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Items: 4

1.

Hyperactivation of Oncogenic JAK3 Mutants Depend on ATP Binding to the Pseudokinase Domain.

Raivola J, Hammarén HM, Virtanen AT, Bulleeraz V, Ward AC, Silvennoinen O.

Front Oncol. 2018 Dec 3;8:560. doi: 10.3389/fonc.2018.00560. eCollection 2018.

2.

Janus kinase 2 activation mechanisms revealed by analysis of suppressing mutations.

Hammarén HM, Virtanen AT, Abraham BG, Peussa H, Hubbard SR, Silvennoinen O.

J Allergy Clin Immunol. 2019 Apr;143(4):1549-1559.e6. doi: 10.1016/j.jaci.2018.07.022. Epub 2018 Aug 6.

PMID:
30092288
3.

The regulation of JAKs in cytokine signaling and its breakdown in disease.

Hammarén HM, Virtanen AT, Raivola J, Silvennoinen O.

Cytokine. 2019 Jun;118:48-63. doi: 10.1016/j.cyto.2018.03.041. Epub 2018 May 21. Review.

4.

Nucleotide-binding mechanisms in pseudokinases.

Hammarén HM, Virtanen AT, Silvennoinen O.

Biosci Rep. 2015 Nov 20;36(1):e00282. doi: 10.1042/BSR20150226. Review.

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