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Items: 1 to 50 of 291

1.

CSF Gusher and Its Management in Cochlear Implant Patient with Enlarged Vestibular Aqueduct.

Chauhan VM, Vishwakarma R.

Indian J Otolaryngol Head Neck Surg. 2019 Sep;71(3):315-319. doi: 10.1007/s12070-019-01696-w. Epub 2019 Jun 29.

PMID:
31559197
2.

Corrigendum to "Design, synthesis and biological evaluation of pyrazolopyrimidinone based potent and selective PDE5 inhibitors for treatment of erectile dysfunction" [Bioorg. Chem. 89 (2019) 103022].

Reddy GL, Dar MI, Hudwekar AD, Mahajan P, Nargotra A, Baba AM, Nandi U, Wazir P, Singh G, Bharate SS, Vishwakarma RA, Syed SH, Sawant SD.

Bioorg Chem. 2019 Sep 13;92:103257. doi: 10.1016/j.bioorg.2019.103257. [Epub ahead of print] No abstract available.

PMID:
31525521
3.

Binary and ternary solid dispersions of an anticancer preclinical lead, IIIM-290: In vitro and in vivo studies.

Kumar V, Mintoo MJ, Mondhe DM, Bharate SB, Vishwakarma RA, Bharate SS.

Int J Pharm. 2019 Oct 30;570:118683. doi: 10.1016/j.ijpharm.2019.118683. Epub 2019 Sep 9.

PMID:
31513869
4.

Direct Synthesis of Large-Area Graphene on Insulating Substrates at Low Temperature using Microwave Plasma CVD.

Vishwakarma R, Zhu R, Abuelwafa AA, Mabuchi Y, Adhikari S, Ichimura S, Soga T, Umeno M.

ACS Omega. 2019 Jun 28;4(6):11263-11270. doi: 10.1021/acsomega.9b00988. eCollection 2019 Jun 30.

5.

Preclinical Development of Crocus sativus-Based Botanical Lead IIIM-141 for Alzheimer's Disease: Chemical Standardization, Efficacy, Formulation Development, Pharmacokinetics, and Safety Pharmacology.

Bharate SS, Kumar V, Singh G, Singh A, Gupta M, Singh D, Kumar A, Vishwakarma RA, Bharate SB.

ACS Omega. 2018 Aug 20;3(8):9572-9585. doi: 10.1021/acsomega.8b00841. eCollection 2018 Aug 31.

6.

Glycyrrhizic Acid Prevents Oxidative Stress Mediated DNA Damage Response through Modulation of Autophagy in Ultraviolet-B-Irradiated Human Primary Dermal Fibroblasts.

Umar SA, Tanveer MA, Nazir LA, Divya G, Vishwakarma RA, Tasduq SA.

Cell Physiol Biochem. 2019;53(1):242-257. doi: 10.33594/000000133.

7.

Preclinical development of gastro-protective botanical candidate from Woodfordia fruticosa (Linn.) Kurz: Chemical standardization, efficacy, pharmacokinetics and safety pharmacology.

Khan IA, Singh A, Mindala DP, Meena S, Vij B, Yadav AK, Roy S, Nandi U, Katare AK, Jaglan S, Singh D, Gupta AP, Gupta P, Singh S, Tikko MK, Singh G, Vishwakarma RA.

J Ethnopharmacol. 2019 Sep 15;241:112023. doi: 10.1016/j.jep.2019.112023. Epub 2019 Jun 11.

PMID:
31195031
8.

Design, synthesis and biological evaluation of pyrazolopyrimidinone based potent and selective PDE5 inhibitors for treatment of erectile dysfunction.

Reddy GL, Dar MI, Hudwekar AD, Mahajan P, Nargotra A, Baba AM, Nandi U, Wazir P, Singh G, Vishwakarma RA, Syed SH, Sawant SD.

Bioorg Chem. 2019 Aug;89:103022. doi: 10.1016/j.bioorg.2019.103022. Epub 2019 May 31. Erratum in: Bioorg Chem. 2019 Sep 13;92:103257.

PMID:
31181491
9.

Transformation of Santonin to a Naproxen Analogue with Anti-Inflammatory Activity.

Singh R, Mandrah K, Asati A, Patel DK, Goel B, Vishwakarma RA, Roy SK, Jain SK.

J Nat Prod. 2019 Jun 28;82(6):1710-1713. doi: 10.1021/acs.jnatprod.8b00318. Epub 2019 May 24.

PMID:
31125226
10.

Trichoderma lixii (IIIM-B4), an endophyte of Bacopa monnieri L. producing peptaibols.

Katoch M, Singh D, Kapoor KK, Vishwakarma RA.

BMC Microbiol. 2019 May 16;19(1):98. doi: 10.1186/s12866-019-1477-8.

11.

Molecular classification of colorectal cancer using the gene expression profile of tumor samples.

Rashid M, Vishwakarma RK, Deeb AM, Hussein MA, Aziz MA.

Exp Biol Med (Maywood). 2019 Sep;244(12):1005-1016. doi: 10.1177/1535370219850788. Epub 2019 May 15. No abstract available.

PMID:
31091989
12.

Isolation of depsipeptides and optimization for enhanced production of valinomycin from the North-Western Himalayan cold desert strain Streptomyces lavendulae.

Singh VP, Sharma R, Sharma V, Raina C, Kapoor KK, Kumar A, Chaubey A, Singh D, Vishwakarma RA.

J Antibiot (Tokyo). 2019 Aug;72(8):617-624. doi: 10.1038/s41429-019-0183-y. Epub 2019 May 9.

PMID:
31073236
13.

Discovery and preclinical development of IIIM-160, a Bergenia ciliata-based anti-inflammatory and anti-arthritic botanical drug candidate.

Bharate SB, Kumar V, Bharate SS, Singh B, Singh G, Singh A, Gupta M, Singh D, Kumar A, Singh S, Vishwakarma RA.

J Integr Med. 2019 May;17(3):192-204. doi: 10.1016/j.joim.2019.03.001. Epub 2019 Mar 6.

PMID:
30898582
14.

Discovery of Quinazolin-4(3 H)-ones as NLRP3 Inflammasome Inhibitors: Computational Design, Metal-Free Synthesis, and in Vitro Biological Evaluation.

Abdullaha M, Mohammed S, Ali M, Kumar A, Vishwakarma RA, Bharate SB.

J Org Chem. 2019 May 3;84(9):5129-5140. doi: 10.1021/acs.joc.9b00138. Epub 2019 Apr 2.

PMID:
30896160
15.

Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway.

Wani A, Gupta M, Ahmad M, Shah AM, Ahsan AU, Qazi PH, Malik F, Singh G, Sharma PR, Kaddoumi A, Bharate SB, Vishwakarma RA, Kumar A.

Autophagy. 2019 Oct;15(10):1810-1828. doi: 10.1080/15548627.2019.1596476. Epub 2019 Apr 2.

PMID:
30894052
16.

Introducing Oxo-Phenylacetyl (OPAc) as a Protecting Group for Carbohydrates.

Kumar A, Gannedi V, Rather SA, Vishwakarma RA, Ahmed QN.

J Org Chem. 2019 Apr 5;84(7):4131-4148. doi: 10.1021/acs.joc.9b00126. Epub 2019 Mar 28.

PMID:
30888192
17.

Analyzing the role of cannabinoids as modulators of Wnt/β-catenin signaling pathway for their use in the management of neuropathic pain.

Nalli Y, Dar MS, Bano N, Rasool JU, Sarkar AR, Banday J, Bhat AQ, Rafia B, Vishwakarma RA, Dar MJ, Ali A.

Bioorg Med Chem Lett. 2019 May 1;29(9):1043-1046. doi: 10.1016/j.bmcl.2019.03.013. Epub 2019 Mar 11.

PMID:
30871771
18.

Rohitukine inhibits NF-κB activation induced by LPS and other inflammatory agents.

Singh A, Chibber P, Kolimi P, Malik TA, Kapoor N, Kumar A, Kumar N, Gandhi SG, Singh S, Abdullah ST, Vishwakarma R, Singh G.

Int Immunopharmacol. 2019 Apr;69:34-49. doi: 10.1016/j.intimp.2019.01.015. Epub 2019 Jan 18.

PMID:
30665042
19.

Influence of nutrient formulations on growth, lipid yield, carbon partitioning and biodiesel quality potential of Botryococcus sp. and Chlorella sp.

Vishwakarma R, Dhar DW, Saxena S.

Environ Sci Pollut Res Int. 2019 Mar;26(8):7589-7600. doi: 10.1007/s11356-019-04213-2. Epub 2019 Jan 19.

PMID:
30659489
20.

Impurity profiling of anticancer preclinical candidate, IIIM-290.

Kumar V, Bhurta D, Sharma A, Kumar P, Bharate SB, Vishwakarma RA, Bharate SS.

J Pharm Biomed Anal. 2019 Mar 20;166:1-5. doi: 10.1016/j.jpba.2018.12.027. Epub 2018 Dec 18.

PMID:
30590350
21.

Cochlear Implant Device Failure in the Postoperative Period: An Institutional Analysis.

Bhadania SR, Vishwakarma R, Keshri A.

Asian J Neurosurg. 2018 Oct-Dec;13(4):1066-1070. doi: 10.4103/ajns.AJNS_93_17.

22.

Orally Effective Aminoalkyl 10H-Indolo[3,2-b]quinoline-11-carboxamide Kills the Malaria Parasite by Inhibiting Host Hemoglobin Uptake.

Mudududdla R, Mohanakrishnan D, Bharate SS, Vishwakarma RA, Sahal D, Bharate SB.

ChemMedChem. 2018 Dec 6;13(23):2581-2598. doi: 10.1002/cmdc.201800579. Epub 2018 Nov 13.

PMID:
30358112
23.

Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells.

Thottacherry JJ, Kosmalska AJ, Kumar A, Vishen AS, Elosegui-Artola A, Pradhan S, Sharma S, Singh PP, Guadamillas MC, Chaudhary N, Vishwakarma R, Trepat X, Del Pozo MA, Parton RG, Rao M, Pullarkat P, Roca-Cusachs P, Mayor S.

Nat Commun. 2018 Oct 11;9(1):4217. doi: 10.1038/s41467-018-06738-5.

24.

Enhanced activity of Withania somnifera family-1 glycosyltransferase (UGT73A16) via mutagenesis.

Singh S, Patel KA, Sonawane PD, Vishwakarma RK, Khan BM.

World J Microbiol Biotechnol. 2018 Sep 25;34(10):150. doi: 10.1007/s11274-018-2534-4.

PMID:
30255239
25.

Room Temperature Metal-Catalyzed Oxidative Acylation of Electron-Deficient Heteroarenes with Alkynes, Its Mechanism, and Application Studies.

Sharma S, Kumar M, Vishwakarma RA, Verma MK, Singh PP.

J Org Chem. 2018 Oct 19;83(20):12420-12431. doi: 10.1021/acs.joc.8b01475. Epub 2018 Oct 9.

PMID:
30238752
26.

Soluble Aβ1-42 suppresses TNF-α and activates NLRP3 inflammasome in THP-1 macrophages.

Gupta M, Wani A, Ul Ahsan A, Chopra M, Vishwakarma RA, Singh G, Kumar A.

Cytokine. 2018 Nov;111:84-87. doi: 10.1016/j.cyto.2018.07.026. Epub 2018 Aug 17.

PMID:
30125779
27.

RbpA relaxes promoter selectivity of M. tuberculosis RNA polymerase.

Sudalaiyadum Perumal A, Vishwakarma RK, Hu Y, Morichaud Z, Brodolin K.

Nucleic Acids Res. 2018 Nov 2;46(19):10106-10118. doi: 10.1093/nar/gky714.

28.

Selection of a Water-Soluble Salt Form of a Preclinical Candidate, IIIM-290: Multiwell-Plate Salt Screening and Characterization.

Kumar V, Bharate SB, Vishwakarma RA, Bharate SS.

ACS Omega. 2018 Jul 31;3(7):8365-8377. doi: 10.1021/acsomega.8b00801. Epub 2018 Jul 27.

29.

Plasma Helicobacter pylori Antibody Titers and Helicobacter pylori Infection Positivity Rates in Patients with Gallbladder Cancer or Cholelithiasis: a Hospital-Based Case-Control Study

Tsuchiya Y, Mishra K, Kapoor VK, Vishwakarma R, Behari A, Ikoma T, Asai T, Endoh K, Nakamura K.

Asian Pac J Cancer Prev. 2018 Jul 27;19(7):1911-1915.

30.

Why Are the Majority of Active Compounds in the CNS Domain Natural Products? A Critical Analysis.

Bharate SS, Mignani S, Vishwakarma RA.

J Med Chem. 2018 Dec 13;61(23):10345-10374. doi: 10.1021/acs.jmedchem.7b01922. Epub 2018 Jul 20. Review.

PMID:
29989814
31.

Single-molecule analysis reveals the mechanism of transcription activation in M. tuberculosis.

Vishwakarma RK, Cao AM, Morichaud Z, Perumal AS, Margeat E, Brodolin K.

Sci Adv. 2018 May 23;4(5):eaao5498. doi: 10.1126/sciadv.aao5498. eCollection 2018 May.

32.

Formulation of a minimal nutritional medium for enhanced lipid productivity in Chlorella sp. and Botryococcus sp. using response surface methodology.

Vishwakarma R, Dhar DW, Pabbi S.

Water Sci Technol. 2018 Mar;77(5-6):1660-1672. doi: 10.2166/wst.2018.044.

PMID:
29595168
33.

Porostereum sp., Associated with Saffron (Crocus sativus L.), is a Latent Pathogen Capable of Producing Phytotoxic Chlorinated Aromatic Compounds.

Wani ZA, Ahmad T, Nalli Y, Ali A, Singh AP, Vishwakarma RA, Ashraf N, Riyaz-Ul-Hassan S.

Curr Microbiol. 2018 Jul;75(7):880-887. doi: 10.1007/s00284-018-1461-9. Epub 2018 Feb 28.

PMID:
29492649
34.

Design and synthesis of 1,4-substituted 1H-1,2,3-triazolo-quinazolin-4(3H)-ones by Huisgen 1,3-dipolar cycloaddition with PI3Kγ isoform selective activity.

Srinivas M, Singh Pathania A, Mahajan P, Verma PK, Chobe SS, Malik FA, Nargotra A, Vishwakarma RA, Sawant SD.

Bioorg Med Chem Lett. 2018 Apr 1;28(6):1005-1010. doi: 10.1016/j.bmcl.2018.02.032. Epub 2018 Feb 16.

PMID:
29486969
35.

Lipovelutibols A-D: Cytotoxic Lipopeptaibols from the Himalayan Cold Habitat Fungus Trichoderma velutinum.

Singh VP, Yedukondalu N, Sharma V, Kushwaha M, Sharma R, Chaubey A, Kumar A, Singh D, Vishwakarma RA.

J Nat Prod. 2018 Feb 23;81(2):219-226. doi: 10.1021/acs.jnatprod.6b00873. Epub 2018 Jan 26.

PMID:
29373791
36.

Corrigendum: Mannitol Stress Directs Flavonoid Metabolism toward Synthesis of Flavones via Differential Regulation of Two Cytochrome P450 Monooxygenases in Coleus forskohlii.

Awasthi P, Gupta AP, Bedi YS, Vishwakarma RA, Gandhi SG.

Front Plant Sci. 2018 Jan 8;8:2222. doi: 10.3389/fpls.2017.02222. eCollection 2017.

37.

Discovery and Preclinical Development of IIIM-290, an Orally Active Potent Cyclin-Dependent Kinase Inhibitor.

Bharate SB, Kumar V, Jain SK, Mintoo MJ, Guru SK, Nuthakki VK, Sharma M, Bharate SS, Gandhi SG, Mondhe DM, Bhushan S, Vishwakarma RA.

J Med Chem. 2018 Feb 22;61(4):1664-1687. doi: 10.1021/acs.jmedchem.7b01765. Epub 2018 Feb 6.

PMID:
29370702
38.

Exploitation of microbial antagonists for the control of postharvest diseases of fruits: a review.

Dukare AS, Paul S, Nambi VE, Gupta RK, Singh R, Sharma K, Vishwakarma RK.

Crit Rev Food Sci Nutr. 2019;59(9):1498-1513. doi: 10.1080/10408398.2017.1417235. Epub 2018 Jan 16.

PMID:
29336595
39.

Present drug-likeness filters in medicinal chemistry during the hit and lead optimization process: how far can they be simplified?

Mignani S, Rodrigues J, Tomas H, Jalal R, Singh PP, Majoral JP, Vishwakarma RA.

Drug Discov Today. 2018 Mar;23(3):605-615. doi: 10.1016/j.drudis.2018.01.010. Epub 2018 Jan 9. Review.

PMID:
29330127
40.

Establishment of LCMS Based Platform for Discovery of Quorum Sensing Inhibitors: Signal Detection in Pseudomonas aeruginosa PAO1.

Kushwaha M, Jain SK, Sharma N, Abrol V, Jaglan S, Vishwakarma RA.

ACS Chem Biol. 2018 Mar 16;13(3):657-665. doi: 10.1021/acschembio.7b00875. Epub 2018 Jan 18.

PMID:
29303546
41.

Determination of ZSTK474, a novel Pan PI3K inhibitor in mouse plasma by LC-MS/MS and its application to Pharmacokinetics.

Singh A, Thatikonda T, Kumar A, Wazir P, V V, Nandi U, Singh PP, Singh S, Gupta AP, Tikoo MK, Singh G, Vishwakarma R.

J Pharm Biomed Anal. 2018 Feb 5;149:387-393. doi: 10.1016/j.jpba.2017.11.031. Epub 2017 Nov 11.

PMID:
29175554
42.

Physicochemical, pharmacokinetic, efficacy and toxicity profiling of a potential nitrofuranyl methyl piperazine derivative IIIM-MCD-211 for oral tuberculosis therapy via in-silico-in-vitro-in-vivo approach.

Magotra A, Sharma A, Singh S, Ojha PK, Kumar S, Bokolia N, Wazir P, Sharma S, Khan IA, Singh PP, Vishwakarma RA, Singh G, Nandi U.

Pulm Pharmacol Ther. 2018 Feb;48:151-160. doi: 10.1016/j.pupt.2017.11.006. Epub 2017 Nov 21.

PMID:
29174840
43.

Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme.

Sharma R, Gatchie L, Williams IS, Jain SK, Vishwakarma RA, Chaudhuri B, Bharate SB.

Bioorg Med Chem Lett. 2017 Dec 15;27(24):5400-5403. doi: 10.1016/j.bmcl.2017.11.013. Epub 2017 Nov 7.

PMID:
29150398
44.

Design of Novel 3-Pyrimidinylazaindole CDK2/9 Inhibitors with Potent In Vitro and In Vivo Antitumor Efficacy in a Triple-Negative Breast Cancer Model.

Singh U, Chashoo G, Khan SU, Mahajan P, Nargotra A, Mahajan G, Singh A, Sharma A, Mintoo MJ, Guru SK, Aruri H, Thatikonda T, Sahu P, Chibber P, Kumar V, Mir SA, Bharate SS, Madishetti S, Nandi U, Singh G, Mondhe DM, Bhushan S, Malik F, Mignani S, Vishwakarma RA, Singh PP.

J Med Chem. 2017 Dec 14;60(23):9470-9489. doi: 10.1021/acs.jmedchem.7b00663. Epub 2017 Dec 5.

PMID:
29144137
45.

A new clerodane furano diterpene glycoside from Tinospora cordifolia triggers autophagy and apoptosis in HCT-116 colon cancer cells.

Sharma N, Kumar A, Sharma PR, Qayum A, Singh SK, Dutt P, Paul S, Gupta V, Verma MK, Satti NK, Vishwakarma R.

J Ethnopharmacol. 2018 Jan 30;211:295-310. doi: 10.1016/j.jep.2017.09.034. Epub 2017 Sep 27.

PMID:
28962889
46.

Synthesis, pH dependent, plasma and enzymatic stability of bergenin prodrugs for potential use against rheumatoid arthritis.

Singh R, Kumar V, Bharate SS, Vishwakarma RA.

Bioorg Med Chem. 2017 Oct 15;25(20):5513-5521. doi: 10.1016/j.bmc.2017.08.011. Epub 2017 Aug 10.

PMID:
28843845
47.

Biotransformation of Chrysin to Baicalein: Selective C6-Hydroxylation of 5,7-Dihydroxyflavone Using Whole Yeast Cells Stably Expressing Human CYP1A1 Enzyme.

Williams IS, Chib S, Nuthakki VK, Gatchie L, Joshi P, Narkhede NA, Vishwakarma RA, Bharate SB, Saran S, Chaudhuri B.

J Agric Food Chem. 2017 Aug 30;65(34):7440-7446. doi: 10.1021/acs.jafc.7b02690. Epub 2017 Aug 15.

PMID:
28782952
48.

Intensified oxalic acid crystallization using ultrasonic reactors: Understanding effect of operating parameters and type of ultrasonic reactor.

Vishwakarma RS, Gogate PR.

Ultrason Sonochem. 2017 Nov;39:111-119. doi: 10.1016/j.ultsonch.2017.04.015. Epub 2017 Apr 12.

PMID:
28732926
49.

Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance.

Williams IS, Joshi P, Gatchie L, Sharma M, Satti NK, Vishwakarma RA, Chaudhuri B, Bharate SB.

Bioorg Med Chem Lett. 2017 Aug 15;27(16):3683-3687. doi: 10.1016/j.bmcl.2017.07.010. Epub 2017 Jul 4.

PMID:
28711350
50.

Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.

Joshi P, Vishwakarma RA, Bharate SB.

Eur J Med Chem. 2017 Sep 29;138:273-292. doi: 10.1016/j.ejmech.2017.06.047. Epub 2017 Jun 27. Review.

PMID:
28675836

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