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Items: 11


Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo.

Su D, Chen J, Cosino E, Dela Cruz-Chuh J, Davis H, Del Rosario G, Figueroa I, Goon L, He J, Kamath AV, Kaur S, Kozak KR, Lau J, Lee D, Lee MV, Leipold D, Liu L, Liu P, Lu GL, Nelson C, Ng C, Pillow TH, Polakis P, Polson AG, Rowntree RK, Saad O, Safina B, Stagg NJ, Tercel M, Vandlen R, Vollmar BS, Wai J, Wang T, Wei B, Xu K, Xue J, Xu Z, Yan G, Yao H, Yu SF, Zhang D, Zhong F, Dragovich PS.

Bioconjug Chem. 2019 May 15;30(5):1356-1370. doi: 10.1021/acs.bioconjchem.9b00133. Epub 2019 Apr 22.


Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads.

Zhang D, Le H, Cruz-Chuh JD, Bobba S, Guo J, Staben L, Zhang C, Ma Y, Kozak KR, Lewis Phillips GD, Vollmar BS, Sadowsky JD, Vandlen R, Wei B, Su D, Fan P, Dragovich PS, Khojasteh SC, Hop CECA, Pillow TH.

Bioconjug Chem. 2018 Feb 21;29(2):267-274. doi: 10.1021/acs.bioconjchem.7b00576. Epub 2018 Feb 7.


Attachment Site Cysteine Thiol pKa Is a Key Driver for Site-Dependent Stability of THIOMAB Antibody-Drug Conjugates.

Vollmar BS, Wei B, Ohri R, Zhou J, He J, Yu SF, Leipold D, Cosino E, Yee S, Fourie-O'Donohue A, Li G, Phillips GL, Kozak KR, Kamath A, Xu K, Lee G, Lazar GA, Erickson HK.

Bioconjug Chem. 2017 Oct 18;28(10):2538-2548. doi: 10.1021/acs.bioconjchem.7b00365. Epub 2017 Sep 22.


Overview of electron crystallography of membrane proteins: crystallization and screening strategies using negative stain electron microscopy.

Nannenga BL, Iadanza MG, Vollmar BS, Gonen T.

Curr Protoc Protein Sci. 2013;Chapter 17:Unit17.15. doi: 10.1002/0471140864.ps1715s72.


HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation.

Filbin ME, Vollmar BS, Shi D, Gonen T, Kieft JS.

Nat Struct Mol Biol. 2013 Feb;20(2):150-8. doi: 10.1038/nsmb.2465. Epub 2012 Dec 23.


The Ndc80 kinetochore complex directly modulates microtubule dynamics.

Umbreit NT, Gestaut DR, Tien JF, Vollmar BS, Gonen T, Asbury CL, Davis TN.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16113-8. doi: 10.1073/pnas.1209615109. Epub 2012 Aug 20.


Computational design of self-assembling protein nanomaterials with atomic level accuracy.

King NP, Sheffler W, Sawaya MR, Vollmar BS, Sumida JP, André I, Gonen T, Yeates TO, Baker D.

Science. 2012 Jun 1;336(6085):1171-4. doi: 10.1126/science.1219364.


N-terminal domain of alphaB-crystallin provides a conformational switch for multimerization and structural heterogeneity.

Jehle S, Vollmar BS, Bardiaux B, Dove KK, Rajagopal P, Gonen T, Oschkinat H, Klevit RE.

Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6409-14. doi: 10.1073/pnas.1014656108. Epub 2011 Apr 4.


Can antimicrobial peptides scavenge around a cell in less than a second?

Chekmenev EY, Vollmar BS, Cotten M.

Biochim Biophys Acta. 2010 Feb;1798(2):228-34. doi: 10.1016/j.bbamem.2009.08.018. Epub 2009 Sep 6.


Investigating molecular recognition and biological function at interfaces using piscidins, antimicrobial peptides from fish.

Chekmenev EY, Vollmar BS, Forseth KT, Manion MN, Jones SM, Wagner TJ, Endicott RM, Kyriss BP, Homem LM, Pate M, He J, Raines J, Gor'kov PL, Brey WW, Mitchell DJ, Auman AJ, Ellard-Ivey MJ, Blazyk J, Cotten M.

Biochim Biophys Acta. 2006 Sep;1758(9):1359-72. Epub 2006 Apr 7.


High-field NMR studies of molecular recognition and structure-function relationships in antimicrobial piscidins at the water-lipid bilayer interface.

Chekmenev EY, Jones SM, Nikolayeva YN, Vollmar BS, Wagner TJ, Gor'kov PL, Brey WW, Manion MN, Daugherty KC, Cotten M.

J Am Chem Soc. 2006 Apr 26;128(16):5308-9.


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