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Items: 1 to 50 of 189

1.

Design, Synthesis, and Biological Characterization of Orally Active 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis.

Abdelsamie AS, Salah M, Siebenbürger L, Merabet A, Scheuer C, Frotscher M, Müller ST, Zierau O, Vollmer G, Menger MD, Laschke MW, van Koppen CJ, Marchais-Oberwinkler S, Hartmann RW.

J Med Chem. 2019 Aug 8;62(15):7289-7301. doi: 10.1021/acs.jmedchem.9b00932. Epub 2019 Jul 25.

PMID:
31343176
2.

Effects of 17β-HSD2 inhibition in bones on osteoporosis based on an animal rat model.

Müller ST, Pählig S, Merabet A, Abdelsamie AS, van Koppen CJ, Marchais-Oberwinkler S, Hartmann RW, Zierau O, Vollmer G.

J Steroid Biochem Mol Biol. 2019 Sep;192:105405. doi: 10.1016/j.jsbmb.2019.105405. Epub 2019 Jun 8.

PMID:
31185280
3.

Novel insight in estrogen homeostasis and bioactivity in the ACI rat model of estrogen-induced mammary gland carcinogenesis.

Pemp D, Esch HL, Hauptstein R, Möller FJ, Zierau O, Bosland MC, Geppert LN, Kleider C, Schlereth K, Vollmer G, Lehmann L.

Arch Toxicol. 2019 Jul;93(7):1979-1992. doi: 10.1007/s00204-019-02483-w. Epub 2019 May 22.

PMID:
31119341
4.

Comparison of the three SARMs RAD-140, GLPG0492 and GSK-2881078 in two different in vitro bioassays, and in an in silico androgen receptor binding assay.

Zierau O, Kolodziejczyk A, Vollmer G, Machalz D, Wolber G, Thieme D, Keiler AM.

J Steroid Biochem Mol Biol. 2019 May;189:81-86. doi: 10.1016/j.jsbmb.2019.02.014. Epub 2019 Feb 27.

PMID:
30825507
5.

Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation.

Hüser S, Guth S, Joost HG, Soukup ST, Köhrle J, Kreienbrock L, Diel P, Lachenmeier DW, Eisenbrand G, Vollmer G, Nöthlings U, Marko D, Mally A, Grune T, Lehmann L, Steinberg P, Kulling SE.

Arch Toxicol. 2018 Sep;92(9):2703-2748. doi: 10.1007/s00204-018-2279-8. Epub 2018 Aug 21. Review.

6.

In vitro metabolism of selected bioactive compounds of Eurycoma longifolia root extract to identify suitable markers in doping control.

Bräuer P, Anielski P, Schwaiger S, Stuppner H, Tran TVA, Vollmer G, Zierau O, Thieme D, Keiler AM.

Drug Test Anal. 2019 Jan;11(1):86-94. doi: 10.1002/dta.2449. Epub 2018 Aug 9.

PMID:
29975460
7.

Structure-based design and profiling of novel 17β-HSD14 inhibitors.

Braun F, Bertoletti N, Möller G, Adamski J, Frotscher M, Guragossian N, Madeira Gírio PA, Le Borgne M, Ettouati L, Falson P, Müller S, Vollmer G, Heine A, Klebe G, Marchais-Oberwinkler S.

Eur J Med Chem. 2018 Jul 15;155:61-76. doi: 10.1016/j.ejmech.2018.05.029. Epub 2018 May 22.

PMID:
29859505
8.

Androgen- and estrogen-receptor mediated activities of 4-hydroxytestosterone, 4-hydroxyandrostenedione and their human metabolites in yeast based assays.

Keiler AM, Zierau O, Wolf S, Diel P, Schänzer W, Vollmer G, Machalz D, Wolber G, Parr MK.

Toxicol Lett. 2018 Aug;292:39-45. doi: 10.1016/j.toxlet.2018.04.026. Epub 2018 Apr 24.

PMID:
29702199
9.

Evaluation of estrogenic potency of a standardized hops extract on mammary gland biology and on MNU-induced mammary tumor growth in rats.

Keiler AM, Macejova D, Dietz BM, Bolton JL, Pauli GF, Chen SN, van Breemen RB, Nikolic D, Goerl F, Muders MH, Zierau O, Vollmer G.

J Steroid Biochem Mol Biol. 2017 Nov;174:234-241. doi: 10.1016/j.jsbmb.2017.09.020. Epub 2017 Sep 28.

10.

A standardized Humulus lupulus (L.) ethanol extract partially prevents ovariectomy-induced bone loss in the rat without induction of adverse effects in the uterus.

Keiler AM, Helle J, Bader MI, Ehrhardt T, Nestler K, Kretzschmar G, Bernhardt R, Vollmer G, Nikolić D, Bolton JL, Pauli GF, Chen SN, Dietz BM, van Breemen RB, Zierau O.

Phytomedicine. 2017 Oct 15;34:50-58. doi: 10.1016/j.phymed.2017.08.001. Epub 2017 Aug 2.

11.

The effect of estrogen on tendon and ligament metabolism and function.

Leblanc DR, Schneider M, Angele P, Vollmer G, Docheva D.

J Steroid Biochem Mol Biol. 2017 Sep;172:106-116. doi: 10.1016/j.jsbmb.2017.06.008. Epub 2017 Jun 16. Review.

12.

Effects of the aryl hydrocarbon receptor agonist 3-methylcholanthrene on the 17β-estradiol regulated mRNA transcriptome of the rat uterus.

Helle J, Keiler AM, Zierau O, Dörfelt P, Vollmer G, Lehmann L, Chittur SV, Tenniswood M, Welsh J, Kretzschmar G.

J Steroid Biochem Mol Biol. 2017 Jul;171:133-143. doi: 10.1016/j.jsbmb.2017.03.004. Epub 2017 Mar 8.

PMID:
28285017
13.

[Isoflavone-containing dietary supplements].

Lehmann L, Soukup ST, Gerhäuser C, Vollmer G, Kulling SE.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2017 Mar;60(3):305-313. doi: 10.1007/s00103-016-2497-2. Review. German.

PMID:
28168353
14.

Synaptopodin is regulated by aromatase activity.

Fester L, Zhou L, Ossig C, Labitzke J, Bläute C, Bader M, Vollmer G, Jarry H, Rune GM.

J Neurochem. 2017 Jan;140(1):126-139. doi: 10.1111/jnc.13889. Epub 2016 Dec 12.

15.

Hefteditorial Ausgabe 1.

Vollmer G.

Klin Monbl Augenheilkd. 2016 Jan;233(1):1. German. No abstract available.

PMID:
27195325
16.

Erratum to: Phase II metabolism of the soy isoflavones genistein and daidzein in humans, rats and mice: a cross-species and sex comparison.

Soukup ST, Helppi J, Müller DR, Zierau O, Watzl B, Vollmer G, Diel P, Bub A, Kulling SE.

Arch Toxicol. 2016 Jun;90(6):1349. No abstract available.

PMID:
27166957
17.

The phytoestrogenic Cyclopia extract, SM6Met, increases median tumor free survival and reduces tumor mass and volume in chemically induced rat mammary gland carcinogenesis.

Visser K, Zierau O, Macejová D, Goerl F, Muders M, Baretton GB, Vollmer G, Louw A.

J Steroid Biochem Mol Biol. 2016 Oct;163:129-35. doi: 10.1016/j.jsbmb.2016.04.019. Epub 2016 Apr 30.

PMID:
27142456
18.

Klinische Monatsblätter für Augenheilkunde.

Vollmer G.

Klin Monbl Augenheilkd. 2015 Nov;232(11):1237. German. No abstract available.

PMID:
26904759
19.

Soy isoflavone exposure through all life stages accelerates 17β-estradiol-induced mammary tumor onset and growth, yet reduces tumor burden, in ACI rats.

Möller FJ, Pemp D, Soukup ST, Wende K, Zhang X, Zierau O, Muders MH, Bosland MC, Kulling SE, Lehmann L, Vollmer G.

Arch Toxicol. 2016 Aug;90(8):1907-16. doi: 10.1007/s00204-016-1674-2. Epub 2016 Feb 9.

PMID:
26861028
20.

Phase II metabolism of the soy isoflavones genistein and daidzein in humans, rats and mice: a cross-species and sex comparison.

Soukup ST, Helppi J, Müller DR, Zierau O, Watzl B, Vollmer G, Diel P, Bub A, Kulling SE.

Arch Toxicol. 2016 Jun;90(6):1335-47. doi: 10.1007/s00204-016-1663-5. Epub 2016 Feb 2. Erratum in: Arch Toxicol. 2016 Jun;90(6):1349.

PMID:
26838042
21.

Klinische Monatsblätter für Augenheilkunde.

Vollmer G.

Klin Monbl Augenheilkd. 2015 Oct;232(10):1137. German. No abstract available.

PMID:
26824113
22.

LC-MS- and (1)H NMR-Based Metabolomic Analysis and in Vitro Toxicological Assessment of 43 Aristolochia Species.

Michl J, Kite GC, Wanke S, Zierau O, Vollmer G, Neinhuis C, Simmonds MS, Heinrich M.

J Nat Prod. 2016 Jan 22;79(1):30-7. doi: 10.1021/acs.jnatprod.5b00556. Epub 2015 Dec 26.

PMID:
26706944
23.

Cross-Talk in the Female Rat Mammary Gland: Influence of Aryl Hydrocarbon Receptor on Estrogen Receptor Signaling.

Helle J, Bader MI, Keiler AM, Zierau O, Vollmer G, Chittur SV, Tenniswood M, Kretzschmar G.

Environ Health Perspect. 2016 May;124(5):601-10. doi: 10.1289/ehp.1509680. Epub 2015 Sep 15.

24.

Oleocanthal Modulates Estradiol-Induced Gene Expression Involving Estrogen Receptor α.

Keiler AM, Djiogue S, Ehrhardt T, Zierau O, Skaltsounis L, Halabalaki M, Vollmer G.

Planta Med. 2015 Sep;81(14):1263-9. doi: 10.1055/s-0035-1546194. Epub 2015 Jul 10.

PMID:
26166135
25.

[Editorial bulletin for Issue 3].

Vollmer G.

Klin Monbl Augenheilkd. 2015 Mar;232(3):225. German. No abstract available.

PMID:
25973466
26.

Alpinumisoflavone and abyssinone V 4'-methylether derived from Erythrina lysistemon (Fabaceae) promote HDL-cholesterol synthesis and prevent cholesterol gallstone formation in ovariectomized rats.

Mvondo MA, Njamen D, Kretzschmar G, Imma Bader M, Tanee Fomum S, Wandji J, Vollmer G.

J Pharm Pharmacol. 2015 Jul;67(7):990-6. doi: 10.1111/jphp.12386. Epub 2015 Feb 14.

PMID:
25683903
27.

Dose-dependent effects of isoflavone exposure during early lifetime on the rat mammary gland: Studies on estrogen sensitivity, isoflavone metabolism, and DNA methylation.

Blei T, Soukup ST, Schmalbach K, Pudenz M, Möller FJ, Egert B, Wörtz N, Kurrat A, Müller D, Vollmer G, Gerhäuser C, Lehmann L, Kulling SE, Diel P.

Mol Nutr Food Res. 2015 Feb;59(2):270-83. doi: 10.1002/mnfr.201400480. Epub 2014 Dec 18.

PMID:
25410811
28.

Assessment of the effects of naringenin-type flavanones in uterus and vagina.

Keiler AM, Dörfelt P, Chatterjee N, Helle J, Bader MI, Vollmer G, Kretzschmar G, Kuhlee F, Thieme D, Zierau O.

J Steroid Biochem Mol Biol. 2015 Jan;145:49-57. doi: 10.1016/j.jsbmb.2014.10.001. Epub 2014 Oct 11.

PMID:
25305411
29.

Functions of Danggui Buxue Tang, a Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, in Uterus and Liver are Both Estrogen Receptor-Dependent and -Independent.

Zierau O, Zheng KY, Papke A, Dong TT, Tsim KW, Vollmer G.

Evid Based Complement Alternat Med. 2014;2014:438531. doi: 10.1155/2014/438531. Epub 2014 Aug 19.

30.

[Clinical Monthly Journal of Ophthalmology. Dear readers].

Vollmer G.

Klin Monbl Augenheilkd. 2014 Jul;231(7):e41. German. No abstract available.

PMID:
25165776
31.

Erythroidine alkaloids: a novel class of phytoestrogens.

Djiogue S, Halabalaki M, Njamen D, Kretzschmar G, Lambrinidis G, Hoepping J, Raffaelli FM, Mikros E, Skaltsounis AL, Vollmer G.

Planta Med. 2014 Jul;80(11):861-9. doi: 10.1055/s-0034-1382861. Epub 2014 Aug 12.

PMID:
25116117
32.

[Dear readers].

Vollmer G.

Klin Monbl Augenheilkd. 2014 Apr;231(4):e21. German. No abstract available.

PMID:
24892167
33.

Assessment of the proliferative capacity of the flavanones 8-prenylnaringenin, 6-(1.1-dimethylallyl)naringenin and naringenin in MCF-7 cells and the rat mammary gland.

Helle J, Kräker K, Bader MI, Keiler AM, Zierau O, Vollmer G, Welsh J, Kretzschmar G.

Mol Cell Endocrinol. 2014 Jul 5;392(1-2):125-35. doi: 10.1016/j.mce.2014.05.014. Epub 2014 May 22.

PMID:
24859648
34.

Oestradiol-induced synapse formation in the female hippocampus: roles of oestrogen receptor subtypes.

Zhou L, Fester L, Haghshenas S, de Vrese X, von Hacht R, Gloger S, Brandt N, Bader M, Vollmer G, Rune GM.

J Neuroendocrinol. 2014 Jul;26(7):439-47. doi: 10.1111/jne.12162.

PMID:
24779550
35.

Progesterone, as well as 17β-estradiol, is important for regulating AHR battery homoeostasis in the rat uterus.

Rataj F, Möller FJ, Jähne M, Hönscheid P, Zierau O, Vollmer G, Kretzschmar G.

Arch Toxicol. 2015 Mar;89(3):393-404. doi: 10.1007/s00204-014-1261-3. Epub 2014 Apr 29.

PMID:
24777823
36.

Increased bone remodelling around titanium implants coated with chondroitin sulfate in ovariectomized rats.

Dudeck J, Rehberg S, Bernhardt R, Schneiders W, Zierau O, Inderchand M, Goebbels J, Vollmer G, Fratzl P, Scharnweber D, Rammelt S.

Acta Biomater. 2014 Jun;10(6):2855-65. doi: 10.1016/j.actbio.2014.01.034. Epub 2014 Feb 15.

PMID:
24534718
37.

Impact of a functionalized olive oil extract on the uterus and the bone in a model of postmenopausal osteoporosis.

Keiler AM, Zierau O, Bernhardt R, Scharnweber D, Lemonakis N, Termetzi A, Skaltsounis L, Vollmer G, Halabalaki M.

Eur J Nutr. 2014 Jun;53(4):1073-81. doi: 10.1007/s00394-013-0609-4. Epub 2013 Oct 30.

PMID:
24170065
38.

Estradiol responsiveness of synaptopodin in hippocampal neurons is mediated by estrogen receptor β.

Fester L, Labitzke J, Hinz R, Behem C, Horling K, Bernhard T, Bader MI, Vollmer G, Rune GM.

J Steroid Biochem Mol Biol. 2013 Nov;138:455-61. doi: 10.1016/j.jsbmb.2013.09.004. Epub 2013 Sep 25.

PMID:
24076016
39.

Detection and quantification of chlordecone in contaminated soils from the French West Indies by GC-MS using the 13C10-chlordecone stable isotope as a tracer.

Martin-Laurent F, Sahnoun MM, Merlin C, Vollmer G, Lübke M.

Environ Sci Pollut Res Int. 2014 Apr;21(7):4928-33. doi: 10.1007/s11356-013-1839-y. Epub 2013 Jun 4.

PMID:
23733305
40.

On a global level, the use of natural products in women's health care is motivated by completely different reasons.

Vollmer G.

Planta Med. 2013 May;79(7):513. doi: 10.1055/s-0032-1328520. Epub 2013 May 13. No abstract available.

PMID:
23670596
41.

Phytotherapy and women's reproductive health: the Cameroonian perspective.

Njamen D, Mvondo MA, Djiogue S, Ketcha Wanda GJ, Magne Nde CB, Vollmer G.

Planta Med. 2013 May;79(7):600-11. doi: 10.1055/s-0032-1328326. Epub 2013 Mar 28. Review.

42.

Comparison of estrogenic responses in bone and uterus depending on the parity status in Lewis rats.

Keiler AM, Bernhardt R, Scharnweber D, Jarry H, Vollmer G, Zierau O.

J Steroid Biochem Mol Biol. 2013 Jan;133:101-9. doi: 10.1016/j.jsbmb.2012.09.023. Epub 2012 Sep 29.

PMID:
23032373
43.

The rat prepubertal uterine myometrium and not the luminal epithelium is predominantly affected by a chronic dietary genistein exposure.

Möller FJ, Ledwig C, Zierau O, Hertrampf T, Degen GH, Diel P, Vollmer G.

Arch Toxicol. 2012 Dec;86(12):1899-910. doi: 10.1007/s00204-012-0907-2. Epub 2012 Jul 19.

PMID:
22811025
44.

Characterization of identity, metabolism and androgenic activity of 17-hydroxyandrosta-3,5-diene by GC-MS and a yeast transactivation system.

Bauer A, Rataj F, Zierau O, Anielski P, Große J, Parr MK, Vollmer G, Thieme D.

Arch Toxicol. 2012 Dec;86(12):1873-84. doi: 10.1007/s00204-012-0905-4. Epub 2012 Jul 19.

PMID:
22811023
45.

Distribution of protein oxidation products in the proteome of thermally processed milk.

Meyer B, Baum F, Vollmer G, Pischetsrieder M.

J Agric Food Chem. 2012 Jul 25;60(29):7306-11. doi: 10.1021/jf301666r. Epub 2012 Jul 12.

PMID:
22746820
46.

Estimation of an early meaningful time point of bone parameter changes in application to an osteoporotic rat model with in vivo microcomputed tomography measurements.

Keiler AM, Zierau O, Vollmer G, Scharnweber D, Bernhardt R.

Lab Anim. 2012 Jul;46(3):237-44. doi: 10.1258/la.2012.011154. Epub 2012 Jun 21.

PMID:
22723650
47.

Regulation of uterine AHR battery gene expression by 17β-Estradiol is predominantly mediated by estrogen receptor α.

Rataj F, Möller FJ, Jähne M, Zierau O, Diel P, Vollmer G, Kretzschmar G.

Arch Toxicol. 2012 Oct;86(10):1603-12. doi: 10.1007/s00204-012-0870-y. Epub 2012 Jun 4.

PMID:
22659940
48.

Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling.

Guo AJ, Choi RC, Zheng KY, Chen VP, Dong TT, Wang ZT, Vollmer G, Lau DT, Tsim KW.

Chin Med. 2012 Apr 30;7:10. doi: 10.1186/1749-8546-7-10.

49.

Effect of 17β-estradiol and flavonoids on the regulation of expression of newly identified oestrogen responsive genes in a rat raphe nuclei-derived cell line.

Amer DA, Jähne M, Weigt C, Kretzschmar G, Vollmer G.

J Cell Physiol. 2012 Oct;227(10):3434-45. doi: 10.1002/jcp.24044.

PMID:
22213181
50.

The EPI bioassay identifies natural compounds with estrogenic activity that are potent inhibitors of androgenic pathways in human prostate stromal and epithelial cells.

Vollmer G, Helle J, Amri H, Liu X, Arnold JT.

J Steroid Biochem Mol Biol. 2012 Apr;129(3-5):153-62. doi: 10.1016/j.jsbmb.2011.12.003. Epub 2011 Dec 22.

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