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Items: 10


Inhibiting the copper efflux system in microbes as a novel approach for developing antibiotics.

Meir A, Lepechkin-Zilbermintz V, Kahremany S, Schwerdtfeger F, Gevorkyan-Airapetov L, Munder A, Viskind O, Gruzman A, Ruthstein S.

PLoS One. 2019 Dec 30;14(12):e0227070. doi: 10.1371/journal.pone.0227070. eCollection 2019.


Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells' proliferation and functions.

Munder A, Moskovitz Y, Meir A, Kahremany S, Levy L, Kolitz-Domb M, Cohen G, Shtriker E, Viskind O, Lellouche JP, Senderowitz H, Chessler SD, Korshin EE, Ruthstein S, Gruzman A.

Medchemcomm. 2018 Dec 13;10(2):280-293. doi: 10.1039/c8md00419f. eCollection 2019 Feb 1.


Mimicking Neuroligin-2 Functions in β-Cells by Functionalized Nanoparticles as a Novel Approach for Antidiabetic Therapy.

Munder A, Israel LL, Kahremany S, Ben-Shabat-Binyamini R, Zhang C, Kolitz-Domb M, Viskind O, Levine A, Senderowitz H, Chessler S, Lellouche JP, Gruzman A.

ACS Appl Mater Interfaces. 2017 Jan 18;9(2):1189-1206. doi: 10.1021/acsami.6b10568. Epub 2017 Jan 3.


Design and synthesis of novel protein kinase R (PKR) inhibitors.

Weintraub S, Yarnitzky T, Kahremany S, Barrera I, Viskind O, Rosenblum K, Niv MY, Gruzman A.

Mol Divers. 2016 Nov;20(4):805-819. Epub 2016 Aug 1.


A chemical chaperone-based drug candidate is effective in a mouse model of amyotrophic lateral sclerosis (ALS).

Getter T, Zaks I, Barhum Y, Ben-Zur T, Böselt S, Gregoire S, Viskind O, Shani T, Gottlieb H, Green O, Shubely M, Senderowitz H, Israelson A, Kwon I, Petri S, Offen D, Gruzman A.

ChemMedChem. 2015 May;10(5):850-61. doi: 10.1002/cmdc.201500045. Epub 2015 Mar 13.


Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via AMPK activation.

Pasternak L, Meltzer-Mats E, Babai-Shani G, Cohen G, Viskind O, Eckel J, Cerasi E, Sasson S, Gruzman A.

Chem Commun (Camb). 2014 Oct 4;50(76):11222-5. doi: 10.1039/c4cc03310h.


Multifunctional cyclic D,L-α-peptide architectures stimulate non-insulin dependent glucose uptake in skeletal muscle cells and protect them against oxidative stress.

Shapira R, Rudnick S, Daniel B, Viskind O, Aisha V, Richman M, Ayasolla KR, Perelman A, Chill JH, Gruzman A, Rahimipour S.

J Med Chem. 2013 Sep 12;56(17):6709-18. doi: 10.1021/jm4005225. Epub 2013 Aug 28.


Riluzole increases the rate of glucose transport in L6 myotubes and NSC-34 motor neuron-like cells via AMPK pathway activation.

Daniel B, Green O, Viskind O, Gruzman A.

Amyotroph Lateral Scler Frontotemporal Degener. 2013 Sep;14(5-6):434-43. doi: 10.3109/21678421.2013.808226. Epub 2013 Jul 8.


Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives.

Meltzer-Mats E, Babai-Shani G, Pasternak L, Uritsky N, Getter T, Viskind O, Eckel J, Cerasi E, Senderowitz H, Sasson S, Gruzman A.

J Med Chem. 2013 Jul 11;56(13):5335-50. doi: 10.1021/jm4001488. Epub 2013 Jun 26.


Antihyperglycaemic activity of 2,4:3,5-dibenzylidene-D-xylose-diethyl dithioacetal in diabetic mice.

Gruzman A, Elgart A, Viskind O, Billauer H, Dotan S, Cohen G, Mishani E, Hoffman A, Cerasi E, Sasson S.

J Cell Mol Med. 2012 Mar;16(3):594-604. doi: 10.1111/j.1582-4934.2011.01340.x.

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