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Items: 1 to 50 of 86

1.

BET bromodomain inhibition cooperates with PD-1 blockade to facilitate antitumor response in Kras-mutant non-small cell lung cancer.

Adeegbe DO, Liu S, Hattersley M, Bowden M, Zhou CW, Li S, Vlahos R, Grondine M, Dolgalev I, Ivanova E, Quinn MM, Gao P, Hammerman PS, Bradner JE, Diehl JA, Rustgi AK, Bass AJ, Tsirigos A, Freeman GJ, Chen H, Wong KK.

Cancer Immunol Res. 2018 Aug 7. pii: canimm.0077.2018. doi: 10.1158/2326-6066.CIR-18-0077. [Epub ahead of print]

PMID:
30087114
2.

Repurposing matrine for the treatment of hepatosteatosis and associated disorders in glucose homeostasis in mice.

Mahzari A, Zeng XY, Zhou X, Li S, Xu J, Tan W, Vlahos R, Robinson S, Ye JM.

Acta Pharmacol Sin. 2018 Jul 6. doi: 10.1038/s41401-018-0016-8. [Epub ahead of print]

PMID:
29980742
3.

Increased hypothalamic microglial activation after viral-induced pneumococcal lung infection is associated with excess serum amyloid A production.

Wang H, Blackall M, Sominsky L, Spencer SJ, Vlahos R, Churchill M, Bozinovski S.

J Neuroinflammation. 2018 Jul 6;15(1):200. doi: 10.1186/s12974-018-1234-1.

4.

E-Cigarettes: Inducing Inflammation that Spans Generations.

Vlahos R.

Am J Respir Cell Mol Biol. 2018 Mar;58(3):286-287. doi: 10.1165/rcmb.2017-0306ED. No abstract available.

PMID:
29493321
5.

Protocols to Evaluate Cigarette Smoke-Induced Lung Inflammation and Pathology in Mice.

Vlahos R, Bozinovski S.

Methods Mol Biol. 2018;1725:53-63. doi: 10.1007/978-1-4939-7568-6_5.

PMID:
29322408
6.

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

Jenkins RW, Aref AR, Lizotte PH, Ivanova E, Stinson S, Zhou CW, Bowden M, Deng J, Liu H, Miao D, He MX, Walker W, Zhang G, Tian T, Cheng C, Wei Z, Palakurthi S, Bittinger M, Vitzthum H, Kim JW, Merlino A, Quinn M, Venkataramani C, Kaplan JA, Portell A, Gokhale PC, Phillips B, Smart A, Rotem A, Jones RE, Keogh L, Anguiano M, Stapleton L, Jia Z, Barzily-Rokni M, Cañadas I, Thai TC, Hammond MR, Vlahos R, Wang ES, Zhang H, Li S, Hanna GJ, Huang W, Hoang MP, Piris A, Eliane JP, Stemmer-Rachamimov AO, Cameron L, Su MJ, Shah P, Izar B, Thakuria M, LeBoeuf NR, Rabinowits G, Gunda V, Parangi S, Cleary JM, Miller BC, Kitajima S, Thummalapalli R, Miao B, Barbie TU, Sivathanu V, Wong J, Richards WG, Bueno R, Yoon CH, Miret J, Herlyn M, Garraway LA, Van Allen EM, Freeman GJ, Kirschmeier PT, Lorch JH, Ott PA, Hodi FS, Flaherty KT, Kamm RD, Boland GM, Wong KK, Dornan D, Paweletz CP, Barbie DA.

Cancer Discov. 2018 Feb;8(2):196-215. doi: 10.1158/2159-8290.CD-17-0833. Epub 2017 Nov 3.

PMID:
29101162
7.

Evaluation of right heart function in a rat model using modified echocardiographic views.

Bernardo I, Wong J, Wlodek ME, Vlahos R, Soeding P.

PLoS One. 2017 Oct 31;12(10):e0187345. doi: 10.1371/journal.pone.0187345. eCollection 2017.

8.

Aspirin-triggered resolvin D1 reduces pneumococcal lung infection and inflammation in a viral and bacterial coinfection pneumonia model.

Wang H, Anthony D, Yatmaz S, Wijburg O, Satzke C, Levy B, Vlahos R, Bozinovski S.

Clin Sci (Lond). 2017 Aug 24;131(18):2347-2362. doi: 10.1042/CS20171006. Print 2017 Sep 15.

PMID:
28779028
9.

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy.

To EE, Vlahos R, Luong R, Halls ML, Reading PC, King PT, Chan C, Drummond GR, Sobey CG, Broughton BRS, Starkey MR, van der Sluis R, Lewin SR, Bozinovski S, O'Neill LAJ, Quach T, Porter CJH, Brooks DA, O'Leary JJ, Selemidis S.

Nat Commun. 2017 Jul 12;8(1):69. doi: 10.1038/s41467-017-00057-x.

10.

Greater endurance capacity and improved dyspnoea with acute oxygen supplementation in idiopathic pulmonary fibrosis patients without resting hypoxaemia.

Dowman LM, McDonald CF, Bozinovski S, Vlahos R, Gillies R, Pouniotis D, Hill CJ, Goh NSL, Holland AE.

Respirology. 2017 Jul;22(5):957-964. doi: 10.1111/resp.13002. Epub 2017 Feb 22.

PMID:
28225205
11.

Tumour-associated neutrophils and loss of epithelial PTEN can promote corticosteroid-insensitive MMP-9 expression in the chronically inflamed lung microenvironment.

Vannitamby A, Seow HJ, Anderson G, Vlahos R, Thompson M, Steinfort D, Irving LB, Bozinovski S.

Thorax. 2017 Dec;72(12):1140-1143. doi: 10.1136/thoraxjnl-2016-209389. Epub 2017 Feb 15.

12.

Therapeutic Targeting of the IL-6 Trans-Signaling/Mechanistic Target of Rapamycin Complex 1 Axis in Pulmonary Emphysema.

Ruwanpura SM, McLeod L, Dousha LF, Seow HJ, Alhayyani S, Tate MD, Deswaerte V, Brooks GD, Bozinovski S, MacDonald M, Garbers C, King PT, Bardin PG, Vlahos R, Rose-John S, Anderson GP, Jenkins BJ.

Am J Respir Crit Care Med. 2016 Dec 15;194(12):1494-1505.

PMID:
27373892
13.

Emerging therapies for the treatment of skeletal muscle wasting in chronic obstructive pulmonary disease.

Passey SL, Hansen MJ, Bozinovski S, McDonald CF, Holland AE, Vlahos R.

Pharmacol Ther. 2016 Oct;166:56-70. doi: 10.1016/j.pharmthera.2016.06.013. Epub 2016 Jun 29. Review.

14.

COPD and stroke: are systemic inflammation and oxidative stress the missing links?

Austin V, Crack PJ, Bozinovski S, Miller AA, Vlahos R.

Clin Sci (Lond). 2016 Jul 1;130(13):1039-50. doi: 10.1042/CS20160043. Review.

15.

Influenza A virus infection and cigarette smoke impair bronchodilator responsiveness to β-adrenoceptor agonists in mouse lung.

Donovan C, Seow HJ, Bourke JE, Vlahos R.

Clin Sci (Lond). 2016 May 1;130(10):829-37. doi: 10.1042/CS20160093. Epub 2016 Apr 10.

16.

Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice.

Oostwoud LC, Gunasinghe P, Seow HJ, Ye JM, Selemidis S, Bozinovski S, Vlahos R.

Sci Rep. 2016 Feb 15;6:20983. doi: 10.1038/srep20983.

17.

Targeting the IL-33/IL-13 Axis for Respiratory Viral Infections.

Donovan C, Bourke JE, Vlahos R.

Trends Pharmacol Sci. 2016 Apr;37(4):252-261. doi: 10.1016/j.tips.2016.01.004. Epub 2016 Jan 29. Review.

PMID:
26833119
18.

Serum Amyloid A Induces Toll-Like Receptor 2-Dependent Inflammatory Cytokine Expression and Atrophy in C2C12 Skeletal Muscle Myotubes.

Passey SL, Bozinovski S, Vlahos R, Anderson GP, Hansen MJ.

PLoS One. 2016 Jan 19;11(1):e0146882. doi: 10.1371/journal.pone.0146882. eCollection 2016.

19.

Do anti-viral neutrophil responses exacerbate lung inflammation in asthma?

Vlahos R, Bozinovski S.

Respirology. 2016 Jan;21(1):10-1. doi: 10.1111/resp.12688. Epub 2015 Nov 20. No abstract available.

20.

Targeting oxidant-dependent mechanisms for the treatment of COPD and its comorbidities.

Bernardo I, Bozinovski S, Vlahos R.

Pharmacol Ther. 2015 Nov;155:60-79. doi: 10.1016/j.pharmthera.2015.08.005. Epub 2015 Aug 19. Review.

21.

Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette- smoke-induced lung inflammation in mice.

Bozinovski S, Seow HJ, Chan SP, Anthony D, McQualter J, Hansen M, Jenkins BJ, Anderson GP, Vlahos R.

Clin Sci (Lond). 2015 Nov;129(9):785-96. doi: 10.1042/CS20140703. Epub 2015 Jul 1.

22.

Multifaceted Role for IL-17A in the Pathogenesis of Chronic Obstructive Pulmonary Disease.

Bozinovski S, Vlahos R.

Am J Respir Crit Care Med. 2015 Jun 1;191(11):1213-4. doi: 10.1164/rccm.201504-0714ED. No abstract available.

PMID:
26029829
23.

Specific Contributions of CSF-1 and GM-CSF to the Dynamics of the Mononuclear Phagocyte System.

Louis C, Cook AD, Lacey D, Fleetwood AJ, Vlahos R, Anderson GP, Hamilton JA.

J Immunol. 2015 Jul 1;195(1):134-44. doi: 10.4049/jimmunol.1500369. Epub 2015 May 27.

24.

COPD and squamous cell lung cancer: aberrant inflammation and immunity is the common link.

Bozinovski S, Vlahos R, Anthony D, McQualter J, Anderson G, Irving L, Steinfort D.

Br J Pharmacol. 2016 Feb;173(4):635-48. doi: 10.1111/bph.13198. Epub 2015 Jul 8. Review.

25.

Lipopolysaccharide does not alter small airway reactivity in mouse lung slices.

Donovan C, Royce SG, Vlahos R, Bourke JE.

PLoS One. 2015 Mar 30;10(3):e0122069. doi: 10.1371/journal.pone.0122069. eCollection 2015.

26.

Preclinical murine models of Chronic Obstructive Pulmonary Disease.

Vlahos R, Bozinovski S.

Eur J Pharmacol. 2015 Jul 15;759:265-71. doi: 10.1016/j.ejphar.2015.03.029. Epub 2015 Mar 24. Review.

PMID:
25818750
27.

Alteration of Airway Reactivity and Reduction of Ryanodine Receptor Expression by Cigarette Smoke in Mice.

Donovan C, Seow HJ, Royce SG, Bourke JE, Vlahos R.

Am J Respir Cell Mol Biol. 2015 Oct;53(4):471-8. doi: 10.1165/rcmb.2014-0400OC.

PMID:
25692207
28.

HSP90 inhibition suppresses lipopolysaccharide-induced lung inflammation in vivo.

Lilja A, Weeden CE, McArthur K, Nguyen T, Donald A, Wong ZX, Dousha L, Bozinovski S, Vlahos R, Burns CJ, Asselin-Labat ML, Anderson GP.

PLoS One. 2015 Jan 23;10(1):e0114975. doi: 10.1371/journal.pone.0114975. eCollection 2015.

29.

Targeting pro-resolution pathways to combat chronic inflammation in COPD.

Bozinovski S, Anthony D, Vlahos R.

J Thorac Dis. 2014 Nov;6(11):1548-56. doi: 10.3978/j.issn.2072-1439.2014.08.08. Review.

30.

Therapeutic potential of Panax ginseng and ginsenosides in the treatment of chronic obstructive pulmonary disease.

Shergis JL, Di YM, Zhang AL, Vlahos R, Helliwell R, Ye JM, Xue CC.

Complement Ther Med. 2014 Oct;22(5):944-53. doi: 10.1016/j.ctim.2014.08.006. Epub 2014 Aug 20. Review.

PMID:
25440386
31.

IL-17A and serum amyloid A are elevated in a cigarette smoke cessation model associated with the persistence of pigmented macrophages, neutrophils and activated NK cells.

Hansen MJ, Chan SP, Langenbach SY, Dousha LF, Jones JE, Yatmaz S, Seow HJ, Vlahos R, Anderson GP, Bozinovski S.

PLoS One. 2014 Nov 18;9(11):e113180. doi: 10.1371/journal.pone.0113180. eCollection 2014.

32.

Role of alveolar macrophages in chronic obstructive pulmonary disease.

Vlahos R, Bozinovski S.

Front Immunol. 2014 Sep 10;5:435. doi: 10.3389/fimmu.2014.00435. eCollection 2014. Review.

33.

NADPH oxidases as novel pharmacologic targets against influenza A virus infection.

Vlahos R, Selemidis S.

Mol Pharmacol. 2014 Dec;86(6):747-59. doi: 10.1124/mol.114.095216. Epub 2014 Oct 9. Review.

34.

Influenza A virus and TLR7 activation potentiate NOX2 oxidase-dependent ROS production in macrophages.

To EE, Broughton BR, Hendricks KS, Vlahos R, Selemidis S.

Free Radic Res. 2014 Aug;48(8):940-7. doi: 10.3109/10715762.2014.927579. Epub 2014 Jun 23.

PMID:
24869957
35.

SAA drives proinflammatory heterotypic macrophage differentiation in the lung via CSF-1R-dependent signaling.

Anthony D, McQualter JL, Bishara M, Lim EX, Yatmaz S, Seow HJ, Hansen M, Thompson M, Hamilton JA, Irving LB, Levy BD, Vlahos R, Anderson GP, Bozinovski S.

FASEB J. 2014 Sep;28(9):3867-77. doi: 10.1096/fj.14-250332. Epub 2014 May 20.

36.

IL-6/Stat3-driven pulmonary inflammation, but not emphysema, is dependent on interleukin-17A in mice.

Ruwanpura SM, McLeod L, Brooks GD, Bozinovski S, Vlahos R, Longano A, Bardin PG, Anderson GP, Jenkins BJ.

Respirology. 2014 Apr;19(3):419-27. doi: 10.1111/resp.12243. Epub 2014 Feb 10.

37.

The lung inflammation and skeletal muscle wasting induced by subchronic cigarette smoke exposure are not altered by a high-fat diet in mice.

Hansen MJ, Chen H, Jones JE, Langenbach SY, Vlahos R, Gualano RC, Morris MJ, Anderson GP.

PLoS One. 2013 Nov 19;8(11):e80471. doi: 10.1371/journal.pone.0080471. eCollection 2013.

38.

Non-essential role for TLR2 and its signaling adaptor Mal/TIRAP in preserving normal lung architecture in mice.

Ruwanpura SM, McLeod L, Lilja AR, Brooks G, Dousha LF, Seow HJ, Bozinovski S, Vlahos R, Hertzog PJ, Anderson GP, Jenkins BJ.

PLoS One. 2013 Oct 29;8(10):e78095. doi: 10.1371/journal.pone.0078095. eCollection 2013.

39.

Recent advances in pre-clinical mouse models of COPD.

Vlahos R, Bozinovski S.

Clin Sci (Lond). 2014 Feb;126(4):253-65. doi: 10.1042/CS20130182. Review.

40.

Treating neutrophilic inflammation in COPD by targeting ALX/FPR2 resolution pathways.

Bozinovski S, Anthony D, Anderson GP, Irving LB, Levy BD, Vlahos R.

Pharmacol Ther. 2013 Dec;140(3):280-9. doi: 10.1016/j.pharmthera.2013.07.007. Epub 2013 Jul 21. Review.

PMID:
23880288
41.

Glutathione peroxidase-1 as a novel therapeutic target for COPD.

Vlahos R, Bozinovski S.

Redox Rep. 2013;18(4):142-9. doi: 10.1179/1351000213Y.0000000053. Review.

PMID:
23849338
42.

Serum amyloid A promotes lung neutrophilia by increasing IL-17A levels in the mucosa and γδ T cells.

Anthony D, Seow HJ, Uddin M, Thompson M, Dousha L, Vlahos R, Irving LB, Levy BD, Anderson GP, Bozinovski S.

Am J Respir Crit Care Med. 2013 Jul 15;188(2):179-86. doi: 10.1164/rccm.201211-2139OC.

43.

Nox1 oxidase suppresses influenza a virus-induced lung inflammation and oxidative stress.

Selemidis S, Seow HJ, Broughton BR, Vinh A, Bozinovski S, Sobey CG, Drummond GR, Vlahos R.

PLoS One. 2013;8(4):e60792. doi: 10.1371/journal.pone.0060792. Epub 2013 Apr 8.

44.

Glutathione peroxidase-1 reduces influenza A virus-induced lung inflammation.

Yatmaz S, Seow HJ, Gualano RC, Wong ZX, Stambas J, Selemidis S, Crack PJ, Bozinovski S, Anderson GP, Vlahos R.

Am J Respir Cell Mol Biol. 2013 Jan;48(1):17-26. doi: 10.1165/rcmb.2011-0345OC. Epub 2012 Sep 20.

PMID:
23002098
45.

Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung disease.

Duan M, Li WC, Vlahos R, Maxwell MJ, Anderson GP, Hibbs ML.

J Immunol. 2012 Jul 15;189(2):946-55. doi: 10.4049/jimmunol.1200660. Epub 2012 Jun 11.

46.

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis.

O'Donoghue RJ, Knight DA, Richards CD, Prêle CM, Lau HL, Jarnicki AG, Jones J, Bozinovski S, Vlahos R, Thiem S, McKenzie BS, Wang B, Stumbles P, Laurent GJ, McAnulty RJ, Rose-John S, Zhu HJ, Anderson GP, Ernst MR, Mutsaers SE.

EMBO Mol Med. 2012 Sep;4(9):939-51. doi: 10.1002/emmm.201100604. Epub 2012 Jun 8.

47.

Glucocorticosteroids differentially regulate MMP-9 and neutrophil elastase in COPD.

Vlahos R, Wark PA, Anderson GP, Bozinovski S.

PLoS One. 2012;7(3):e33277. doi: 10.1371/journal.pone.0033277. Epub 2012 Mar 7.

48.

Glutathione peroxidase-1 primes pro-inflammatory cytokine production after LPS challenge in vivo.

Bozinovski S, Seow HJ, Crack PJ, Anderson GP, Vlahos R.

PLoS One. 2012;7(3):e33172. doi: 10.1371/journal.pone.0033172. Epub 2012 Mar 6.

49.

Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice.

Ruwanpura SM, McLeod L, Miller A, Jones J, Vlahos R, Ramm G, Longano A, Bardin PG, Bozinovski S, Anderson GP, Jenkins BJ.

Am J Physiol Lung Cell Mol Physiol. 2012 Apr 1;302(7):L627-39. doi: 10.1152/ajplung.00285.2011. Epub 2012 Jan 20.

50.

Serum amyloid A opposes lipoxin A₄ to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease.

Bozinovski S, Uddin M, Vlahos R, Thompson M, McQualter JL, Merritt AS, Wark PA, Hutchinson A, Irving LB, Levy BD, Anderson GP.

Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):935-40. doi: 10.1073/pnas.1109382109. Epub 2012 Jan 3.

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