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Items: 16

1.

Recent Advances in Drug Repurposing for Parkinson's Disease.

Chen X, Gumina G, Virga KG.

Curr Med Chem. 2018 Jul 19. doi: 10.2174/0929867325666180719144850. [Epub ahead of print]

PMID:
30027839
2.

Effects of JWH015 in cytokine secretion in primary human keratinocytes and fibroblasts and its suitability for topical/transdermal delivery.

Bort A, Alvarado-Vazquez PA, Moracho-Vilrriales C, Virga KG, Gumina G, Romero-Sandoval A, Asbill S.

Mol Pain. 2017 Jan;13:1744806916688220. doi: 10.1177/1744806916688220.

3.

Recent Advances in the Rational Design and Optimization of Antibacterial Agents.

Jones JA, Virga KG, Gumina G, Hevener KE.

Medchemcomm. 2016 Sep 1;7(9):1694-1715. Epub 2016 Jul 7.

4.

Using membrane composition to fine-tune the pKa of an optical liposome pH sensor.

Clear KJ, Virga K, Gray L, Smith BD.

J Mater Chem C Mater. 2016 Apr 14;4(14):2925-2930. Epub 2015 Dec 1.

5.

Naegleria fowleri: pathogenesis, diagnosis, and treatment options.

Grace E, Asbill S, Virga K.

Antimicrob Agents Chemother. 2015 Nov;59(11):6677-81. doi: 10.1128/AAC.01293-15. Epub 2015 Aug 10. Review.

6.

Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated.

Spry C, Macuamule C, Lin Z, Virga KG, Lee RE, Strauss E, Saliba KJ.

PLoS One. 2013;8(2):e54974. doi: 10.1371/journal.pone.0054974. Epub 2013 Feb 6.

7.

Synthesis of bi-substrate state mimics of dihydropteroate synthase as potential inhibitors and molecular probes.

Qi J, Virga KG, Das S, Zhao Y, Yun MK, White SW, Lee RE.

Bioorg Med Chem. 2011 Feb 1;19(3):1298-305. doi: 10.1016/j.bmc.2010.12.003. Epub 2010 Dec 15.

8.

Diastereoselective synthesis of a spironoraristeromycin using an acylnitroso Diels-Alder reaction.

Lin W, Virga KG, Kim KH, Zajicek J, Mendel D, Miller MJ.

J Org Chem. 2009 Aug 21;74(16):5941-6. doi: 10.1021/jo900877b.

9.

Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.

Zhang YM, Chohnan S, Virga KG, Stevens RD, Ilkayeva OR, Wenner BR, Bain JR, Newgard CB, Lee RE, Rock CO, Jackowski S.

Chem Biol. 2007 Mar;14(3):291-302.

10.

Development of an etoposide prodrug for dual prodrug-enzyme antitumor therapy.

Yoon KJ, Qi J, Remack JS, Virga KG, Hatfield MJ, Potter PM, Lee RE, Danks MK.

Mol Cancer Ther. 2006 Jun;5(6):1577-84.

11.

Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors.

Virga KG, Zhang YM, Leonardi R, Ivey RA, Hevener K, Park HW, Jackowski S, Rock CO, Lee RE.

Bioorg Med Chem. 2006 Feb 15;14(4):1007-20. Epub 2005 Oct 5.

PMID:
16213731
12.

Discovery of non-carbohydrate inhibitors of aminoglycoside-modifying enzymes.

Welch KT, Virga KG, Whittemore NA, Ozen C, Wright E, Brown CL, Lee RE, Serpersu EH.

Bioorg Med Chem. 2005 Nov 15;13(22):6252-63.

PMID:
16140014
13.

A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A.

Leonardi R, Chohnan S, Zhang YM, Virga KG, Lee RE, Rock CO, Jackowski S.

J Biol Chem. 2005 Feb 4;280(5):3314-22. Epub 2004 Nov 17.

14.

Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites.

Zhang YM, Frank MW, Virga KG, Lee RE, Rock CO, Jackowski S.

J Biol Chem. 2004 Dec 3;279(49):50969-75. Epub 2004 Sep 30.

15.

The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites.

Ivey RA, Zhang YM, Virga KG, Hevener K, Lee RE, Rock CO, Jackowski S, Park HW.

J Biol Chem. 2004 Aug 20;279(34):35622-9. Epub 2004 May 10.

16.

Adapted crutches for patients with little or no hand grasp.

Virga K.

Phys Ther. 1979 Jan;59(1):37. No abstract available.

PMID:
424449

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