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Items: 1 to 50 of 303

1.

Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates.

Ducommun S, Deak M, Zeigerer A, Göransson O, Seitz S, Collodet C, Madsen AB, Jensen TE, Viollet B, Foretz M, Gut P, Sumpton D, Sakamoto K.

Cell Signal. 2019 Feb 14. pii: S0898-6568(19)30030-0. doi: 10.1016/j.cellsig.2019.02.001. [Epub ahead of print]

PMID:
30772465
2.

AMP-Activated Protein Kinase Signalling.

Neumann D, Viollet B.

Int J Mol Sci. 2019 Feb 12;20(3). pii: E766. doi: 10.3390/ijms20030766.

3.

Endothelial α1AMPK modulates angiotensin II-mediated vascular inflammation and dysfunction.

Kröller-Schön S, Jansen T, Tran TLP, Kvandová M, Kalinovic S, Oelze M, Keaney JF Jr, Foretz M, Viollet B, Daiber A, Kossmann S, Lagrange J, Frenis K, Wenzel P, Münzel T, Schulz E.

Basic Res Cardiol. 2019 Jan 14;114(2):8. doi: 10.1007/s00395-019-0717-2.

PMID:
30643968
4.

Loss of AMPKα2 Impairs Hedgehog-Driven Medulloblastoma Tumorigenesis.

Zhang H, Kuick R, Park SS, Peabody C, Yoon J, Fernández EC, Wang J, Thomas D, Viollet B, Inoki K, Camelo-Piragua S, Rual JF.

Int J Mol Sci. 2018 Oct 23;19(11). pii: E3287. doi: 10.3390/ijms19113287.

5.

A functional role for AMPK in female fertility and endometrial regeneration

McCallum ML, Pru CA, Smith AR, Kelp NC, Foretz M, Viollet B, Du M, Pru JK.

Reproduction. 2018 Sep 12. pii: REP-18-0372. doi: 10.1530/REP-18-0372. [Epub ahead of print]

PMID:
30328345
6.

Finely-tuned regulation of AMP-activated protein kinase (AMPK) is crucial for human adult erythropoiesis.

Ladli M, Richard C, Cantero Aguilar L, Ducamp S, Bondu S, Sujobert P, Tamburini J, Lacombe C, Azar N, Foretz M, Zermati Y, Mayeux P, Viollet B, Verdier F.

Haematologica. 2018 Oct 11. pii: haematol.2018.191403. doi: 10.3324/haematol.2018.191403. [Epub ahead of print]

7.

The LKB1-AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria.

Moral-Sanz J, Lewis SA, MacMillan S, Ross FA, Thomson A, Viollet B, Foretz M, Moran C, Hardie DG, Evans AM.

Sci Signal. 2018 Oct 2;11(550). pii: eaau0296. doi: 10.1126/scisignal.aau0296.

PMID:
30279167
8.

AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation In Vivo.

Foretz M, Even PC, Viollet B.

Int J Mol Sci. 2018 Sep 19;19(9). pii: E2826. doi: 10.3390/ijms19092826.

9.

Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle.

Hingst JR, Bruhn L, Hansen MB, Rosschou MF, Birk JB, Fentz J, Foretz M, Viollet B, Sakamoto K, Færgeman NJ, Havelund JF, Parker BL, James DE, Kiens B, Richter EA, Jensen J, Wojtaszewski JFP.

Mol Metab. 2018 Oct;16:24-34. doi: 10.1016/j.molmet.2018.07.001. Epub 2018 Jul 25.

10.

α1AMPK deletion in myelomonocytic cells induces a pro-inflammatory phenotype and enhances angiotensin II-induced vascular dysfunction.

Jansen T, Kröller-Schön S, Schönfelder T, Foretz M, Viollet B, Daiber A, Oelze M, Brandt M, Steven S, Kvandová M, Kalinovic S, Lagrange J, Keaney JF Jr, Münzel T, Wenzel P, Schulz E.

Cardiovasc Res. 2018 Dec 1;114(14):1883-1893. doi: 10.1093/cvr/cvy172.

PMID:
29982418
11.

Activation of AMPK for a Break in Hepatic Lipid Accumulation and Circulating Cholesterol.

Foretz M, Viollet B.

EBioMedicine. 2018 May;31:15-16. doi: 10.1016/j.ebiom.2018.05.009. Epub 2018 May 10. No abstract available.

12.

Metformin directly targets the H3K27me3 demethylase KDM6A/UTX.

Cuyàs E, Verdura S, Llorach-Pares L, Fernández-Arroyo S, Luciano-Mateo F, Cabré N, Stursa J, Werner L, Martin-Castillo B, Viollet B, Neuzil J, Joven J, Nonell-Canals A, Sanchez-Martinez M, Menendez JA.

Aging Cell. 2018 May 8:e12772. doi: 10.1111/acel.12772. [Epub ahead of print]

13.

AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2.

Philippe C, Pinson B, Dompierre J, Pantesco V, Viollet B, Daignan-Fornier B, Moenner M.

Neoplasia. 2018 Jun;20(6):555-562. doi: 10.1016/j.neo.2018.03.006. Epub 2018 May 3.

14.

The adenosine monophosphate-activated protein kinase-vacuolar adenosine triphosphatase-pH axis: A key regulator of the profibrogenic phenotype of human hepatic stellate cells.

Marrone G, De Chiara F, Böttcher K, Levi A, Dhar D, Longato L, Mazza G, Zhang Z, Marrali M, Fernández-Iglesias A, Hall A, Luong TV, Viollet B, Pinzani M, Rombouts K.

Hepatology. 2018 Sep;68(3):1140-1153. doi: 10.1002/hep.30029. Epub 2018 Jul 16.

PMID:
29663481
15.

A RAS-CaMKKβ-AMPKα2 pathway promotes senescence by licensing post-translational activation of C/EBPβ through a novel 3'UTR mechanism.

Basu SK, Gonit M, Salotti J, Chen J, Bhat A, Gorospe M, Viollet B, Claffey KP, Johnson PF.

Oncogene. 2018 Jun;37(26):3528-3548. doi: 10.1038/s41388-018-0190-7. Epub 2018 Mar 22.

16.

Measurement of AMPK-Induced Inhibition of Lipid Synthesis Flux in Cultured Cells.

Foretz M, Viollet B.

Methods Mol Biol. 2018;1732:363-371. doi: 10.1007/978-1-4939-7598-3_23.

17.

Knockdown of Human AMPK Using the CRISPR/Cas9 Genome-Editing System.

Grenier A, Sujobert P, Olivier S, Guermouche H, Mondésir J, Kosmider O, Viollet B, Tamburini J.

Methods Mol Biol. 2018;1732:171-194. doi: 10.1007/978-1-4939-7598-3_11.

PMID:
29480475
18.

LKB1 as a Gatekeeper of Hepatocyte Proliferation and Genomic Integrity during Liver Regeneration.

Maillet V, Boussetta N, Leclerc J, Fauveau V, Foretz M, Viollet B, Couty JP, Celton-Morizur S, Perret C, Desdouets C.

Cell Rep. 2018 Feb 20;22(8):1994-2005. doi: 10.1016/j.celrep.2018.01.086.

19.

Promise and challenges for direct small molecule AMPK activators.

Olivier S, Foretz M, Viollet B.

Biochem Pharmacol. 2018 Jul;153:147-158. doi: 10.1016/j.bcp.2018.01.049. Epub 2018 Feb 3. Review.

20.

AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation.

Gélinas R, Mailleux F, Dontaine J, Bultot L, Demeulder B, Ginion A, Daskalopoulos EP, Esfahani H, Dubois-Deruy E, Lauzier B, Gauthier C, Olson AK, Bouchard B, Des Rosiers C, Viollet B, Sakamoto K, Balligand JL, Vanoverschelde JL, Beauloye C, Horman S, Bertrand L.

Nat Commun. 2018 Jan 25;9(1):374. doi: 10.1038/s41467-017-02795-4.

21.

AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development.

Boudaba N, Marion A, Huet C, Pierre R, Viollet B, Foretz M.

EBioMedicine. 2018 Feb;28:194-209. doi: 10.1016/j.ebiom.2018.01.008. Epub 2018 Jan 9.

22.

AMPK in skeletal muscle function and metabolism.

Kjøbsted R, Hingst JR, Fentz J, Foretz M, Sanz MN, Pehmøller C, Shum M, Marette A, Mounier R, Treebak JT, Wojtaszewski JFP, Viollet B, Lantier L.

FASEB J. 2018 Apr;32(4):1741-1777. doi: 10.1096/fj.201700442R. Epub 2018 Jan 5. Review.

23.

Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway.

Ollila S, Domènech-Moreno E, Laajanen K, Wong IP, Tripathi S, Pentinmikko N, Gao Y, Yan Y, Niemelä EH, Wang TC, Viollet B, Leone G, Katajisto P, Vaahtomeri K, Mäkelä TP.

J Clin Invest. 2018 Jan 2;128(1):402-414. doi: 10.1172/JCI93597. Epub 2017 Dec 4.

24.

Endothelial autophagic flux hampers atherosclerotic lesion development.

Kheloufi M, Vion AC, Hammoutene A, Poisson J, Lasselin J, Devue C, Pic I, Dupont N, Busse J, Stark K, Lafaurie-Janvore J, Barakat AI, Loyer X, Souyri M, Viollet B, Julia P, Tedgui A, Codogno P, Boulanger CM, Rautou PE.

Autophagy. 2018;14(1):173-175. doi: 10.1080/15548627.2017.1395114. Epub 2018 Jan 29.

25.

Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism.

Cuyàs E, Fernández-Arroyo S, Verdura S, García RÁ, Stursa J, Werner L, Blanco-González E, Montes-Bayón M, Joven J, Viollet B, Neuzil J, Menendez JA.

Oncogene. 2018 Feb 15;37(7):963-970. doi: 10.1038/onc.2017.367. Epub 2017 Oct 23.

PMID:
29059169
26.

CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation.

Lopez-Mejia IC, Lagarrigue S, Giralt A, Martinez-Carreres L, Zanou N, Denechaud PD, Castillo-Armengol J, Chavey C, Orpinell M, Delacuisine B, Nasrallah A, Collodet C, Zhang L, Viollet B, Hardie DG, Fajas L.

Mol Cell. 2017 Oct 19;68(2):336-349.e6. doi: 10.1016/j.molcel.2017.09.034.

27.

Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice.

Hughey CC, James FD, Bracy DP, Donahue EP, Young JD, Viollet B, Foretz M, Wasserman DH.

J Biol Chem. 2017 Dec 8;292(49):20125-20140. doi: 10.1074/jbc.M117.811547. Epub 2017 Oct 16.

28.

AMPK is not required for the effect of metformin on the inhibition of BMP6-induced hepcidin gene expression in hepatocytes.

Deschemin JC, Foretz M, Viollet B, Vaulont S.

Sci Rep. 2017 Oct 4;7(1):12679. doi: 10.1038/s41598-017-12976-2.

29.

Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow.

Vion AC, Kheloufi M, Hammoutene A, Poisson J, Lasselin J, Devue C, Pic I, Dupont N, Busse J, Stark K, Lafaurie-Janvore J, Barakat AI, Loyer X, Souyri M, Viollet B, Julia P, Tedgui A, Codogno P, Boulanger CM, Rautou PE.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8675-E8684. doi: 10.1073/pnas.1702223114. Epub 2017 Sep 25.

30.

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs.

Dite TA, Ling NXY, Scott JW, Hoque A, Galic S, Parker BL, Ngoei KRW, Langendorf CG, O'Brien MT, Kundu M, Viollet B, Steinberg GR, Sakamoto K, Kemp BE, Oakhill JS.

Nat Commun. 2017 Sep 18;8(1):571. doi: 10.1038/s41467-017-00628-y.

31.

Chronic Intermittent Hypoxia Impairs Insulin Sensitivity but Improves Whole-Body Glucose Tolerance by Activating Skeletal Muscle AMPK.

Thomas A, Belaidi E, Moulin S, Horman S, van der Zon GC, Viollet B, Levy P, Bertrand L, Pepin JL, Godin-Ribuot D, Guigas B.

Diabetes. 2017 Dec;66(12):2942-2951. doi: 10.2337/db17-0186. Epub 2017 Sep 7.

32.

Correction: Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation.

Hasenour CM, Wall ML, Ridley DE, James FD, Hughey CC, Donahue EP, Viollet B, Foretz M, Young JD, Wasserman DH.

PLoS One. 2017 Aug 16;12(8):e0183601. doi: 10.1371/journal.pone.0183601. eCollection 2017.

33.

Modifying the Dietary Carbohydrate-to-Protein Ratio Alters the Postprandial Macronutrient Oxidation Pattern in Liver of AMPK-Deficient Mice.

Chalvon-Demersay T, Even PC, Chaumontet C, Piedcoq J, Viollet B, Gaudichon C, Tomé D, Foretz M, Azzout-Marniche D.

J Nutr. 2017 Sep;147(9):1669-1676. doi: 10.3945/jn.117.250803. Epub 2017 Jul 26.

PMID:
28747486
34.

AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis.

Theret M, Gsaier L, Schaffer B, Juban G, Ben Larbi S, Weiss-Gayet M, Bultot L, Collodet C, Foretz M, Desplanches D, Sanz P, Zang Z, Yang L, Vial G, Viollet B, Sakamoto K, Brunet A, Chazaud B, Mounier R.

EMBO J. 2017 Jul 3;36(13):1946-1962. doi: 10.15252/embj.201695273. Epub 2017 May 17.

35.

Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.

Cokorinos EC, Delmore J, Reyes AR, Albuquerque B, Kjøbsted R, Jørgensen NO, Tran JL, Jatkar A, Cialdea K, Esquejo RM, Meissen J, Calabrese MF, Cordes J, Moccia R, Tess D, Salatto CT, Coskran TM, Opsahl AC, Flynn D, Blatnik M, Li W, Kindt E, Foretz M, Viollet B, Ward J, Kurumbail RG, Kalgutkar AS, Wojtaszewski JFP, Cameron KO, Miller RA.

Cell Metab. 2017 May 2;25(5):1147-1159.e10. doi: 10.1016/j.cmet.2017.04.010.

36.

Corrigendum to "Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms" [Mol. Cell. Endocrinol. 440 15 January 2017 57-68].

Chen SC, Brooks R, Houskeeper J, Bremner SK, Dunlop J, Viollet B, Logan PJ, Salt IP, Ahmed SF, Yarwood SJ.

Mol Cell Endocrinol. 2017 Mar 5;443:176. doi: 10.1016/j.mce.2017.01.049. No abstract available.

PMID:
28183460
37.

Kidney-specific genetic deletion of both AMPK α-subunits causes salt and water wasting.

Lazo-Fernández Y, Baile G, Meade P, Torcal P, Martínez L, Ibañez C, Bernal ML, Viollet B, Giménez I.

Am J Physiol Renal Physiol. 2017 Feb 1;312(2):F352-F365. doi: 10.1152/ajprenal.00169.2016. Epub 2016 Nov 9.

38.

Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation.

Hasenour CM, Ridley DE, James FD, Hughey CC, Donahue EP, Viollet B, Foretz M, Young JD, Wasserman DH.

PLoS One. 2017 Jan 20;12(1):e0170382. doi: 10.1371/journal.pone.0170382. eCollection 2017. Erratum in: PLoS One. 2017 Aug 16;12 (8):e0183601.

39.

Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival.

Zhao B, Qiang L, Joseph J, Kalyanaraman B, Viollet B, He YY.

Genes Dis. 2016 Mar;3(1):82-87. doi: 10.1016/j.gendis.2015.12.002. Epub 2016 Jan 4.

40.

GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis.

Zibrova D, Vandermoere F, Göransson O, Peggie M, Mariño KV, Knierim A, Spengler K, Weigert C, Viollet B, Morrice NA, Sakamoto K, Heller R.

Biochem J. 2017 Mar 7;474(6):983-1001. doi: 10.1042/BCJ20160980.

PMID:
28008135
41.

Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling.

Rutherford C, Speirs C, Williams JJ, Ewart MA, Mancini SJ, Hawley SA, Delles C, Viollet B, Costa-Pereira AP, Baillie GS, Salt IP, Palmer TM.

Sci Signal. 2016 Nov 8;9(453):ra109.

42.

Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms.

Chen SC, Brooks R, Houskeeper J, Bremner SK, Dunlop J, Viollet B, Logan PJ, Salt IP, Ahmed SF, Yarwood SJ.

Mol Cell Endocrinol. 2017 Jan 15;440:57-68. doi: 10.1016/j.mce.2016.11.011. Epub 2016 Nov 14. Erratum in: Mol Cell Endocrinol. 2017 Mar 5;443:176.

43.

Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation.

Mancini SJ, White AD, Bijland S, Rutherford C, Graham D, Richter EA, Viollet B, Touyz RM, Palmer TM, Salt IP.

Mol Cell Endocrinol. 2017 Jan 15;440:44-56. doi: 10.1016/j.mce.2016.11.010. Epub 2016 Nov 11.

44.

Animal Models to Study AMPK.

Viollet B, Foretz M.

Exp Suppl. 2016;107:441-469. Review.

45.

Targeting AMPK: From Ancient Drugs to New Small-Molecule Activators.

Guigas B, Viollet B.

Exp Suppl. 2016;107:327-350. Review.

PMID:
27812986
46.

Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK.

Kjøbsted R, Munk-Hansen N, Birk JB, Foretz M, Viollet B, Björnholm M, Zierath JR, Treebak JT, Wojtaszewski JF.

Diabetes. 2017 Mar;66(3):598-612. doi: 10.2337/db16-0530. Epub 2016 Oct 26.

47.

AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis.

Yang Q, Liang X, Sun X, Zhang L, Fu X, Rogers CJ, Berim A, Zhang S, Wang S, Wang B, Foretz M, Viollet B, Gang DR, Rodgers BD, Zhu MJ, Du M.

Cell Metab. 2016 Oct 11;24(4):542-554. doi: 10.1016/j.cmet.2016.08.010. Epub 2016 Sep 15.

48.

p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing.

Deng W, Cha J, Yuan J, Haraguchi H, Bartos A, Leishman E, Viollet B, Bradshaw HB, Hirota Y, Dey SK.

J Clin Invest. 2016 Aug 1;126(8):2941-54. doi: 10.1172/JCI87715. Epub 2016 Jul 25.

49.

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status.

Cameron AR, Morrison VL, Levin D, Mohan M, Forteath C, Beall C, McNeilly AD, Balfour DJ, Savinko T, Wong AK, Viollet B, Sakamoto K, Fagerholm SC, Foretz M, Lang CC, Rena G.

Circ Res. 2016 Aug 19;119(5):652-65. doi: 10.1161/CIRCRESAHA.116.308445. Epub 2016 Jul 14.

50.

AMP-activated Protein Kinase Up-regulates Mitogen-activated Protein (MAP) Kinase-interacting Serine/Threonine Kinase 1a-dependent Phosphorylation of Eukaryotic Translation Initiation Factor 4E.

Zhu X, Dahlmans V, Thali R, Preisinger C, Viollet B, Voncken JW, Neumann D.

J Biol Chem. 2016 Aug 12;291(33):17020-7. doi: 10.1074/jbc.C116.740498. Epub 2016 Jul 13.

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