Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 119

1.

Bone loss from Wnt inhibition mitigated by concurrent alendronate therapy.

Madan B, McDonald MJ, Foxa GE, Diegel CR, Williams BO, Virshup DM.

Bone Res. 2018 May 25;6:17. doi: 10.1038/s41413-018-0017-8. eCollection 2018.

2.

CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch.

Narasimamurthy R, Hunt SR, Lu Y, Fustin JM, Okamura H, Partch CL, Forger DB, Kim JK, Virshup DM.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):5986-5991. doi: 10.1073/pnas.1721076115. Epub 2018 May 21.

3.

PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo.

Greicius G, Kabiri Z, Sigmundsson K, Liang C, Bunte R, Singh MK, Virshup DM.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):E3173-E3181. doi: 10.1073/pnas.1713510115. Epub 2018 Mar 20.

4.

Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis.

Lee HY, Itahana Y, Schuechner S, Fukuda M, Je HS, Ogris E, Virshup DM, Itahana K.

Sci Signal. 2018 Jan 9;11(512). pii: eaam7893. doi: 10.1126/scisignal.aam7893.

PMID:
29317521
5.

Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis.

Zhang F, Virshup DM, Cheong JK.

Oncogene. 2018 Jan 18;37(3):363-376. doi: 10.1038/onc.2017.334. Epub 2017 Sep 25.

6.

Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors.

Ho SY, Alam J, Jeyaraj DA, Wang W, Lin GR, Ang SH, Tan ESW, Lee MA, Ke Z, Madan B, Virshup DM, Ding LJ, Manoharan V, Chew YS, Low CB, Pendharkar V, Sangthongpitag K, Hill J, Keller TH, Poulsen A.

J Med Chem. 2017 Aug 10;60(15):6678-6692. doi: 10.1021/acs.jmedchem.7b00662. Epub 2017 Jul 20.

PMID:
28671458
7.

Site-specific phosphorylation of casein kinase 1 δ (CK1δ) regulates its activity towards the circadian regulator PER2.

Eng GWL, Edison, Virshup DM.

PLoS One. 2017 May 17;12(5):e0177834. doi: 10.1371/journal.pone.0177834. eCollection 2017.

8.

A Flick of the Tail Keeps the Circadian Clock in Line.

Narasimamurthy R, Virshup DM.

Mol Cell. 2017 May 18;66(4):437-438. doi: 10.1016/j.molcel.2017.05.008.

9.

Molecular Mechanisms Regulating Temperature Compensation of the Circadian Clock.

Narasimamurthy R, Virshup DM.

Front Neurol. 2017 Apr 27;8:161. doi: 10.3389/fneur.2017.00161. eCollection 2017. Review.

10.

Wnt proteins synergize to activate β-catenin signaling.

Alok A, Lei Z, Jagannathan NS, Kaur S, Harmston N, Rozen SG, Tucker-Kellogg L, Virshup DM.

J Cell Sci. 2017 May 1;130(9):1532-1544. doi: 10.1242/jcs.198093. Epub 2017 Mar 13.

11.

CK1δ: a pharmacologically tractable Achilles' heel of Wnt-driven cancers?

Cheong JK, Virshup DM.

Ann Transl Med. 2016 Nov;4(21):433.

12.

Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2.

Lim SK, Lu SY, Kang SA, Tan HJ, Li Z, Adrian Wee ZN, Guan JS, Reddy Chichili VP, Sivaraman J, Putti T, Thike AA, Tan PH, Sudol M, Virshup DM, Chan SW, Hong W, Lim YP.

Cancer Res. 2016 Nov 1;76(21):6278-6289. Epub 2016 Aug 30.

13.

Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization.

Wang J, Wang Z, Yu T, Yang H, Virshup DM, Kops GJ, Lee SH, Zhou W, Li X, Xu W, Rao Z.

Protein Cell. 2016 Jul;7(7):516-26. doi: 10.1007/s13238-016-0283-4. Epub 2016 Jun 28.

14.

Keeping autophagy in cheCK1.

Cheong JK, Virshup DM.

Mol Cell Oncol. 2015 May 26;3(3):e1045117. doi: 10.1080/23723556.2015.1045117. eCollection 2016 May.

15.

Distinct Responses of Stem Cells to Telomere Uncapping-A Potential Strategy to Improve the Safety of Cell Therapy.

Liu CC, Ma DL, Yan TD, Fan X, Poon Z, Poon LF, Goh SA, Rozen SG, Hwang WY, Tergaonkar V, Tan P, Ghosh S, Virshup DM, Goh EL, Li S.

Stem Cells. 2016 Oct;34(10):2471-2484. doi: 10.1002/stem.2431. Epub 2016 Jun 30.

16.

USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds.

Madan B, Walker MP, Young R, Quick L, Orgel KA, Ryan M, Gupta P, Henrich IC, Ferrer M, Marine S, Roberts BS, Arthur WT, Berndt JD, Oliveira AM, Moon RT, Virshup DM, Chou MM, Major MB.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2945-54. doi: 10.1073/pnas.1605691113. Epub 2016 May 9.

17.

Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis.

Madan B, Patel MB, Zhang J, Bunte RM, Rudemiller NP, Griffiths R, Virshup DM, Crowley SD.

Kidney Int. 2016 May;89(5):1062-1074. doi: 10.1016/j.kint.2016.01.017. Epub 2016 Mar 25.

18.

NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition.

Madan B, Ke Z, Lei ZD, Oliver FA, Oshima M, Lee MA, Rozen S, Virshup DM.

Oncotarget. 2016 Mar 15;7(11):12386-92. doi: 10.18632/oncotarget.7157.

19.

Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways.

Somarelli JA, Schaeffer D, Marengo MS, Bepler T, Rouse D, Ware KE, Hish AJ, Zhao Y, Buckley AF, Epstein JI, Armstrong AJ, Virshup DM, Garcia-Blanco MA.

Oncogene. 2016 Aug 18;35(33):4302-11. doi: 10.1038/onc.2015.497. Epub 2016 Jan 11.

20.

A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period.

Zhou M, Kim JK, Eng GW, Forger DB, Virshup DM.

Mol Cell. 2015 Oct 1;60(1):77-88. doi: 10.1016/j.molcel.2015.08.022.

21.

Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration.

Xiang W, Cheong JK, Ang SH, Teo B, Xu P, Asari K, Sun WT, Than H, Bunte RM, Virshup DM, Chuah C.

Oncotarget. 2015 Oct 20;6(32):33769-80. doi: 10.18632/oncotarget.5615.

22.

Wnt addiction of genetically defined cancers reversed by PORCN inhibition.

Madan B, Ke Z, Harmston N, Ho SY, Frois AO, Alam J, Jeyaraj DA, Pendharkar V, Ghosh K, Virshup IH, Manoharan V, Ong EH, Sangthongpitag K, Hill J, Petretto E, Keller TH, Lee MA, Matter A, Virshup DM.

Oncogene. 2016 Apr 28;35(17):2197-207. doi: 10.1038/onc.2015.280. Epub 2015 Aug 10.

23.

Discovery and Optimization of a Porcupine Inhibitor.

Duraiswamy AJ, Lee MA, Madan B, Ang SH, Tan ES, Cheong WW, Ke Z, Pendharkar V, Ding LJ, Chew YS, Manoharan V, Sangthongpitag K, Alam J, Poulsen A, Ho SY, Virshup DM, Keller TH.

J Med Chem. 2015 Aug 13;58(15):5889-99. doi: 10.1021/acs.jmedchem.5b00507. Epub 2015 Jul 16.

PMID:
26110200
24.

Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells.

Kabiri Z, Numata A, Kawasaki A, Edison, Tenen DG, Virshup DM.

Blood. 2015 Aug 27;126(9):1086-94. doi: 10.1182/blood-2014-09-598540. Epub 2015 Jun 18.

25.

Targeting Wnts at the source--new mechanisms, new biomarkers, new drugs.

Madan B, Virshup DM.

Mol Cancer Ther. 2015 May;14(5):1087-94. doi: 10.1158/1535-7163.MCT-14-1038. Epub 2015 Apr 21. Review.

26.

Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.

Cheong JK, Zhang F, Chua PJ, Bay BH, Thorburn A, Virshup DM.

J Clin Invest. 2015 Apr;125(4):1401-18. doi: 10.1172/JCI78018. Epub 2015 Mar 23.

27.

TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome.

Ribi S, Baumhoer D, Lee K, Edison, Teo AS, Madan B, Zhang K, Kohlmann WK, Yao F, Lee WH, Hoi Q, Cai S, Woo XY, Tan P, Jundt G, Smida J, Nathrath M, Sung WK, Schiffman JD, Virshup DM, Hillmer AM.

Oncotarget. 2015 Apr 10;6(10):7727-40.

28.

Moving upstream in the war on WNTs.

Virshup DM.

J Clin Invest. 2015 Mar 2;125(3):975-7. doi: 10.1172/JCI80819. Epub 2015 Feb 17.

29.

Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression.

Stewart J, James J, McCluggage GW, McQuaid S, Arthur K, Boyle D, Mullan P, McArt D, Yan B, Irwin G, Harkin DP, Zhengdeng L, Ong CW, Yu J, Virshup DM, Salto-Tellez M.

Mod Pathol. 2015 Mar;28(3):428-36. doi: 10.1038/modpathol.2014.114. Epub 2014 Sep 26.

30.

Updating the Wnt pathways.

Yu J, Virshup DM.

Biosci Rep. 2014 Oct 17;34(5). pii: e00142. doi: 10.1042/BSR20140119.

31.

B56-PP2A regulates motor dynamics for mitotic chromosome alignment.

Xu P, Virshup DM, Lee SH.

J Cell Sci. 2014 Nov 1;127(Pt 21):4567-73. doi: 10.1242/jcs.154609. Epub 2014 Sep 1.

32.

Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity.

Low IC, Loh T, Huang Y, Virshup DM, Pervaiz S.

Blood. 2014 Oct 2;124(14):2223-34. doi: 10.1182/blood-2014-03-563296. Epub 2014 Jul 31.

33.

Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging.

Zhu Y, Demidov ON, Goh AM, Virshup DM, Lane DP, Bulavin DV.

J Clin Invest. 2014 Jul;124(7):3263-73. doi: 10.1172/JCI73015. Epub 2014 Jun 9.

34.

Disulfide bond requirements for active Wnt ligands.

MacDonald BT, Hien A, Zhang X, Iranloye O, Virshup DM, Waterman ML, He X.

J Biol Chem. 2014 Jun 27;289(26):18122-36. doi: 10.1074/jbc.M114.575027. Epub 2014 May 19.

35.

Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts.

Kabiri Z, Greicius G, Madan B, Biechele S, Zhong Z, Zaribafzadeh H, Edison, Aliyev J, Wu Y, Bunte R, Williams BO, Rossant J, Virshup DM.

Development. 2014 Jun;141(11):2206-15.

36.

WLS retrograde transport to the endoplasmic reticulum during Wnt secretion.

Yu J, Chia J, Canning CA, Jones CM, Bard FA, Virshup DM.

Dev Cell. 2014 May 12;29(3):277-91. doi: 10.1016/j.devcel.2014.03.016. Epub 2014 Apr 24.

37.

Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling.

Yim DG, Ghosh S, Guy GR, Virshup DM.

Oncogene. 2015 Jan 22;34(4):474-84. doi: 10.1038/onc.2013.564. Epub 2014 Jan 27.

PMID:
24469046
38.

BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression.

Xu P, Raetz EA, Kitagawa M, Virshup DM, Lee SH.

Biol Open. 2013 Mar 25;2(5):479-86. doi: 10.1242/bio.20134051. Print 2013 May 15.

39.

Unwinding the Wnt action of casein kinase 1.

Yim DG, Virshup DM.

Cell Res. 2013 Jun;23(6):737-8. doi: 10.1038/cr.2013.51. Epub 2013 Apr 9.

40.

Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer.

Proffitt KD, Madan B, Ke Z, Pendharkar V, Ding L, Lee MA, Hannoush RN, Virshup DM.

Cancer Res. 2013 Jan 15;73(2):502-7. doi: 10.1158/0008-5472.CAN-12-2258. Epub 2012 Nov 27.

41.

Precise regulation of porcupine activity is required for physiological Wnt signaling.

Proffitt KD, Virshup DM.

J Biol Chem. 2012 Oct 5;287(41):34167-78. doi: 10.1074/jbc.M112.381970. Epub 2012 Aug 10.

42.

A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities.

Najdi R, Proffitt K, Sprowl S, Kaur S, Yu J, Covey TM, Virshup DM, Waterman ML.

Differentiation. 2012 Sep;84(2):203-13. doi: 10.1016/j.diff.2012.06.004. Epub 2012 Jul 9.

43.

PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation.

Covey TM, Kaur S, Tan Ong T, Proffitt KD, Wu Y, Tan P, Virshup DM.

PLoS One. 2012;7(4):e34532. doi: 10.1371/journal.pone.0034532. Epub 2012 Apr 11.

44.

A densely interconnected genome-wide network of microRNAs and oncogenic pathways revealed using gene expression signatures.

Ooi CH, Oh HK, Wang HZ, Tan AL, Wu J, Lee M, Rha SY, Chung HC, Virshup DM, Tan P.

PLoS Genet. 2011 Dec;7(12):e1002415. doi: 10.1371/journal.pgen.1002415. Epub 2011 Dec 15.

45.

Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer.

Coombs GS, Schmitt AA, Canning CA, Alok A, Low IC, Banerjee N, Kaur S, Utomo V, Jones CM, Pervaiz S, Toone EJ, Virshup DM.

Oncogene. 2012 Jan 12;31(2):213-25. doi: 10.1038/onc.2011.228. Epub 2011 Jun 13.

46.

IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.

Cheong JK, Nguyen TH, Wang H, Tan P, Voorhoeve PM, Lee SH, Virshup DM.

Oncogene. 2011 Jun 2;30(22):2558-69. doi: 10.1038/onc.2010.627. Epub 2011 Jan 24.

47.

Cell biology. Enforcing the Greatwall in mitosis.

Virshup DM, Kaldis P.

Science. 2010 Dec 17;330(6011):1638-9. doi: 10.1126/science.1199898. No abstract available.

PMID:
21164006
48.

Casein kinase 1: Complexity in the family.

Cheong JK, Virshup DM.

Int J Biochem Cell Biol. 2011 Apr;43(4):465-9. doi: 10.1016/j.biocel.2010.12.004. Epub 2010 Dec 9. Review.

PMID:
21145983
49.

Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer.

Covey TM, Edes K, Coombs GS, Virshup DM, Fitzpatrick FA.

PLoS One. 2010 Oct 21;5(10):e13545. doi: 10.1371/journal.pone.0013545.

50.

WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification.

Coombs GS, Yu J, Canning CA, Veltri CA, Covey TM, Cheong JK, Utomo V, Banerjee N, Zhang ZH, Jadulco RC, Concepcion GP, Bugni TS, Harper MK, Mihalek I, Jones CM, Ireland CM, Virshup DM.

J Cell Sci. 2010 Oct 1;123(Pt 19):3357-67. doi: 10.1242/jcs.072132. Epub 2010 Sep 7.

Supplemental Content

Loading ...
Support Center