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Influenza "Trains" the Host for Enhanced Susceptibility to Secondary Bacterial Infection.

Shirey KA, Perkins DJ, Lai W, Zhang W, Fernando LR, Gusovsky F, Blanco JCG, Vogel SN.

MBio. 2019 May 7;10(3). pii: e00810-19. doi: 10.1128/mBio.00810-19.


Mycobacterium tuberculosis Inhibits Autocrine Type I IFN Signaling to Increase Intracellular Survival.

Banks DA, Ahlbrand SE, Hughitt VK, Shah S, Mayer-Barber KD, Vogel SN, El-Sayed NM, Briken V.

J Immunol. 2019 Apr 15;202(8):2348-2359. doi: 10.4049/jimmunol.1801303. Epub 2019 Mar 4.


Myeloid-derived suppressor cells are bound and inhibited by anti-thymocyte globulin.

Suk Lee Y, Davila E, Zhang T, Milmoe HP, Vogel SN, Bromberg JS, Scalea JR.

Innate Immun. 2019 Jan;25(1):46-59. doi: 10.1177/1753425918820427.


Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling.

Perkins DJ, Richard K, Hansen AM, Lai W, Nallar S, Koller B, Vogel SN.

Nat Immunol. 2018 Dec;19(12):1309-1318. doi: 10.1038/s41590-018-0243-7. Epub 2018 Nov 5.


Novel role of gastrin releasing peptide-mediated signaling in the host response to influenza infection.

Shirey KA, Sunday ME, Lai W, Patel MC, Blanco JCG, Cuttitta F, Vogel SN.

Mucosal Immunol. 2019 Jan;12(1):223-231. doi: 10.1038/s41385-018-0081-9. Epub 2018 Oct 16.


A multifaceted approach to RSV vaccination.

Blanco JCG, Boukhvalova MS, Morrison TG, Vogel SN.

Hum Vaccin Immunother. 2018 Jul 3;14(7):1734-1745. doi: 10.1080/21645515.2018.1472183. Epub 2018 Jun 19. Review.


Serum High-Mobility-Group Box 1 as a Biomarker and a Therapeutic Target during Respiratory Virus Infections.

Patel MC, Shirey KA, Boukhvalova MS, Vogel SN, Blanco JCG.

MBio. 2018 Mar 13;9(2). pii: e00246-18. doi: 10.1128/mBio.00246-18.


Immunization with Live Human Rhinovirus (HRV) 16 Induces Protection in Cotton Rats against HRV14 Infection.

Patel MC, Pletneva LM, Boukhvalova MS, Vogel SN, Kajon AE, Blanco JCG.

Front Microbiol. 2017 Aug 31;8:1646. doi: 10.3389/fmicb.2017.01646. eCollection 2017.


The θ-defensin retrocyclin 101 inhibits TLR4- and TLR2-dependent signaling and protects mice against influenza infection.

Prantner D, Shirey KA, Lai W, Lu W, Cole AM, Vogel SN, Garzino-Demo A.

J Leukoc Biol. 2017 Oct;102(4):1103-1113. doi: 10.1189/jlb.2A1215-567RR. Epub 2017 Jul 20.


Preclinical assessment of safety of maternal vaccination against respiratory syncytial virus (RSV) in cotton rats.

Blanco JCG, Pletneva LM, Otoa RO, Patel MC, Vogel SN, Boukhvalova MS.

Vaccine. 2017 Jul 13;35(32):3951-3958. doi: 10.1016/j.vaccine.2017.06.009. Epub 2017 Jun 16.


Measurement of Tumor Necrosis Factor and Lymphotoxins.

Hogan MM, Vogel SN.

Curr Protoc Immunol. 2017 Apr 3;117:6.10.1-6.10.7. doi: 10.1002/cpim.23.


TLR4 antagonist FP7 inhibits LPS-induced cytokine production and glycolytic reprogramming in dendritic cells, and protects mice from lethal influenza infection.

Perrin-Cocon L, Aublin-Gex A, Sestito SE, Shirey KA, Patel MC, André P, Blanco JC, Vogel SN, Peri F, Lotteau V.

Sci Rep. 2017 Jan 20;7:40791. doi: 10.1038/srep40791.


Monophosphoryl Lipid A Enhances Efficacy of a Francisella tularensis LVS-Catanionic Nanoparticle Subunit Vaccine against F. tularensis Schu S4 Challenge by Augmenting both Humoral and Cellular Immunity.

Richard K, Mann BJ, Qin A, Barry EM, Ernst RK, Vogel SN.

Clin Vaccine Immunol. 2017 Mar 6;24(3). pii: e00574-16. doi: 10.1128/CVI.00574-16. Print 2017 Mar.


AMP-activated Kinase (AMPK) Promotes Innate Immunity and Antiviral Defense through Modulation of Stimulator of Interferon Genes (STING) Signaling.

Prantner D, Perkins DJ, Vogel SN.

J Biol Chem. 2017 Jan 6;292(1):292-304. doi: 10.1074/jbc.M116.763268. Epub 2016 Nov 22.


Enterovirus D-68 Infection, Prophylaxis, and Vaccination in a Novel Permissive Animal Model, the Cotton Rat (Sigmodon hispidus).

Patel MC, Wang W, Pletneva LM, Rajagopala SV, Tan Y, Hartert TV, Boukhvalova MS, Vogel SN, Das SR, Blanco JC.

PLoS One. 2016 Nov 4;11(11):e0166336. doi: 10.1371/journal.pone.0166336. eCollection 2016.


Epigenetic Mechanisms Governing Innate Inflammatory Responses.

Perkins DJ, Patel MC, Blanco JC, Vogel SN.

J Interferon Cytokine Res. 2016 Jul;36(7):454-61. doi: 10.1089/jir.2016.0003. Review.


Type I interferon licenses enhanced innate recognition and transcriptional responses to Franciscella tularensis live vaccine strain.

Richard K, Vogel SN, Perkins DJ.

Innate Immun. 2016 Jul;22(5):363-72. doi: 10.1177/1753425916650027. Epub 2016 May 26.


Enhanced allergic responsiveness after early childhood infection with respiratory viruses: Are long-lived alternatively activated macrophages the missing link?

Keegan AD, Shirey KA, Bagdure D, Blanco J, Viscardi RM, Vogel SN.

Pathog Dis. 2016 Jul;74(5). pii: ftw047. doi: 10.1093/femspd/ftw047. Epub 2016 May 12.


Inflammation: Species-specific TLR signalling -- insight into human disease.

Perkins DJ, Vogel SN.

Nat Rev Rheumatol. 2016 Apr;12(4):198-200. doi: 10.1038/nrrheum.2016.36.


Novel strategies for targeting innate immune responses to influenza.

Shirey KA, Lai W, Patel MC, Pletneva LM, Pang C, Kurt-Jones E, Lipsky M, Roger T, Calandra T, Tracey KJ, Al-Abed Y, Bowie AG, Fasano A, Dinarello CA, Gusovsky F, Blanco JC, Vogel SN.

Mucosal Immunol. 2016 Sep;9(5):1173-82. doi: 10.1038/mi.2015.141. Epub 2016 Jan 27.


Salmonella Typhimurium Co-Opts the Host Type I IFN System To Restrict Macrophage Innate Immune Transcriptional Responses Selectively.

Perkins DJ, Rajaiah R, Tennant SM, Ramachandran G, Higginson EE, Dyson TN, Vogel SN.

J Immunol. 2015 Sep 1;195(5):2461-71. doi: 10.4049/jimmunol.1500105. Epub 2015 Jul 22.


CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance.

Rajaiah R, Perkins DJ, Ireland DD, Vogel SN.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8391-6. doi: 10.1073/pnas.1424980112. Epub 2015 Jun 23.


A Decoy Peptide that Disrupts TIRAP Recruitment to TLRs Is Protective in a Murine Model of Influenza.

Piao W, Shirey KA, Ru LW, Lai W, Szmacinski H, Snyder GA, Sundberg EJ, Lakowicz JR, Vogel SN, Toshchakov VY.

Cell Rep. 2015 Jun 30;11(12):1941-52. doi: 10.1016/j.celrep.2015.05.035. Epub 2015 Jun 18.


Characterization of Francisella tularensis Schu S4 defined mutants as live-attenuated vaccine candidates.

Santiago AE, Mann BJ, Qin A, Cunningham AL, Cole LE, Grassel C, Vogel SN, Levine MM, Barry EM.

Pathog Dis. 2015 Aug;73(6):ftv036. doi: 10.1093/femspd/ftv036. Epub 2015 May 17.


Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain.

Mistry P, Laird MH, Schwarz RS, Greene S, Dyson T, Snyder GA, Xiao TS, Chauhan J, Fletcher S, Toshchakov VY, MacKerell AD Jr, Vogel SN.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5455-60. doi: 10.1073/pnas.1422576112. Epub 2015 Apr 13.


Space and time: New considerations about the relationship between Toll-like receptors (TLRs) and type I interferons (IFNs).

Perkins DJ, Vogel SN.

Cytokine. 2015 Aug;74(2):171-4. doi: 10.1016/j.cyto.2015.03.001. Epub 2015 Mar 25. Review.


Modeling Human Respiratory Viral Infections in the Cotton Rat (Sigmodon hispidus).

Blanco JC, Boukhvalova MS, Perez DR, Vogel SN, Kajon A.

J Antivir Antiretrovir. 2014 Mar 3;6:40-42.


Novel drugs targeting Toll-like receptors for antiviral therapy.

Patel MC, Shirey KA, Pletneva LM, Boukhvalova MS, Garzino-Demo A, Vogel SN, Blanco JC.

Future Virol. 2014 Sep;9(9):811-829.


Macrophage activation and polarization: nomenclature and experimental guidelines.

Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, Locati M, Mantovani A, Martinez FO, Mege JL, Mosser DM, Natoli G, Saeij JP, Schultze JL, Shirey KA, Sica A, Suttles J, Udalova I, van Ginderachter JA, Vogel SN, Wynn TA.

Immunity. 2014 Jul 17;41(1):14-20. doi: 10.1016/j.immuni.2014.06.008.


An essential role for IFN-β in the induction of IFN-stimulated gene expression by LPS in macrophages.

Sheikh F, Dickensheets H, Gamero AM, Vogel SN, Donnelly RP.

J Leukoc Biol. 2014 Oct;96(4):591-600. doi: 10.1189/jlb.2A0414-191R. Epub 2014 Jul 14.


Agents that increase AAM differentiation blunt RSV-mediated lung pathology.

Shirey KA, Lai W, Pletneva LM, Finkelman FD, Feola DJ, Blanco JC, Vogel SN.

J Leukoc Biol. 2014 Dec;96(6):951-5. doi: 10.1189/jlb.4HI0414-226R. Epub 2014 Jul 9.


Novel catanionic surfactant vesicle vaccines protect against Francisella tularensis LVS and confer significant partial protection against F. tularensis Schu S4 strain.

Richard K, Mann BJ, Stocker L, Barry EM, Qin A, Cole LE, Hurley MT, Ernst RK, Michalek SM, Stein DC, Deshong P, Vogel SN.

Clin Vaccine Immunol. 2014 Feb;21(2):212-26. doi: 10.1128/CVI.00738-13. Epub 2013 Dec 18.


A recombinant anchorless respiratory syncytial virus (RSV) fusion (F) protein/monophosphoryl lipid A (MPL) vaccine protects against RSV-induced replication and lung pathology.

Blanco JC, Boukhvalova MS, Pletneva LM, Shirey KA, Vogel SN.

Vaccine. 2014 Mar 14;32(13):1495-500. doi: 10.1016/j.vaccine.2013.11.032. Epub 2013 Nov 16.


Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain.

Piao W, Ru LW, Piepenbrink KH, Sundberg EJ, Vogel SN, Toshchakov VY.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19036-41. doi: 10.1073/pnas.1313575110. Epub 2013 Nov 5.


Neuraminidase reprograms lung tissue and potentiates lipopolysaccharide-induced acute lung injury in mice.

Feng C, Zhang L, Nguyen C, Vogel SN, Goldblum SE, Blackwelder WC, Cross AS.

J Immunol. 2013 Nov 1;191(9):4828-37. doi: 10.4049/jimmunol.1202673. Epub 2013 Sep 25.


Role of the lipoxygenase pathway in RSV-induced alternatively activated macrophages leading to resolution of lung pathology.

Shirey KA, Lai W, Pletneva LM, Karp CL, Divanovic S, Blanco JC, Vogel SN.

Mucosal Immunol. 2014 May;7(3):549-57. doi: 10.1038/mi.2013.71. Epub 2013 Sep 25.


Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-β and AIM2 inflammasome-dependent IL-1β production via its ESX-1 secretion system.

Shah S, Bohsali A, Ahlbrand SE, Srinivasan L, Rathinam VA, Vogel SN, Fitzgerald KA, Sutterwala FS, Briken V.

J Immunol. 2013 Oct 1;191(7):3514-8. doi: 10.4049/jimmunol.1301331. Epub 2013 Aug 30.


Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15.

Doyle SL, Shirey KA, McGettrick AF, Kenny EF, Carpenter S, Caffrey BE, Gargan S, Quinn SR, Caamaño JH, Moynagh P, Vogel SN, O'Neill LA.

J Biol Chem. 2013 Aug 30;288(35):25066-75. doi: 10.1074/jbc.M113.469122. Epub 2013 Jul 19.


Reprogramming of murine macrophages through TLR2 confers viral resistance via TRAF3-mediated, enhanced interferon production.

Perkins DJ, Polumuri SK, Pennini ME, Lai W, Xie P, Vogel SN.

PLoS Pathog. 2013;9(7):e1003479. doi: 10.1371/journal.ppat.1003479. Epub 2013 Jul 11.


IRAK4 kinase activity is not required for induction of endotoxin tolerance but contributes to TLR2-mediated tolerance.

Xiong Y, Pennini M, Vogel SN, Medvedev AE.

J Leukoc Biol. 2013 Aug;94(2):291-300. doi: 10.1189/jlb.0812401. Epub 2013 May 21.


The TLR4 antagonist Eritoran protects mice from lethal influenza infection.

Shirey KA, Lai W, Scott AJ, Lipsky M, Mistry P, Pletneva LM, Karp CL, McAlees J, Gioannini TL, Weiss J, Chen WH, Ernst RK, Rossignol DP, Gusovsky F, Blanco JC, Vogel SN.

Nature. 2013 May 23;497(7450):498-502. doi: 10.1038/nature12118. Epub 2013 May 1.


Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid.

Conlon J, Burdette DL, Sharma S, Bhat N, Thompson M, Jiang Z, Rathinam VA, Monks B, Jin T, Xiao TS, Vogel SN, Vance RE, Fitzgerald KA.

J Immunol. 2013 May 15;190(10):5216-25. doi: 10.4049/jimmunol.1300097. Epub 2013 Apr 12.


Dissociation of endotoxin tolerance and differentiation of alternatively activated macrophages.

Rajaiah R, Perkins DJ, Polumuri SK, Zhao A, Keegan AD, Vogel SN.

J Immunol. 2013 May 1;190(9):4763-72. doi: 10.4049/jimmunol.1202407. Epub 2013 Mar 29.


Single nucleotide polymorphism in toll-like receptor 6 is associated with a decreased risk for ureaplasma respiratory tract colonization and bronchopulmonary dysplasia in preterm infants.

Winters AH, Levan TD, Vogel SN, Chesko KL, Pollin TI, Viscardi RM.

Pediatr Infect Dis J. 2013 Aug;32(8):898-904. doi: 10.1097/INF.0b013e31828fc693.


Inhibition of TLR4 signaling by TRAM-derived decoy peptides in vitro and in vivo.

Piao W, Vogel SN, Toshchakov VY.

J Immunol. 2013 Mar 1;190(5):2263-72. doi: 10.4049/jimmunol.1202703. Epub 2013 Jan 23.


IL-33-induced alterations in murine intestinal function and cytokine responses are MyD88, STAT6, and IL-13 dependent.

Yang Z, Sun R, Grinchuk V, Fernández-Blanco JA, Notari L, Bohl JA, McLean LP, Ramalingam TR, Wynn TA, Urban JF Jr, Vogel SN, Shea-Donohue T, Zhao A.

Am J Physiol Gastrointest Liver Physiol. 2013 Feb 15;304(4):G381-9. doi: 10.1152/ajpgi.00357.2012. Epub 2012 Dec 20. Erratum in: Am J Physiol Gastrointest Liver Physiol. 2013 Jun 15;304(12):G1137. Blanco, Joan Antoni Fernandez [corrected to Fernández-Blanco, Joan Antoni].


Induced pluripotent stem cell model recapitulates pathologic hallmarks of Gaucher disease.

Panicker LM, Miller D, Park TS, Patel B, Azevedo JL, Awad O, Masood MA, Veenstra TD, Goldin E, Stubblefield BK, Tayebi N, Polumuri SK, Vogel SN, Sidransky E, Zambidis ET, Feldman RA.

Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18054-9. doi: 10.1073/pnas.1207889109. Epub 2012 Oct 15.


5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential.

Prantner D, Perkins DJ, Lai W, Williams MS, Sharma S, Fitzgerald KA, Vogel SN.

J Biol Chem. 2012 Nov 16;287(47):39776-88. doi: 10.1074/jbc.M112.382986. Epub 2012 Oct 1.


Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1.

Qualls JE, Subramanian C, Rafi W, Smith AM, Balouzian L, DeFreitas AA, Shirey KA, Reutterer B, Kernbauer E, Stockinger S, Decker T, Miyairi I, Vogel SN, Salgame P, Rock CO, Murray PJ.

Cell Host Microbe. 2012 Sep 13;12(3):313-23. doi: 10.1016/j.chom.2012.07.012.

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