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Items: 24


Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance.

DiStefano MT, Roth Flach RJ, Senol-Cosar O, Danai LV, Virbasius JV, Nicoloro SM, Straubhaar J, Dagdeviren S, Wabitsch M, Gupta OT, Kim JK, Czech MP.

Mol Metab. 2016 Sep 28;5(12):1149-1161. doi: 10.1016/j.molmet.2016.09.009. eCollection 2016 Dec.


Map4k4 Signaling Nodes in Metabolic and Cardiovascular Diseases.

Virbasius JV, Czech MP.

Trends Endocrinol Metab. 2016 Jul;27(7):484-492. doi: 10.1016/j.tem.2016.04.006. Epub 2016 May 6. Review.


Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues.

Danai LV, Flach RJ, Virbasius JV, Menendez LG, Jung DY, Kim JH, Kim JK, Czech MP.

Mol Cell Biol. 2015 Jul;35(13):2356-65.


Glucan particles for selective delivery of siRNA to phagocytic cells in mice.

Tesz GJ, Aouadi M, Prot M, Nicoloro SM, Boutet E, Amano SU, Goller A, Wang M, Guo CA, Salomon WE, Virbasius JV, Baum RA, O'Connor MJ Jr, Soto E, Ostroff GR, Czech MP.

Biochem J. 2011 Jun 1;436(2):351-62. doi: 10.1042/BJ20110352.


Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

Guilherme A, Virbasius JV, Puri V, Czech MP.

Nat Rev Mol Cell Biol. 2008 May;9(5):367-77. doi: 10.1038/nrm2391. Review.


RNAi screens reveal novel metabolic regulators: RIP140, MAP4k4 and the lipid droplet associated fat specific protein (FSP) 27.

Puri V, Virbasius JV, Guilherme A, Czech MP.

Acta Physiol (Oxf). 2008 Jan;192(1):103-15. doi: 10.1111/j.1748-1716.2007.01786.x. Review.


RNAi-based gene silencing in primary mouse and human adipose tissues.

Puri V, Chakladar A, Virbasius JV, Konda S, Powelka AM, Chouinard M, Hagan GN, Perugini R, Czech MP.

J Lipid Res. 2007 Feb;48(2):465-71. Epub 2006 Nov 8.


An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport.

Tang X, Guilherme A, Chakladar A, Powelka AM, Konda S, Virbasius JV, Nicoloro SM, Straubhaar J, Czech MP.

Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2087-92. Epub 2006 Feb 3.


Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes.

Powelka AM, Seth A, Virbasius JV, Kiskinis E, Nicoloro SM, Guilherme A, Tang X, Straubhaar J, Cherniack AD, Parker MG, Czech MP.

J Clin Invest. 2006 Jan;116(1):125-36. Epub 2005 Dec 22.


Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2alpha.

Liu L, Song X, He D, Komma C, Kita A, Virbasius JV, Huang G, Bellamy HD, Miki K, Czech MP, Zhou GW.

J Biol Chem. 2006 Feb 17;281(7):4254-60. Epub 2005 Dec 7.


Essential role of Ca2+/calmodulin in Early Endosome Antigen-1 localization.

Lawe DC, Sitouah N, Hayes S, Chawla A, Virbasius JV, Tuft R, Fogarty K, Lifshitz L, Lambright D, Corvera S.

Mol Biol Cell. 2003 Jul;14(7):2935-45. Epub 2003 Mar 20.


The p40phox and p47phox PX domains of NADPH oxidase target cell membranes via direct and indirect recruitment by phosphoinositides.

Zhan Y, Virbasius JV, Song X, Pomerleau DP, Zhou GW.

J Biol Chem. 2002 Feb 8;277(6):4512-8. Epub 2001 Nov 29.


Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate.

Virbasius JV, Song X, Pomerleau DP, Zhan Y, Zhou GW, Czech MP.

Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12908-13. Epub 2001 Oct 23.


Phox homology domains specifically bind phosphatidylinositol phosphates.

Song X, Xu W, Zhang A, Huang G, Liang X, Virbasius JV, Czech MP, Zhou GW.

Biochemistry. 2001 Jul 31;40(30):8940-4.


A functional PtdIns(3)P-binding motif.

Patki V, Lawe DC, Corvera S, Virbasius JV, Chawla A.

Nature. 1998 Jul 30;394(6692):433-4. No abstract available.


Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains.

Klarlund JK, Guilherme A, Holik JJ, Virbasius JV, Chawla A, Czech MP.

Science. 1997 Mar 28;275(5308):1927-30.


Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain.

Virbasius JV, Guilherme A, Czech MP.

J Biol Chem. 1996 Jun 7;271(23):13304-7.


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