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Items: 1 to 50 of 126

1.

A Chemical Genetic Method for Monitoring Genome-Wide Dynamics of O-GlcNAc Turnover on Chromatin-Associated Proteins.

Liu TW, Myschyshyn M, Sinclair DA, Vocadlo DJ.

ACS Cent Sci. 2019 Apr 24;5(4):663-670. doi: 10.1021/acscentsci.9b00044. Epub 2019 Mar 1.

2.

Molecular Basis for the Potent Inhibition of the Emerging Carbapenemase VCC-1 by Avibactam.

Mangat CS, Vadlamani G, Holicek V, Chu M, Larmour VLC, Vocadlo DJ, Mulvey MR, Mark BL.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02112-18. doi: 10.1128/AAC.02112-18. Print 2019 Apr.

PMID:
30782990
3.

Direct One-Step Fluorescent Labeling of O-GlcNAc-Modified Proteins in Live Cells Using Metabolic Intermediates.

Tan HY, Eskandari R, Shen D, Zhu Y, Liu TW, Willems LI, Alteen MG, Madden Z, Vocadlo DJ.

J Am Chem Soc. 2018 Nov 14;140(45):15300-15308. doi: 10.1021/jacs.8b08260. Epub 2018 Oct 22.

PMID:
30296064
4.

A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa.

Ho LA, Winogrodzki JL, Debowski AW, Madden Z, Vocadlo DJ, Mark BL, Stubbs KA.

Chem Commun (Camb). 2018 Sep 25;54(75):10630-10633. doi: 10.1039/c8cc05281f. Epub 2018 Sep 4.

PMID:
30178799
5.

Quinolinic Acid Amyloid-like Fibrillar Assemblies Seed α-Synuclein Aggregation.

Tavassoly O, Sade D, Bera S, Shaham-Niv S, Vocadlo DJ, Gazit E.

J Mol Biol. 2018 Oct 12;430(20):3847-3862. doi: 10.1016/j.jmb.2018.08.002. Epub 2018 Aug 8.

PMID:
30098337
6.

Metabolic Inhibitors of O-GlcNAc Transferase That Act In Vivo Implicate Decreased O-GlcNAc Levels in Leptin-Mediated Nutrient Sensing.

Liu TW, Zandberg WF, Gloster TM, Deng L, Murray KD, Shan X, Vocadlo DJ.

Angew Chem Int Ed Engl. 2018 Jun 25;57(26):7644-7648. doi: 10.1002/anie.201803254. Epub 2018 May 24.

7.

Pharmacological Inhibition of O-GlcNAcase Enhances Autophagy in Brain through an mTOR-Independent Pathway.

Zhu Y, Shan X, Safarpour F, Erro Go N, Li N, Shan A, Huang MC, Deen M, Holicek V, Ashmus R, Madden Z, Gorski S, Silverman MA, Vocadlo DJ.

ACS Chem Neurosci. 2018 Jun 20;9(6):1366-1379. doi: 10.1021/acschemneuro.8b00015. Epub 2018 Mar 5.

PMID:
29460617
8.

Fluorescence-Quenched Substrates for Quantitative Live Cell Imaging of Glucocerebrosidase Activity.

Ashmus RA, Shen DL, Vocadlo DJ.

Methods Enzymol. 2018;598:199-215. doi: 10.1016/bs.mie.2017.06.014. Epub 2017 Oct 31.

PMID:
29306435
9.

Carbohydrate Bis-acetal-Based Substrates as Tunable Fluorescence-Quenched Probes for Monitoring exo-Glycosidase Activity.

Cecioni S, Vocadlo DJ.

J Am Chem Soc. 2017 Jun 28;139(25):8392-8395. doi: 10.1021/jacs.7b01948. Epub 2017 Jun 20.

PMID:
28631482
10.

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice.

Hastings NB, Wang X, Song L, Butts BD, Grotz D, Hargreaves R, Fred Hess J, Hong KK, Huang CR, Hyde L, Laverty M, Lee J, Levitan D, Lu SX, Maguire M, Mahadomrongkul V, McEachern EJ, Ouyang X, Rosahl TW, Selnick H, Stanton M, Terracina G, Vocadlo DJ, Wang G, Duffy JL, Parker EM, Zhang L.

Mol Neurodegener. 2017 May 18;12(1):39. doi: 10.1186/s13024-017-0181-0.

11.

Selective trihydroxylated azepane inhibitors of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibiotics.

Bouquet J, King DT, Vadlamani G, Benzie GR, Iorga B, Ide D, Adachi I, Kato A, Vocadlo DJ, Mark BL, Blériot Y, Désiré J.

Org Biomol Chem. 2017 May 31;15(21):4609-4619. doi: 10.1039/c7ob00838d.

PMID:
28513749
12.

Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance.

Vadlamani G, Stubbs KA, Désiré J, Blériot Y, Vocadlo DJ, Mark BL.

Protein Sci. 2017 Jun;26(6):1161-1170. doi: 10.1002/pro.3166. Epub 2017 Apr 7.

13.

Structural and functional insight into human O-GlcNAcase.

Roth C, Chan S, Offen WA, Hemsworth GR, Willems LI, King DT, Varghese V, Britton R, Vocadlo DJ, Davies GJ.

Nat Chem Biol. 2017 Jun;13(6):610-612. doi: 10.1038/nchembio.2358. Epub 2017 Mar 27.

14.

Cura Annonae-Chemically Boosting Crop Yields Through Metabolic Feeding of a Plant Signaling Precursor.

Vocadlo DJ.

Angew Chem Int Ed Engl. 2017 May 22;56(22):5980-5982. doi: 10.1002/anie.201701474. Epub 2017 Mar 9.

PMID:
28276613
15.
16.

Genome-wide chemical mapping of O-GlcNAcylated proteins in Drosophila melanogaster.

Liu TW, Myschyshyn M, Sinclair DA, Cecioni S, Beja K, Honda BM, Morin RD, Vocadlo DJ.

Nat Chem Biol. 2017 Feb;13(2):161-167. doi: 10.1038/nchembio.2247. Epub 2016 Dec 5.

PMID:
27918560
17.

A Fluorescent Transport Assay Enables Studying AmpG Permeases Involved in Peptidoglycan Recycling and Antibiotic Resistance.

Perley-Robertson GE, Yadav AK, Winogrodzki JL, Stubbs KA, Mark BL, Vocadlo DJ.

ACS Chem Biol. 2016 Sep 16;11(9):2626-35. doi: 10.1021/acschembio.6b00552. Epub 2016 Aug 5.

18.

Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human O-GlcNAcase.

Cekic N, Heinonen JE, Stubbs KA, Roth C, He Y, Bennet AJ, McEachern EJ, Davies GJ, Vocadlo DJ.

Chem Sci. 2016 Jun 1;7(6):3742-3750. doi: 10.1039/c6sc00370b. Epub 2016 Feb 15.

19.

Mechanism of Human Nucleocytoplasmic Hexosaminidase D.

Alteen MG, Oehler V, Nemčovičová I, Wilson IB, Vocadlo DJ, Gloster TM.

Biochemistry. 2016 May 17;55(19):2735-47. doi: 10.1021/acs.biochem.5b01285. Epub 2016 May 5.

20.

The Details of Glycolipid Glycan Hydrolysis by the Structural Analysis of a Family 123 Glycoside Hydrolase from Clostridium perfringens.

Noach I, Pluvinage B, Laurie C, Abe KT, Alteen MG, Vocadlo DJ, Boraston AB.

J Mol Biol. 2016 Aug 14;428(16):3253-3265. doi: 10.1016/j.jmb.2016.03.020. Epub 2016 Mar 30.

PMID:
27038508
21.

Modifying the phenyl group of PUGNAc: reactivity tuning to deliver selective inhibitors for N-acetyl-D-glucosaminidases.

Hattie M, Cekic N, Debowski AW, Vocadlo DJ, Stubbs KA.

Org Biomol Chem. 2016 Mar 28;14(12):3193-7. doi: 10.1039/c6ob00297h.

PMID:
26924385
22.

A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors.

Bergeron-Brlek M, Goodwin-Tindall J, Cekic N, Roth C, Zandberg WF, Shan X, Varghese V, Chan S, Davies GJ, Vocadlo DJ, Britton R.

Angew Chem Int Ed Engl. 2015 Dec 14;54(51):15429-33. doi: 10.1002/anie.201507985. Epub 2015 Nov 6.

PMID:
26545827
23.

Structural Analysis of a Family 101 Glycoside Hydrolase in Complex with Carbohydrates Reveals Insights into Its Mechanism.

Gregg KJ, Suits MD, Deng L, Vocadlo DJ, Boraston AB.

J Biol Chem. 2015 Oct 16;290(42):25657-69. doi: 10.1074/jbc.M115.680470. Epub 2015 Aug 24.

24.

Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter.

Zhu Y, Liu TW, Madden Z, Yuzwa SA, Murray K, Cecioni S, Zachara N, Vocadlo DJ.

J Mol Cell Biol. 2016 Feb;8(1):2-16. doi: 10.1093/jmcb/mjv033. Epub 2015 Jun 1.

25.

O-GlcNAc occurs cotranslationally to stabilize nascent polypeptide chains.

Zhu Y, Liu TW, Cecioni S, Eskandari R, Zandberg WF, Vocadlo DJ.

Nat Chem Biol. 2015 May;11(5):319-25. doi: 10.1038/nchembio.1774. Epub 2015 Mar 16.

PMID:
25774941
26.

Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms.

Kolappan S, Shen DL, Mosi R, Sun J, McEachern EJ, Vocadlo DJ, Craig L.

Acta Crystallogr D Biol Crystallogr. 2015 Feb;71(Pt 2):185-95. doi: 10.1107/S1399004714024791. Epub 2015 Jan 23.

PMID:
25664730
27.

mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer.

Sodi VL, Khaku S, Krutilina R, Schwab LP, Vocadlo DJ, Seagroves TN, Reginato MJ.

Mol Cancer Res. 2015 May;13(5):923-33. doi: 10.1158/1541-7786.MCR-14-0536. Epub 2015 Jan 30.

28.

Fluorescence-quenched substrates for live cell imaging of human glucocerebrosidase activity.

Yadav AK, Shen DL, Shan X, He X, Kermode AR, Vocadlo DJ.

J Am Chem Soc. 2015 Jan 28;137(3):1181-9. doi: 10.1021/ja5106738. Epub 2015 Jan 15.

PMID:
25562638
29.

The β-lactamase gene regulator AmpR is a tetramer that recognizes and binds the D-Ala-D-Ala motif of its repressor UDP-N-acetylmuramic acid (MurNAc)-pentapeptide.

Vadlamani G, Thomas MD, Patel TR, Donald LJ, Reeve TM, Stetefeld J, Standing KG, Vocadlo DJ, Mark BL.

J Biol Chem. 2015 Jan 30;290(5):2630-43. doi: 10.1074/jbc.M114.618199. Epub 2014 Dec 5.

30.

A mechanism-based inactivator of glycoside hydrolases involving formation of a transient non-classical carbocation.

Chakladar S, Wang Y, Clark T, Cheng L, Ko S, Vocadlo DJ, Bennet AJ.

Nat Commun. 2014 Dec 5;5:5590. doi: 10.1038/ncomms6590.

PMID:
25475952
31.

Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice.

Yuzwa SA, Shan X, Jones BA, Zhao G, Woodward ML, Li X, Zhu Y, McEachern EJ, Silverman MA, Watson NV, Gong CX, Vocadlo DJ.

Mol Neurodegener. 2014 Oct 26;9:42. doi: 10.1186/1750-1326-9-42.

32.

The emerging link between O-GlcNAc and Alzheimer disease.

Zhu Y, Shan X, Yuzwa SA, Vocadlo DJ.

J Biol Chem. 2014 Dec 12;289(50):34472-81. doi: 10.1074/jbc.R114.601351. Epub 2014 Oct 21. Review.

33.

Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2.

Lira-Navarrete E, Iglesias-Fernández J, Zandberg WF, Compañón I, Kong Y, Corzana F, Pinto BM, Clausen H, Peregrina JM, Vocadlo DJ, Rovira C, Hurtado-Guerrero R.

Angew Chem Int Ed Engl. 2014 Jul 28;53(31):8206-10. doi: 10.1002/anie.201402781. Epub 2014 Jun 20.

PMID:
24954443
34.

O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway.

Ferrer CM, Lynch TP, Sodi VL, Falcone JN, Schwab LP, Peacock DL, Vocadlo DJ, Seagroves TN, Reginato MJ.

Mol Cell. 2014 Jun 5;54(5):820-31. doi: 10.1016/j.molcel.2014.04.026. Epub 2014 May 22.

35.

O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond.

Yuzwa SA, Vocadlo DJ.

Chem Soc Rev. 2014 Oct 7;43(19):6839-58. doi: 10.1039/c4cs00038b. Epub 2014 Apr 24. Review.

PMID:
24759912
36.
37.

O-GlcNAc modification of tau directly inhibits its aggregation without perturbing the conformational properties of tau monomers.

Yuzwa SA, Cheung AH, Okon M, McIntosh LP, Vocadlo DJ.

J Mol Biol. 2014 Apr 17;426(8):1736-52. doi: 10.1016/j.jmb.2014.01.004. Epub 2014 Jan 18.

PMID:
24444746
38.

Conformational itinerary of Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramic acid kinase during its catalytic cycle.

Bacik JP, Tavassoli M, Patel TR, McKenna SA, Vocadlo DJ, Khajehpour M, Mark BL.

J Biol Chem. 2014 Feb 14;289(7):4504-14. doi: 10.1074/jbc.M113.521633. Epub 2013 Dec 20.

39.

HCF-1 is cleaved in the active site of O-GlcNAc transferase.

Lazarus MB, Jiang J, Kapuria V, Bhuiyan T, Janetzko J, Zandberg WF, Vocadlo DJ, Herr W, Walker S.

Science. 2013 Dec 6;342(6163):1235-9. doi: 10.1126/science.1243990.

40.

Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams.

Mondon M, Hur S, Vadlamani G, Rodrigues P, Tsybina P, Oliver A, Mark BL, Vocadlo DJ, Blériot Y.

Chem Commun (Camb). 2013 Dec 4;49(93):10983-5. doi: 10.1039/c3cc46646a.

PMID:
24136176
41.

Inhibition of the family 20 glycoside hydrolase catalytic modules in the Streptococcus pneumoniae exo-β-D-N-acetylglucosaminidase, StrH.

Pluvinage B, Stubbs KA, Hattie M, Vocadlo DJ, Boraston AB.

Org Biomol Chem. 2013 Dec 7;11(45):7907-15. doi: 10.1039/c3ob41579a. Epub 2013 Oct 16.

PMID:
24132305
42.

The development of selective inhibitors of NagZ: increased susceptibility of Gram-negative bacteria to β-lactams.

Stubbs KA, Bacik JP, Perley-Robertson GE, Whitworth GE, Gloster TM, Vocadlo DJ, Mark BL.

Chembiochem. 2013 Oct 11;14(15):1973-81. doi: 10.1002/cbic.201300395. Epub 2013 Sep 5.

43.

Tools for probing and perturbing O-GlcNAc in cells and in vivo.

Cecioni S, Vocadlo DJ.

Curr Opin Chem Biol. 2013 Oct;17(5):719-28. doi: 10.1016/j.cbpa.2013.06.030. Epub 2013 Jul 30. Review.

PMID:
23906602
44.

Characterization and downstream mannose phosphorylation of human recombinant α-L-iduronidase produced in Arabidopsis complex glycan-deficient (cgl) seeds.

He X, Pierce O, Haselhorst T, von Itzstein M, Kolarich D, Packer NH, Gloster TM, Vocadlo DJ, Qian Y, Brooks D, Kermode AR.

Plant Biotechnol J. 2013 Dec;11(9):1034-43. doi: 10.1111/pbi.12096. Epub 2013 Jul 31.

45.

Synthesis of 4-methylumbelliferyl α-d-mannopyranosyl-(1→6)-β-d-mannopyranoside and development of a coupled fluorescent assay for GH125 exo-α-1,6-mannosidases.

Deng L, Tsybina P, Gregg KJ, Mosi R, Zandberg WF, Boraston AB, Vocadlo DJ.

Bioorg Med Chem. 2013 Aug 15;21(16):4839-45. doi: 10.1016/j.bmc.2013.05.062. Epub 2013 Jun 11.

PMID:
23816041
46.

Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells.

Ma Z, Vocadlo DJ, Vosseller K.

J Biol Chem. 2013 May 24;288(21):15121-30. doi: 10.1074/jbc.M113.470047. Epub 2013 Apr 16.

47.

Active site plasticity within the glycoside hydrolase NagZ underlies a dynamic mechanism of substrate distortion.

Bacik JP, Whitworth GE, Stubbs KA, Vocadlo DJ, Mark BL.

Chem Biol. 2012 Nov 21;19(11):1471-82. doi: 10.1016/j.chembiol.2012.09.016.

48.

How to make a difference: mechanisms of protein and nucleic acid modifying enzymes.

Vocadlo DJ, Withers SG.

Curr Opin Chem Biol. 2012 Dec;16(5-6):461-4. doi: 10.1016/j.cbpa.2012.10.033. Epub 2012 Nov 16. No abstract available.

PMID:
23168221
49.

O-GlcNAc processing enzymes: catalytic mechanisms, substrate specificity, and enzyme regulation.

Vocadlo DJ.

Curr Opin Chem Biol. 2012 Dec;16(5-6):488-97. doi: 10.1016/j.cbpa.2012.10.021. Epub 2012 Nov 10. Review.

PMID:
23146438
50.

Structural snapshots of the reaction coordinate for O-GlcNAc transferase.

Lazarus MB, Jiang J, Gloster TM, Zandberg WF, Whitworth GE, Vocadlo DJ, Walker S.

Nat Chem Biol. 2012 Dec;8(12):966-8. doi: 10.1038/nchembio.1109. Epub 2012 Oct 28.

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