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Excessive Oxidative Stress Contributes to Increased Acute ER Stress Kidney Injury in Aged Mice.

Liu X, Zhang R, Huang L, Zheng Z, Vlassara H, Striker G, Zhang X, Guan Y, Zheng F.

Oxid Med Cell Longev. 2019 Jan 28;2019:2746521. doi: 10.1155/2019/2746521. eCollection 2019.


Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice.

Grosjean F, Yubero-Serrano EM, Zheng F, Esposito V, Swamy S, Elliot SJ, Cai W, Vlassara H, Salem F, Striker GE.

PLoS One. 2018 Sep 25;13(9):e0204366. doi: 10.1371/journal.pone.0204366. eCollection 2018.


Oral AGE restriction ameliorates insulin resistance in obese individuals with the metabolic syndrome: a randomised controlled trial.

Vlassara H, Cai W, Tripp E, Pyzik R, Yee K, Goldberg L, Tansman L, Chen X, Mani V, Fayad ZA, Nadkarni GN, Striker GE, He JC, Uribarri J.

Diabetologia. 2016 Oct;59(10):2181-92. doi: 10.1007/s00125-016-4053-x. Epub 2016 Jul 29.


Uremic Toxicity of Advanced Glycation End Products in CKD.

Stinghen AE, Massy ZA, Vlassara H, Striker GE, Boullier A.

J Am Soc Nephrol. 2016 Feb;27(2):354-70. doi: 10.1681/ASN.2014101047. Epub 2015 Aug 26. Review.


Diabetes Mellitus 2014.

Migdalis I, Leslie D, Mavrogiannaki A, Papanas N, Valensi P, Vlassara H.

Int J Endocrinol. 2015;2015:845759. doi: 10.1155/2015/845759. Epub 2015 May 25. No abstract available.


Effects of sevelamer carbonate on advanced glycation end products and antioxidant/pro-oxidant status in patients with diabetic kidney disease.

Yubero-Serrano EM, Woodward M, Poretsky L, Vlassara H, Striker GE; AGE-less Study Group.

Clin J Am Soc Nephrol. 2015 May 7;10(5):759-66. doi: 10.2215/CJN.07750814. Epub 2015 Feb 20.


Elevated serum advanced glycation endproducts in obese indicate risk for the metabolic syndrome: a link between healthy and unhealthy obesity?

Uribarri J, Cai W, Woodward M, Tripp E, Goldberg L, Pyzik R, Yee K, Tansman L, Chen X, Mani V, Fayad ZA, Vlassara H.

J Clin Endocrinol Metab. 2015 May;100(5):1957-66. doi: 10.1210/jc.2014-3925. Epub 2015 Feb 19.


Chronic ingestion of advanced glycation end products induces degenerative spinal changes and hypertrophy in aging pre-diabetic mice.

Illien-Jünger S, Lu Y, Qureshi SA, Hecht AC, Cai W, Vlassara H, Striker GE, Iatridis JC.

PLoS One. 2015 Feb 10;10(2):e0116625. doi: 10.1371/journal.pone.0116625. eCollection 2015.


Dietary consumption of advanced glycation end products and pancreatic cancer in the prospective NIH-AARP Diet and Health Study.

Jiao L, Stolzenberg-Solomon R, Zimmerman TP, Duan Z, Chen L, Kahle L, Risch A, Subar AF, Cross AJ, Hollenbeck A, Vlassara H, Striker G, Sinha R.

Am J Clin Nutr. 2015 Jan;101(1):126-34. doi: 10.3945/ajcn.114.098061. Epub 2014 Nov 19.


Dietary advanced glycation end products are associated with decline in memory in young elderly.

West RK, Moshier E, Lubitz I, Schmeidler J, Godbold J, Cai W, Uribarri J, Vlassara H, Silverman JM, Beeri MS.

Mech Ageing Dev. 2014 Sep;140:10-2. doi: 10.1016/j.mad.2014.07.001. Epub 2014 Jul 15.


Diabetes mellitus.

Migdalis I, Leslie D, Papanas N, Valensi P, Vlassara H.

Int J Endocrinol. 2014;2014:108419. doi: 10.1155/2014/108419. Epub 2014 Jan 23. No abstract available.


Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans.

Cai W, Uribarri J, Zhu L, Chen X, Swamy S, Zhao Z, Grosjean F, Simonaro C, Kuchel GA, Schnaider-Beeri M, Woodward M, Striker GE, Vlassara H.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4940-5. doi: 10.1073/pnas.1316013111. Epub 2014 Feb 24.


Advanced glycation end products (AGE) and diabetes: cause, effect, or both?

Vlassara H, Uribarri J.

Curr Diab Rep. 2014 Jan;14(1):453. doi: 10.1007/s11892-013-0453-1. Review.


Advanced glycation endproducts in diabetes and diabetic complications.

Vlassara H, Striker GE.

Endocrinol Metab Clin North Am. 2013 Dec;42(4):697-719. doi: 10.1016/j.ecl.2013.07.005. Review.


Combined anti-inflammatory and anti-AGE drug treatments have a protective effect on intervertebral discs in mice with diabetes.

Illien-Junger S, Grosjean F, Laudier DM, Vlassara H, Striker GE, Iatridis JC.

PLoS One. 2013 May 17;8(5):e64302. doi: 10.1371/journal.pone.0064302. Print 2013. Erratum in: PLoS One. 2015;10(3):e0119112.


Suppression of native defense mechanisms, SIRT1 and PPARγ, by dietary glycoxidants precedes disease in adult humans; relevance to lifestyle-engendered chronic diseases.

Uribarri J, Cai W, Pyzik R, Goodman S, Chen X, Zhu L, Ramdas M, Striker GE, Vlassara H.

Amino Acids. 2014 Feb;46(2):301-9. doi: 10.1007/s00726-013-1502-4. Epub 2013 May 1.


Increased circulating advanced glycation endproducts (AGEs) in acute trauma patients.

Schulman CI, Uribarri J, Cai W, Manning R, Landy DC, Gallardo M, Castillo A, Namias N, Striker GE, Livingstone A, Vlassara H.

Clin Chem Lab Med. 2014 Jan 1;52(1):103-8. doi: 10.1515/cclm-2012-0834.


Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses.

Schuchman EH, Ge Y, Lai A, Borisov Y, Faillace M, Eliyahu E, He X, Iatridis J, Vlassara H, Striker G, Simonaro CM.

PLoS One. 2013;8(1):e54459. doi: 10.1371/journal.pone.0054459. Epub 2013 Jan 24.


Managing chronic inflammation in the aging diabetic patient with CKD by diet or sevelamer carbonate: a modern paradigm shift.

Vlassara H, Cai W, Chen X, Serrano EJ, Shobha MS, Uribarri J, Woodward M, Striker GE.

J Gerontol A Biol Sci Med Sci. 2012 Dec;67(12):1410-6. doi: 10.1093/gerona/gls195. Epub 2012 Oct 29. Review.


Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1.

Cai W, Ramdas M, Zhu L, Chen X, Striker GE, Vlassara H.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15888-93. Epub 2012 Aug 20.


Effect of dietary advanced glycation end products on mouse liver.

Patel R, Baker SS, Liu W, Desai S, Alkhouri R, Kozielski R, Mastrandrea L, Sarfraz A, Cai W, Vlassara H, Patel MS, Baker RD, Zhu L.

PLoS One. 2012;7(4):e35143. doi: 10.1371/journal.pone.0035143. Epub 2012 Apr 4.


Effects of sevelamer on HbA1c, inflammation, and advanced glycation end products in diabetic kidney disease.

Vlassara H, Uribarri J, Cai W, Goodman S, Pyzik R, Post J, Grosjean F, Woodward M, Striker GE.

Clin J Am Soc Nephrol. 2012 Jun;7(6):934-42. doi: 10.2215/CJN.12891211. Epub 2012 Mar 29.


Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individuals.

Beeri MS, Moshier E, Schmeidler J, Godbold J, Uribarri J, Reddy S, Sano M, Grossman HT, Cai W, Vlassara H, Silverman JM.

Mech Ageing Dev. 2011 Nov-Dec;132(11-12):583-7. doi: 10.1016/j.mad.2011.10.007. Epub 2011 Nov 3.


Pentosan polysulfate inhibits atherosclerosis in Watanabe heritable hyperlipidemic rabbits: differential modulation of metalloproteinase-2 and -9.

Lupia E, Zheng F, Grosjean F, Tack I, Doublier S, Elliot SJ, Vlassara H, Striker GE.

Lab Invest. 2012 Feb;92(2):236-45. doi: 10.1038/labinvest.2011.154. Epub 2011 Oct 31.


Phosphate and CVD: it's all in what's on the table.

Striker GE, Grosjean F, Vlassara H.

Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):1951-2. doi: 10.1161/ATVBAHA.111.231928. No abstract available.


Inhibition of inflammation by pentosan polysulfate impedes the development and progression of severe diabetic nephropathy in aging C57B6 mice.

Wu J, Guan TJ, Zheng S, Grosjean F, Liu W, Xiong H, Gordon R, Vlassara H, Striker GE, Zheng F.

Lab Invest. 2011 Oct;91(10):1459-71. doi: 10.1038/labinvest.2011.93. Epub 2011 Aug 1.


Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1.

Uribarri J, Cai W, Ramdas M, Goodman S, Pyzik R, Chen X, Zhu L, Striker GE, Vlassara H.

Diabetes Care. 2011 Jul;34(7):1610-6. doi: 10.2337/dc11-0091.


AGE restriction in diabetes mellitus: a paradigm shift.

Vlassara H, Striker GE.

Nat Rev Endocrinol. 2011 May 24;7(9):526-39. doi: 10.1038/nrendo.2011.74. Review.


Maternally transmitted and food-derived glycotoxins: a factor preconditioning the young to diabetes?

Mericq V, Piccardo C, Cai W, Chen X, Zhu L, Striker GE, Vlassara H, Uribarri J.

Diabetes Care. 2010 Oct;33(10):2232-7. doi: 10.2337/dc10-1058. Epub 2010 Jul 13.


Advanced glycation end products in foods and a practical guide to their reduction in the diet.

Uribarri J, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R, Yong A, Striker GE, Vlassara H.

J Am Diet Assoc. 2010 Jun;110(6):911-16.e12. doi: 10.1016/j.jada.2010.03.018.


Induction of diabetes in aged C57B6 mice results in severe nephropathy: an association with oxidative stress, endoplasmic reticulum stress, and inflammation.

Wu J, Zhang R, Torreggiani M, Ting A, Xiong H, Striker GE, Vlassara H, Zheng F.

Am J Pathol. 2010 May;176(5):2163-76. doi: 10.2353/ajpath.2010.090386. Epub 2010 Apr 2.


Identifying advanced glycation end products as a major source of oxidants in aging: implications for the management and/or prevention of reduced renal function in elderly persons.

Vlassara H, Uribarri J, Ferrucci L, Cai W, Torreggiani M, Post JB, Zheng F, Striker GE.

Semin Nephrol. 2009 Nov;29(6):594-603. doi: 10.1016/j.semnephrol.2009.07.013.


Aging and the kidney: introduction.

Striker GE, Vlassara H, Ferrucci L.

Semin Nephrol. 2009 Nov;29(6):549-50. doi: 10.1016/j.semnephrol.2009.07.014. No abstract available.


AGER1 regulates endothelial cell NADPH oxidase-dependent oxidant stress via PKC-delta: implications for vascular disease.

Cai W, Torreggiani M, Zhu L, Chen X, He JC, Striker GE, Vlassara H.

Am J Physiol Cell Physiol. 2010 Mar;298(3):C624-34. doi: 10.1152/ajpcell.00463.2009. Epub 2009 Dec 2.


Role of oxidants/inflammation in declining renal function in chronic kidney disease and normal aging.

Vlassara H, Torreggiani M, Post JB, Zheng F, Uribarri J, Striker GE.

Kidney Int Suppl. 2009 Dec;(114):S3-11. doi: 10.1038/ki.2009.401. Review.


Protection against loss of innate defenses in adulthood by low advanced glycation end products (AGE) intake: role of the antiinflammatory AGE receptor-1.

Vlassara H, Cai W, Goodman S, Pyzik R, Yong A, Chen X, Zhu L, Neade T, Beeri M, Silverman JM, Ferrucci L, Tansman L, Striker GE, Uribarri J.

J Clin Endocrinol Metab. 2009 Nov;94(11):4483-91. doi: 10.1210/jc.2009-0089. Epub 2009 Oct 9.


Advanced glycation end product receptor-1 transgenic mice are resistant to inflammation, oxidative stress, and post-injury intimal hyperplasia.

Torreggiani M, Liu H, Wu J, Zheng F, Cai W, Striker G, Vlassara H.

Am J Pathol. 2009 Oct;175(4):1722-32. doi: 10.2353/ajpath.2009.090138. Epub 2009 Sep 24.


Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells.

Wu J, Mei C, Vlassara H, Striker GE, Zheng F.

Am J Physiol Renal Physiol. 2009 Dec;297(6):F1622-31. doi: 10.1152/ajprenal.00078.2009. Epub 2009 Sep 23.


Advanced glycation end products strongly activate platelets.

Gawlowski T, Stratmann B, Ruetter R, Buenting CE, Menart B, Weiss J, Vlassara H, Koschinsky T, Tschoepe D.

Eur J Nutr. 2009 Dec;48(8):475-81. doi: 10.1007/s00394-009-0038-6. Epub 2009 Jul 26.


Advanced glycation end products inhibit glucose-stimulated insulin secretion through nitric oxide-dependent inhibition of cytochrome c oxidase and adenosine triphosphate synthesis.

Zhao Z, Zhao C, Zhang XH, Zheng F, Cai W, Vlassara H, Ma ZA.

Endocrinology. 2009 Jun;150(6):2569-76. doi: 10.1210/en.2008-1342. Epub 2009 Feb 26.


Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation.

Catera R, Silverman GJ, Hatzi K, Seiler T, Didier S, Zhang L, Hervé M, Meffre E, Oscier DG, Vlassara H, Scofield RH, Chen Y, Allen SL, Kolitz J, Rai KR, Chu CC, Chiorazzi N.

Mol Med. 2008 Nov-Dec;14(11-12):665-74. doi: 10.2119/2008-00102.Catera. Epub 2008 Sep 25.


Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan.

Cai W, He JC, Zhu L, Chen X, Zheng F, Striker GE, Vlassara H.

Am J Pathol. 2008 Aug;173(2):327-36. doi: 10.2353/ajpath.2008.080152. Epub 2008 Jul 3.


Aging and glycoxidant stress.

Peppa M, Uribarri J, Vlassara H.

Hormones (Athens). 2008 Apr-Jun;7(2):123-32. Review.


Dietary advanced glycation endproducts and oxidative stress: in vivo effects on endothelial function and adipokines.

Stirban A, Negrean M, Götting C, Uribarri J, Gawlowski T, Stratmann B, Kleesiek K, Koschinsky T, Vlassara H, Tschoepe D.

Ann N Y Acad Sci. 2008 Apr;1126:276-9. doi: 10.1196/annals.1433.042.


Advanced glycation end product homeostasis: exogenous oxidants and innate defenses.

Vlassara H, Uribarri J, Cai W, Striker G.

Ann N Y Acad Sci. 2008 Apr;1126:46-52. doi: 10.1196/annals.1433.055.


Endothelial dysfunction in patients with chronic kidney disease results from advanced glycation end products (AGE)-mediated inhibition of endothelial nitric oxide synthase through RAGE activation.

Linden E, Cai W, He JC, Xue C, Li Z, Winston J, Vlassara H, Uribarri J.

Clin J Am Soc Nephrol. 2008 May;3(3):691-8. doi: 10.2215/CJN.04291007. Epub 2008 Feb 6.


AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation.

Cai W, He JC, Zhu L, Chen X, Striker GE, Vlassara H.

Am J Physiol Cell Physiol. 2008 Jan;294(1):C145-52. Epub 2007 Nov 21.


Glycotoxins in the diet promote diabetes and diabetic complications.

Vlassara H, Striker G.

Curr Diab Rep. 2007 Jun;7(3):235-41. Review.


Reduced oxidant stress and extended lifespan in mice exposed to a low glycotoxin diet: association with increased AGER1 expression.

Cai W, He JC, Zhu L, Chen X, Wallenstein S, Striker GE, Vlassara H.

Am J Pathol. 2007 Jun;170(6):1893-902.


Single oral challenge by advanced glycation end products acutely impairs endothelial function in diabetic and nondiabetic subjects.

Uribarri J, Stirban A, Sander D, Cai W, Negrean M, Buenting CE, Koschinsky T, Vlassara H.

Diabetes Care. 2007 Oct;30(10):2579-82. Epub 2007 May 11.


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