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Single-dose cardioplegia protects myocardium as well as traditional repetitive dosing: A noninferiority randomized study.

Vivacqua A, Robinson J, Abbas AE, Altshuler JM, Shannon FL, Podolsky RH, Sakwa MP.

J Thorac Cardiovasc Surg. 2019 May 11. pii: S0022-5223(19)30978-X. doi: 10.1016/j.jtcvs.2019.03.125. [Epub ahead of print]


Differential MicroRNA Landscape Triggered by Estrogens in Cancer Associated Fibroblasts (CAFs) of Primary and Metastatic Breast Tumors.

Vivacqua A, Muoio MG, Miglietta AM, Maggiolini M.

Cancers (Basel). 2019 Mar 23;11(3). pii: E412. doi: 10.3390/cancers11030412.


GPER Mediates a Feedforward FGF2/FGFR1 Paracrine Activation Coupling CAFs to Cancer Cells toward Breast Tumor Progression.

Santolla MF, Vivacqua A, Lappano R, Rigiracciolo DC, Cirillo F, Galli GR, Talia M, Brunetti G, Miglietta AM, Belfiore A, Maggiolini M.

Cells. 2019 Mar 7;8(3). pii: E223. doi: 10.3390/cells8030223.


Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells.

Rigiracciolo DC, Santolla MF, Lappano R, Vivacqua A, Cirillo F, Galli GR, Talia M, Muglia L, Pellegrino M, Nohata N, Di Martino MT, Maggiolini M.

J Exp Clin Cancer Res. 2019 Feb 6;38(1):58. doi: 10.1186/s13046-019-1056-8.


miR-338-3p Is Regulated by Estrogens through GPER in Breast Cancer Cells and Cancer-Associated Fibroblasts (CAFs).

Vivacqua A, Sebastiani A, Miglietta AM, Rigiracciolo DC, Cirillo F, Galli GR, Talia M, Santolla MF, Lappano R, Giordano F, Panno ML, Maggiolini M.

Cells. 2018 Nov 9;7(11). pii: E203. doi: 10.3390/cells7110203.


The Mysterious Mitral Mass: A Case of Valvular Myxoma.

Mando R, Barbat JJ, Vivacqua A.

Case Rep Cardiol. 2018 Jul 19;2018:3927948. doi: 10.1155/2018/3927948. eCollection 2018.


Emergency Valve-in-Valve Transcatheter Aortic Valve Implantation for the Treatment of Acute Stentless Bioprosthetic Aortic Insufficiency and Cardiogenic Shock.

Hanson ID, Dalal PK, Renard BM, Hanzel GS, Vivacqua A.

Case Rep Cardiol. 2018 Mar 13;2018:6872748. doi: 10.1155/2018/6872748. eCollection 2018.


miR-221 stimulates breast cancer cells and cancer-associated fibroblasts (CAFs) through selective interference with the A20/c-Rel/CTGF signaling.

Santolla MF, Lappano R, Cirillo F, Rigiracciolo DC, Sebastiani A, Abonante S, Tassone P, Tagliaferri P, Di Martino MT, Maggiolini M, Vivacqua A.

J Exp Clin Cancer Res. 2018 May 2;37(1):94. doi: 10.1186/s13046-018-0767-6.


GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer.

Cirillo F, Pellegrino M, Malivindi R, Rago V, Avino S, Muto L, Dolce V, Vivacqua A, Rigiracciolo DC, De Marco P, Sebastiani A, Abonante S, Nakajima M, Lappano R, Maggiolini M.

Oncotarget. 2017 Nov 20;8(63):106608-106624. doi: 10.18632/oncotarget.22541. eCollection 2017 Dec 5.


Recent Advances on the Role of microRNAs in both Insulin Resistance and Cancer.

Vivacqua A, De Marco P, Belfiore A, Maggiolini M.

Curr Pharm Des. 2017;23(25):3658-3666. doi: 10.2174/1381612823666170622105123. Review.


Endoscopic Repair of Recurrent Tracheoesophageal Fistula With an Atrial Septal Occluder Device.

Vivacqua A, Malankar D, Idrees JJ, Rice TW, Raymond DP, Roselli EE.

Ann Thorac Surg. 2016 Dec;102(6):e485-e487. doi: 10.1016/j.athoracsur.2016.04.090.


Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells.

Avino S, De Marco P, Cirillo F, Santolla MF, De Francesco EM, Perri MG, Rigiracciolo D, Dolce V, Belfiore A, Maggiolini M, Lappano R, Vivacqua A.

Oncotarget. 2016 Aug 16;7(33):52710-52728. doi: 10.18632/oncotarget.10348.


GPER, IGF-IR, and EGFR transduction signaling are involved in stimulatory effects of zinc in breast cancer cells and cancer-associated fibroblasts.

Pisano A, Santolla MF, De Francesco EM, De Marco P, Rigiracciolo DC, Perri MG, Vivacqua A, Abonante S, Cappello AR, Dolce V, Belfiore A, Maggiolini M, Lappano R.

Mol Carcinog. 2017 Feb;56(2):580-593. doi: 10.1002/mc.22518. Epub 2016 Jul 4.


GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response.

De Marco P, Lappano R, De Francesco EM, Cirillo F, Pupo M, Avino S, Vivacqua A, Abonante S, Picard D, Maggiolini M.

Sci Rep. 2016 Apr 13;6:24354. doi: 10.1038/srep24354.


Androgens downregulate miR-21 expression in breast cancer cells underlining the protective role of androgen receptor.

Casaburi I, Cesario MG, Donà A, Rizza P, Aquila S, Avena P, Lanzino M, Pellegrino M, Vivacqua A, Tucci P, Morelli C, Andò S, Sisci D.

Oncotarget. 2016 Mar 15;7(11):12651-61. doi: 10.18632/oncotarget.7207.


The G protein estrogen receptor (GPER) is regulated by endothelin-1 mediated signaling in cancer cells.

Bartella V, De Francesco EM, Perri MG, Curcio R, Dolce V, Maggiolini M, Vivacqua A.

Cell Signal. 2016 Feb;28(2):61-71. doi: 10.1016/j.cellsig.2015.11.010. Epub 2015 Nov 19.


Macromolecular Modelling and Docking Simulations for the Discovery of Selective GPER Ligands.

Rosano C, Ponassi M, Santolla MF, Pisano A, Felli L, Vivacqua A, Maggiolini M, Lappano R.

AAPS J. 2016 Jan;18(1):41-6. doi: 10.1208/s12248-015-9844-3. Epub 2015 Nov 16. Review.


Thoracic endovascular repair first for extensive aortic disease: the staged hybrid approach†.

Vivacqua A, Idrees JJ, Johnston DR, Soltesz EG, Svensson LG, Roselli EE.

Eur J Cardiothorac Surg. 2016 Mar;49(3):764-9. doi: 10.1093/ejcts/ezv274. Epub 2015 Aug 13.


SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer.

Santolla MF, Avino S, Pellegrino M, De Francesco EM, De Marco P, Lappano R, Vivacqua A, Cirillo F, Rigiracciolo DC, Scarpelli A, Abonante S, Maggiolini M.

Cell Death Dis. 2015 Jul 30;6:e1834. doi: 10.1038/cddis.2015.201.


Estrogenic gper signaling regulates mir144 expression in cancer cells and cancer-associated fibroblasts (cafs).

Vivacqua A, De Marco P, Santolla MF, Cirillo F, Pellegrino M, Panno ML, Abonante S, Maggiolini M.

Oncotarget. 2015 Jun 30;6(18):16573-87.


Novel Aspects Concerning the Functional Cross-Talk between the Insulin/IGF-I System and Estrogen Signaling in Cancer Cells.

De Marco P, Cirillo F, Vivacqua A, Malaguarnera R, Belfiore A, Maggiolini M.

Front Endocrinol (Lausanne). 2015 Mar 6;6:30. doi: 10.3389/fendo.2015.00030. eCollection 2015. Review.


Lymphoma of prosthetic aortic graft presenting as recurrent embolization.

Vivacqua A, Kerwin KJ, Tubbs R, Roselli EE.

Ann Thorac Surg. 2015 Jan;99(1):306-7. doi: 10.1016/j.athoracsur.2013.12.089.


Isolated anomalous retroaortic left brachiocephalic vein in an adult organ donor.

Hussain ST, Vivacqua A, Keshavamurthy S, Soltesz EG.

Ann Thorac Surg. 2014 Sep;98(3):1115. doi: 10.1016/j.athoracsur.2014.05.017. No abstract available.


GPER1 is regulated by insulin in cancer cells and cancer-associated fibroblasts.

De Marco P, Romeo E, Vivacqua A, Malaguarnera R, Abonante S, Romeo F, Pezzi V, Belfiore A, Maggiolini M.

Endocr Relat Cancer. 2014 Oct;21(5):739-53. doi: 10.1530/ERC-14-0245. Epub 2014 Jul 10.


Long-term durability of bicuspid aortic valve repair.

Svensson LG, Al Kindi AH, Vivacqua A, Pettersson GB, Gillinov AM, Mihaljevic T, Roselli EE, Sabik JF 3rd, Griffin B, Hammer DF, Rodriguez L, Williams SJ, Blackstone EH, Lytle BW.

Ann Thorac Surg. 2014 May;97(5):1539-47; discussion 1548. doi: 10.1016/j.athoracsur.2013.11.036. Epub 2014 Mar 27.


Multibranched Frozen Elephant Trunk with Left Subclavian Artery Cannulation.

Martinelli GL, Vivacqua A, Braccio M, Cotroneo A, Greco P, Cassese M.

Aorta (Stamford). 2014 Apr 1;2(2):87-90. doi: 10.12945/j.aorta.2014.13-057. eCollection 2014 Apr.


Process improvement in cardiac surgery: development and implementation of a reoperation for bleeding checklist.

Loor G, Vivacqua A, Sabik JF 3rd, Li L, Hixson ED, Blackstone EH, Koch CG.

J Thorac Cardiovasc Surg. 2013 Nov;146(5):1028-32. doi: 10.1016/j.jtcvs.2013.05.043. Epub 2013 Jul 18.


The nuclear localization signal is required for nuclear GPER translocation and function in breast Cancer-Associated Fibroblasts (CAFs).

Pupo M, Vivacqua A, Perrotta I, Pisano A, Aquila S, Abonante S, Gasperi-Campani A, Pezzi V, Maggiolini M.

Mol Cell Endocrinol. 2013 Aug 25;376(1-2):23-32. doi: 10.1016/j.mce.2013.05.023. Epub 2013 Jun 5.


In vitro mechanism for downregulation of ER-α expression by epigallocatechin gallate in ER+/PR+ human breast cancer cells.

De Amicis F, Russo A, Avena P, Santoro M, Vivacqua A, Bonofiglio D, Mauro L, Aquila S, Tramontano D, Fuqua SA, Andò S.

Mol Nutr Food Res. 2013 May;57(5):840-53. doi: 10.1002/mnfr.201200560. Epub 2013 Jan 16.


Midterm results of David reimplantation in patients with connective tissue disorder.

Svensson LG, Blackstone EH, Alsalihi M, Batizy LH, Roselli EE, McCullough R, Vivacqua A, Moran RT, Gillinov AM, Thamilarasan M, Griffin B, Hammer DF, Stewart WJ, Sabik JF 3rd, Lytle BW.

Ann Thorac Surg. 2013 Feb;95(2):555-62. doi: 10.1016/j.athoracsur.2012.08.043. Epub 2012 Dec 31.


G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17β-estradiol in cancer cells and cancer-associated fibroblasts.

Santolla MF, Lappano R, De Marco P, Pupo M, Vivacqua A, Sisci D, Abonante S, Iacopetta D, Cappello AR, Dolce V, Maggiolini M.

J Biol Chem. 2012 Dec 21;287(52):43234-45. doi: 10.1074/jbc.M112.417303. Epub 2012 Nov 7.


Bergapten induces ER depletion in breast cancer cells through SMAD4-mediated ubiquitination.

Panno ML, Giordano F, Rizza P, Pellegrino M, Zito D, Giordano C, Mauro L, Catalano S, Aquila S, Sisci D, De Amicis F, Vivacqua A, Fuqua SW, Andò S.

Breast Cancer Res Treat. 2012 Nov;136(2):443-55. doi: 10.1007/s10549-012-2282-3. Epub 2012 Oct 9.


Surgical management of right aortic arch with tailored surgical approach.

Albacker TB, Roselli EE, Pettersson GB, Vivacqua A, Keshavamurthy S, Smedira NG, Lytle BW, Clair DG, Svensson LG.

J Card Surg. 2012 Jul;27(4):511-7. doi: 10.1111/j.1540-8191.2012.01488.x.


Insulin-like growth factor-I regulates GPER expression and function in cancer cells.

De Marco P, Bartella V, Vivacqua A, Lappano R, Santolla MF, Morcavallo A, Pezzi V, Belfiore A, Maggiolini M.

Oncogene. 2013 Feb 7;32(6):678-88. doi: 10.1038/onc.2012.97. Epub 2012 Mar 19.


Total arch replacement after a failed repair for Takayasu's ascending aortitis.

Shafii AE, Vivacqua A, Albacker TB, Sheih C, Svensson LG.

Ann Thorac Surg. 2012 Jan;93(1):300-2. doi: 10.1016/j.athoracsur.2011.06.064.


GPER mediates the Egr-1 expression induced by 17β-estradiol and 4-hydroxitamoxifen in breast and endometrial cancer cells.

Vivacqua A, Romeo E, De Marco P, De Francesco EM, Abonante S, Maggiolini M.

Breast Cancer Res Treat. 2012 Jun;133(3):1025-35. doi: 10.1007/s10549-011-1901-8. Epub 2011 Dec 7.


Hybrid thoracoabdominal aneurysm repair with antegrade visceral debranching from the ascending aorta: concomitant cardiac surgery and stent-grafting.

Vivacqua A, Albacker TB, Roselli EE.

Ann Thorac Surg. 2011 Dec;92(6):2275-7. doi: 10.1016/j.athoracsur.2011.06.018.


Resveratrol, through NF-Y/p53/Sin3/HDAC1 complex phosphorylation, inhibits estrogen receptor alpha gene expression via p38MAPK/CK2 signaling in human breast cancer cells.

De Amicis F, Giordano F, Vivacqua A, Pellegrino M, Panno ML, Tramontano D, Fuqua SA, Andò S.

FASEB J. 2011 Oct;25(10):3695-707. doi: 10.1096/fj.10-178871. Epub 2011 Jul 7.


Morbidity of bleeding after cardiac surgery: is it blood transfusion, reoperation for bleeding, or both?

Vivacqua A, Koch CG, Yousuf AM, Nowicki ER, Houghtaling PL, Blackstone EH, Sabik JF 3rd.

Ann Thorac Surg. 2011 Jun;91(6):1780-90. doi: 10.1016/j.athoracsur.2011.03.105.


The G protein-coupled receptor 30 is up-regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) in breast cancer cells and cardiomyocytes.

Recchia AG, De Francesco EM, Vivacqua A, Sisci D, Panno ML, Andò S, Maggiolini M.

J Biol Chem. 2011 Mar 25;286(12):10773-82. doi: 10.1074/jbc.M110.172247. Epub 2011 Jan 25.


Parachute-like asymmetric mitral valve associated with mitral valve cleft and atrial septal defect in an adult.

Mamaladze V, Capdeville M, Navia J, Vivacqua A.

J Cardiothorac Vasc Anesth. 2011 Dec;25(6):1106-8. doi: 10.1053/j.jvca.2010.09.015. Epub 2010 Nov 19. No abstract available.


Images in cardiology. Ventricular outflow tract papillary fibroelastoma presenting with non-ST-segment elevation myocardial infarction.

Vivacqua A, Shafii A, Kalahasti V, Tan C, Gonzalez-Stawinski G.

J Am Coll Cardiol. 2010 Jun 8;55(23):2607. doi: 10.1016/j.jacc.2009.07.080. No abstract available.


G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells.

Vivacqua A, Lappano R, De Marco P, Sisci D, Aquila S, De Amicis F, Fuqua SA, Andò S, Maggiolini M.

Mol Endocrinol. 2009 Nov;23(11):1815-26. doi: 10.1210/me.2009-0120. Epub 2009 Sep 11.


E-cadherin mediates the aggregation of breast cancer cells induced by tamoxifen and epidermal growth factor.

Mauro L, Pellegrino M, Lappano R, Vivacqua A, Giordano F, Palma MG, Andò S, Maggiolini M.

Breast Cancer Res Treat. 2010 May;121(1):79-89. doi: 10.1007/s10549-009-0456-4. Epub 2009 Jul 11.


Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells.

Albanito L, Sisci D, Aquila S, Brunelli E, Vivacqua A, Madeo A, Lappano R, Pandey DP, Picard D, Mauro L, Andò S, Maggiolini M.

Endocrinology. 2008 Aug;149(8):3799-808. doi: 10.1210/en.2008-0117. Epub 2008 May 8.


G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells.

Albanito L, Madeo A, Lappano R, Vivacqua A, Rago V, Carpino A, Oprea TI, Prossnitz ER, Musti AM, Andò S, Maggiolini M.

Cancer Res. 2007 Feb 15;67(4):1859-66.


17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30.

Vivacqua A, Bonofiglio D, Albanito L, Madeo A, Rago V, Carpino A, Musti AM, Picard D, Andò S, Maggiolini M.

Mol Pharmacol. 2006 Oct;70(4):1414-23. Epub 2006 Jul 11.


The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells.

Vivacqua A, Bonofiglio D, Recchia AG, Musti AM, Picard D, Andò S, Maggiolini M.

Mol Endocrinol. 2006 Mar;20(3):631-46. Epub 2005 Oct 20.


The red wine phenolics piceatannol and myricetin act as agonists for estrogen receptor alpha in human breast cancer cells.

Maggiolini M, Recchia AG, Bonofiglio D, Catalano S, Vivacqua A, Carpino A, Rago V, Rossi R, Andò S.

J Mol Endocrinol. 2005 Oct;35(2):269-81.


Differential expression of estrogen receptors (ERalpha/ERbeta) in testis of mature and immature pigs.

Rago V, Maggiolini M, Vivacqua A, Palma A, Carpino A.

Anat Rec A Discov Mol Cell Evol Biol. 2004 Dec;281(2):1234-9.

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