Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 171


Update on novel purinergic P2X3 and P2X2/3 receptor antagonists and their potential therapeutic applications.

Marucci G, Dal Ben D, Buccioni M, Martí Navia A, Spinaci A, Volpini R, Lambertucci C.

Expert Opin Ther Pat. 2019 Dec;29(12):943-963. doi: 10.1080/13543776.2019.1693542. Epub 2019 Nov 20.


Amino-3,5-Dicyanopyridines Targeting the Adenosine Receptors Ranging from Pan Ligands to Combined A1/A2B Partial Agonists.

Catarzi D, Varano F, Varani K, Vincenzi F, Pasquini S, Dal Ben D, Volpini R, Colotta V.

Pharmaceuticals (Basel). 2019 Oct 22;12(4). pii: E159. doi: 10.3390/ph12040159.


Non-Nucleoside Agonists of the Adenosine Receptors: An Overview.

Dal Ben D, Lambertucci C, Buccioni M, Martí Navia A, Marucci G, Spinaci A, Volpini R.

Pharmaceuticals (Basel). 2019 Oct 8;12(4). pii: E150. doi: 10.3390/ph12040150. Review.


Antioxidant-Conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain.

Falsini M, Catarzi D, Varano F, Ceni C, Dal Ben D, Marucci G, Buccioni M, Volpini R, Di Cesare Mannelli L, Lucarini E, Ghelardini C, Bartolucci G, Menicatti M, Colotta V.

J Med Chem. 2019 Sep 26;62(18):8511-8531. doi: 10.1021/acs.jmedchem.9b00778. Epub 2019 Sep 10.


New A2A adenosine receptor antagonists: a structure-based upside-down interaction in the receptor cavity.

Lambertucci C, Spinaci A, Buccioni M, Dal Ben D, Ngouadjeu Ngnintedem MA, Kachler S, Marucci G, Klotz KN, Volpini R.

Bioorg Chem. 2019 Nov;92:103183. doi: 10.1016/j.bioorg.2019.103183. Epub 2019 Aug 5.


Pathogenic role of innate immunity in a model of chronic NO inhibition associated with salt overload.

Zambom FFF, Oliveira KC, Foresto-Neto O, Faustino VD, Ávila VF, Albino AH, Arias SCA, Volpini RA, Malheiros DMAC, Saraiva Camara NO, Zatz R, Fujihara CK.

Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F1058-F1067. doi: 10.1152/ajprenal.00251.2019. Epub 2019 Aug 14.


Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms.

Felizardo RJF, de Almeida DC, Pereira RL, Watanabe IKM, Doimo NTS, Ribeiro WR, Cenedeze MA, Hiyane MI, Amano MT, Braga TT, Ferreira CM, Parmigiani RB, Andrade-Oliveira V, Volpini RA, Vinolo MAR, Mariño E, Robert R, Mackay CR, Camara NOS.

FASEB J. 2019 Nov;33(11):11894-11908. doi: 10.1096/fj.201901080R. Epub 2019 Jul 31.


Vitamin D deficiency is a potential risk factor for lipid Amphotericin B nephrotoxicity.

Ferreira D, de Bragança AC, Volpini RA, Shimizu MHM, Gois PHF, Girardi ACC, Seguro AC, Canale D.

PLoS Negl Trop Dis. 2019 Jul 11;13(7):e0007567. doi: 10.1371/journal.pntd.0007567. eCollection 2019 Jul.


New sensible method to quantize the intestinal absorption of receptor ligands.

Buccioni M, Dal Ben D, Lambertucci C, Martí Navia A, Ricciutelli M, Spinaci A, Volpini R, Marucci G.

Bioorg Med Chem. 2019 Aug 1;27(15):3328-3333. doi: 10.1016/j.bmc.2019.06.011. Epub 2019 Jun 6.


Regulation of adenosine A2A receptor gene expression in a model of binge eating in the amygdaloid complex of female rats.

Micioni Di Bonaventura MV, Pucci M, Giusepponi ME, Romano A, Lambertucci C, Volpini R, Micioni Di Bonaventura E, Gaetani S, Maccarrone M, D'Addario C, Cifani C.

J Psychopharmacol. 2019 Dec;33(12):1550-1561. doi: 10.1177/0269881119845798. Epub 2019 Jun 4.


Preventive effect of exercise training on diabetic kidney disease in ovariectomized rats with type 1 diabetes.

Souza CS, de Sousa Oliveira BS, Viana GN, Correia TML, de Bragança AC, Canale D, Oliveira MV, de Magalhães ACM, Volpini RA, de Brito Amaral LS, de Jesus Soares T.

Exp Biol Med (Maywood). 2019 Jun;244(9):758-769. doi: 10.1177/1535370219843830. Epub 2019 May 1.


Investigation on 2',3'-O-Substituted ATP Derivatives and Analogs as Novel P2X3 Receptor Antagonists.

Dal Ben D, Buccioni M, Lambertucci C, Marucci G, Spinaci A, Marchenkova A, Abdelrahman A, Nistri A, Müller CE, Volpini R.

ACS Med Chem Lett. 2018 Dec 26;10(4):493-498. doi: 10.1021/acsmedchemlett.8b00524. eCollection 2019 Apr 11.


Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A1 and A2A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells.

Falsini M, Catarzi D, Varano F, Dal Ben D, Marucci G, Buccioni M, Volpini R, Di Cesare Mannelli L, Ghelardini C, Colotta V.

Bioorg Chem. 2019 Jun;87:380-394. doi: 10.1016/j.bioorg.2019.03.046. Epub 2019 Mar 16.


The Th17/Treg Cytokine Imbalance in Chronic Obstructive Pulmonary Disease Exacerbation in an Animal Model of Cigarette Smoke Exposure and Lipopolysaccharide Challenge Association.

Cervilha DAB, Ito JT, Lourenço JD, Olivo CR, Saraiva-Romanholo BM, Volpini RA, Oliveira-Junior MC, Mauad T, Martins MA, Tibério IFLC, Vieira RP, Lopes FDTQS.

Sci Rep. 2019 Feb 13;9(1):1921. doi: 10.1038/s41598-019-38600-z.


GPR17 receptor modulators and their therapeutic implications: review of recent patents.

Marucci G, Dal Ben D, Lambertucci C, Martí Navia A, Spinaci A, Volpini R, Buccioni M.

Expert Opin Ther Pat. 2019 Feb;29(2):85-95. doi: 10.1080/13543776.2019.1568990. Epub 2019 Jan 24. Review.


Biomarkers mapping of neuropathic pain in a nerve chronic constriction injury mice model.

Vincenzetti S, Pucciarelli S, Huang Y, Ricciutelli M, Lambertucci C, Volpini R, Scuppa G, Soverchia L, Ubaldi M, Polzonetti V.

Biochimie. 2019 Mar;158:172-179. doi: 10.1016/j.biochi.2019.01.005. Epub 2019 Jan 11.


Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity.

Varano F, Catarzi D, Falsini M, Dal Ben D, Buccioni M, Marucci G, Volpini R, Colotta V.

Bioorg Med Chem Lett. 2019 Feb 15;29(4):563-569. doi: 10.1016/j.bmcl.2018.12.062. Epub 2018 Dec 31.


Th17/Treg imbalance in COPD progression: A temporal analysis using a CS-induced model.

Ito JT, Cervilha DAB, Lourenço JD, Gonçalves NG, Volpini RA, Caldini EG, Landman G, Lin CJ, Velosa APP, Teodoro WPR, Tibério IFLC, Mauad T, Martins MA, Macchione M, Lopes FDTQDS.

PLoS One. 2019 Jan 10;14(1):e0209351. doi: 10.1371/journal.pone.0209351. eCollection 2019.


Neuroprotective potential of adenosine A1 receptor partial agonists in experimental models of cerebral ischemia.

Martire A, Lambertucci C, Pepponi R, Ferrante A, Benati N, Buccioni M, Dal Ben D, Marucci G, Klotz KN, Volpini R, Popoli P.

J Neurochem. 2019 Apr;149(2):211-230. doi: 10.1111/jnc.14660. Epub 2019 Feb 11.


Vitamin D Deficiency Aggravates the Renal Features of Moderate Chronic Kidney Disease in 5/6 Nephrectomized Rats.

de Bragança AC, Canale D, Gonçalves JG, Shimizu MHM, Seguro AC, Volpini RA.

Front Med (Lausanne). 2018 Oct 10;5:282. doi: 10.3389/fmed.2018.00282. eCollection 2018.


Simultaneous activation of innate and adaptive immunity participates in the development of renal injury in a model of heavy proteinuria.

Faustino VD, Arias SCA, Ferreira Ávila V, Foresto-Neto O, Zambom FFF, Machado FG, Machado Dos Reis L, Malheiros DMAC, Volpini RA, Camara NOS, Zatz R, Fujihara CK.

Biosci Rep. 2018 Jul 12;38(4). pii: BSR20180762. doi: 10.1042/BSR20180762. Print 2018 Aug 31.


Previous Exercise Training Reduces Markers of Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Female Rats.

Amaral LSB, Souza CS, Volpini RA, Shimizu MHM, de Bragança AC, Canale D, Seguro AC, Coimbra TM, de Magalhães ACM, Soares TJ.

J Diabetes Res. 2018 Mar 29;2018:6170352. doi: 10.1155/2018/6170352. eCollection 2018.


Anticancer activity study of A3 adenosine receptor agonists.

Marucci G, Santinelli C, Buccioni M, Navia AM, Lambertucci C, Zhurina A, Yli-Harja O, Volpini R, Kandhavelu M.

Life Sci. 2018 Jul 15;205:155-163. doi: 10.1016/j.lfs.2018.05.028. Epub 2018 May 13.


Up-regulation of renal renin-angiotensin system and inflammatory mechanisms in the prenatal programming by low-protein diet: beneficial effect of the post-weaning losartan treatment.

Watanabe IKM, Jara ZP, Volpini RA, Franco MDC, Jung FF, Casarini DE.

J Dev Orig Health Dis. 2018 Oct;9(5):530-535. doi: 10.1017/S2040174418000296. Epub 2018 May 6.


New potent and selective A1 adenosine receptor antagonists as potential tools for the treatment of gastrointestinal diseases.

Lambertucci C, Marucci G, Dal Ben D, Buccioni M, Spinaci A, Kachler S, Klotz KN, Volpini R.

Eur J Med Chem. 2018 May 10;151:199-213. doi: 10.1016/j.ejmech.2018.03.067. Epub 2018 Mar 27.


Ex-vivo absorption study of lysine R-lipoate salt, a new pharmaceutical form of R-ALA.

Amenta F, Buccioni M, Ben DD, Lambertucci C, Navia AM, Ngouadjeu Ngnintedem MA, Ricciutelli M, Spinaci A, Volpini R, Marucci G.

Eur J Pharm Sci. 2018 Jun 15;118:200-207. doi: 10.1016/j.ejps.2018.03.025. Epub 2018 Mar 26.


Purinergic Ligands as Potential Therapeutic Tools for the Treatment of Inflammation-Related Intestinal Diseases.

Dal Ben D, Antonioli L, Lambertucci C, Fornai M, Blandizzi C, Volpini R.

Front Pharmacol. 2018 Mar 14;9:212. doi: 10.3389/fphar.2018.00212. eCollection 2018. Review.


The Role of β-Adrenergic Overstimulation in the Early Stages of Renal Injury.

de Ponte MC, Casare FAM, Costa-Pessoa JM, Cardoso VG, Malnic G, Mello-Aires M, Volpini RA, Thieme K, Oliveira-Souza M.

Kidney Blood Press Res. 2017;42(6):1277-1289. doi: 10.1159/000485931. Epub 2017 Dec 14.


Maternal Hypercholesterolemia Associated with Nicotine Exposure in Adulthood May Induce Kidney Injury in Male Rats if Hypomagnesemia Occurs.

Helou CMB, Volpini RA, Santinho MAR, Fonseca FL, Simião AL.

Kidney Blood Press Res. 2017;42(6):974-982. doi: 10.1159/000485343. Epub 2017 Nov 27.


Allopurinol attenuates acute kidney injury following Bothrops jararaca envenomation.

Gois PHF, Martines MS, Ferreira D, Volpini R, Canale D, Malaque C, Crajoinas R, Girardi ACC, Massola Shimizu MH, Seguro AC.

PLoS Negl Trop Dis. 2017 Nov 20;11(11):e0006024. doi: 10.1371/journal.pntd.0006024. eCollection 2017 Nov.


The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A2A Receptor Subtype.

Falsini M, Squarcialupi L, Catarzi D, Varano F, Betti M, Dal Ben D, Marucci G, Buccioni M, Volpini R, De Vita T, Cavalli A, Colotta V.

J Med Chem. 2017 Jul 13;60(13):5772-5790. doi: 10.1021/acs.jmedchem.7b00457. Epub 2017 Jun 16.


Synthesis and Ability of New Ligands for G Protein-Coupled Receptors 17 (GPR17).

Zhuo T, Zhou S, Zhang W, Lambertucci C, Volpini R.

Med Sci Monit. 2017 Feb 22;23:953-959.


Human umbilical cord-derived mesenchymal stromal cells protect against premature renal senescence resulting from oxidative stress in rats with acute kidney injury.

Rodrigues CE, Capcha JM, de Bragança AC, Sanches TR, Gouveia PQ, de Oliveira PA, Malheiros DM, Volpini RA, Santinho MA, Santana BA, Calado RD, Noronha IL, Andrade L.

Stem Cell Res Ther. 2017 Jan 28;8(1):19. doi: 10.1186/s13287-017-0475-8.


The G Protein-Coupled Receptor GPR17: Overview and Update.

Marucci G, Dal Ben D, Lambertucci C, Santinelli C, Spinaci A, Thomas A, Volpini R, Buccioni M.

ChemMedChem. 2016 Dec 6;11(23):2567-2574. doi: 10.1002/cmdc.201600453. Epub 2016 Nov 14. Review.


N-acetylcysteine protects against star fruit-induced acute kidney injury.

Shimizu MH, Gois PH, Volpini RA, Canale D, Luchi WM, Froeder L, Heilberg IP, Seguro AC.

Ren Fail. 2017 Nov;39(1):193-202. doi: 10.1080/0886022X.2016.1256315. Epub 2016 Nov 15.


Allopurinol attenuates rhabdomyolysis-associated acute kidney injury: Renal and muscular protection.

Gois PHF, Canale D, Volpini RA, Ferreira D, Veras MM, Andrade-Oliveira V, Câmara NOS, Shimizu MHM, Seguro AC.

Free Radic Biol Med. 2016 Dec;101:176-189. doi: 10.1016/j.freeradbiomed.2016.10.012. Epub 2016 Oct 18.


Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring.

Argeri R, Nishi EE, Volpini RA, Palma BD, Tufik S, Gomes GN.

Physiol Rep. 2016 Aug;4(16). pii: e12888. Epub 2016 Aug 22.


2',3'-O-Substituted ATP derivatives as potent antagonists of purinergic P2X3 receptors and potential analgesic agents.

Dal Ben D, Marchenkova A, Thomas A, Lambertucci C, Spinaci A, Marucci G, Nistri A, Volpini R.

Purinergic Signal. 2017 Mar;13(1):61-74. doi: 10.1007/s11302-016-9539-y. Epub 2016 Oct 18.


Vasopressin analog terlipressin attenuates kidney injury in hemorrhagic shock.

Cardoso de Castro LU, Ida KK, Otsuki DA, Sanches TR, Volpini RA, Borges EDS, Malbouisson LS, Andrade L.

Trauma Surg Acute Care Open. 2016 Sep 26;1(1):e000039. doi: 10.1136/tsaco-2016-000039. eCollection 2016.


Simulation and Comparative Analysis of Different Binding Modes of Non-nucleoside Agonists at the A2A Adenosine Receptor.

Dal Ben D, Buccioni M, Lambertucci C, Marucci G, Santinelli C, Spinaci A, Thomas A, Volpini R.

Mol Inform. 2016 Sep;35(8-9):403-13. doi: 10.1002/minf.201501042. Epub 2016 Jun 28.


Overview on Radiolabel-Free in vitro Assays for GPCRs.

Buccioni M, Santinelli C, Angeli P, Dal Ben D, Lambertucci C, Thomas A, Volpini R, Marucci G.

Mini Rev Med Chem. 2017;17(1):3-14. Review.


Vitamin D deficiency contributes to vascular damage in sustained ischemic acute kidney injury.

de Bragança AC, Volpini RA, Mehrotra P, Andrade L, Basile DP.

Physiol Rep. 2016 Jul;4(13). pii: e12829. doi: 10.14814/phy2.12829.


Treatment With Human Wharton's Jelly-Derived Mesenchymal Stem Cells Attenuates Sepsis-Induced Kidney Injury, Liver Injury, and Endothelial Dysfunction.

Cóndor JM, Rodrigues CE, Sousa Moreira Rd, Canale D, Volpini RA, Shimizu MH, Camara NO, Noronha Ide L, Andrade L.

Stem Cells Transl Med. 2016 Aug;5(8):1048-57. doi: 10.5966/sctm.2015-0138. Epub 2016 Jun 8.


Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors.

Squarcialupi L, Falsini M, Catarzi D, Varano F, Betti M, Varani K, Vincenzi F, Dal Ben D, Lambertucci C, Volpini R, Colotta V.

Bioorg Med Chem. 2016 Jun 15;24(12):2794-808. doi: 10.1016/j.bmc.2016.04.048. Epub 2016 Apr 23.


The Length and Flexibility of the 2-Substituent of 9-Ethyladenine Derivatives Modulate Affinity and Selectivity for the Human A2A Adenosine Receptor.

Thomas A, Buccioni M, Dal Ben D, Lambertucci C, Marucci G, Santinelli C, Spinaci A, Kachler S, Klotz KN, Volpini R.

ChemMedChem. 2016 Aug 19;11(16):1829-39. doi: 10.1002/cmdc.201500595. Epub 2016 Apr 1.


Beneficial effects of previous exercise training on renal changes in streptozotocin-induced diabetic female rats.

Amaral LS, Silva FA, Correia VB, Andrade CE, Dutra BA, Oliveira MV, de Magalhães AC, Volpini RA, Seguro AC, Coimbra TM, Soares Tde J.

Exp Biol Med (Maywood). 2016 Feb;241(4):437-45. doi: 10.1177/1535370215609696. Epub 2015 Oct 20.


The role of dexamethasone in scorpion venom-induced deregulation of sodium and water transport in rat lungs.

Malaque CM, de Bragança AC, Sanches TR, Volpini RA, Shimizu MH, Hiyane MI, Câmara NO, Seguro AC, Andrade L.

Intensive Care Med Exp. 2015 Dec;3(1):28. doi: 10.1186/s40635-015-0063-0. Epub 2015 Sep 21.


Vitamin D deficiency is a potential risk factor for contrast-induced nephropathy.

Luchi WM, Shimizu MH, Canale D, Gois PH, de Bragança AC, Volpini RA, Girardi AC, Seguro AC.

Am J Physiol Regul Integr Comp Physiol. 2015 Aug 1;309(3):R215-22. doi: 10.1152/ajpregu.00526.2014. Epub 2015 Jun 3.


Dual target strategy: combining distinct non-dopaminergic treatments reduces neuronal cell loss and synergistically modulates L-DOPA-induced rotational behavior in a rodent model of Parkinson's disease.

Fuzzati-Armentero MT, Cerri S, Levandis G, Ambrosi G, Montepeloso E, Antoninetti G, Blandini F, Baqi Y, Müller CE, Volpini R, Costa G, Simola N, Pinna A.

J Neurochem. 2015 Aug;134(4):740-7. doi: 10.1111/jnc.13162. Epub 2015 Jun 4.


Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine core for the design of new human adenosine A3 receptor antagonists. Synthesis, molecular modeling studies and pharmacological evaluation.

Varano F, Catarzi D, Squarcialupi L, Betti M, Vincenzi F, Ravani A, Varani K, Dal Ben D, Thomas A, Volpini R, Colotta V.

Eur J Med Chem. 2015;96:105-21. doi: 10.1016/j.ejmech.2015.04.010. Epub 2015 Apr 4.


Supplemental Content

Loading ...
Support Center