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Items: 1 to 50 of 223

1.

Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block.

Tomek J, Bueno-Orovio A, Passini E, Zhou X, Minchole A, Britton O, Bartolucci C, Severi S, Shrier A, Virag L, Varro A, Rodriguez B.

Elife. 2019 Dec 23;8. pii: e48890. doi: 10.7554/eLife.48890. [Epub ahead of print]

2.

Poly(ADP-ribose) polymerase-1 depletion enhances the severity of inflammation in an imiquimod-induced model of psoriasis.

Kiss B, Szántó M, Hegedűs C, Antal D, Szödényi A, Márton J, Méhes G, Virág L, Szegedi A, Bai P.

Exp Dermatol. 2019 Nov 22. doi: 10.1111/exd.14061. [Epub ahead of print]

PMID:
31755591
3.

Implication of frequency-dependent protocols in antiarrhythmic and proarrhythmic drug testing.

Nánási PP, Szabó Z, Kistamás K, Horváth B, Virág L, Jost N, Bányász T, Almássy J, Varró A.

Prog Biophys Mol Biol. 2019 Nov 11. pii: S0079-6107(19)30226-3. doi: 10.1016/j.pbiomolbio.2019.11.001. [Epub ahead of print] Review.

PMID:
31726065
4.

Spilanthol Inhibits Inflammatory Transcription Factors and iNOS Expression in Macrophages and Exerts Anti-inflammatory Effects in Dermatitis and Pancreatitis.

Bakondi E, Singh SB, Hajnády Z, Nagy-Pénzes M, Regdon Z, Kovács K, Hegedűs C, Madácsy T, Maléth J, Hegyi P, Demény MÁ, Nagy T, Kéki S, Szabó É, Virág L.

Int J Mol Sci. 2019 Sep 3;20(17). pii: E4308. doi: 10.3390/ijms20174308.

5.

Lithocholic Acid, a Metabolite of the Microbiome, Increases Oxidative Stress in Breast Cancer.

Kovács P, Csonka T, Kovács T, Sári Z, Ujlaki G, Sipos A, Karányi Z, Szeőcs D, Hegedűs C, Uray K, Jankó L, Kiss M, Kiss B, Laoui D, Virág L, Méhes G, Bai P, Mikó E.

Cancers (Basel). 2019 Aug 27;11(9). pii: E1255. doi: 10.3390/cancers11091255.

6.

Self-defense of macrophages against oxidative injury: Fighting for their own survival.

Virág L, Jaén RI, Regdon Z, Boscá L, Prieto P.

Redox Biol. 2019 Sep;26:101261. doi: 10.1016/j.redox.2019.101261. Epub 2019 Jun 28. Review.

7.

Programmed necrotic cell death of macrophages: Focus on pyroptosis, necroptosis, and parthanatos.

Robinson N, Ganesan R, Hegedűs C, Kovács K, Kufer TA, Virág L.

Redox Biol. 2019 Sep;26:101239. doi: 10.1016/j.redox.2019.101239. Epub 2019 Jun 9. Review.

8.

Data-driven Identification of Stochastic Model Parameters and State Variables: Application to the Study of Cardiac Beat-to-beat Variability.

Sampedro-Puente DA, Fernandez-Bes J, Virag L, Varro A, Pueyo E.

IEEE J Biomed Health Inform. 2019 Jun 10. doi: 10.1109/JBHI.2019.2921881. [Epub ahead of print]

PMID:
31180875
9.

Redox Profiling Reveals Clear Differences between Molecular Patterns of Wound Fluids from Acute and Chronic Wounds.

Bodnár E, Bakondi E, Kovács K, Hegedűs C, Lakatos P, Robaszkiewicz A, Regdon Z, Virág L, Szabó É.

Oxid Med Cell Longev. 2018 Nov 18;2018:5286785. doi: 10.1155/2018/5286785. eCollection 2018.

10.

Evaluation of Possible Proarrhythmic Potency: Comparison of the Effect of Dofetilide, Cisapride, Sotalol, Terfenadine, and Verapamil on hERG and Native IKr Currents and on Cardiac Action Potential.

Orvos P, Kohajda Z, Szlovák J, Gazdag P, Árpádffy-Lovas T, Tóth D, Geramipour A, Tálosi L, Jost N, Varró A, Virág L.

Toxicol Sci. 2019 Apr 1;168(2):365-380. doi: 10.1093/toxsci/kfy299.

PMID:
30561737
11.

PARP1-LSD1 functional interplay controls transcription of SOD2 that protects human pro-inflammatory macrophages from death under an oxidative condition.

Tokarz P, Płoszaj T, Regdon Z, Virág L, Robaszkiewicz A.

Free Radic Biol Med. 2019 Feb 1;131:218-224. doi: 10.1016/j.freeradbiomed.2018.12.004. Epub 2018 Dec 6.

PMID:
30529301
12.

Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain.

Whittington RA, Virág L, Gratuze M, Lewkowitz-Shpuntoff H, Cheheltanan M, Petry F, Poitras I, Morin F, Planel E.

Neurobiol Aging. 2019 Mar;75:11-24. doi: 10.1016/j.neurobiolaging.2018.10.027. Epub 2018 Nov 8.

PMID:
30508732
13.

LPS protects macrophages from AIF-independent parthanatos by downregulation of PARP1 expression, induction of SOD2 expression, and a metabolic shift to aerobic glycolysis.

Regdon Z, Robaszkiewicz A, Kovács K, Rygielska Ż, Hegedűs C, Bodoor K, Szabó É, Virág L.

Free Radic Biol Med. 2019 Feb 1;131:184-196. doi: 10.1016/j.freeradbiomed.2018.11.034. Epub 2018 Nov 28.

PMID:
30502458
14.

Glucose Metabolism Changes in Patients with Chronic Hepatitis C Treated with Direct Acting Antivirals.

Drazilova S, Janicko M, Skladany L, Kristian P, Oltman M, Szantova M, Krkoska D, Mazuchova E, Piesecka L, Vahalova V, Rac M, Schreter I, Virag L, Koller T, Liptakova A, Ondrasova M, Jarcuska P.

Can J Gastroenterol Hepatol. 2018 Oct 3;2018:6095097. doi: 10.1155/2018/6095097. eCollection 2018.

15.

PARP1 promoter links cell cycle progression with adaptation to oxidative environment.

Pietrzak J, Spickett CM, Płoszaj T, Virág L, Robaszkiewicz A.

Redox Biol. 2018 Sep;18:1-5. doi: 10.1016/j.redox.2018.05.017. Epub 2018 Jun 2. Review.

16.

Correction: Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition.

Pueyo E, Dangerfield CE, Britton OJ, Virág L, Kistamás K, Szentandrássy N, Jost N, Varró A, Nánási PP, Burrage K, Rodríguez B.

PLoS One. 2018 May 17;13(5):e0197871. doi: 10.1371/journal.pone.0197871. eCollection 2018.

17.

Redox control of cancer cell destruction.

Hegedűs C, Kovács K, Polgár Z, Regdon Z, Szabó É, Robaszkiewicz A, Forman HJ, Martner A, Virág L.

Redox Biol. 2018 Jun;16:59-74. doi: 10.1016/j.redox.2018.01.015. Epub 2018 Feb 3. Review.

18.

Diverse effect of BMP-2 homodimer on mesenchymal progenitors of different origin.

Hrubi E, Imre L, Robaszkiewicz A, Virág L, Kerényi F, Nagy K, Varga G, Jenei A, Hegedüs C.

Hum Cell. 2018 Apr;31(2):139-148. doi: 10.1007/s13577-018-0202-5. Epub 2018 Feb 13.

19.

PARP1 facilitates EP300 recruitment to the promoters of the subset of RBL2-dependent genes.

Robaszkiewicz A, Wiśnik E, Regdon Z, Chmielewska K, Virág L.

Biochim Biophys Acta Gene Regul Mech. 2017 Dec 4. pii: S1874-9399(17)30290-0. doi: 10.1016/j.bbagrm.2017.12.001. [Epub ahead of print]

PMID:
29313809
20.

Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair.

Tempka D, Tokarz P, Chmielewska K, Kluska M, Pietrzak J, Rygielska Ż, Virág L, Robaszkiewicz A.

Redox Biol. 2018 May;15:316-326. doi: 10.1016/j.redox.2017.12.017. Epub 2017 Dec 29.

21.

Corrigendum: The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study.

Britton OJ, Bueno-Orovio A, Virág L, Varró A, Rodriguez B.

Front Physiol. 2017 Nov 17;8:954. doi: 10.3389/fphys.2017.00954. eCollection 2017.

22.

Comparison of the effects of IK,ACh, IKr, and INa block in conscious dogs with atrial fibrillation and on action potentials in remodeled atrial trabeculae.

Juhász V, Hornyik T, Benák A, Nagy N, Husti Z, Pap R, Sághy L, Virág L, Varró A, Baczkó I.

Can J Physiol Pharmacol. 2018 Jan;96(1):18-25. doi: 10.1139/cjpp-2017-0342. Epub 2017 Sep 11.

PMID:
28892643
23.

A2A adenosine receptors control pancreatic dysfunction in high-fat-diet-induced obesity.

Csóka B, Törő G, Vindeirinho J, Varga ZV, Koscsó B, Németh ZH, Kókai E, Antonioli L, Suleiman M, Marchetti P, Cseri K, Deák Á, Virág L, Pacher P, Bai P, Haskó G.

FASEB J. 2017 Nov;31(11):4985-4997. doi: 10.1096/fj.201700398R. Epub 2017 Aug 1.

24.

The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study.

Britton OJ, Bueno-Orovio A, Virág L, Varró A, Rodriguez B.

Front Physiol. 2017 May 5;8:278. doi: 10.3389/fphys.2017.00278. eCollection 2017. Erratum in: Front Physiol. 2017 Nov 17;8:954.

25.

Potential biomechanical roles of risk factors in the evolution of thrombus-laden abdominal aortic aneurysms.

Virag L, Wilson JS, Humphrey JD, Karšaj I.

Int J Numer Method Biomed Eng. 2017 Dec;33(12). doi: 10.1002/cnm.2893. Epub 2017 Jun 2.

26.

Different electrophysiological effects of the levo- and dextro-rotatory isomers of mexiletine in isolated rabbit cardiac muscle.

Gurabi Z, Patocskai B, Györe B, Virág L, Mátyus P, Papp JG, Varró A, Koncz I.

Can J Physiol Pharmacol. 2017 Jul;95(7):830-836. doi: 10.1139/cjpp-2016-0599. Epub 2017 Feb 22.

PMID:
28226224
27.

The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments.

Kohajda Z, Farkas-Morvay N, Jost N, Nagy N, Geramipour A, Horváth A, Varga RS, Hornyik T, Corici C, Acsai K, Horváth B, Prorok J, Ördög B, Déri S, Tóth D, Levijoki J, Pollesello P, Koskelainen T, Otsomaa L, Tóth A, Baczkó I, Leprán I, Nánási PP, Papp JG, Varró A, Virág L.

PLoS One. 2016 Nov 10;11(11):e0166041. doi: 10.1371/journal.pone.0166041. eCollection 2016.

28.

Diabetes-induced oxidative stress in the vitreous humor.

Géhl Z, Bakondi E, Resch MD, Hegedűs C, Kovács K, Lakatos P, Szabó A, Nagy Z, Virág L.

Redox Biol. 2016 Oct;9:100-103. doi: 10.1016/j.redox.2016.07.003. Epub 2016 Jul 8.

29.

Autophagy requires poly(adp-ribosyl)ation-dependent AMPK nuclear export.

Rodríguez-Vargas JM, Rodríguez MI, Majuelos-Melguizo J, García-Diaz Á, González-Flores A, López-Rivas A, Virág L, Illuzzi G, Schreiber V, Dantzer F, Oliver FJ.

Cell Death Differ. 2016 Dec;23(12):2007-2018. doi: 10.1038/cdd.2016.80. Epub 2016 Sep 30.

30.

The investigation of the cellular electrophysiological and antiarrhythmic effects of a novel selective sodium-calcium exchanger inhibitor, GYKB-6635, in canine and guinea-pig hearts.

Geramipour A, Kohajda Z, Corici C, Prorok J, Szakonyi Z, Oravecz K, Márton Z, Nagy N, Tóth A, Acsai K, Virág L, Varró A, Jost N.

Can J Physiol Pharmacol. 2016 Oct;94(10):1090-1101. Epub 2016 Jul 1.

PMID:
27508313
31.

The PARP inhibitor PJ-34 sensitizes cells to UVA-induced phototoxicity by a PARP independent mechanism.

Lakatos P, Hegedűs C, Salazar Ayestarán N, Juarranz Á, Kövér KE, Szabó É, Virág L.

Mutat Res. 2016 Aug;790:31-40. doi: 10.1016/j.mrfmmm.2016.07.001. Epub 2016 Jul 5.

PMID:
27427773
32.

Rabbit models as tools for preclinical cardiac electrophysiological safety testing: Importance of repolarization reserve.

Baczkó I, Jost N, Virág L, Bősze Z, Varró A.

Prog Biophys Mol Biol. 2016 Jul;121(2):157-68. doi: 10.1016/j.pbiomolbio.2016.05.002. Epub 2016 May 18. Review.

PMID:
27208697
33.

A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant-negative mutation of the KCNE1 gene.

Major P, Baczkó I, Hiripi L, Odening KE, Juhász V, Kohajda Z, Horváth A, Seprényi G, Kovács M, Virág L, Jost N, Prorok J, Ördög B, Doleschall Z, Nattel S, Varró A, Bősze Z.

Br J Pharmacol. 2016 Jun;173(12):2046-61. doi: 10.1111/bph.13500. Epub 2016 May 19.

34.

Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition.

Pueyo E, Dangerfield CE, Britton OJ, Virág L, Kistamás K, Szentandrássy N, Jost N, Varró A, Nánási PP, Burrage K, Rodríguez B.

PLoS One. 2016 Mar 28;11(3):e0151461. doi: 10.1371/journal.pone.0151461. eCollection 2016. Erratum in: PLoS One. 2018 May 17;13(5):e0197871.

35.

Mitochondrial poly(ADP-ribose) polymerase: The Wizard of Oz at work.

Brunyanszki A, Szczesny B, Virág L, Szabo C.

Free Radic Biol Med. 2016 Nov;100:257-270. doi: 10.1016/j.freeradbiomed.2016.02.024. Epub 2016 Mar 8. Review.

36.

Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area μ Opioid Receptors.

Hipólito L, Wilson-Poe A, Campos-Jurado Y, Zhong E, Gonzalez-Romero J, Virag L, Whittington R, Comer SD, Carlton SM, Walker BM, Bruchas MR, Morón JA.

J Neurosci. 2015 Sep 2;35(35):12217-31. doi: 10.1523/JNEUROSCI.1053-15.2015.

37.

High Throughput Screening Identifies a Novel Compound Protecting Cardiomyocytes from Doxorubicin-Induced Damage.

Gergely S, Hegedűs C, Lakatos P, Kovács K, Gáspár R, Csont T, Virág L.

Oxid Med Cell Longev. 2015;2015:178513. doi: 10.1155/2015/178513. Epub 2015 Jun 7.

38.

A Computational Model of Biochemomechanical Effects of Intraluminal Thrombus on the Enlargement of Abdominal Aortic Aneurysms.

Virag L, Wilson JS, Humphrey JD, Karšaj I.

Ann Biomed Eng. 2015 Dec;43(12):2852-2867. doi: 10.1007/s10439-015-1354-z. Epub 2015 Jun 13.

39.

Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro.

Whittington RA, Virág L, Gratuze M, Petry FR, Noël A, Poitras I, Truchetti G, Marcouiller F, Papon MA, El Khoury N, Wong K, Bretteville A, Morin F, Planel E.

Neurobiol Aging. 2015 Aug;36(8):2414-28. doi: 10.1016/j.neurobiolaging.2015.05.002. Epub 2015 May 9.

40.

Poly(ADP-ribose) in the bone: from oxidative stress signal to structural element.

Hegedűs C, Robaszkiewicz A, Lakatos P, Szabó É, Virág L.

Free Radic Biol Med. 2015 May;82:179-86. doi: 10.1016/j.freeradbiomed.2015.01.027. Epub 2015 Feb 4. Review.

PMID:
25660995
41.

Poly(ADP) ribose polymerase-1 ablation alters eicosanoid and docosanoid signaling and metabolism in a murine model of contact hypersensitivity.

Kiss B, Szántó M, Szklenár M, Brunyánszki A, Marosvölgyi T, Sárosi E, Remenyik É, Gergely P, Virág L, Decsi T, Rühl R, Bai P.

Mol Med Rep. 2015 Apr;11(4):2861-7. doi: 10.3892/mmr.2014.3044. Epub 2014 Dec 4.

PMID:
25482287
42.

Effects of Chelidonium majus extracts and major alkaloids on hERG potassium channels and on dog cardiac action potential - a safety approach.

Orvos P, Virág L, Tálosi L, Hajdú Z, Csupor D, Jedlinszki N, Szél T, Varró A, Hohmann J.

Fitoterapia. 2015 Jan;100:156-65. doi: 10.1016/j.fitote.2014.11.023. Epub 2014 Dec 4.

PMID:
25481375
43.

Inputs and outputs of poly(ADP-ribosyl)ation: Relevance to oxidative stress.

Hegedűs C, Virág L.

Redox Biol. 2014;2:978-82. doi: 10.1016/j.redox.2014.08.003. Epub 2014 Aug 21. Review.

44.

Protein phosphatase-1 is involved in the maintenance of normal homeostasis and in UVA irradiation-induced pathological alterations in HaCaT cells and in mouse skin.

Dedinszki D, Sipos A, Kiss A, Bátori R, Kónya Z, Virág L, Erdődi F, Lontay B.

Biochim Biophys Acta. 2015 Jan;1852(1):22-33. doi: 10.1016/j.bbadis.2014.11.005. Epub 2014 Nov 8.

45.

The role of p38 signaling and poly(ADP-ribosyl)ation-induced metabolic collapse in the osteogenic differentiation-coupled cell death pathway.

Robaszkiewicz A, Valkó Z, Kovács K, Hegedűs C, Bakondi E, Bai P, Virág L.

Free Radic Biol Med. 2014 Nov;76:69-79. doi: 10.1016/j.freeradbiomed.2014.07.027. Epub 2014 Jul 29.

PMID:
25078118
46.

Selective Na(+) /Ca(2+) exchanger inhibition prevents Ca(2+) overload-induced triggered arrhythmias.

Nagy N, Kormos A, Kohajda Z, Szebeni Á, Szepesi J, Pollesello P, Levijoki J, Acsai K, Virág L, Nánási PP, Papp JG, Varró A, Tóth A.

Br J Pharmacol. 2014 Dec;171(24):5665-81. doi: 10.1111/bph.12867.

47.

Activation of poly(ADP-ribose) polymerase-1 delays wound healing by regulating keratinocyte migration and production of inflammatory mediators.

El-Hamoly T, Hegedűs C, Lakatos P, Kovács K, Bai P, El-Ghazaly MA, El-Denshary ES, Szabó É, Virág L.

Mol Med. 2014 Aug 26;20:363-71. doi: 10.2119/molmed.2014.00130.

48.

Association between metabolic syndrome and hepatitis B virus infection in the Roma population in eastern Slovakia: a population-based study.

Janicko M, Senajová G, Drazilová S, Veselíny E, Fedacko J, Siegfried L, Kristian P, Virág L, Pella D, Mareková M, Gecková AM, Kalanin P, Jarcuska P, Halánová M; HepaMeta Team.

Cent Eur J Public Health. 2014 Mar;22 Suppl:S37-42.

49.

Deletion of PARP-2 induces hepatic cholesterol accumulation and decrease in HDL levels.

Szántó M, Brunyánszki A, Márton J, Vámosi G, Nagy L, Fodor T, Kiss B, Virág L, Gergely P, Bai P.

Biochim Biophys Acta. 2014 Apr;1842(4):594-602. doi: 10.1016/j.bbadis.2013.12.006. Epub 2013 Dec 21. Erratum in: Biochim Biophys Acta. 2014 Dec;1842(12):2529-30.

50.

A2B adenosine receptors prevent insulin resistance by inhibiting adipose tissue inflammation via maintaining alternative macrophage activation.

Csóka B, Koscsó B, Töro G, Kókai E, Virág L, Németh ZH, Pacher P, Bai P, Haskó G.

Diabetes. 2014 Mar;63(3):850-66. doi: 10.2337/db13-0573. Epub 2013 Nov 5.

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