Ethiopia.

Ameni G, Tafess K, Zewde A, Eguale T, Tilahun M, Hailu T, Sirak A, Salguero FJ, Berg S, Aseffa A, Hewinson RG, Vordermeier HM.

Transbound Emerg Dis. 2018 Feb;65(1):96-104. doi: 10.1111/tbed.12618. Epub 2017 Feb 6.


Oral vaccination of cattle with heat inactivated Mycobacterium bovis does not compromise bovine TB diagnostic tests.

Jones GJ, Steinbach S, Sevilla IA, Garrido JM, Juste R, Vordermeier HM.

Vet Immunol Immunopathol. 2016 Dec;182:85-88. doi: 10.1016/j.vetimm.2016.10.010. Epub 2016 Oct 19.


Increased TNF-α/IFN-γ/IL-2 and Decreased TNF-α/IFN-γ Production by Central Memory T Cells Are Associated with Protective Responses against Bovine Tuberculosis Following BCG Vaccination.

Maggioli MF, Palmer MV, Thacker TC, Vordermeier HM, McGill JL, Whelan AO, Larsen MH, Jacobs WR Jr, Waters WR.

Front Immunol. 2016 Oct 17;7:421. eCollection 2016.


Experimental Infection Models of Tuberculosis in Domestic Livestock.

Buddle BM, Vordermeier HM, Hewinson RG.

Microbiol Spectr. 2016 Aug;4(4). doi: 10.1128/microbiolspec.TBTB2-0017-2016. Review.


Differential Cell Composition and Cytokine Expression Within Lymph Node Granulomas from BCG-Vaccinated and Non-vaccinated Cattle Experimentally Infected with Mycobacterium bovis.

Salguero FJ, Gibson S, Garcia-Jimenez W, Gough J, Strickland TS, Vordermeier HM, Villarreal-Ramos B.

Transbound Emerg Dis. 2017 Dec;64(6):1734-1749. doi: 10.1111/tbed.12561. Epub 2016 Sep 11.


Vaccination of cattle with a high dose of BCG vaccine 3 weeks after experimental infection with Mycobacterium bovis increased the inflammatory response, but not tuberculous pathology.

Buddle BM, Shu D, Parlane NA, Subharat S, Heiser A, Hewinson RG, Vordermeier HM, Wedlock DN.

Tuberculosis (Edinb). 2016 Jul;99:120-7. doi: 10.1016/ Epub 2016 May 27.


CD4+ and γδ T Cells are the main Producers of IL-22 and IL-17A in Lymphocytes from Mycobacterium bovis-infected Cattle.

Steinbach S, Vordermeier HM, Jones GJ.

Sci Rep. 2016 Jul 18;6:29990. doi: 10.1038/srep29990.


Development of immune-diagnostic reagents to diagnose bovine tuberculosis in cattle.

Vordermeier HM, Jones GJ, Buddle BM, Hewinson RG.

Vet Immunol Immunopathol. 2016 Nov 15;181:10-14. doi: 10.1016/j.vetimm.2016.02.003. Epub 2016 Feb 10. Review.


Bovine Tuberculosis in Cattle: Vaccines, DIVA Tests, and Host Biomarker Discovery.

Vordermeier HM, Jones GJ, Buddle BM, Hewinson RG, Villarreal-Ramos B.

Annu Rev Anim Biosci. 2016;4:87-109. doi: 10.1146/annurev-animal-021815-111311. Review.


Interleukin-17A as a Biomarker for Bovine Tuberculosis.

Waters WR, Maggioli MF, Palmer MV, Thacker TC, McGill JL, Vordermeier HM, Berney-Meyer L, Jacobs WR Jr, Larsen MH.

Clin Vaccine Immunol. 2015 Dec 16;23(2):168-80. doi: 10.1128/CVI.00637-15. Print 2016 Feb.


Phenotypic characterization of bovine memory cells responding to mycobacteria in IFNγ enzyme linked immunospot assays.

Blunt L, Hogarth PJ, Kaveh DA, Webb P, Villarreal-Ramos B, Vordermeier HM.

Vaccine. 2015 Dec 16;33(51):7276-7282. doi: 10.1016/j.vaccine.2015.10.113. Epub 2015 Nov 6.


Protection Induced by Simultaneous Subcutaneous and Endobronchial Vaccination with BCG/BCG and BCG/Adenovirus Expressing Antigen 85A against Mycobacterium bovis in Cattle.

Dean GS, Clifford D, Whelan AO, Tchilian EZ, Beverley PC, Salguero FJ, Xing Z, Vordermeier HM, Villarreal-Ramos B.

PLoS One. 2015 Nov 6;10(11):e0142270. doi: 10.1371/journal.pone.0142270. eCollection 2015.


Display of Antigens on Polyester Inclusions Lowers the Antigen Concentration Required for a Bovine Tuberculosis Skin Test.

Parlane NA, Chen S, Jones GJ, Vordermeier HM, Wedlock DN, Rehm BH, Buddle BM.

Clin Vaccine Immunol. 2015 Oct 28;23(1):19-26. doi: 10.1128/CVI.00462-15. Print 2016 Jan.


Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle.

Maggioli MF, Palmer MV, Vordermeier HM, Whelan AO, Fosse JM, Nonnecke BJ, Waters WR.

J Vis Exp. 2015 Jul 11;(101):e52833. doi: 10.3791/52833.


Admixture mapping of tuberculosis and pigmentation-related traits in an African-European hybrid cattle population.

Kassahun Y, Mattiangeli V, Ameni G, Hailu E, Aseffa A, Young DB, Hewinson RG, Vordermeier HM, Bradley DG.

Front Genet. 2015 Jun 15;6:210. doi: 10.3389/fgene.2015.00210. eCollection 2015.


Erratum for Pirson et al., Highly purified mycobacterial phosphatidylinositol mannosides drive cell-mediated responses and activate NKT cells in cattle.

Pirson C, Engel R, Jones GJ, Holder T, Holst O, Vordermeier HM.

Clin Vaccine Immunol. 2015 May;22(5):609. doi: 10.1128/CVI.00139-15.


Characterization of effector and memory T cell subsets in the immune response to bovine tuberculosis in cattle.

Maggioli MF, Palmer MV, Thacker TC, Vordermeier HM, Waters WR.

PLoS One. 2015 Apr 16;10(4):e0122571. doi: 10.1371/journal.pone.0122571. eCollection 2015.


Highly purified mycobacterial phosphatidylinositol mannosides drive cell-mediated responses and activate NKT cells in cattle.

Pirson C, Engel R, Jones GJ, Holder T, Holst O, Vordermeier HM.

Clin Vaccine Immunol. 2015 Feb;22(2):178-84. doi: 10.1128/CVI.00638-14. Epub 2014 Dec 10. Erratum in: Clin Vaccine Immunol. 2015 May;22(5):609.


Vaccination of domestic animals against tuberculosis: review of progress and contributions to the field of the TBSTEP project.

Vordermeier HM, Pérez de Val B, Buddle BM, Villarreal-Ramos B, Jones GJ, Hewinson RG, Domingo M.

Res Vet Sci. 2014 Oct;97 Suppl:S53-60. doi: 10.1016/j.rvsc.2014.04.015. Epub 2014 May 6. Review.


Innate cytokine profiling of bovine alveolar macrophages reveals commonalities and divergence in the response to Mycobacterium bovis and Mycobacterium tuberculosis infection.

Magee DA, Conlon KM, Nalpas NC, Browne JA, Pirson C, Healy C, McLoughlin KE, Chen J, Vordermeier HM, Gormley E, MacHugh DE, Gordon SV.

Tuberculosis (Edinb). 2014 Jul;94(4):441-50. doi: 10.1016/ Epub 2014 May 5.


Effect of dose and route of immunisation on the immune response induced in cattle by heterologous Bacille Calmette-Guerin priming and recombinant adenoviral vector boosting.

Dean G, Clifford D, Gilbert S, McShane H, Hewinson RG, Vordermeier HM, Villarreal-Ramos B.

Vet Immunol Immunopathol. 2014 Apr 15;158(3-4):208-13. doi: 10.1016/j.vetimm.2014.01.010. Epub 2014 Jan 28.


BCG Δzmp1 vaccine induces enhanced antigen specific immune responses in cattle.

Khatri B, Whelan A, Clifford D, Petrera A, Sander P, Vordermeier HM.

Vaccine. 2014 Feb 7;32(7):779-84. doi: 10.1016/j.vaccine.2013.12.055. Epub 2014 Jan 4.


A multi-antigenic adenoviral-vectored vaccine improves BCG-induced protection of goats against pulmonary tuberculosis infection and prevents disease progression.

Pérez de Val B, Vidal E, Villarreal-Ramos B, Gilbert SC, Andaluz A, Moll X, Martín M, Nofrarías M, McShane H, Vordermeier HM, Domingo M.

PLoS One. 2013 Nov 21;8(11):e81317. doi: 10.1371/journal.pone.0081317. eCollection 2013.


Use of antigen-specific interleukin-2 to differentiate between cattle vaccinated with Mycobacterium bovis BCG and cattle infected with M. bovis.

Rhodes SG, McKinna LC, Steinbach S, Dean GS, Villarreal-Ramos B, Whelan AO, Pirson C, Jones GJ, Clifford D, Vordermeier HM.

Clin Vaccine Immunol. 2014 Jan;21(1):39-45. doi: 10.1128/CVI.00522-13. Epub 2013 Oct 30.


Immunisation with ID83 fusion protein induces antigen-specific cell mediated and humoral immune responses in cattle.

Jones GJ, Steinbach S, Clifford D, Baldwin SL, Ireton GC, Coler RN, Reed SG, Vordermeier HM.

Vaccine. 2013 Oct 25;31(45):5250-5. doi: 10.1016/j.vaccine.2013.08.051. Epub 2013 Sep 5.


Development of an unbiased antigen-mining approach to identify novel vaccine antigens and diagnostic reagents for bovine tuberculosis.

Jones GJ, Khatri BL, Garcia-Pelayo MC, Kaveh DA, Bachy VS, Hogarth PJ, Wooff E, Golby P, Vordermeier HM.

Clin Vaccine Immunol. 2013 Nov;20(11):1675-82. doi: 10.1128/CVI.00416-13. Epub 2013 Aug 28.


The consequences of vaccination with the Johne's disease vaccine, Gudair, on diagnosis of bovine tuberculosis.

Coad M, Clifford DJ, Vordermeier HM, Whelan AO.

Vet Rec. 2013 Mar 9;172(10):266. doi: 10.1136/vr.101201. Epub 2012 Dec 21.


Global gene transcriptome analysis in vaccinated cattle revealed a dominant role of IL-22 for protection against bovine tuberculosis.

Bhuju S, Aranday-Cortes E, Villarreal-Ramos B, Xing Z, Singh M, Vordermeier HM.

PLoS Pathog. 2012 Dec;8(12):e1003077. doi: 10.1371/journal.ppat.1003077. Epub 2012 Dec 27.


Bioinformatic and empirical analysis of novel hypoxia-inducible targets of the human antituberculosis T cell response.

Gideon HP, Wilkinson KA, Rustad TR, Oni T, Guio H, Sherman DR, Vordermeier HM, Robertson BD, Young DB, Wilkinson RJ.

J Immunol. 2012 Dec 15;189(12):5867-76. doi: 10.4049/jimmunol.1202281. Epub 2012 Nov 19.


Effects of vaccination against paratuberculosis on tuberculosis in goats: diagnostic interferences and cross-protection.

Pérez de Val B, Nofrarías M, López-Soria S, Garrido JM, Vordermeier HM, Villarreal-Ramos B, Martín M, Puentes E, Juste RA, Domingo M.

BMC Vet Res. 2012 Oct 16;8:191. doi: 10.1186/1746-6148-8-191.


A natural-transmission model of bovine tuberculosis provides novel disease insights.

Khatri BL, Coad M, Clifford DJ, Hewinson RG, Whelan AO, Vordermeier HM.

Vet Rec. 2012 Nov 3;171(18):448. doi: 10.1136/vr.101072. Epub 2012 Aug 30. No abstract available.


Upregulation of IL-17A, CXCL9 and CXCL10 in early-stage granulomas induced by Mycobacterium bovis in cattle.

Aranday-Cortes E, Bull NC, Villarreal-Ramos B, Gough J, Hicks D, Ortiz-Peláez A, Vordermeier HM, Salguero FJ.

Transbound Emerg Dis. 2013 Dec;60(6):525-37. doi: 10.1111/j.1865-1682.2012.01370.x. Epub 2012 Aug 22.


Conserved immune recognition hierarchy of mycobacterial PE/PPE proteins during infection in natural hosts.

Vordermeier HM, Hewinson RG, Wilkinson RJ, Wilkinson KA, Gideon HP, Young DB, Sampson SL.

PLoS One. 2012;7(8):e40890. doi: 10.1371/journal.pone.0040890. Epub 2012 Aug 1.


Goats primed with Mycobacterium bovis BCG and boosted with a recombinant adenovirus expressing Ag85A show enhanced protection against tuberculosis.

Pérez de Val B, Villarreal-Ramos B, Nofrarías M, López-Soria S, Romera N, Singh M, Abad FX, Xing Z, Vordermeier HM, Domingo M.

Clin Vaccine Immunol. 2012 Sep;19(9):1339-47. doi: 10.1128/CVI.00275-12. Epub 2012 Jul 3.


Differential effects of Mycobacterium bovis--derived polar and apolar lipid fractions on bovine innate immune cells.

Pirson C, Jones GJ, Steinbach S, Besra GS, Vordermeier HM.

Vet Res. 2012 Jun 27;43:54. doi: 10.1186/1297-9716-43-54.


Duration of immunity against Mycobacterium bovis following neonatal vaccination with bacillus Calmette-Guérin Danish: significant protection against infection at 12, but not 24, months.

Thom ML, McAulay M, Vordermeier HM, Clifford D, Hewinson RG, Villarreal-Ramos B, Hope JC.

Clin Vaccine Immunol. 2012 Aug;19(8):1254-60. doi: 10.1128/CVI.00301-12. Epub 2012 Jun 20.

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