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Items: 1 to 50 of 65

1.

Putative interaction site for membrane phospholipids controls activation of TRPA1 channel at physiological membrane potentials.

Macikova L, Sinica V, Kadkova A, Villette S, Ciaccafava A, Faherty J, Lecomte S, Alves ID, Vlachova V.

FEBS J. 2019 May 22. doi: 10.1111/febs.14931. [Epub ahead of print]

PMID:
31116904
2.

Heat-resistant action potentials require TTX-resistant sodium channels NaV1.8 and NaV1.9.

Touska F, Turnquist B, Vlachova V, Reeh PW, Leffler A, Zimmermann K.

J Gen Physiol. 2018 Aug 6;150(8):1125-1144. doi: 10.1085/jgp.201711786. Epub 2018 Jul 3.

3.

Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel.

Zimova L, Sinica V, Kadkova A, Vyklicka L, Zima V, Barvik I, Vlachova V.

Sci Signal. 2018 Jan 23;11(514). pii: eaan8621. doi: 10.1126/scisignal.aan8621.

PMID:
29363587
4.

Acute exposure to high-induction electromagnetic field affects activity of model peripheral sensory neurons.

Prucha J, Krusek J, Dittert I, Sinica V, Kadkova A, Vlachova V.

J Cell Mol Med. 2018 Feb;22(2):1355-1362. doi: 10.1111/jcmm.13423. Epub 2017 Dec 6.

5.

The human transient receptor potential vanilloid 3 channel is sensitized via the ERK pathway.

Vyklicka L, Boukalova S, Macikova L, Chvojka S, Vlachova V.

J Biol Chem. 2017 Dec 22;292(51):21083-21091. doi: 10.1074/jbc.M117.801167. Epub 2017 Oct 30.

6.

Molecular basis of TRPA1 regulation in nociceptive neurons. A review.

Kádková A, Synytsya V, Krusek J, Zímová L, Vlachová V.

Physiol Res. 2017 Jul 18;66(3):425-439. Review.

7.

The First Extracellular Linker Is Important for Several Aspects of the Gating Mechanism of Human TRPA1 Channel.

Marsakova L, Barvik I, Zima V, Zimova L, Vlachova V.

Front Mol Neurosci. 2017 Jan 31;10:16. doi: 10.3389/fnmol.2017.00016. eCollection 2017.

8.

N-terminal tetrapeptide T/SPLH motifs contribute to multimodal activation of human TRPA1 channel.

Hynkova A, Marsakova L, Vaskova J, Vlachova V.

Sci Rep. 2016 Jun 27;6:28700. doi: 10.1038/srep28700.

9.

Comprehensive thermal preference phenotyping in mice using a novel automated circular gradient assay.

Touska F, Winter Z, Mueller A, Vlachova V, Larsen J, Zimmermann K.

Temperature (Austin). 2016 Mar 2;3(1):77-91. doi: 10.1080/23328940.2015.1135689. eCollection 2016 Jan-Mar.

10.

Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state.

Zíma V, Witschas K, Hynkova A, Zímová L, Barvík I, Vlachova V.

Neuropharmacology. 2015 Jun;93:294-307. doi: 10.1016/j.neuropharm.2015.02.018. Epub 2015 Feb 25.

PMID:
25724085
11.

Interaction of a peptide derived from C-terminus of human TRPA1 channel with model membranes mimicking the inner leaflet of the plasma membrane.

Witschas K, Jobin ML, Korkut DN, Vladan MM, Salgado G, Lecomte S, Vlachova V, Alves ID.

Biochim Biophys Acta. 2015 May;1848(5):1147-56. doi: 10.1016/j.bbamem.2015.02.003. Epub 2015 Feb 14.

12.

Gain-of-function mutations in the transient receptor potential channels TRPV1 and TRPA1: how painful?

Boukalova S, Touska F, Marsakova L, Hynkova A, Sura L, Chvojka S, Dittert I, Vlachova V.

Physiol Res. 2014;63 Suppl 1:S205-13. Review. Erratum in: Physiol Res. 2014;63(5):667.

13.

Amplified cold transduction in native nociceptors by M-channel inhibition.

Vetter I, Hein A, Sattler S, Hessler S, Touska F, Bressan E, Parra A, Hager U, Leffler A, Boukalova S, Nissen M, Lewis RJ, Belmonte C, Alzheimer C, Huth T, Vlachova V, Reeh PW, Zimmermann K.

J Neurosci. 2013 Oct 16;33(42):16627-41. doi: 10.1523/JNEUROSCI.1473-13.2013.

14.

Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel.

Boukalova S, Teisinger J, Vlachova V.

Biochim Biophys Acta. 2013 Mar;1833(3):520-8. doi: 10.1016/j.bbamcr.2012.11.017. Epub 2012 Dec 4.

15.

Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling.

Vetter I, Touska F, Hess A, Hinsbey R, Sattler S, Lampert A, Sergejeva M, Sharov A, Collins LS, Eberhardt M, Engel M, Cabot PJ, Wood JN, Vlachová V, Reeh PW, Lewis RJ, Zimmermann K.

EMBO J. 2012 Oct 3;31(19):3795-808. doi: 10.1038/emboj.2012.207. Epub 2012 Jul 31.

16.

C-terminal acidic cluster is involved in Ca2+-induced regulation of human transient receptor potential ankyrin 1 channel.

Sura L, Zíma V, Marsakova L, Hynkova A, Barvík I, Vlachova V.

J Biol Chem. 2012 May 25;287(22):18067-77. doi: 10.1074/jbc.M112.341859. Epub 2012 Mar 29.

17.

Pore helix domain is critical to camphor sensitivity of transient receptor potential vanilloid 1 channel.

Marsakova L, Touska F, Krusek J, Vlachova V.

Anesthesiology. 2012 Apr;116(4):903-17. doi: 10.1097/ALN.0b013e318249cf62.

PMID:
22314297
18.

TRP channels: from understanding to action.

Vlachova V.

Curr Pharm Biotechnol. 2011 Jan 1;12(1):1-2. No abstract available.

PMID:
21244360
19.

Conserved residues within the putative S4-S5 region serve distinct functions among thermosensitive vanilloid transient receptor potential (TRPV) channels.

Boukalova S, Marsakova L, Teisinger J, Vlachova V.

J Biol Chem. 2010 Dec 31;285(53):41455-62. doi: 10.1074/jbc.M110.145466. Epub 2010 Nov 2.

20.

The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1.

Samad A, Sura L, Benedikt J, Ettrich R, Minofar B, Teisinger J, Vlachova V.

Biochem J. 2011 Jan 1;433(1):197-204. doi: 10.1042/BJ20101256.

21.

A "cute" desensitization of TRPV1.

Touska F, Marsakova L, Teisinger J, Vlachova V.

Curr Pharm Biotechnol. 2011 Jan 1;12(1):122-9. Review.

PMID:
20932251
22.

Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel.

Benedikt J, Samad A, Ettrich R, Teisinger J, Vlachova V.

Biochim Biophys Acta. 2009 Jul;1793(7):1279-88. doi: 10.1016/j.bbamcr.2009.04.014. Epub 2009 May 5.

23.

Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin.

Vyklický L, Nováková-Tousová K, Benedikt J, Samad A, Touska F, Vlachová V.

Physiol Res. 2008;57 Suppl 3:S59-68. Epub 2008 May 13.

24.

Functional changes in the vanilloid receptor subtype 1 channel during and after acute desensitization.

Novakova-Tousova K, Vyklicky L, Susankova K, Benedikt J, Samad A, Teisinger J, Vlachova V.

Neuroscience. 2007 Oct 12;149(1):144-54. Epub 2007 Aug 8.

PMID:
17869438
25.

ATP binding site on the C-terminus of the vanilloid receptor.

Grycova L, Lansky Z, Friedlova E, Vlachova V, Kubala M, Obsilova V, Obsil T, Teisinger J.

Arch Biochem Biophys. 2007 Sep 15;465(2):389-98. Epub 2007 Jul 21.

PMID:
17706589
26.

Contribution of the putative inner-pore region to the gating of the transient receptor potential vanilloid subtype 1 channel (TRPV1).

Susankova K, Ettrich R, Vyklicky L, Teisinger J, Vlachova V.

J Neurosci. 2007 Jul 11;27(28):7578-85.

27.

Ethanol inhibits cold-menthol receptor TRPM8 by modulating its interaction with membrane phosphatidylinositol 4,5-bisphosphate.

Benedikt J, Teisinger J, Vyklicky L, Vlachova V.

J Neurochem. 2007 Jan;100(1):211-24. Epub 2006 Oct 27.

28.

Reducing and oxidizing agents sensitize heat-activated vanilloid receptor (TRPV1) current.

Susankova K, Tousova K, Vyklicky L, Teisinger J, Vlachova V.

Mol Pharmacol. 2006 Jul;70(1):383-94. Epub 2006 Apr 13.

PMID:
16614139
29.

Improved superfusion technique for rapid cooling or heating of cultured cells under patch-clamp conditions.

Dittert I, Benedikt J, Vyklický L, Zimmermann K, Reeh PW, Vlachová V.

J Neurosci Methods. 2006 Mar 15;151(2):178-85. Epub 2005 Aug 29.

PMID:
16129494
30.

Gadolinium activates and sensitizes the vanilloid receptor TRPV1 through the external protonation sites.

Tousova K, Vyklicky L, Susankova K, Benedikt J, Vlachova V.

Mol Cell Neurosci. 2005 Oct;30(2):207-17.

PMID:
16099171
31.

Oxidizing reagent copper-o-phenanthroline is an open channel blocker of the vanilloid receptor TRPV1.

Tousova K, Susankova K, Teisinger J, Vyklicky L, Vlachova V.

Neuropharmacology. 2004 Aug;47(2):273-85.

PMID:
15223306
32.

Intracellular spermine decreases open probability of N-methyl-D-aspartate receptor channels.

Turecek R, Vlcek K, Petrovic M, Horak M, Vlachova V, Vyklicky L Jr.

Neuroscience. 2004;125(4):879-87.

PMID:
15120849
33.

Activation and modulation of ligand-gated ion channels.

Krůsek J, Dittert I, Hendrych T, Hník P, Horák M, Petrovic M, Sedlácek M, Susánková K, Svobodová L, Tousová K, Ujec E, Vlachová V, Vyklický L, Vyskocil F, Vyklický L Jr.

Physiol Res. 2004;53 Suppl 1:S103-13. Review.

34.

Vanilloid receptor TRPV1 is not activated by vanilloids applied intracellularly.

Vyklický L, Lyfenko A, Kuffler DP, Vlachová V.

Neuroreport. 2003 May 23;14(7):1061-5.

PMID:
12802203
35.

Functional role of C-terminal cytoplasmic tail of rat vanilloid receptor 1.

Vlachová V, Teisinger J, Susánková K, Lyfenko A, Ettrich R, Vyklický L.

J Neurosci. 2003 Feb 15;23(4):1340-50.

36.

Cellular mechanisms of nociception in the frog.

Kuffler DP, Lyfenko A, Vyklický L, Vlachová V.

J Neurophysiol. 2002 Oct;88(4):1843-50.

37.
38.

Reducing agent dithiothreitol facilitates activity of the capsaicin receptor VR-1.

Vyklický L, Lyfenko A, Susánková K, Teisinger J, Vlachová V.

Neuroscience. 2002;111(3):435-41.

PMID:
12031340
39.

Modelling the consequences of receptor-G-protein promiscuity.

Tucek S, Michal P, Vlachová V.

Trends Pharmacol Sci. 2002 Apr;23(4):171-6. Review.

PMID:
11931992
40.

The effects of excessive heat on heat-activated membrane currents in cultured dorsal root ganglia neurons from neonatal rat.

Lyfenko A, Vlachová V, Vyklický L, Dittert I, Kress M, Reeh PW.

Pain. 2002 Feb;95(3):207-14.

PMID:
11839420
41.
42.

Dual effects of muscarinic M2 receptors on the synthesis of cyclic AMP in CHO cells: background and model.

Tucek S, Michal P, Vlachova V.

Life Sci. 2001 Apr 27;68(22-23):2501-10.

PMID:
11392619
43.
44.

Molecular and functional properties of synaptically activated NMDA receptors in neonatal motoneurons in rat spinal cord slices.

Abdrachmanova G, Teisinger J, Vlachová V, Vyklický L Jr.

Eur J Neurosci. 2000 Mar;12(3):955-63.

PMID:
10762325
45.

Temperature coefficient of membrane currents induced by noxious heat in sensory neurones in the rat.

Vyklický L, Vlachová V, Vitásková Z, Dittert I, Kabát M, Orkand RK.

J Physiol. 1999 May 15;517 ( Pt 1):181-92.

46.

Procaine excites nociceptors in cultures from dorsal root ganglion of the rat.

Vlachová V, Vitásková Z, Vyklický L, Orkand RK.

Neurosci Lett. 1999 Mar 19;263(1):49-52.

PMID:
10218908
47.

Properties of NMDA receptors in rat spinal cord motoneurons.

Palecek JI, Abdrachmanova G, Vlachová V, Vyklick L Jr.

Eur J Neurosci. 1999 Mar;11(3):827-36.

PMID:
10103076
48.

A technique for fast application of heated solutions of different composition to cultured neurones.

Dittert I, Vlachová V, Knotková H, Vitásková Z, Vyklicky L, Kress M, Reeh PW.

J Neurosci Methods. 1998 Aug 1;82(2):195-201.

PMID:
9700692
49.

Inflammatory mediators at acidic pH activate capsaicin receptors in cultured sensory neurons from newborn rats.

Vyklický L, Knotková-Urbancová H, Vitásková Z, Vlachová V, Kress M, Reeh PW.

J Neurophysiol. 1998 Feb;79(2):670-6.

50.

Spontaneous openings of NMDA receptor channels in cultured rat hippocampal neurons.

Turecek R, Vlachová V, Vyklický L Jr.

Eur J Neurosci. 1997 Oct;9(10):1999-2008.

PMID:
9421161

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