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Corrigendum: Xenopus tropicalis: Joining the Armada in the Fight Against Blood Cancer.

Dimitrakopoulou D, Tulkens D, Van Vlierberghe P, Vleminckx K.

Front Physiol. 2019 Mar 14;10:210. doi: 10.3389/fphys.2019.00210. eCollection 2019.


Xenopus tropicalis: Joining the Armada in the Fight Against Blood Cancer.

Dimitrakopoulou D, Tulkens D, Van Vlierberghe P, Vleminckx K.

Front Physiol. 2019 Feb 1;10:48. doi: 10.3389/fphys.2019.00048. eCollection 2019. Erratum in: Front Physiol. 2019 Mar 14;10:210.


CRISPR/Cas9 disease models in zebrafish and Xenopus: The genetic renaissance of fish and frogs.

Naert T, Vleminckx K.

Drug Discov Today Technol. 2018 Aug;28:41-52. doi: 10.1016/j.ddtec.2018.07.001. Epub 2018 Jul 31. Review.


Cell Cycle Analysis of the Embryonic Brain of Fluorescent Reporter Xenopus tropicalis by Flow Cytometry.

Noelanders R, Vleminckx K.

Methods Mol Biol. 2018;1865:243-250. doi: 10.1007/978-1-4939-8784-9_17.


Cancer Models in Xenopus tropicalis by CRISPR/Cas9 Mediated Knockout of Tumor Suppressors.

Naert T, Vleminckx K.

Methods Mol Biol. 2018;1865:147-161. doi: 10.1007/978-1-4939-8784-9_11.


Genotyping of CRISPR/Cas9 Genome Edited Xenopus tropicalis.

Naert T, Vleminckx K.

Methods Mol Biol. 2018;1865:67-82. doi: 10.1007/978-1-4939-8784-9_5.


Targeted Genome Engineering in Xenopus Using the Transcription Activator-Like Effector Nuclease (TALEN) Technology.

Van Nieuwenhuysen T, Vleminckx K.

Methods Mol Biol. 2018;1865:55-65. doi: 10.1007/978-1-4939-8784-9_4.


Methods for CRISPR/Cas9 Xenopus tropicalis Tissue-Specific Multiplex Genome Engineering.

Naert T, Vleminckx K.

Methods Mol Biol. 2018;1865:33-54. doi: 10.1007/978-1-4939-8784-9_3.


Author Correction: RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6.

Szenker-Ravi E, Altunoglu U, Leushacke M, Bosso-Lefèvre C, Khatoo M, Thi Tran H, Naert T, Noelanders R, Hajamohideen A, Beneteau C, de Sousa SB, Karaman B, Latypova X, Başaran S, Yücel EB, Tan TT, Vlaminck L, Nayak SS, Shukla A, Girisha KM, Le Caignec C, Soshnikova N, Uyguner ZO, Vleminckx K, Barker N, Kayserili H, Reversade B.

Nature. 2018 Sep;561(7722):E7. doi: 10.1038/s41586-018-0296-7.


RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6.

Szenker-Ravi E, Altunoglu U, Leushacke M, Bosso-Lefèvre C, Khatoo M, Thi Tran H, Naert T, Noelanders R, Hajamohideen A, Beneteau C, de Sousa SB, Karaman B, Latypova X, Başaran S, Yücel EB, Tan TT, Vlaminck L, Nayak SS, Shukla A, Girisha KM, Le Caignec C, Soshnikova N, Uyguner ZO, Vleminckx K, Barker N, Kayserili H, Reversade B.

Nature. 2018 May;557(7706):564-569. doi: 10.1038/s41586-018-0118-y. Epub 2018 May 16. Erratum in: Nature. 2018 Sep;561(7722):E7.


An atlas of Wnt activity during embryogenesis in Xenopus tropicalis.

Borday C, Parain K, Thi Tran H, Vleminckx K, Perron M, Monsoro-Burq AH.

PLoS One. 2018 Apr 19;13(4):e0193606. doi: 10.1371/journal.pone.0193606. eCollection 2018.


CRISPR/Cas9-Mediated Knockout of Rb1 in Xenopus tropicalis.

Naert T, Vleminckx K.

Methods Mol Biol. 2018;1726:177-193. doi: 10.1007/978-1-4939-7565-5_16.


Caspase-9 has a nonapoptotic function in Xenopus embryonic primitive blood formation.

Tran HT, Fransen M, Dimitrakopoulou D, Van Imschoot G, Willemarck N, Vleminckx K.

J Cell Sci. 2017 Jul 15;130(14):2371-2381. doi: 10.1242/jcs.186411. Epub 2017 Jun 2.


TALENs and CRISPR/Cas9 fuel genetically engineered clinically relevant Xenopus tropicalis tumor models.

Naert T, Van Nieuwenhuysen T, Vleminckx K.

Genesis. 2017 Jan;55(1-2). doi: 10.1002/dvg.23005. Review.


CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis.

Naert T, Colpaert R, Van Nieuwenhuysen T, Dimitrakopoulou D, Leoen J, Haustraete J, Boel A, Steyaert W, Lepez T, Deforce D, Willaert A, Creytens D, Vleminckx K.

Sci Rep. 2016 Oct 14;6:35264. doi: 10.1038/srep35264.


How Wnt Signaling Builds the Brain: Bridging Development and Disease.

Noelanders R, Vleminckx K.

Neuroscientist. 2017 Jun;23(3):314-329. doi: 10.1177/1073858416667270. Epub 2016 Sep 13. Review.


Genetic Defects in TAPT1 Disrupt Ciliogenesis and Cause a Complex Lethal Osteochondrodysplasia.

Symoens S, Barnes AM, Gistelinck C, Malfait F, Guillemyn B, Steyaert W, Syx D, D'hondt S, Biervliet M, De Backer J, Witten EP, Leikin S, Makareeva E, Gillessen-Kaesbach G, Huysseune A, Vleminckx K, Willaert A, De Paepe A, Marini JC, Coucke PJ.

Am J Hum Genet. 2015 Oct 1;97(4):521-34. doi: 10.1016/j.ajhg.2015.08.009. Epub 2015 Sep 10.


Hearing loss in Waardenburg syndrome: a systematic review.

Song J, Feng Y, Acke FR, Coucke P, Vleminckx K, Dhooge IJ.

Clin Genet. 2016 Apr;89(4):416-425. doi: 10.1111/cge.12631. Epub 2015 Jul 17. Review.


TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis.

Van Nieuwenhuysen T, Naert T, Tran HT, Van Imschoot G, Geurs S, Sanders E, Creytens D, Van Roy F, Vleminckx K.

Oncoscience. 2015 May 19;2(5):555-66. eCollection 2015.


Fezf2 promotes neuronal differentiation through localised activation of Wnt/β-catenin signalling during forebrain development.

Zhang S, Li J, Lea R, Vleminckx K, Amaya E.

Development. 2014 Dec;141(24):4794-805. doi: 10.1242/dev.115691.


A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes.

De Groote P, Tran HT, Fransen M, Tanghe G, Urwyler C, De Craene B, Leurs K, Gilbert B, Van Imschoot G, De Rycke R, Guérin CJ, Holland P, Berx G, Vandenabeele P, Lippens S, Vleminckx K, Declercq W.

Cell Death Differ. 2015 Jun;22(6):1012-24. doi: 10.1038/cdd.2014.191. Epub 2014 Nov 28.


A Molecular atlas of Xenopus respiratory system development.

Rankin SA, Thi Tran H, Wlizla M, Mancini P, Shifley ET, Bloor SD, Han L, Vleminckx K, Wert SE, Zorn AM.

Dev Dyn. 2015 Jan;244(1):69-85. doi: 10.1002/dvdy.24180. Epub 2014 Sep 11.


Design and use of transgenic reporter strains for detecting activity of signaling pathways in Xenopus.

Tran HT, Vleminckx K.

Methods. 2014 Apr 1;66(3):422-32. doi: 10.1016/j.ymeth.2013.06.028. Epub 2013 Jun 29.


The Wnt signaling mediator tcf1 is required for expression of foxd3 during Xenopus gastrulation.

Janssens S, Van Den Broek O, Davenport IR, Akkers RC, Liu F, Veenstra GJ, Hoppler S, Vleminckx K, Destrée O.

Int J Dev Biol. 2013;57(1):49-54. doi: 10.1387/ijdb.120191kv.


Hes4 controls proliferative properties of neural stem cells during retinal ontogenesis.

El Yakoubi W, Borday C, Hamdache J, Parain K, Tran HT, Vleminckx K, Perron M, Locker M.

Stem Cells. 2012 Dec;30(12):2784-95. doi: 10.1002/stem.1231.


Antagonistic cross-regulation between Wnt and Hedgehog signalling pathways controls post-embryonic retinal proliferation.

Borday C, Cabochette P, Parain K, Mazurier N, Janssens S, Tran HT, Sekkali B, Bronchain O, Vleminckx K, Locker M, Perron M.

Development. 2012 Oct;139(19):3499-509. doi: 10.1242/dev.079582. Epub 2012 Aug 16.


Plakophilin-3 is required for late embryonic amphibian development, exhibiting roles in ectodermal and neural tissues.

Munoz WA, Kloc M, Cho K, Lee M, Hofmann I, Sater A, Vleminckx K, McCrea PD.

PLoS One. 2012;7(4):e34342. doi: 10.1371/journal.pone.0034342. Epub 2012 Apr 5.


ARVCF depletion cooperates with Tbx1 deficiency in the development of 22q11.2DS-like phenotypes in Xenopus.

Tran HT, Delvaeye M, Verschuere V, Descamps E, Crabbe E, Van Hoorebeke L, McCrea P, Adriaens D, Van Roy F, Vleminckx K.

Dev Dyn. 2011 Dec;240(12):2680-7. doi: 10.1002/dvdy.22765. Epub 2011 Oct 25.


Transcription factor Zic2 inhibits Wnt/β-catenin protein signaling.

Pourebrahim R, Houtmeyers R, Ghogomu S, Janssens S, Thelie A, Tran HT, Langenberg T, Vleminckx K, Bellefroid E, Cassiman JJ, Tejpar S.

J Biol Chem. 2011 Oct 28;286(43):37732-40. doi: 10.1074/jbc.M111.242826. Epub 2011 Sep 9.


You'd better catch that Wnt: primitive hematopoiesis requires canonical Wnt signaling.

Tran HT, Vleminckx K.

Cell Cycle. 2011 Feb 1;10(3):366-7. Epub 2011 Feb 1. No abstract available.


Direct control of Hoxd1 and Irx3 expression by Wnt/beta-catenin signaling during anteroposterior patterning of the neural axis in Xenopus.

Janssens S, Denayer T, Deroo T, Van Roy F, Vleminckx K.

Int J Dev Biol. 2010;54(10):1435-42. doi: 10.1387/ijdb.092985sj.


Aberrant activation of fatty acid synthesis suppresses primary cilium formation and distorts tissue development.

Willemarck N, Rysman E, Brusselmans K, Van Imschoot G, Vanderhoydonc F, Moerloose K, Lerut E, Verhoeven G, van Roy F, Vleminckx K, Swinnen JV.

Cancer Res. 2010 Nov 15;70(22):9453-62. doi: 10.1158/0008-5472.CAN-10-2324. Epub 2010 Oct 1.


The chronic toxicity of molybdate to freshwater organisms. I. Generating reliable effects data.

De Schamphelaere KA, Stubblefield W, Rodriguez P, Vleminckx K, Janssen CR.

Sci Total Environ. 2010 Oct 15;408(22):5362-71. doi: 10.1016/j.scitotenv.2010.07.041. Epub 2010 Sep 1.


Wnt/beta-catenin signaling is involved in the induction and maintenance of primitive hematopoiesis in the vertebrate embryo.

Tran HT, Sekkali B, Van Imschoot G, Janssens S, Vleminckx K.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16160-5. doi: 10.1073/pnas.1007725107. Epub 2010 Aug 30.


Chemical inhibition of a subset of Arabidopsis thaliana GSK3-like kinases activates brassinosteroid signaling.

De Rybel B, Audenaert D, Vert G, Rozhon W, Mayerhofer J, Peelman F, Coutuer S, Denayer T, Jansen L, Nguyen L, Vanhoutte I, Beemster GT, Vleminckx K, Jonak C, Chory J, Inzé D, Russinova E, Beeckman T.

Chem Biol. 2009 Jun 26;16(6):594-604. doi: 10.1016/j.chembiol.2009.04.008.


Transgenic reporter tools tracing endogenous canonical Wnt signaling in Xenopus.

Denayer T, Tran HT, Vleminckx K.

Methods Mol Biol. 2008;469:381-400. doi: 10.1007/978-1-60327-469-2_24.


Requirement of Wnt/beta-catenin signaling in pronephric kidney development.

Lyons JP, Miller RK, Zhou X, Weidinger G, Deroo T, Denayer T, Park JI, Ji H, Hong JY, Li A, Moon RT, Jones EA, Vleminckx K, Vize PD, McCrea PD.

Mech Dev. 2009 Mar-Apr;126(3-4):142-59. doi: 10.1016/j.mod.2008.11.007. Epub 2008 Dec 7.


Canonical Wnt signaling controls proliferation of retinal stem/progenitor cells in postembryonic Xenopus eyes.

Denayer T, Locker M, Borday C, Deroo T, Janssens S, Hecht A, van Roy F, Perron M, Vleminckx K.

Stem Cells. 2008 Aug;26(8):2063-74. doi: 10.1634/stemcells.2007-0900. Epub 2008 Jun 12.


Chicken beta-globin insulator overcomes variegation of transgenes in Xenopus embryos.

Sekkali B, Tran HT, Crabbe E, De Beule C, Van Roy F, Vleminckx K.

FASEB J. 2008 Jul;22(7):2534-40. doi: 10.1096/fj.07-098111. Epub 2008 Mar 21.


Mycobacterium liflandii infection in European colony of Silurana tropicalis.

Suykerbuyk P, Vleminckx K, Pasmans F, Stragier P, Ablordey A, Tran HT, Hermans K, Fleetwood M, Meyers WM, Portaels F.

Emerg Infect Dis. 2007 May;13(5):743-6.


A new generation of JASPAR, the open-access repository for transcription factor binding site profiles.

Vlieghe D, Sandelin A, De Bleser PJ, Vleminckx K, Wasserman WW, van Roy F, Lenhard B.

Nucleic Acids Res. 2006 Jan 1;34(Database issue):D95-7.


In vivo tracing of canonical Wnt signaling in Xenopus tadpoles by means of an inducible transgenic reporter tool.

Denayer T, Van Roy F, Vleminckx K.

FEBS Lett. 2006 Jan 23;580(2):393-8. Epub 2005 Dec 19.


A genetic Xenopus laevis tadpole model to study lymphangiogenesis.

Ny A, Koch M, Schneider M, Neven E, Tong RT, Maity S, Fischer C, Plaisance S, Lambrechts D, Héligon C, Terclavers S, Ciesiolka M, Kälin R, Man WY, Senn I, Wyns S, Lupu F, Brändli A, Vleminckx K, Collen D, Dewerchin M, Conway EM, Moons L, Jain RK, Carmeliet P.

Nat Med. 2005 Sep;11(9):998-1004. Epub 2005 Aug 14.


Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets.

Park JI, Kim SW, Lyons JP, Ji H, Nguyen TT, Cho K, Barton MC, Deroo T, Vleminckx K, Moon RT, McCrea PD.

Dev Cell. 2005 Jun;8(6):843-54. Erratum in: Dev Cell. 2005 Aug;9(2):305. Moon, Randall T [added].


Global inhibition of Lef1/Tcf-dependent Wnt signaling at its nuclear end point abrogates development in transgenic Xenopus embryos.

Deroo T, Denayer T, Van Roy F, Vleminckx K.

J Biol Chem. 2004 Dec 3;279(49):50670-5. Epub 2004 Sep 14.


p120 catenin is required for morphogenetic movements involved in the formation of the eyes and the craniofacial skeleton in Xenopus.

Ciesiolka M, Delvaeye M, Van Imschoot G, Verschuere V, McCrea P, van Roy F, Vleminckx K.

J Cell Sci. 2004 Aug 15;117(Pt 18):4325-39. Epub 2004 Aug 3.


Evolution of neural precursor selection: functional divergence of proneural proteins.

Quan XJ, Denayer T, Yan J, Jafar-Nejad H, Philippi A, Lichtarge O, Vleminckx K, Hassan BA.

Development. 2004 Apr;131(8):1679-89. Epub 2004 Mar 17.


The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates.

Hecht A, Vleminckx K, Stemmler MP, van Roy F, Kemler R.

EMBO J. 2000 Apr 17;19(8):1839-50.


Cadherins and tissue formation: integrating adhesion and signaling.

Vleminckx K, Kemler R.

Bioessays. 1999 Mar;21(3):211-20. Review.


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