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Radiation-Induced Lung Injury (RILI).

Giuranno L, Ient J, De Ruysscher D, Vooijs MA.

Front Oncol. 2019 Sep 6;9:877. doi: 10.3389/fonc.2019.00877. eCollection 2019. Review.


NOTCH signaling promotes the survival of irradiated basal airway stem cells.

Giuranno L, Wansleeben C, Iannone R, Arathoon L, Hounjet J, Groot AJ, Vooijs M.

Am J Physiol Lung Cell Mol Physiol. 2019 Sep 1;317(3):L414-L423. doi: 10.1152/ajplung.00197.2019. Epub 2019 Jul 19.


The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to γ-secretase inhibition.

Hounjet J, Habets R, Schaaf MB, Hendrickx TC, Barbeau LMO, Yahyanejad S, Rouschop KM, Groot AJ, Vooijs M.

Oncogene. 2019 Jul;38(27):5457-5468. doi: 10.1038/s41388-019-0802-x. Epub 2019 Apr 9.


HIF-1α and HIF-2α Differently Regulate the Radiation Sensitivity of NSCLC Cells.

Moreno Roig E, Groot AJ, Yaromina A, Hendrickx TC, Barbeau LMO, Giuranno L, Dams G, Ient J, Olivo Pimentel V, van Gisbergen MW, Dubois LJ, Vooijs MA.

Cells. 2019 Jan 12;8(1). pii: E45. doi: 10.3390/cells8010045.


Moving Breast Cancer Therapy up a Notch.

Mollen EWJ, Ient J, Tjan-Heijnen VCG, Boersma LJ, Miele L, Smidt ML, Vooijs MAGG.

Front Oncol. 2018 Nov 20;8:518. doi: 10.3389/fonc.2018.00518. eCollection 2018. Review.


An orthotopic non-small cell lung cancer model for image-guided small animal radiotherapy platforms.

Sosa Iglesias V, van Hoof SJ, Vaniqui A, Schyns LE, Lieuwes N, Yaromina A, Spiegelberg L, Groot AJ, Verhaegen F, Theys J, Dubois L, Vooijs M.

Br J Radiol. 2019 Mar;92(1095):20180476. doi: 10.1259/bjr.20180476. Epub 2018 Nov 30.


Synergistic Effects of NOTCH/γ-Secretase Inhibition and Standard of Care Treatment Modalities in Non-small Cell Lung Cancer Cells.

Sosa Iglesias V, Theys J, Groot AJ, Barbeau LMO, Lemmens A, Yaromina A, Losen M, Houben R, Dubois L, Vooijs M.

Front Oncol. 2018 Nov 7;8:460. doi: 10.3389/fonc.2018.00460. eCollection 2018.


A training programme facilitating guideline use of occupational health professionals: a feasibility study.

Vooijs M, Bossen D, Hoving JL, Wind H, Frings-Dresen MHW.

BMC Med Educ. 2018 Oct 3;18(1):226. doi: 10.1186/s12909-018-1223-1.


Drug Resistance in Non-Small Cell Lung Cancer: A Potential for NOTCH Targeting?

Sosa Iglesias V, Giuranno L, Dubois LJ, Theys J, Vooijs M.

Front Oncol. 2018 Jul 24;8:267. doi: 10.3389/fonc.2018.00267. eCollection 2018. Review.


Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis.

Moreno Roig E, Yaromina A, Houben R, Groot AJ, Dubois L, Vooijs M.

Front Oncol. 2018 Jun 11;8:224. doi: 10.3389/fonc.2018.00224. eCollection 2018.


Codon-specific translation reprogramming promotes resistance to targeted therapy.

Rapino F, Delaunay S, Rambow F, Zhou Z, Tharun L, De Tullio P, Sin O, Shostak K, Schmitz S, Piepers J, Ghesquière B, Karim L, Charloteaux B, Jamart D, Florin A, Lambert C, Rorive A, Jerusalem G, Leucci E, Dewaele M, Vooijs M, Leidel SA, Georges M, Voz M, Peers B, Büttner R, Marine JC, Chariot A, Close P.

Nature. 2018 Jun;558(7711):605-609. doi: 10.1038/s41586-018-0243-7. Epub 2018 Jun 20.


Noninvasive Glioblastoma Testing: Multimodal Approach to Monitoring and Predicting Treatment Response.

Verduin M, Compter I, Steijvers D, Postma AA, Eekers DBP, Anten MM, Ackermans L, Ter Laan M, Leijenaar RTH, van de Weijer T, Tjan-Heijnen VCG, Hoeben A, Vooijs M.

Dis Markers. 2018 Jan 17;2018:2908609. doi: 10.1155/2018/2908609. eCollection 2018. Review.


PD-(L)1 Inhibition and Cardiac Damage: A Relevant Toxicity?

De Ruysscher D, Dingemans AM, Vooijs M, Heymans S.

J Thorac Oncol. 2018 Apr;13(4):478-479. doi: 10.1016/j.jtho.2018.02.008. No abstract available.


EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition.

Jutten B, Keulers TG, Peeters HJM, Schaaf MBE, Savelkouls KGM, Compter I, Clarijs R, Schijns OEMG, Ackermans L, Teernstra OPM, Zonneveld MI, Colaris RME, Dubois L, Vooijs MA, Bussink J, Sotelo J, Theys J, Lammering G, Rouschop KMA.

Autophagy. 2018;14(2):283-295. doi: 10.1080/15548627.2017.1409926. Epub 2018 Jan 29.


[Guideline 'The chronically ill and work'].

Wind H, van der Heide I, Vooijs M, Bossen D, Hoving JL, Frings-Dresen MHW.

Ned Tijdschr Geneeskd. 2018;161:D2030. Dutch.


Value of work for employees with a chronic disease.

Vooijs M, Leensen MCJ, Hoving JL, Wind H, Frings-Dresen MHW.

Occup Med (Lond). 2018 Feb 16;68(1):26-31. doi: 10.1093/occmed/kqx178.


Blocking 17β-hydroxysteroid dehydrogenase type 1 in endometrial cancer: a potential novel endocrine therapeutic approach.

Konings GF, Cornel KM, Xanthoulea S, Delvoux B, Skowron MA, Kooreman L, Koskimies P, Krakstad C, Salvesen HB, van Kuijk K, Schrooders YJ, Vooijs M, Groot AJ, Bongers MY, Kruitwagen RF; ENITEC, Romano A.

J Pathol. 2018 Feb;244(2):203-214. doi: 10.1002/path.5004. Epub 2018 Jan 3.


Perspectives of People with a Chronic Disease on Participating in Work: A Focus Group Study.

Vooijs M, Leensen MCJ, Hoving JL, Wind H, Frings-Dresen MHW.

J Occup Rehabil. 2017 Dec;27(4):593-600. doi: 10.1007/s10926-016-9694-6.


Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in Ldlr-/- Mice.

Jeurissen ML, Walenbergh SM, Houben T, Hendrikx T, Li J, Oligschlaeger Y, van Gorp PJ, Gijbels MJ, Bitorina A, Nessel I, Radtke F, Vooijs M, Theys J, Shiri-Sverdlov R.

PLoS One. 2016 Nov 29;11(11):e0167199. doi: 10.1371/journal.pone.0167199. eCollection 2016.


LC3/GABARAP family proteins: autophagy-(un)related functions.

Schaaf MB, Keulers TG, Vooijs MA, Rouschop KM.

FASEB J. 2016 Dec;30(12):3961-3978. Epub 2016 Sep 6. Review.


Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool.

Sannerud R, Esselens C, Ejsmont P, Mattera R, Rochin L, Tharkeshwar AK, De Baets G, De Wever V, Habets R, Baert V, Vermeire W, Michiels C, Groot AJ, Wouters R, Dillen K, Vints K, Baatsen P, Munck S, Derua R, Waelkens E, Basi GS, Mercken M, Vooijs M, Bollen M, Schymkowitz J, Rousseau F, Bonifacino JS, Van Niel G, De Strooper B, Annaert W.

Cell. 2016 Jun 30;166(1):193-208. doi: 10.1016/j.cell.2016.05.020. Epub 2016 Jun 9.


NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma.

Yahyanejad S, King H, Iglesias VS, Granton PV, Barbeau LM, van Hoof SJ, Groot AJ, Habets R, Prickaerts J, Chalmers AJ, Eekers DB, Theys J, Short SC, Verhaegen F, Vooijs M.

Oncotarget. 2016 Jul 5;7(27):41251-41264. doi: 10.18632/oncotarget.9275.


Targeting Notch to overcome radiation resistance.

Yahyanejad S, Theys J, Vooijs M.

Oncotarget. 2016 Feb 16;7(7):7610-28. doi: 10.18632/oncotarget.6714. Review.


Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling.

Li H, Koo Y, Mao X, Sifuentes-Dominguez L, Morris LL, Jia D, Miyata N, Faulkner RA, van Deursen JM, Vooijs M, Billadeau DD, van de Sluis B, Cleaver O, Burstein E.

J Cell Biol. 2015 Nov 9;211(3):605-17. doi: 10.1083/jcb.201505108.


Therapeutic validity and effectiveness of supervised physical exercise training on exercise capacity in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis.

Vooijs M, Siemonsma PC, Heus I, Sont JK, Rövekamp TA, van Meeteren NL.

Clin Rehabil. 2016 Nov;30(11):1037-1048. doi: 10.1177/0269215515609413. Epub 2016 Jul 11. Review.


Interventions to enhance work participation of workers with a chronic disease: a systematic review of reviews.

Vooijs M, Leensen MC, Hoving JL, Wind H, Frings-Dresen MH.

Occup Environ Med. 2015 Nov;72(11):820-6. doi: 10.1136/oemed-2015-103062. Epub 2015 Sep 25. Review.


New ways to image and target tumour hypoxia and its molecular responses.

Dubois LJ, Niemans R, van Kuijk SJ, Panth KM, Parvathaneni NK, Peeters SG, Zegers CM, Rekers NH, van Gisbergen MW, Biemans R, Lieuwes NG, Spiegelberg L, Yaromina A, Winum JY, Vooijs M, Lambin P.

Radiother Oncol. 2015 Sep;116(3):352-7. doi: 10.1016/j.radonc.2015.08.022. Epub 2015 Aug 28. Review.


GABARAPL1 is required for increased EGFR membrane expression during hypoxia.

Keulers TG, Schaaf MB, Peeters HJ, Savelkouls KG, Vooijs MA, Bussink J, Jutten B, Rouschop KM.

Radiother Oncol. 2015 Sep;116(3):417-22. doi: 10.1016/j.radonc.2015.06.023. Epub 2015 Jul 8.


An image guided small animal radiation therapy platform (SmART) to monitor glioblastoma progression and therapy response.

Yahyanejad S, van Hoof SJ, Theys J, Barbeau LM, Granton PV, Paesmans K, Verhaegen F, Vooijs M.

Radiother Oncol. 2015 Sep;116(3):467-72. doi: 10.1016/j.radonc.2015.06.020. Epub 2015 Jul 7.


High dose rate and flattening filter free irradiation can be safely implemented in clinical practice.

Dubois L, Biemans R, Reniers B, Bosmans G, Trani D, Podesta M, Kollaard R, Rouschop KM, Theys J, Vooijs M, Pruschy M, Verhaegen F, Lambin P.

Int J Radiat Biol. 2015;91(10):778-85. doi: 10.3109/09553002.2015.1068457. Epub 2015 Aug 27.


Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region.

Xu X, Choi SH, Hu T, Tiyanont K, Habets R, Groot AJ, Vooijs M, Aster JC, Chopra R, Fryer C, Blacklow SC.

Structure. 2015 Jul 7;23(7):1227-35. doi: 10.1016/j.str.2015.05.001. Epub 2015 Jun 4.


SmART-ER imaging and treatment of glioblastoma.

Granton PV, Yahyanejad S, Vooijs MA.

J Neurooncol. 2015 Jun;123(2):319-20. doi: 10.1007/s11060-015-1801-6. Epub 2015 May 8. No abstract available.


Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17.

Habets RA, Groot AJ, Yahyanejad S, Tiyanont K, Blacklow SC, Vooijs M.

J Biol Chem. 2015 Jun 5;290(23):14705-16. doi: 10.1074/jbc.M115.643676. Epub 2015 Apr 27.


Canonical autophagy does not contribute to cellular radioresistance.

Schaaf MB, Jutten B, Keulers TG, Savelkouls KG, Peeters HJ, van den Beucken T, van Schooten FJ, Godschalk RW, Vooijs M, Rouschop KM.

Radiother Oncol. 2015 Mar;114(3):406-12. doi: 10.1016/j.radonc.2015.02.019. Epub 2015 Mar 13.


Complementary use of bioluminescence imaging and contrast-enhanced micro-computed tomography in an orthotopic brain tumor model.

Yahyanejad S, Granton PV, Lieuwes NG, Gilmour L, Dubois L, Theys J, Chalmers AJ, Verhaegen F, Vooijs M.

Mol Imaging. 2014;13. doi: 10.2310/7290.2014.00038.


Disease-generic factors of work participation of workers with a chronic disease: a systematic review.

Vooijs M, Leensen MC, Hoving JL, Daams JG, Wind H, Frings-Dresen MH.

Int Arch Occup Environ Health. 2015 Nov;88(8):1015-29. doi: 10.1007/s00420-015-1025-2. Epub 2015 Feb 25. Review.


Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia.

Doi K, Imai T, Kressler C, Yagita H, Agata Y, Vooijs M, Hamazaki Y, Inoue J, Minato N.

Sci Rep. 2015 Jan 23;5:7978. doi: 10.1038/srep07978.


Validity and usability of low-cost accelerometers for internet-based self-monitoring of physical activity in patients with chronic obstructive pulmonary disease.

Vooijs M, Alpay LL, Snoeck-Stroband JB, Beerthuizen T, Siemonsma PC, Abbink JJ, Sont JK, Rövekamp TA.

Interact J Med Res. 2014 Oct 27;3(4):e14. doi: 10.2196/ijmr.3056.


ADAM10 and ADAM17 have opposite roles during sprouting angiogenesis.

Caolo V, Swennen G, Chalaris A, Wagenaar A, Verbruggen S, Rose-John S, Molin DG, Vooijs M, Post MJ.

Angiogenesis. 2015 Jan;18(1):13-22. doi: 10.1007/s10456-014-9443-4. Epub 2014 Sep 14.


Epigenetics in radiotherapy: where are we heading?

Smits KM, Melotte V, Niessen HE, Dubois L, Oberije C, Troost EG, Starmans MH, Boutros PC, Vooijs M, van Engeland M, Lambin P.

Radiother Oncol. 2014 May;111(2):168-77. doi: 10.1016/j.radonc.2014.05.001. Epub 2014 May 23. Review.


Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins.

Groot AJ, Habets R, Yahyanejad S, Hodin CM, Reiss K, Saftig P, Theys J, Vooijs M.

Mol Cell Biol. 2014 Aug;34(15):2822-32. doi: 10.1128/MCB.00206-14. Epub 2014 May 19.


The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation.

el Azzouzi H, Leptidis S, Dirkx E, Hoeks J, van Bree B, Brand K, McClellan EA, Poels E, Sluimer JC, van den Hoogenhof MM, Armand AS, Yin X, Langley S, Bourajjaj M, Olieslagers S, Krishnan J, Vooijs M, Kurihara H, Stubbs A, Pinto YM, Krek W, Mayr M, da Costa Martins PA, Schrauwen P, De Windt LJ.

Cell Metab. 2013 Sep 3;18(3):341-54. doi: 10.1016/j.cmet.2013.08.009.


High NOTCH activity induces radiation resistance in non small cell lung cancer.

Theys J, Yahyanejad S, Habets R, Span P, Dubois L, Paesmans K, Kattenbeld B, Cleutjens J, Groot AJ, Schuurbiers OCJ, Lambin P, Bussink J, Vooijs M.

Radiother Oncol. 2013 Sep;108(3):440-445. doi: 10.1016/j.radonc.2013.06.020. Epub 2013 Jul 25.


EGFR overexpressing cells and tumors are dependent on autophagy for growth and survival.

Jutten B, Keulers TG, Schaaf MB, Savelkouls K, Theys J, Span PN, Vooijs MA, Bussink J, Rouschop KM.

Radiother Oncol. 2013 Sep;108(3):479-83. doi: 10.1016/j.radonc.2013.06.033. Epub 2013 Jul 25.


Hypoxia inducible NOD2 interacts with 3-O-sulfogalactoceramide and regulates vesicular homeostasis.

Nabatov AA, Hatzis P, Rouschop KM, van Diest P, Vooijs M.

Biochim Biophys Acta. 2013 Nov;1830(11):5277-86. doi: 10.1016/j.bbagen.2013.07.017. Epub 2013 Jul 21.


FER kinase promotes breast cancer metastasis by regulating α6- and β1-integrin-dependent cell adhesion and anoikis resistance.

Ivanova IA, Vermeulen JF, Ercan C, Houthuijzen JM, Saig FA, Vlug EJ, van der Wall E, van Diest PJ, Vooijs M, Derksen PW.

Oncogene. 2013 Dec 12;32(50):5582-92. doi: 10.1038/onc.2013.277. Epub 2013 Jul 22.


Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: a new concept of dual targeting drugs.

Dubois L, Peeters SG, van Kuijk SJ, Yaromina A, Lieuwes NG, Saraya R, Biemans R, Rami M, Parvathaneni NK, Vullo D, Vooijs M, Supuran CT, Winum JY, Lambin P.

Radiother Oncol. 2013 Sep;108(3):523-8. doi: 10.1016/j.radonc.2013.06.018. Epub 2013 Jul 9.


The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia.

Schaaf MB, Cojocari D, Keulers TG, Jutten B, Starmans MH, de Jong MC, Begg AC, Savelkouls KG, Bussink J, Vooijs M, Wouters BG, Rouschop KM.

Radiother Oncol. 2013 Sep;108(3):529-34. doi: 10.1016/j.radonc.2013.06.015. Epub 2013 Jul 9.


Epidermal ADAM17 is dispensable for notch activation.

Groot AJ, Cobzaru C, Weber S, Saftig P, Blobel CP, Kopan R, Vooijs M, Franzke CW.

J Invest Dermatol. 2013 Sep;133(9):2286-8. doi: 10.1038/jid.2013.162. Epub 2013 Apr 3. No abstract available.


State of the art radiation therapy for lung cancer 2012: a glimpse of the future.

De Ruysscher D, Belderbos J, Reymen B, van Elmpt W, van Baardwijk A, Wanders R, Hoebers F, Vooijs M, Ollers M, Lambin P.

Clin Lung Cancer. 2013 Mar;14(2):89-95. doi: 10.1016/j.cllc.2012.06.006. Epub 2012 Jul 31. Review.


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