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Therapeutic Targeting of High-Mobility Group Box-1 in Pulmonary Arterial Hypertension.

Goldenberg NM, Hu Y, Hu X, Volchuk A, Zhao YD, Kucherenko MM, Knosalla C, de Perrot M, Tracey KJ, Al-Abed Y, Steinberg BE, Kuebler WM.

Am J Respir Crit Care Med. 2019 Jun 15;199(12):1566-1569. doi: 10.1164/rccm.201808-1597LE. No abstract available.


Glucose-Induced β-Cell Dysfunction In Vivo: Evidence for a Causal Role of C-jun N-terminal Kinase Pathway.

Tang C, Yeung LSN, Koulajian K, Zhang L, Tai K, Volchuk A, Giacca A.

Endocrinology. 2018 Nov 1;159(11):3643-3654. doi: 10.1210/en.2018-00566.


Male Mice Lacking NLRX1 Are Partially Protected From High-Fat Diet-Induced Hyperglycemia.

Costford SR, Tattoli I, Duan FT, Volchuk A, Klip A, Philpott DJ, Woo M, Girardin SE.

J Endocr Soc. 2018 Feb 21;2(4):336-347. doi: 10.1210/js.2017-00360. eCollection 2018 Apr 1.


Mesenchymal stem cells enhance NOX2-dependent reactive oxygen species production and bacterial killing in macrophages during sepsis.

Rabani R, Volchuk A, Jerkic M, Ormesher L, Garces-Ramirez L, Canton J, Masterson C, Gagnon S, Tatham KC, Marshall J, Grinstein S, Laffey JG, Szaszi K, Curley GF.

Eur Respir J. 2018 Apr 26;51(4). pii: 1702021. doi: 10.1183/13993003.02021-2017. Print 2018 Apr.


IKKβ inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents.

Ivovic A, Oprescu AI, Koulajian K, Mori Y, Eversley JA, Zhang L, Nino-Fong R, Lewis GF, Donath MY, Karin M, Wheeler MB, Ehses J, Volchuk A, Chan CB, Giacca A.

Diabetologia. 2017 Oct;60(10):2021-2032. doi: 10.1007/s00125-017-4345-9. Epub 2017 Jul 20.


Whole exome sequencing of families with 1q21.1 microdeletion or microduplication.

Qiao Y, Badduke C, Tang F, Cowieson D, Martell S, Lewis SME, Peñaherrera MS, Robinson WP, Volchuk A, Rajcan-Separovic E.

Am J Med Genet A. 2017 Jul;173(7):1782-1791. doi: 10.1002/ajmg.a.38247. Epub 2017 May 5.


Highly efficient adenoviral transduction of pancreatic islets using a microfluidic device.

Silva PN, Atto Z, Regeenes R, Tufa U, Chen YY, Chan WC, Volchuk A, Kilkenny DM, Rocheleau JV.

Lab Chip. 2016 Aug 7;16(15):2921-34. doi: 10.1039/c6lc00345a. Epub 2016 Jul 5.


Jagn1 Is Induced in Response to ER Stress and Regulates Proinsulin Biosynthesis.

Nosak C, Silva PN, Sollazzo P, Moon KM, Odisho T, Foster LJ, Rocheleau JV, Volchuk A.

PLoS One. 2016 Feb 16;11(2):e0149177. doi: 10.1371/journal.pone.0149177. eCollection 2016.


NADPH oxidase-dependent production of reactive oxygen species induces endoplasmatic reticulum stress in neutrophil-like HL60 cells.

Kuwabara WM, Zhang L, Schuiki I, Curi R, Volchuk A, Alba-Loureiro TC.

PLoS One. 2015 Feb 10;10(2):e0116410. doi: 10.1371/journal.pone.0116410. eCollection 2015.


ATF6β regulates the Wfs1 gene and has a cell survival role in the ER stress response in pancreatic β-cells.

Odisho T, Zhang L, Volchuk A.

Exp Cell Res. 2015 Jan 1;330(1):111-22. doi: 10.1016/j.yexcr.2014.10.007. Epub 2014 Oct 16.


IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis.

Zhang L, Nosak C, Sollazzo P, Odisho T, Volchuk A.

BMC Cell Biol. 2014 Jul 10;15:29. doi: 10.1186/1471-2121-15-29.


GRP78 overproduction in pancreatic beta cells protects against high-fat-diet-induced diabetes in mice.

Teodoro-Morrison T, Schuiki I, Zhang L, Belsham DD, Volchuk A.

Diabetologia. 2013 May;56(5):1057-67. doi: 10.1007/s00125-013-2855-7. Epub 2013 Mar 9.


SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic β-cells.

Tiwari A, Schuiki I, Zhang L, Allister EM, Wheeler MB, Volchuk A.

J Cell Sci. 2013 May 1;126(Pt 9):1962-8. doi: 10.1242/jcs.117374. Epub 2013 Feb 26.


Diverse roles for the p24 family of proteins in eukaryotic cells.

Schuiki I, Volchuk A.

Biomol Concepts. 2012 Dec;3(6):561-70. doi: 10.1515/bmc-2012-0028.


A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity.

Noyan-Ashraf MH, Shikatani EA, Schuiki I, Mukovozov I, Wu J, Li RK, Volchuk A, Robinson LA, Billia F, Drucker DJ, Husain M.

Circulation. 2013 Jan 1;127(1):74-85. doi: 10.1161/CIRCULATIONAHA.112.091215. Epub 2012 Nov 27.


Endoplasmic reticulum redox state is not perturbed by pharmacological or pathological endoplasmic reticulum stress in live pancreatic β-cells.

Schuiki I, Zhang L, Volchuk A.

PLoS One. 2012;7(11):e48626. doi: 10.1371/journal.pone.0048626. Epub 2012 Nov 8.


Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress.

Tang C, Koulajian K, Schuiki I, Zhang L, Desai T, Ivovic A, Wang P, Robson-Doucette C, Wheeler MB, Minassian B, Volchuk A, Giacca A.

Diabetologia. 2012 May;55(5):1366-79. doi: 10.1007/s00125-012-2474-8. Epub 2012 Mar 1.


Pancreatic β-cells depend on basal expression of active ATF6α-p50 for cell survival even under nonstress conditions.

Teodoro T, Odisho T, Sidorova E, Volchuk A.

Am J Physiol Cell Physiol. 2012 Apr 1;302(7):C992-1003. doi: 10.1152/ajpcell.00160.2011. Epub 2011 Dec 21.


Action of protein disulfide isomerase on proinsulin exit from endoplasmic reticulum of pancreatic β-cells.

Rajpal G, Schuiki I, Liu M, Volchuk A, Arvan P.

J Biol Chem. 2012 Jan 2;287(1):43-7. doi: 10.1074/jbc.C111.279927. Epub 2011 Nov 21.


Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression.

Amyot J, Benterki I, Fontés G, Hagman DK, Ferdaoussi M, Teodoro T, Volchuk A, Joly É, Poitout V.

J Mol Endocrinol. 2011 Sep 30;47(3):273-83. doi: 10.1530/JME-11-0016. Print 2011 Dec.


The endoplasmic reticulum stress response in the pancreatic β-cell.

Volchuk A, Ron D.

Diabetes Obes Metab. 2010 Oct;12 Suppl 2:48-57. doi: 10.1111/j.1463-1326.2010.01271.x. Review.


Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B.

Bousette N, Chugh S, Fong V, Isserlin R, Kim KH, Volchuk A, Backx PH, Liu P, Kislinger T, MacLennan DH, Emili A, Gramolini AO.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18481-6. doi: 10.1073/pnas.1013555107. Epub 2010 Oct 11.


OASIS/CREB3L1 induces expression of genes involved in extracellular matrix production but not classical endoplasmic reticulum stress response genes in pancreatic beta-cells.

Vellanki RN, Zhang L, Guney MA, Rocheleau JV, Gannon M, Volchuk A.

Endocrinology. 2010 Sep;151(9):4146-57. doi: 10.1210/en.2010-0137. Epub 2010 Jul 28.


Endoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin.

Hartley T, Siva M, Lai E, Teodoro T, Zhang L, Volchuk A.

BMC Cell Biol. 2010 Jul 26;11:59. doi: 10.1186/1471-2121-11-59.


p24 family type 1 transmembrane proteins are required for insulin biosynthesis and secretion in pancreatic beta-cells.

Zhang L, Volchuk A.

FEBS Lett. 2010 Jun 3;584(11):2298-304. doi: 10.1016/j.febslet.2010.03.041. Epub 2010 Mar 28.


GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic {beta}-Cells.

Zhang L, Lai E, Teodoro T, Volchuk A.

J Biol Chem. 2009 Feb 20;284(8):5289-98. doi: 10.1074/jbc.M805477200. Epub 2008 Dec 22.


Emerging roles for the ubiquitin-proteasome system and autophagy in pancreatic beta-cells.

Hartley T, Brumell J, Volchuk A.

Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E1-10. doi: 10.1152/ajpendo.90538.2008. Epub 2008 Sep 23. Review.


Oleanolic acid enhances insulin secretion in pancreatic beta-cells.

Teodoro T, Zhang L, Alexander T, Yue J, Vranic M, Volchuk A.

FEBS Lett. 2008 Apr 16;582(9):1375-80. doi: 10.1016/j.febslet.2008.03.026. Epub 2008 Mar 24.


Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells.

Lai E, Bikopoulos G, Wheeler MB, Rozakis-Adcock M, Volchuk A.

Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E540-50. doi: 10.1152/ajpendo.00478.2007. Epub 2008 Jan 15.


Endoplasmic reticulum stress: signaling the unfolded protein response.

Lai E, Teodoro T, Volchuk A.

Physiology (Bethesda). 2007 Jun;22:193-201. Review.


Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy.

Kaniuk NA, Kiraly M, Bates H, Vranic M, Volchuk A, Brumell JH.

Diabetes. 2007 Apr;56(4):930-9.


Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis.

Karaskov E, Scott C, Zhang L, Teodoro T, Ravazzola M, Volchuk A.

Endocrinology. 2006 Jul;147(7):3398-407. Epub 2006 Apr 6.


Dynamic transport of SNARE proteins in the Golgi apparatus.

Cosson P, Ravazzola M, Varlamov O, Söllner TH, Di Liberto M, Volchuk A, Rothman JE, Orci L.

Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14647-52. Epub 2005 Sep 30.


Sequence characteristics of functional siRNAs.

Jagla B, Aulner N, Kelly PD, Song D, Volchuk A, Zatorski A, Shum D, Mayer T, De Angelis DA, Ouerfelli O, Rutishauser U, Rothman JE.

RNA. 2005 Jun;11(6):864-72.


Differential use of endoplasmic reticulum membrane for phagocytosis in J774 macrophages.

Becker T, Volchuk A, Rothman JE.

Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4022-6. Epub 2005 Mar 7.


Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack.

Volchuk A, Ravazzola M, Perrelet A, Eng WS, Di Liberto M, Varlamov O, Fukasawa M, Engel T, Söllner TH, Rothman JE, Orci L.

Mol Biol Cell. 2004 Apr;15(4):1506-18. Epub 2004 Jan 23.


i-SNAREs: inhibitory SNAREs that fine-tune the specificity of membrane fusion.

Varlamov O, Volchuk A, Rahimian V, Doege CA, Paumet F, Eng WS, Arango N, Parlati F, Ravazzola M, Orci L, Söllner TH, Rothman JE.

J Cell Biol. 2004 Jan 5;164(1):79-88. Epub 2003 Dec 29.


Megavesicles implicated in the rapid transport of intracisternal aggregates across the Golgi stack.

Volchuk A, Amherdt M, Ravazzola M, Brügger B, Rivera VM, Clackson T, Perrelet A, Söllner TH, Rothman JE, Orci L.

Cell. 2000 Aug 4;102(3):335-48.


Anterograde flow of cargo across the golgi stack potentially mediated via bidirectional "percolating" COPI vesicles.

Orci L, Ravazzola M, Volchuk A, Engel T, Gmachl M, Amherdt M, Perrelet A, Sollner TH, Rothman JE.

Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10400-5.


VAMP2, but not VAMP3/cellubrevin, mediates insulin-dependent incorporation of GLUT4 into the plasma membrane of L6 myoblasts.

Randhawa VK, Bilan PJ, Khayat ZA, Daneman N, Liu Z, Ramlal T, Volchuk A, Peng XR, Coppola T, Regazzi R, Trimble WS, Klip A.

Mol Biol Cell. 2000 Jul;11(7):2403-17.


Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum.

Rivera VM, Wang X, Wardwell S, Courage NL, Volchuk A, Keenan T, Holt DA, Gilman M, Orci L, Cerasoli F Jr, Rothman JE, Clackson T.

Science. 2000 Feb 4;287(5454):826-30.


Tissue distribution of SNAP-23 and its subcellular localization in 3T3-L1 cells.

Wong PP, Daneman N, Volchuk A, Lassam N, Wilson MC, Klip A, Trimble WS.

Biochem Biophys Res Commun. 1997 Jan 3;230(1):64-8.


Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins.

Cheatham B, Volchuk A, Kahn CR, Wang L, Rhodes CJ, Klip A.

Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15169-73.


Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway.

Estrada DE, Ewart HS, Tsakiridis T, Volchuk A, Ramlal T, Tritschler H, Klip A.

Diabetes. 1996 Dec;45(12):1798-804.


Syntaxin 4 in 3T3-L1 adipocytes: regulation by insulin and participation in insulin-dependent glucose transport.

Volchuk A, Wang Q, Ewart HS, Liu Z, He L, Bennett MK, Klip A.

Mol Biol Cell. 1996 Jul;7(7):1075-82.


Subcellular distribution of docking/fusion proteins in neutrophils, secretory cells with multiple exocytic compartments.

Brumell JH, Volchuk A, Sengelov H, Borregaard N, Cieutat AM, Bainton DF, Grinstein S, Klip A.

J Immunol. 1995 Dec 15;155(12):5750-9.


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