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Items: 46


Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo.

Patterson JR, Polinski NK, Duffy MF, Kemp CJ, Luk KC, Volpicelli-Daley LA, Kanaan NM, Sortwell CE.

J Vis Exp. 2019 Jun 2;(148). doi: 10.3791/59758.


Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice.

Froula JM, Castellana-Cruz M, Anabtawi NM, Camino JD, Chen SW, Thrasher DR, Freire J, Yazdi AA, Fleming S, Dobson CM, Kumita JR, Cremades N, Volpicelli-Daley LA.

J Biol Chem. 2019 Jul 5;294(27):10392-10406. doi: 10.1074/jbc.RA119.007743. Epub 2019 May 29.


Assays for Neuronal Defects Caused by Early Formation of α-Synuclein Inclusions in Primary Cultured Neurons.

Volpicelli-Daley LA.

Methods Mol Biol. 2019;1948:1-14. doi: 10.1007/978-1-4939-9124-2_1.


Pα-syn* mitotoxicity is linked to MAPK activation and involves tau phosphorylation and aggregation at the mitochondria.

Grassi D, Diaz-Perez N, Volpicelli-Daley LA, Lasmézas CI.

Neurobiol Dis. 2019 Apr;124:248-262. doi: 10.1016/j.nbd.2018.11.015. Epub 2018 Nov 22.


14-3-3 Proteins Reduce Cell-to-Cell Transfer and Propagation of Pathogenic α-Synuclein.

Wang B, Underwood R, Kamath A, Britain C, McFerrin MB, McLean PJ, Volpicelli-Daley LA, Whitaker RH, Placzek WJ, Becker K, Ma J, Yacoubian TA.

J Neurosci. 2018 Sep 19;38(38):8211-8232. doi: 10.1523/JNEUROSCI.1134-18.2018. Epub 2018 Aug 9.


Sensitivity and specificity of phospho-Ser129 α-synuclein monoclonal antibodies.

Delic V, Chandra S, Abdelmotilib H, Maltbie T, Wang S, Kem D, Scott HJ, Underwood RN, Liu Z, Volpicelli-Daley LA, West AB.

J Comp Neurol. 2018 Aug 15;526(12):1978-1990. doi: 10.1002/cne.24468.


Prion-like propagation of pathology in Parkinson disease.

Volpicelli-Daley L, Brundin P.

Handb Clin Neurol. 2018;153:321-335. doi: 10.1016/B978-0-444-63945-5.00017-9. Review.


α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons.

Froula JM, Henderson BW, Gonzalez JC, Vaden JH, Mclean JW, Wu Y, Banumurthy G, Overstreet-Wadiche L, Herskowitz JH, Volpicelli-Daley LA.

Acta Neuropathol Commun. 2018 May 1;6(1):35. doi: 10.1186/s40478-018-0537-x.


Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson's disease.

Grassi D, Howard S, Zhou M, Diaz-Perez N, Urban NT, Guerrero-Given D, Kamasawa N, Volpicelli-Daley LA, LoGrasso P, Lasmézas CI.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):E2634-E2643. doi: 10.1073/pnas.1713849115. Epub 2018 Feb 27.


Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson's Disease in Rodents.

Polinski NK, Volpicelli-Daley LA, Sortwell CE, Luk KC, Cremades N, Gottler LM, Froula J, Duffy MF, Lee VMY, Martinez TN, Dave KD.

J Parkinsons Dis. 2018;8(2):303-322. doi: 10.3233/JPD-171248.


Editorial: Pathogenic templating proteins in Neurodegenerative Disease.

Volpicelli-Daley L, Brundin P.

Neurobiol Dis. 2018 Jan;109(Pt B):175-177. doi: 10.1016/j.nbd.2017.11.004. No abstract available.


LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson's Disease Mouse Model.

Zhao HT, John N, Delic V, Ikeda-Lee K, Kim A, Weihofen A, Swayze EE, Kordasiewicz HB, West AB, Volpicelli-Daley LA.

Mol Ther Nucleic Acids. 2017 Sep 15;8:508-519. doi: 10.1016/j.omtn.2017.08.002. Epub 2017 Aug 10.


α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration.

Abdelmotilib H, Maltbie T, Delic V, Liu Z, Hu X, Fraser KB, Moehle MS, Stoyka L, Anabtawi N, Krendelchtchikova V, Volpicelli-Daley LA, West A.

Neurobiol Dis. 2017 Sep;105:84-98. doi: 10.1016/j.nbd.2017.05.014. Epub 2017 May 30.


Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils.

Redmann M, Wani WY, Volpicelli-Daley L, Darley-Usmar V, Zhang J.

Redox Biol. 2017 Apr;11:429-437. doi: 10.1016/j.redox.2016.12.032. Epub 2017 Jan 3.


Effects of α-synuclein on axonal transport.

Volpicelli-Daley LA.

Neurobiol Dis. 2017 Sep;105:321-327. doi: 10.1016/j.nbd.2016.12.008. Epub 2016 Dec 9. Review.


G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons.

Volpicelli-Daley LA, Abdelmotilib H, Liu Z, Stoyka L, Daher JP, Milnerwood AJ, Unni VK, Hirst WD, Yue Z, Zhao HT, Fraser K, Kennedy RE, West AB.

J Neurosci. 2016 Jul 13;36(28):7415-27. doi: 10.1523/JNEUROSCI.3642-15.2016.


How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?

Volpicelli-Daley LA, Kirik D, Stoyka LE, Standaert DG, Harms AS.

J Neurochem. 2016 Oct;139 Suppl 1:131-155. doi: 10.1111/jnc.13627. Epub 2016 May 4. Review.


microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease.

Thome AD, Harms AS, Volpicelli-Daley LA, Standaert DG.

J Neurosci. 2016 Feb 24;36(8):2383-90. doi: 10.1523/JNEUROSCI.3900-15.2016.


Trophic factors for Parkinson's disease: To live or let die.

Olanow CW, Bartus RT, Volpicelli-Daley LA, Kordower JH.

Mov Disord. 2015 Nov;30(13):1715-24. doi: 10.1002/mds.26426. Review.


Invisible Killers.

Volpicelli-Daley LA, Standaert DG.

Mov Disord. 2016 Jan;31(1):44. doi: 10.1002/mds.26465. Epub 2016 Jan 9. No abstract available.


Transforming Growth Factor Beta (TGF-β) Is a Muscle Biomarker of Disease Progression in ALS and Correlates with Smad Expression.

Si Y, Kim S, Cui X, Zheng L, Oh SJ, Anderson T, AlSharabati M, Kazamel M, Volpicelli-Daley L, Bamman MM, Yu S, King PH.

PLoS One. 2015 Sep 16;10(9):e0138425. doi: 10.1371/journal.pone.0138425. eCollection 2015.


Trib3 Is Elevated in Parkinson's Disease and Mediates Death in Parkinson's Disease Models.

Aimé P, Sun X, Zareen N, Rao A, Berman Z, Volpicelli-Daley L, Bernd P, Crary JF, Levy OA, Greene LA.

J Neurosci. 2015 Jul 29;35(30):10731-49. doi: 10.1523/JNEUROSCI.0614-15.2015.


Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration.

Daher JP, Abdelmotilib HA, Hu X, Volpicelli-Daley LA, Moehle MS, Fraser KB, Needle E, Chen Y, Steyn SJ, Galatsis P, Hirst WD, West AB.

J Biol Chem. 2015 Aug 7;290(32):19433-44. doi: 10.1074/jbc.M115.660001. Epub 2015 Jun 15.


Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes.

Volpicelli-Daley LA, Gamble KL, Schultheiss CE, Riddle DM, West AB, Lee VM.

Mol Biol Cell. 2014 Dec 15;25(25):4010-23. doi: 10.1091/mbc.E14-02-0741. Epub 2014 Oct 8.


Unique functional and structural properties of the LRRK2 protein ATP-binding pocket.

Liu Z, Galemmo RA Jr, Fraser KB, Moehle MS, Sen S, Volpicelli-Daley LA, DeLucas LJ, Ross LJ, Valiyaveettil J, Moukha-Chafiq O, Pathak AK, Ananthan S, Kezar H, White EL, Gupta V, Maddry JA, Suto MJ, West AB.

J Biol Chem. 2014 Nov 21;289(47):32937-51. doi: 10.1074/jbc.M114.602318. Epub 2014 Sep 16.


Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats.

Daher JP, Volpicelli-Daley LA, Blackburn JP, Moehle MS, West AB.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9289-94. doi: 10.1073/pnas.1403215111. Epub 2014 Jun 9.


Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents.

West AB, Cowell RM, Daher JP, Moehle MS, Hinkle KM, Melrose HL, Standaert DG, Volpicelli-Daley LA.

J Comp Neurol. 2014 Aug 1;522(11):2465-80. doi: 10.1002/cne.23583. Epub 2014 Apr 12.


Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model.

Zhu L, Zhong M, Zhao J, Rhee H, Caesar I, Knight EM, Volpicelli-Daley L, Bustos V, Netzer W, Liu L, Lucast L, Ehrlich ME, Robakis NK, Gandy SE, Cai D.

J Biol Chem. 2013 Nov 1;288(44):32050-63. doi: 10.1074/jbc.M113.504365. Epub 2013 Sep 19.


Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons.

Dryanovski DI, Guzman JN, Xie Z, Galteri DJ, Volpicelli-Daley LA, Lee VM, Miller RJ, Schumacker PT, Surmeier DJ.

J Neurosci. 2013 Jun 12;33(24):10154-64. doi: 10.1523/JNEUROSCI.5311-12.2013.


Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagy.

Tanik SA, Schultheiss CE, Volpicelli-Daley LA, Brunden KR, Lee VM.

J Biol Chem. 2013 May 24;288(21):15194-210. doi: 10.1074/jbc.M113.457408. Epub 2013 Mar 26.


Role of dynamin, synaptojanin, and endophilin in podocyte foot processes.

Soda K, Balkin DM, Ferguson SM, Paradise S, Milosevic I, Giovedi S, Volpicelli-Daley L, Tian X, Wu Y, Ma H, Son SH, Zheng R, Moeckel G, Cremona O, Holzman LB, De Camilli P, Ishibe S.

J Clin Invest. 2012 Dec;122(12):4401-11. doi: 10.1172/JCI65289. Epub 2012 Nov 26.


TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.

Chen-Plotkin AS, Unger TL, Gallagher MD, Bill E, Kwong LK, Volpicelli-Daley L, Busch JI, Akle S, Grossman M, Van Deerlin V, Trojanowski JQ, Lee VM.

J Neurosci. 2012 Aug 15;32(33):11213-27. doi: 10.1523/JNEUROSCI.0521-12.2012.


Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.

Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, Clark L, Moskowitz C, Mazzulli J, Chen L, Volpicelli-Daley L, Romero N, Jiang H, Uitti RJ, Huang Z, Opala G, Scarffe LA, Dawson VL, Klein C, Feng J, Ross OA, Trojanowski JQ, Lee VM, Marder K, Surmeier DJ, Wszolek ZK, Przedborski S, Krainc D, Dawson TM, Isacson O.

Sci Transl Med. 2012 Jul 4;4(141):141ra90. doi: 10.1126/scitranslmed.3003985.


Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death.

Volpicelli-Daley LA, Luk KC, Patel TP, Tanik SA, Riddle DM, Stieber A, Meaney DF, Trojanowski JQ, Lee VM.

Neuron. 2011 Oct 6;72(1):57-71. doi: 10.1016/j.neuron.2011.08.033.


Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin.

Shen H, Ferguson SM, Dephoure N, Park R, Yang Y, Volpicelli-Daley L, Gygi S, Schlessinger J, De Camilli P.

Mol Biol Cell. 2011 Feb 15;22(4):493-502. doi: 10.1091/mbc.E10-07-0637. Epub 2010 Dec 17.


Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain.

Volpicelli-Daley LA, Lucast L, Gong LW, Liu L, Sasaki J, Sasaki T, Abrams CS, Kanaho Y, De Camilli P.

J Biol Chem. 2010 Sep 10;285(37):28708-14. doi: 10.1074/jbc.M110.132191. Epub 2010 Jul 9.


The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells.

Vasudevan L, Jeromin A, Volpicelli-Daley L, De Camilli P, Holowka D, Baird B.

J Cell Sci. 2009 Jul 15;122(Pt 14):2567-74. doi: 10.1242/jcs.048124. Epub 2009 Jun 23.


Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation.

Pan W, Choi SC, Wang H, Qin Y, Volpicelli-Daley L, Swan L, Lucast L, Khoo C, Zhang X, Li L, Abrams CS, Sokol SY, Wu D.

Science. 2008 Sep 5;321(5894):1350-3. doi: 10.1126/science.1160741.


Immunohistochemical localization of proteins in the nervous system.

Volpicelli-Daley LA, Levey A.

Curr Protoc Neurosci. 2004 Feb;Chapter 1:Unit 1.2. doi: 10.1002/0471142301.ns0102s25.


Phosphoinositides' link to neurodegeneration.

Volpicelli-Daley L, De Camilli P.

Nat Med. 2007 Jul;13(7):784-6. No abstract available.


Arf family GTPases: roles in membrane traffic and microtubule dynamics.

Kahn RA, Volpicelli-Daley L, Bowzard B, Shrivastava-Ranjan P, Li Y, Zhou C, Cunningham L.

Biochem Soc Trans. 2005 Dec;33(Pt 6):1269-72. Review.


Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic.

Volpicelli-Daley LA, Li Y, Zhang CJ, Kahn RA.

Mol Biol Cell. 2005 Oct;16(10):4495-508. Epub 2005 Jul 19.


Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice.

Volpicelli-Daley LA, Hrabovska A, Duysen EG, Ferguson SM, Blakely RD, Lockridge O, Levey AI.

Mol Pharmacol. 2003 Dec;64(6):1309-16.


Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient mice.

Volpicelli-Daley LA, Duysen EG, Lockridge O, Levey AI.

Ann Neurol. 2003 Jun;53(6):788-96.


Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice.

Li B, Duysen EG, Volpicelli-Daley LA, Levey AI, Lockridge O.

Pharmacol Biochem Behav. 2003 Mar;74(4):977-86.


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