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Lipids in COPD: A Target for Future Therapy?

Vlahos R.

Am J Respir Cell Mol Biol. 2019 Oct 2. doi: 10.1165/rcmb.2019-0338ED. [Epub ahead of print] No abstract available.


Cigarette Smoking Exacerbates Skeletal Muscle Injury Without Compromising its Regenerative Capacity.

Chan SM, Cerni C, Passey S, Seow HJ, Bernardo I, van der Poel C, Dobric A, Brassington K, Selemidis S, Bozinovski S, Vlahos R.

Am J Respir Cell Mol Biol. 2019 Aug 28. doi: 10.1165/rcmb.2019-0106OC. [Epub ahead of print]


Mitochondrial Reactive Oxygen Species Contribute to Pathological Inflammation During Influenza A Virus Infection in Mice.

To EE, Erlich JR, Liong F, Luong R, Liong S, Esaq F, Oseghale O, Anthony D, McQualter J, Bozinovski S, Vlahos R, O'Leary JJ, Brooks DA, Selemidis S.

Antioxid Redox Signal. 2019 Jul 12. doi: 10.1089/ars.2019.7727. [Epub ahead of print]


Excessive Reactive Oxygen Species Inhibit IL-17A+ γδ T Cells and Innate Cellular Responses to Bacterial Lung Infection.

Anthony D, Papanicolaou A, Wang H, Seow HJ, To EE, Yatmaz S, Anderson GP, Wijburg O, Selemidis S, Vlahos R, Bozinovski S.

Antioxid Redox Signal. 2019 Jul 17. doi: 10.1089/ars.2018.7716. [Epub ahead of print]


New frontiers in the treatment of comorbid cardiovascular disease in chronic obstructive pulmonary disease.

Brassington K, Selemidis S, Bozinovski S, Vlahos R.

Clin Sci (Lond). 2019 Apr 12;133(7):885-904. doi: 10.1042/CS20180316. Print 2019 Apr 15. Review.


Prior cigarette smoke exposure does not affect acute post-stroke outcomes in mice.

Austin V, Miller A, Vlahos R.

PLoS One. 2019 Mar 21;14(3):e0214246. doi: 10.1371/journal.pone.0214246. eCollection 2019.


Novel endosomal NOX2 oxidase inhibitor ameliorates pandemic influenza A virus-induced lung inflammation in mice.

To EE, Luong R, Diao J, O' Leary JJ, Brooks DA, Vlahos R, Selemidis S.

Respirology. 2019 Oct;24(10):1011-1017. doi: 10.1111/resp.13524. Epub 2019 Mar 18.


Ischaemic stroke in mice induces lung inflammation but not acute lung injury.

Austin V, Ku JM, Miller AA, Vlahos R.

Sci Rep. 2019 Mar 6;9(1):3622. doi: 10.1038/s41598-019-40392-1.


Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies.

Chan SMH, Selemidis S, Bozinovski S, Vlahos R.

Pharmacol Ther. 2019 Jun;198:160-188. doi: 10.1016/j.pharmthera.2019.02.013. Epub 2019 Feb 26.


Intranasal and epicutaneous administration of Toll-like receptor 7 (TLR7) agonists provides protection against influenza A virus-induced morbidity in mice.

To EE, Erlich J, Liong F, Luong R, Liong S, Bozinovski S, Seow HJ, O'Leary JJ, Brooks DA, Vlahos R, Selemidis S.

Sci Rep. 2019 Feb 20;9(1):2366. doi: 10.1038/s41598-019-38864-5.


Matrine reduces cigarette smoke-induced airway neutrophilic inflammation by enhancing neutrophil apoptosis.

Yu X, Seow HJ, Wang H, Anthony D, Bozinovski S, Lin L, Ye JM, Vlahos R.

Clin Sci (Lond). 2019 Feb 18;133(4):551-564. doi: 10.1042/CS20180912. Print 2019 Feb 28.


Resolving Viral-Induced Secondary Bacterial Infection in COPD: A Concise Review.

Wang H, Anthony D, Selemidis S, Vlahos R, Bozinovski S.

Front Immunol. 2018 Oct 16;9:2345. doi: 10.3389/fimmu.2018.02345. eCollection 2018. Review.


Clinical utility of pulmonary function and blood biomarker measurements.

Vlahos R.

Respirology. 2019 Jan;24(1):13-14. doi: 10.1111/resp.13430. Epub 2018 Oct 19. No abstract available.


CSF3R/CD114 mediates infection-dependent transition to severe asthma.

Wang H, FitzPatrick M, Wilson NJ, Anthony D, Reading PC, Satzke C, Dunne EM, Licciardi PV, Seow HJ, Nichol K, Adcock IM, Chung KF, Anderson GP, Vlahos R, Wark P, Bozinovski S.

J Allergy Clin Immunol. 2019 Feb;143(2):785-788.e6. doi: 10.1016/j.jaci.2018.10.001. Epub 2018 Oct 9. No abstract available.


Modelling COPD co-morbidities in preclinical models.

Vlahos R, Bozinovski S.

Respirology. 2018 Dec;23(12):1094-1095. doi: 10.1111/resp.13416. Epub 2018 Oct 4. Review. No abstract available.


BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non-Small Cell Lung Cancer.

Adeegbe DO, Liu S, Hattersley MM, Bowden M, Zhou CW, Li S, Vlahos R, Grondine M, Dolgalev I, Ivanova EV, Quinn MM, Gao P, Hammerman PS, Bradner JE, Diehl JA, Rustgi AK, Bass AJ, Tsirigos A, Freeman GJ, Chen H, Wong KK.

Cancer Immunol Res. 2018 Oct;6(10):1234-1245. doi: 10.1158/2326-6066.CIR-18-0077. Epub 2018 Aug 7.


Repurposing matrine for the treatment of hepatosteatosis and associated disorders in glucose homeostasis in mice.

Mahzari A, Zeng XY, Zhou X, Li S, Xu J, Tan W, Vlahos R, Robinson S, Ye JM.

Acta Pharmacol Sin. 2018 Nov;39(11):1753-1759. doi: 10.1038/s41401-018-0016-8. Epub 2018 Jul 6.


Increased hypothalamic microglial activation after viral-induced pneumococcal lung infection is associated with excess serum amyloid A production.

Wang H, Blackall M, Sominsky L, Spencer SJ, Vlahos R, Churchill M, Bozinovski S.

J Neuroinflammation. 2018 Jul 6;15(1):200. doi: 10.1186/s12974-018-1234-1.


E-Cigarettes: Inducing Inflammation that Spans Generations.

Vlahos R.

Am J Respir Cell Mol Biol. 2018 Mar;58(3):286-287. doi: 10.1165/rcmb.2017-0306ED. No abstract available.


Protocols to Evaluate Cigarette Smoke-Induced Lung Inflammation and Pathology in Mice.

Vlahos R, Bozinovski S.

Methods Mol Biol. 2018;1725:53-63. doi: 10.1007/978-1-4939-7568-6_5.


Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

Jenkins RW, Aref AR, Lizotte PH, Ivanova E, Stinson S, Zhou CW, Bowden M, Deng J, Liu H, Miao D, He MX, Walker W, Zhang G, Tian T, Cheng C, Wei Z, Palakurthi S, Bittinger M, Vitzthum H, Kim JW, Merlino A, Quinn M, Venkataramani C, Kaplan JA, Portell A, Gokhale PC, Phillips B, Smart A, Rotem A, Jones RE, Keogh L, Anguiano M, Stapleton L, Jia Z, Barzily-Rokni M, Cañadas I, Thai TC, Hammond MR, Vlahos R, Wang ES, Zhang H, Li S, Hanna GJ, Huang W, Hoang MP, Piris A, Eliane JP, Stemmer-Rachamimov AO, Cameron L, Su MJ, Shah P, Izar B, Thakuria M, LeBoeuf NR, Rabinowits G, Gunda V, Parangi S, Cleary JM, Miller BC, Kitajima S, Thummalapalli R, Miao B, Barbie TU, Sivathanu V, Wong J, Richards WG, Bueno R, Yoon CH, Miret J, Herlyn M, Garraway LA, Van Allen EM, Freeman GJ, Kirschmeier PT, Lorch JH, Ott PA, Hodi FS, Flaherty KT, Kamm RD, Boland GM, Wong KK, Dornan D, Paweletz CP, Barbie DA.

Cancer Discov. 2018 Feb;8(2):196-215. doi: 10.1158/2159-8290.CD-17-0833. Epub 2017 Nov 3.


Evaluation of right heart function in a rat model using modified echocardiographic views.

Bernardo I, Wong J, Wlodek ME, Vlahos R, Soeding P.

PLoS One. 2017 Oct 31;12(10):e0187345. doi: 10.1371/journal.pone.0187345. eCollection 2017.


Aspirin-triggered resolvin D1 reduces pneumococcal lung infection and inflammation in a viral and bacterial coinfection pneumonia model.

Wang H, Anthony D, Yatmaz S, Wijburg O, Satzke C, Levy B, Vlahos R, Bozinovski S.

Clin Sci (Lond). 2017 Aug 24;131(18):2347-2362. doi: 10.1042/CS20171006. Print 2017 Sep 15.


Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy.

To EE, Vlahos R, Luong R, Halls ML, Reading PC, King PT, Chan C, Drummond GR, Sobey CG, Broughton BRS, Starkey MR, van der Sluis R, Lewin SR, Bozinovski S, O'Neill LAJ, Quach T, Porter CJH, Brooks DA, O'Leary JJ, Selemidis S.

Nat Commun. 2017 Jul 12;8(1):69. doi: 10.1038/s41467-017-00057-x.


Greater endurance capacity and improved dyspnoea with acute oxygen supplementation in idiopathic pulmonary fibrosis patients without resting hypoxaemia.

Dowman LM, McDonald CF, Bozinovski S, Vlahos R, Gillies R, Pouniotis D, Hill CJ, Goh NSL, Holland AE.

Respirology. 2017 Jul;22(5):957-964. doi: 10.1111/resp.13002. Epub 2017 Feb 22.


Tumour-associated neutrophils and loss of epithelial PTEN can promote corticosteroid-insensitive MMP-9 expression in the chronically inflamed lung microenvironment.

Vannitamby A, Seow HJ, Anderson G, Vlahos R, Thompson M, Steinfort D, Irving LB, Bozinovski S.

Thorax. 2017 Dec;72(12):1140-1143. doi: 10.1136/thoraxjnl-2016-209389. Epub 2017 Feb 15.


Therapeutic Targeting of the IL-6 Trans-Signaling/Mechanistic Target of Rapamycin Complex 1 Axis in Pulmonary Emphysema.

Ruwanpura SM, McLeod L, Dousha LF, Seow HJ, Alhayyani S, Tate MD, Deswaerte V, Brooks GD, Bozinovski S, MacDonald M, Garbers C, King PT, Bardin PG, Vlahos R, Rose-John S, Anderson GP, Jenkins BJ.

Am J Respir Crit Care Med. 2016 Dec 15;194(12):1494-1505.


Emerging therapies for the treatment of skeletal muscle wasting in chronic obstructive pulmonary disease.

Passey SL, Hansen MJ, Bozinovski S, McDonald CF, Holland AE, Vlahos R.

Pharmacol Ther. 2016 Oct;166:56-70. doi: 10.1016/j.pharmthera.2016.06.013. Epub 2016 Jun 29. Review.


COPD and stroke: are systemic inflammation and oxidative stress the missing links?

Austin V, Crack PJ, Bozinovski S, Miller AA, Vlahos R.

Clin Sci (Lond). 2016 Jul 1;130(13):1039-50. doi: 10.1042/CS20160043. Review.


Influenza A virus infection and cigarette smoke impair bronchodilator responsiveness to β-adrenoceptor agonists in mouse lung.

Donovan C, Seow HJ, Bourke JE, Vlahos R.

Clin Sci (Lond). 2016 May 1;130(10):829-37. doi: 10.1042/CS20160093. Epub 2016 Apr 10.


Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice.

Oostwoud LC, Gunasinghe P, Seow HJ, Ye JM, Selemidis S, Bozinovski S, Vlahos R.

Sci Rep. 2016 Feb 15;6:20983. doi: 10.1038/srep20983.


Targeting the IL-33/IL-13 Axis for Respiratory Viral Infections.

Donovan C, Bourke JE, Vlahos R.

Trends Pharmacol Sci. 2016 Apr;37(4):252-261. doi: 10.1016/ Epub 2016 Jan 29. Review.


Serum Amyloid A Induces Toll-Like Receptor 2-Dependent Inflammatory Cytokine Expression and Atrophy in C2C12 Skeletal Muscle Myotubes.

Passey SL, Bozinovski S, Vlahos R, Anderson GP, Hansen MJ.

PLoS One. 2016 Jan 19;11(1):e0146882. doi: 10.1371/journal.pone.0146882. eCollection 2016.


Do anti-viral neutrophil responses exacerbate lung inflammation in asthma?

Vlahos R, Bozinovski S.

Respirology. 2016 Jan;21(1):10-1. doi: 10.1111/resp.12688. Epub 2015 Nov 20. No abstract available.


Targeting oxidant-dependent mechanisms for the treatment of COPD and its comorbidities.

Bernardo I, Bozinovski S, Vlahos R.

Pharmacol Ther. 2015 Nov;155:60-79. doi: 10.1016/j.pharmthera.2015.08.005. Epub 2015 Aug 19. Review.


Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette- smoke-induced lung inflammation in mice.

Bozinovski S, Seow HJ, Chan SP, Anthony D, McQualter J, Hansen M, Jenkins BJ, Anderson GP, Vlahos R.

Clin Sci (Lond). 2015 Nov;129(9):785-96. doi: 10.1042/CS20140703. Epub 2015 Jul 1.


Multifaceted Role for IL-17A in the Pathogenesis of Chronic Obstructive Pulmonary Disease.

Bozinovski S, Vlahos R.

Am J Respir Crit Care Med. 2015 Jun 1;191(11):1213-4. doi: 10.1164/rccm.201504-0714ED. No abstract available.


Specific Contributions of CSF-1 and GM-CSF to the Dynamics of the Mononuclear Phagocyte System.

Louis C, Cook AD, Lacey D, Fleetwood AJ, Vlahos R, Anderson GP, Hamilton JA.

J Immunol. 2015 Jul 1;195(1):134-44. doi: 10.4049/jimmunol.1500369. Epub 2015 May 27.


COPD and squamous cell lung cancer: aberrant inflammation and immunity is the common link.

Bozinovski S, Vlahos R, Anthony D, McQualter J, Anderson G, Irving L, Steinfort D.

Br J Pharmacol. 2016 Feb;173(4):635-48. doi: 10.1111/bph.13198. Epub 2015 Jul 8. Review.


Lipopolysaccharide does not alter small airway reactivity in mouse lung slices.

Donovan C, Royce SG, Vlahos R, Bourke JE.

PLoS One. 2015 Mar 30;10(3):e0122069. doi: 10.1371/journal.pone.0122069. eCollection 2015.


Preclinical murine models of Chronic Obstructive Pulmonary Disease.

Vlahos R, Bozinovski S.

Eur J Pharmacol. 2015 Jul 15;759:265-71. doi: 10.1016/j.ejphar.2015.03.029. Epub 2015 Mar 24. Review.


Alteration of Airway Reactivity and Reduction of Ryanodine Receptor Expression by Cigarette Smoke in Mice.

Donovan C, Seow HJ, Royce SG, Bourke JE, Vlahos R.

Am J Respir Cell Mol Biol. 2015 Oct;53(4):471-8. doi: 10.1165/rcmb.2014-0400OC.


HSP90 inhibition suppresses lipopolysaccharide-induced lung inflammation in vivo.

Lilja A, Weeden CE, McArthur K, Nguyen T, Donald A, Wong ZX, Dousha L, Bozinovski S, Vlahos R, Burns CJ, Asselin-Labat ML, Anderson GP.

PLoS One. 2015 Jan 23;10(1):e0114975. doi: 10.1371/journal.pone.0114975. eCollection 2015.


Targeting pro-resolution pathways to combat chronic inflammation in COPD.

Bozinovski S, Anthony D, Vlahos R.

J Thorac Dis. 2014 Nov;6(11):1548-56. doi: 10.3978/j.issn.2072-1439.2014.08.08. Review.


Therapeutic potential of Panax ginseng and ginsenosides in the treatment of chronic obstructive pulmonary disease.

Shergis JL, Di YM, Zhang AL, Vlahos R, Helliwell R, Ye JM, Xue CC.

Complement Ther Med. 2014 Oct;22(5):944-53. doi: 10.1016/j.ctim.2014.08.006. Epub 2014 Aug 20. Review.


IL-17A and serum amyloid A are elevated in a cigarette smoke cessation model associated with the persistence of pigmented macrophages, neutrophils and activated NK cells.

Hansen MJ, Chan SP, Langenbach SY, Dousha LF, Jones JE, Yatmaz S, Seow HJ, Vlahos R, Anderson GP, Bozinovski S.

PLoS One. 2014 Nov 18;9(11):e113180. doi: 10.1371/journal.pone.0113180. eCollection 2014.


Role of alveolar macrophages in chronic obstructive pulmonary disease.

Vlahos R, Bozinovski S.

Front Immunol. 2014 Sep 10;5:435. doi: 10.3389/fimmu.2014.00435. eCollection 2014. Review.


NADPH oxidases as novel pharmacologic targets against influenza A virus infection.

Vlahos R, Selemidis S.

Mol Pharmacol. 2014 Dec;86(6):747-59. doi: 10.1124/mol.114.095216. Epub 2014 Oct 9. Review.


Influenza A virus and TLR7 activation potentiate NOX2 oxidase-dependent ROS production in macrophages.

To EE, Broughton BR, Hendricks KS, Vlahos R, Selemidis S.

Free Radic Res. 2014 Aug;48(8):940-7. doi: 10.3109/10715762.2014.927579. Epub 2014 Jun 23.


SAA drives proinflammatory heterotypic macrophage differentiation in the lung via CSF-1R-dependent signaling.

Anthony D, McQualter JL, Bishara M, Lim EX, Yatmaz S, Seow HJ, Hansen M, Thompson M, Hamilton JA, Irving LB, Levy BD, Vlahos R, Anderson GP, Bozinovski S.

FASEB J. 2014 Sep;28(9):3867-77. doi: 10.1096/fj.14-250332. Epub 2014 May 20.

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