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Commentary: Mitochondria are more than just the cells' powerhouse.

Vinten-Johansen J.

J Thorac Cardiovasc Surg. 2019 Jul 25. pii: S0022-5223(19)31492-8. doi: 10.1016/j.jtcvs.2019.07.029. [Epub ahead of print] No abstract available.


Commentary: No one drug does only one thing in only one setting.

Vinten-Johansen J.

J Thorac Cardiovasc Surg. 2019 Jul;158(1):299-300. doi: 10.1016/j.jtcvs.2019.02.081. Epub 2019 Mar 2. No abstract available.


Do we see ourselves in the rat?

Vinten-Johansen J.

J Thorac Cardiovasc Surg. 2017 Nov;154(5):1740-1741. doi: 10.1016/j.jtcvs.2017.07.058. Epub 2017 Aug 12. No abstract available.


Melatonin as a cardioprotective therapy following ST-segment elevation myocardial infarction: is it really promising? Reply.

Hausenloy DJ, Garcia-Dorado D, Erik Bøtker H, Davidson SM, Downey J, Engel FB, Jennings R, Lecour S, Leor J, Madonna R, Ovize M, Perrino C, Prunier F, Schulz R, Sluijter JPG, Van Laake LW, Vinten-Johansen J, Yellon DM, Ytrehus K, Heusch G, Ferdinandy P.

Cardiovasc Res. 2017 Sep 1;113(11):1418-1419. doi: 10.1093/cvr/cvx137. No abstract available.


Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart.

Hausenloy DJ, Garcia-Dorado D, Bøtker HE, Davidson SM, Downey J, Engel FB, Jennings R, Lecour S, Leor J, Madonna R, Ovize M, Perrino C, Prunier F, Schulz R, Sluijter JPG, Van Laake LW, Vinten-Johansen J, Yellon DM, Ytrehus K, Heusch G, Ferdinandy P.

Cardiovasc Res. 2017 May 1;113(6):564-585. doi: 10.1093/cvr/cvx049. Review.


Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery.

Hausenloy DJ, Barrabes JA, Bøtker HE, Davidson SM, Di Lisa F, Downey J, Engstrom T, Ferdinandy P, Carbrera-Fuentes HA, Heusch G, Ibanez B, Iliodromitis EK, Inserte J, Jennings R, Kalia N, Kharbanda R, Lecour S, Marber M, Miura T, Ovize M, Perez-Pinzon MA, Piper HM, Przyklenk K, Schmidt MR, Redington A, Ruiz-Meana M, Vilahur G, Vinten-Johansen J, Yellon DM, Garcia-Dorado D.

Basic Res Cardiol. 2016 Nov;111(6):70. Epub 2016 Oct 20. Review.


Whole Blood Cardioplegia: Do We Still Need to Dilute?

Vinten-Johansen J.

J Extra Corpor Technol. 2016 Jun;48(2):P9-P14. No abstract available.


Pre-clinical Experience with a Multi-Chordal Patch for Mitral Valve Repair.

Chawla SK, Shi W, McIver BV, Vinten-Johansen J, Frater RW, Padala M.

J Cardiovasc Transl Res. 2016 Apr;9(2):127-34. doi: 10.1007/s12265-016-9674-4. Epub 2016 Jan 22.


Controlled reperfusion is a rose by any other name.

Vinten-Johansen J.

J Thorac Cardiovasc Surg. 2015 Dec;150(6):1649-50. doi: 10.1016/j.jtcvs.2015.09.014. Epub 2015 Sep 16. No abstract available.


Adenosine, lidocaine and Mg2+ improves cardiac and pulmonary function, induces reversible hypotension and exerts anti-inflammatory effects in an endotoxemic porcine model.

Granfeldt A, Letson HL, Dobson GP, Shi W, Vinten-Johansen J, Tønnesen E.

Crit Care. 2014 Dec 11;18(6):682. doi: 10.1186/s13054-014-0682-y.


Small-volume 7.5% NaCl adenosine, lidocaine, and Mg2+ has multiple benefits during hypotensive and blood resuscitation in the pig following severe blood loss: rat to pig translation.

Granfeldt A, Letson HL, Hyldebrandt JA, Wang ER, Salcedo PA, Nielsen TK, Tønnesen E, Vinten-Johansen J, Dobson GP.

Crit Care Med. 2014 May;42(5):e329-44. doi: 10.1097/CCM.0000000000000225.


Automatic detection of left and right ventricles from CTA enables efficient alignment of anatomy with myocardial perfusion data.

Piccinelli M, Faber TL, Arepalli CD, Appia V, Vinten-Johansen J, Schmarkey SL, Folks RD, Garcia EV, Yezzi A.

J Nucl Cardiol. 2014 Feb;21(1):96-108. doi: 10.1007/s12350-013-9812-1. Epub 2013 Nov 2.


Hyperkalemic cardioplegia for adult and pediatric surgery: end of an era?

Dobson GP, Faggian G, Onorati F, Vinten-Johansen J.

Front Physiol. 2013 Aug 28;4:228. doi: 10.3389/fphys.2013.00228. eCollection 2013. Review.


The effects of adenocaine (adenosine and lidocaine) on early post-resuscitation cardiac and neurological dysfunction in a porcine model of cardiac arrest.

Granfeldt A, Shi W, Schmarkey SL, Jiang R, Bone CC, Cline JM, Wogensen L, Dobson GP, Tønnesen E, Vinten-Johansen J.

Resuscitation. 2013 Nov;84(11):1611-8. doi: 10.1016/j.resuscitation.2013.07.001. Epub 2013 Jul 11.


Adenosine-procaine cardioplegia and adenosine-lidocaine cardioplegia: Two sides of the same coin?

Vinten-Johansen J, Dobson GP.

J Thorac Cardiovasc Surg. 2013 Jun;145(6):1684-5. doi: 10.1016/j.jtcvs.2013.01.049. No abstract available.


Postconditioning attenuates acute intestinal ischemia-reperfusion injury.

Sengul I, Sengul D, Guler O, Hasanoglu A, Urhan MK, Taner AS, Vinten-Johansen J.

Kaohsiung J Med Sci. 2013 Mar;29(3):119-27. doi: 10.1016/j.kjms.2012.08.021. Epub 2012 Oct 10.


The science and clinical translation of remote postconditioning.

Vinten-Johansen J, Shi W.

J Cardiovasc Med (Hagerstown). 2013 Mar;14(3):206-13. doi: 10.2459/JCM.0b013e32835cecc6. Review.


Adenosine-lidocaine-magnesium non-depolarizing cardioplegia: moving forward from bench to bedside.

Vinten-Johansen J.

Int J Cardiol. 2013 Jun 20;166(2):537-8. doi: 10.1016/j.ijcard.2012.09.193. Epub 2012 Oct 15. No abstract available.


Trials, tribulations and speculation! Report from the 7th Biennial Hatter Cardiovascular Institute Workshop.

Bell R, Beeuwkes R, Bøtker HE, Davidson S, Downey J, Garcia-Dorado D, Hausenloy DJ, Heusch G, Ibanez B, Kitakaze M, Lecour S, Mentzer R, Miura T, Opie L, Ovize M, Ruiz-Meana M, Schulz R, Shannon R, Walker M, Vinten-Johansen J, Yellon D.

Basic Res Cardiol. 2012 Nov;107(6):300. Epub 2012 Sep 25. No abstract available.


Adenocaine and Mg(2+) reduce fluid requirement to maintain hypotensive resuscitation and improve cardiac and renal function in a porcine model of severe hemorrhagic shock*.

Granfeldt A, Nielsen TK, Sølling C, Hyldebrandt JA, Frøkiær J, Wogensen L, Dobson GP, Vinten-Johansen J, Tønnesen E.

Crit Care Med. 2012 Nov;40(11):3013-25. doi: 10.1097/CCM.0b013e31825fd4ed.


Ischemia-reperfusion increases transfection efficiency of intracoronary adenovirus type 5 in pig heart in situ.

Shi W, Schmarkey LS, Jiang R, Bone CC, Condit ME, Dillehay DL, Engler RL, Rubanyi GM, Vinten-Johansen J.

Hum Gene Ther Methods. 2012 Jun;23(3):204-12. doi: 10.1089/hgtb.2012.048. Epub 2012 Jul 20.


Editorial comment: myocardial protection with postconditioning in cardiac surgery: the importance of the model.

Vinten-Johansen J.

Eur J Cardiothorac Surg. 2012 Sep;42(3):539-41. doi: 10.1093/ejcts/ezs045. Epub 2012 Feb 29. No abstract available.


Endogenous cardioprotection by ischaemic postconditioning and remote conditioning.

Shi W, Vinten-Johansen J.

Cardiovasc Res. 2012 May 1;94(2):206-16. doi: 10.1093/cvr/cvs088. Epub 2012 Feb 9.


Neutrophil inhibition contributes to cardioprotection by postconditioning.

Granfeldt A, Jiang R, Wang NP, Mykytenko J, Eldaif S, Deneve J, Zhao ZQ, Guyton RA, Tønnesen E, Vinten-Johansen J.

Acta Anaesthesiol Scand. 2012 Jan;56(1):48-56. doi: 10.1111/j.1399-6576.2011.02577.x. Epub 2011 Nov 21.


The nondepolarizing, normokalemic cardioplegia formulation adenosine-lidocaine (adenocaine) exerts anti-neutrophil effects by synergistic actions of its components.

Shi W, Jiang R, Dobson GP, Granfeldt A, Vinten-Johansen J.

J Thorac Cardiovasc Surg. 2012 May;143(5):1167-75. doi: 10.1016/j.jtcvs.2011.06.045. Epub 2011 Nov 12.


Invited commentary.

Vinten-Johansen J.

Ann Thorac Surg. 2011 Nov;92(5):1732-3. doi: 10.1016/j.athoracsur.2011.08.007. Epub 2011 Oct 31. No abstract available.


New horizons in cardioprotection: recommendations from the 2010 National Heart, Lung, and Blood Institute Workshop.

Schwartz Longacre L, Kloner RA, Arai AE, Baines CP, Bolli R, Braunwald E, Downey J, Gibbons RJ, Gottlieb RA, Heusch G, Jennings RB, Lefer DJ, Mentzer RM, Murphy E, Ovize M, Ping P, Przyklenk K, Sack MN, Vander Heide RS, Vinten-Johansen J, Yellon DM; National Heart, Lung, and Blood Institute, National Institutes of Health.

Circulation. 2011 Sep 6;124(10):1172-9. doi: 10.1161/CIRCULATIONAHA.111.032698. No abstract available.


Perconditioning and postconditioning: current knowledge, knowledge gaps, barriers to adoption, and future directions.

Vinten-Johansen J, Shi W.

J Cardiovasc Pharmacol Ther. 2011 Sep-Dec;16(3-4):260-6. doi: 10.1177/1074248411415270. Review.


Adhesive epicardial corticosteroids prevent postoperative atrial fibrillation.

Yoo D, Vinten-Johansen J, Schmarkey LS, Whalen SP, Bone CC, Katzmark SL, Langberg J.

Circ Arrhythm Electrophysiol. 2010 Oct;3(5):505-10. doi: 10.1161/CIRCEP.109.934299. Epub 2010 Sep 21.


The multidimensional physiological responses to postconditioning.

Vinten-Johansen J, Granfeldt A, Mykytenko J, Undyala VV, Dong Y, Przyklenk K.

Antioxid Redox Signal. 2011 Mar 1;14(5):791-810. doi: 10.1089/ars.2010.3396. Epub 2010 Nov 2. Review.


Factor Xa induces tissue factor expression in endothelial cells by P44/42 MAPK and NF-κB-dependent pathways.

Jiang R, Wang NP, Tanaka KA, Levy JH, Guyton RA, Zhao ZQ, Vinten-Johansen J.

J Surg Res. 2011 Aug;169(2):319-27. doi: 10.1016/j.jss.2010.01.041. Epub 2010 Feb 23.


Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology.

Ovize M, Baxter GF, Di Lisa F, Ferdinandy P, Garcia-Dorado D, Hausenloy DJ, Heusch G, Vinten-Johansen J, Yellon DM, Schulz R; Working Group of Cellular Biology of Heart of European Society of Cardiology.

Cardiovasc Res. 2010 Aug 1;87(3):406-23. doi: 10.1093/cvr/cvq129. Epub 2010 May 6. Review.


Improvement in cardiac function with small intestine extracellular matrix is associated with recruitment of C-kit cells, myofibroblasts, and macrophages after myocardial infarction.

Zhao ZQ, Puskas JD, Xu D, Wang NP, Mosunjac M, Guyton RA, Vinten-Johansen J, Matheny R.

J Am Coll Cardiol. 2010 Mar 23;55(12):1250-61. doi: 10.1016/j.jacc.2009.10.049.


Postconditioning and controlled reperfusion: the nerve of it all.

Vinten-Johansen J.

Anesthesiology. 2009 Dec;111(6):1177-9. doi: 10.1097/ALN.0b013e3181bf1dac. No abstract available.


Nonanticoagulant heparin reduces myocyte Na+ and Ca2+ loading during simulated ischemia and decreases reperfusion injury.

Barry WH, Zhang XQ, Halkos ME, Vinten-Johansen J, Saegusa N, Spitzer KW, Matsuoka N, Sheets M, Rao NV, Kennedy TP.

Am J Physiol Heart Circ Physiol. 2010 Jan;298(1):H102-11. doi: 10.1152/ajpheart.00316.2009. Epub 2009 Oct 23.


Attenuation of renal ischemia-reperfusion injury by postconditioning involves adenosine receptor and protein kinase C activation.

Eldaif SM, Deneve JA, Wang NP, Jiang R, Mosunjac M, Mutrie CJ, Guyton RA, Zhao ZQ, Vinten-Johansen J.

Transpl Int. 2010 Feb;23(2):217-26. doi: 10.1111/j.1432-2277.2009.00949.x. Epub 2009 Sep 2.


Protective ischaemia in patients: preconditioning and postconditioning.

Granfeldt A, Lefer DJ, Vinten-Johansen J.

Cardiovasc Res. 2009 Jul 15;83(2):234-46. doi: 10.1093/cvr/cvp129. Epub 2009 Apr 27. Review.


Invited commentary.

Vinten-Johansen J.

Ann Thorac Surg. 2009 Apr;87(4):1213. doi: 10.1016/j.athoracsur.2009.02.051. No abstract available.


A novel peptide agonist of formyl-peptide receptor-like 1 (ALX) displays anti-inflammatory and cardioprotective effects.

Hecht I, Rong J, Sampaio AL, Hermesh C, Rutledge C, Shemesh R, Toporik A, Beiman M, Dassa L, Niv H, Cojocaru G, Zauberman A, Rotman G, Perretti M, Vinten-Johansen J, Cohen Y.

J Pharmacol Exp Ther. 2009 Feb;328(2):426-34. doi: 10.1124/jpet.108.145821. Epub 2008 Nov 20.


Intravenous infusion of mesenchymal stem cells enhances regional perfusion and improves ventricular function in a porcine model of myocardial infarction.

Halkos ME, Zhao ZQ, Kerendi F, Wang NP, Jiang R, Schmarkey LS, Martin BJ, Quyyumi AA, Few WL, Kin H, Guyton RA, Vinten-Johansen J.

Basic Res Cardiol. 2008 Nov;103(6):525-36. doi: 10.1007/s00395-008-0741-0. Epub 2008 Aug 14.


Persistent beneficial effect of postconditioning against infarct size: role of mitochondrial K(ATP) channels during reperfusion.

Mykytenko J, Reeves JG, Kin H, Wang NP, Zatta AJ, Jiang R, Guyton RA, Vinten-Johansen J, Zhao ZQ.

Basic Res Cardiol. 2008 Sep;103(5):472-84. doi: 10.1007/s00395-008-0731-2. Epub 2008 Jul 3.


Inhibition of myocardial apoptosis by postconditioning is associated with attenuation of oxidative stress-mediated nuclear factor-kappa B translocation and TNF alpha release.

Kin H, Wang NP, Mykytenko J, Reeves J, Deneve J, Jiang R, Zatta AJ, Guyton RA, Vinten-Johansen J, Zhao ZQ.

Shock. 2008 Jun;29(6):761-8. doi: 10.1097/SHK.0b013e31815cfd5a.


Evidence that cardioprotection by postconditioning involves preservation of myocardial opioid content and selective opioid receptor activation.

Zatta AJ, Kin H, Yoshishige D, Jiang R, Wang N, Reeves JG, Mykytenko J, Guyton RA, Zhao ZQ, Caffrey JL, Vinten-Johansen J.

Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1444-51. doi: 10.1152/ajpheart.01279.2006. Epub 2008 Jan 18.


Thrombin-activated thrombelastography for evaluation of thrombin interaction with thrombin inhibitors.

Taketomi T, Szlam F, Vinten-Johansen J, Levy JH, Tanaka KA.

Blood Coagul Fibrinolysis. 2007 Dec;18(8):761-7.


Reduction in myocardial infarct size by postconditioning in patients after percutaneous coronary intervention.

Yang XC, Liu Y, Wang LF, Cui L, Wang T, Ge YG, Wang HS, Li WM, Xu L, Ni ZH, Liu SH, Zhang L, Jia HM, Vinten-Johansen J, Zhao ZQ.

J Invasive Cardiol. 2007 Oct;19(10):424-30.


PAR-2 activation at the time of reperfusion salvages myocardium via an ERK1/2 pathway in in vivo rat hearts.

Jiang R, Zatta A, Kin H, Wang N, Reeves JG, Mykytenko J, Deneve J, Zhao ZQ, Guyton RA, Vinten-Johansen J.

Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2845-52. Epub 2007 Aug 24.


Preconditioning and postconditioning: innate cardioprotection from ischemia-reperfusion injury.

Vinten-Johansen J, Zhao ZQ, Jiang R, Zatta AJ, Dobson GP.

J Appl Physiol (1985). 2007 Oct;103(4):1441-8. Epub 2007 Jul 5. Review.


Warm nondepolarizing adenosine and lidocaine cardioplegia: continuous versus intermittent delivery.

Sloots KL, Vinten-Johansen J, Dobson GP.

J Thorac Cardiovasc Surg. 2007 May;133(5):1171-8.


Speckle-tracking strain echocardiography for detecting cardiac dyssynchrony in a canine model of dyssynchrony and heart failure.

Arita T, Sorescu GP, Schuler BT, Schmarkey LS, Merlino JD, Vinten-Johansen J, Leon AR, Martin RP, Sorescu D.

Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H735-42. Epub 2007 Apr 20.

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