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Items: 14


Characterization of ABBV-221, a Tumor-Selective EGFR-Targeting Antibody Drug Conjugate.

Phillips AC, Boghaert ER, Vaidya KS, Falls HD, Mitten MJ, DeVries PJ, Benatuil L, Hsieh CM, Meulbroek JA, Panchal SC, Buchanan FG, Durbin KR, Voorbach MJ, Reuter DR, Mudd SR, Loberg LI, Ralston SL, Cao D, Gan HK, Scott AM, Reilly EB.

Mol Cancer Ther. 2018 Apr;17(4):795-805. doi: 10.1158/1535-7163.MCT-17-0710. Epub 2018 Feb 26.


Image quality of Zr-89 PET imaging in the Siemens microPET Focus 220 preclinical scanner.

Bradshaw TJ, Voorbach MJ, Reuter DR, Giamis AM, Mudd SR, Beaver JD.

Mol Imaging Biol. 2016 Jun;18(3):377-85. doi: 10.1007/s11307-015-0903-z.


Multimodal assessment of nervous and immune system responses following sciatic nerve injury.

Lasko L, Huang X, Voorbach MJ, Lewis LG, Stavropoulos J, Carriker J, Seifert TR, Baker SJ, Upadhyay J.

Pain. 2013 Dec;154(12):2782-93. doi: 10.1016/j.pain.2013.08.016. Epub 2013 Aug 21.


Monitoring tumor response to linifanib therapy with SPECT/CT using the integrin αvβ3-targeted radiotracer 99mTc-3P-RGD2.

Ji S, Zhou Y, Voorbach MJ, Shao G, Zhang Y, Fox GB, Albert DH, Luo Y, Liu S, Mudd SR.

J Pharmacol Exp Ther. 2013 Aug;346(2):251-8. doi: 10.1124/jpet.112.202622. Epub 2013 Jun 7.


FDG-PET as a pharmacodynamic biomarker for early assessment of treatment response to linifanib (ABT-869) in a non-small cell lung cancer xenograft model.

Mudd SR, Voorbach MJ, Reuter DR, Tapang P, Hickson JA, Refici-Buhr M, Fox GB, Albert DH, Luo Y, Day M.

Cancer Chemother Pharmacol. 2012 Jun;69(6):1669-72. doi: 10.1007/s00280-012-1840-z. Epub 2012 Feb 12.


Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1.

Yeh VS, Beno DW, Brodjian S, Brune ME, Cullen SC, Dayton BD, Dhaon MK, Falls HD, Gao J, Grihalde N, Hajduk P, Hansen TM, Judd AS, King AJ, Klix RC, Larson KJ, Lau YY, Marsh KC, Mittelstadt SW, Plata D, Rozema MJ, Segreti JA, Stoner EJ, Voorbach MJ, Wang X, Xin X, Zhao G, Collins CA, Cox BF, Reilly RM, Kym PR, Souers AJ.

J Med Chem. 2012 Feb 23;55(4):1751-7. doi: 10.1021/jm201524g. Epub 2012 Feb 10.


Pharmacodynamic evaluation of irinotecan therapy by FDG and FLT PET/CT imaging in a colorectal cancer xenograft model.

Mudd SR, Holich KD, Voorbach MJ, Cole TB, Reuter DR, Tapang P, Bukofzer G, Chakravartty A, Donawho CK, Palma JP, Fox GB, Day M, Luo Y.

Mol Imaging Biol. 2012 Oct;14(5):617-24. doi: 10.1007/s11307-011-0529-8.


In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia.

King AJ, Segreti JA, Larson KJ, Souers AJ, Kym PR, Reilly RM, Collins CA, Voorbach MJ, Zhao G, Mittelstadt SW, Cox BF.

Eur J Pharmacol. 2010 Jul 10;637(1-3):155-61. doi: 10.1016/j.ejphar.2010.03.056. Epub 2010 Apr 10.


Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice.

Yang R, Wilcox DM, Haasch DL, Jung PM, Nguyen PT, Voorbach MJ, Doktor S, Brodjian S, Bush EN, Lin E, Jacobson PB, Collins CA, Landschulz KT, Trevillyan JM, Rondinone CM, Surowy TK.

J Biol Chem. 2007 Aug 3;282(31):22765-74. Epub 2007 Jun 5.


An ultraefficient affinity-based high-throughout screening process: application to bacterial cell wall biosynthesis enzyme MurF.

Comess KM, Schurdak ME, Voorbach MJ, Coen M, Trumbull JD, Yang H, Gao L, Tang H, Cheng X, Lerner CG, McCall JO, Burns DJ, Beutel BA.

J Biomol Screen. 2006 Oct;11(7):743-54. Epub 2006 Sep 14.


Kinase drug discovery by affinity selection/mass spectrometry (ASMS): application to DNA damage checkpoint kinase Chk1.

Comess KM, Trumbull JD, Park C, Chen Z, Judge RA, Voorbach MJ, Coen M, Gao L, Tang H, Kovar P, Cheng X, Schurdak ME, Zhang H, Sowin T, Burns DJ.

J Biomol Screen. 2006 Oct;11(7):755-64. Epub 2006 Sep 6.


Delivery of RNAi reagents in murine models of obesity and diabetes.

Wilcox DM, Yang R, Morgan SJ, Nguyen PT, Voorbach MJ, Jung PM, Haasch DL, Lin E, Bush EN, Opgenorth TJ, Jacobson PB, Collins CA, Rondinone CM, Surowy T, Landschulz KT.

J RNAi Gene Silencing. 2006 Nov 29;3(1):225-36.


Discovery of novel inhibitors of Bcl-xL using multiple high-throughput screening platforms.

Qian J, Voorbach MJ, Huth JR, Coen ML, Zhang H, Ng SC, Comess KM, Petros AM, Rosenberg SH, Warrior U, Burns DJ.

Anal Biochem. 2004 May 15;328(2):131-8.


Complex gel permeation assays for screening combinatorial libraries.

Schurdak ME, Voorbach MJ, Gao L, Cheng X, Comess KM, Rottinghaus SM, Warrior U, Truong HN, Burns DJ, Beutel BA.

J Biomol Screen. 2001 Oct;6(5):313-23.


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