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Items: 6

1.

Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases.

Vinh NB, Drinkwater N, Malcolm TR, Kassiou M, Lucantoni L, Grin PM, Butler GS, Duffy S, Overall CM, Avery VM, Scammells PJ, McGowan S.

J Med Chem. 2019 Jan 24;62(2):622-640. doi: 10.1021/acs.jmedchem.8b01310. Epub 2019 Jan 4.

PMID:
30537832
2.

Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum.

Drinkwater N, Sivaraman KK, Bamert RS, Rut W, Mohamed K, Vinh NB, Scammells PJ, Drag M, McGowan S.

Biochem J. 2016 Oct 1;473(19):3189-204. doi: 10.1042/BCJ20160550. Epub 2016 Jul 26.

PMID:
27462122
3.

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.

Drinkwater N, Vinh NB, Mistry SN, Bamert RS, Ruggeri C, Holleran JP, Loganathan S, Paiardini A, Charman SA, Powell AK, Avery VM, McGowan S, Scammells PJ.

Eur J Med Chem. 2016 Mar 3;110:43-64. doi: 10.1016/j.ejmech.2016.01.015. Epub 2016 Jan 13.

PMID:
26807544
4.

4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor.

Mistry SN, Jörg M, Lim H, Vinh NB, Sexton PM, Capuano B, Christopoulos A, Lane JR, Scammells PJ.

J Med Chem. 2016 Jan 14;59(1):388-409. doi: 10.1021/acs.jmedchem.5b01562. Epub 2015 Dec 31.

PMID:
26624844
5.

Design, Synthesis, and Biological Evaluation of Tetra-Substituted Thiophenes as Inhibitors of p38α MAPK.

Vinh NB, Devine SM, Munoz L, Ryan RM, Wang BH, Krum H, Chalmers DK, Simpson JS, Scammells PJ.

ChemistryOpen. 2015 Feb;4(1):56-64. doi: 10.1002/open.201402076. Epub 2014 Nov 11.

6.

Virtual screening using a conformationally flexible target protein: models for ligand binding to p38α MAPK.

Vinh NB, Simpson JS, Scammells PJ, Chalmers DK.

J Comput Aided Mol Des. 2012 Apr;26(4):409-23. doi: 10.1007/s10822-012-9569-7. Epub 2012 Apr 20.

PMID:
22527960

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