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Items: 1 to 50 of 99

1.

Mitotic regulators TPX2 and Aurora A protect DNA forks during replication stress by counteracting 53BP1 function.

Byrum AK, Carvajal-Maldonado D, Mudge MC, Valle-Garcia D, Majid MC, Patel R, Sowa ME, Gygi SP, Harper JW, Shi Y, Vindigni A, Mosammaparast N.

J Cell Biol. 2019 Feb 4;218(2):422-432. doi: 10.1083/jcb.201803003. Epub 2019 Jan 2.

PMID:
30602538
2.

Superfast DNA replication causes damage in cancer cells.

Quinet A, Vindigni A.

Nature. 2018 Jul;559(7713):186-187. doi: 10.1038/d41586-018-05501-6. No abstract available.

PMID:
29988050
3.

Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing.

Carvajal-Maldonado D, Byrum AK, Jackson J, Wessel S, Lemaçon D, Guitton-Sert L, Quinet A, Tirman S, Graziano S, Masson JY, Cortez D, Gonzalo S, Mosammaparast N, Vindigni A.

Nucleic Acids Res. 2018 Jun 18. doi: 10.1093/nar/gky519. [Epub ahead of print]

PMID:
29917110
4.

A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.

Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.

Cell Rep. 2018 Feb 20;22(8):2006-2015. doi: 10.1016/j.celrep.2018.01.090.

5.

Replication Fork Reversal: Players and Guardians.

Quinet A, Lemaçon D, Vindigni A.

Mol Cell. 2017 Dec 7;68(5):830-833. doi: 10.1016/j.molcel.2017.11.022. Review.

6.

Nucleases Acting at Stalled Forks: How to Reboot the Replication Program with a Few Shortcuts.

Pasero P, Vindigni A.

Annu Rev Genet. 2017 Nov 27;51:477-499. doi: 10.1146/annurev-genet-120116-024745. Review.

PMID:
29178820
7.

Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2.

Elango R, Sheng Z, Jackson J, DeCata J, Ibrahim Y, Pham NT, Liang DH, Sakofsky CJ, Vindigni A, Lobachev KS, Ira G, Malkova A.

Nat Commun. 2017 Nov 27;8(1):1790. doi: 10.1038/s41467-017-01987-2.

8.

A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.

Brickner JR, Soll JM, Lombardi PM, Vågbø CB, Mudge MC, Oyeniran C, Rabe R, Jackson J, Sullender ME, Blazosky E, Byrum AK, Zhao Y, Corbett MA, Gécz J, Field M, Vindigni A, Slupphaug G, Wolberger C, Mosammaparast N.

Nature. 2017 Nov 16;551(7680):389-393. doi: 10.1038/nature24484. Epub 2017 Nov 8.

PMID:
29144457
9.

Spin-polarised electrons in a one-magnet-only Mott spin junction.

De Pietro L, Bertolini G, Peter Q, Cabrera H, Vindigni A, Gürlü O, Pescia D, Ramsperger U.

Sci Rep. 2017 Oct 16;7(1):13237. doi: 10.1038/s41598-017-13453-6.

10.

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells.

Lemaçon D, Jackson J, Quinet A, Brickner JR, Li S, Yazinski S, You Z, Ira G, Zou L, Mosammaparast N, Vindigni A.

Nat Commun. 2017 Oct 16;8(1):860. doi: 10.1038/s41467-017-01180-5.

11.

Human ribonuclease H1 resolves R-loops and thereby enables progression of the DNA replication fork.

Parajuli S, Teasley DC, Murali B, Jackson J, Vindigni A, Stewart SA.

J Biol Chem. 2017 Sep 15;292(37):15216-15224. doi: 10.1074/jbc.M117.787473. Epub 2017 Jul 17.

12.

DNA Fiber Analysis: Mind the Gap!

Quinet A, Carvajal-Maldonado D, Lemacon D, Vindigni A.

Methods Enzymol. 2017;591:55-82. doi: 10.1016/bs.mie.2017.03.019. Epub 2017 May 3. Review.

PMID:
28645379
13.

Special issue: "At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy".

Vindigni A.

Biophys Chem. 2017 Jun;225:1-2. doi: 10.1016/j.bpc.2017.04.007. No abstract available.

PMID:
28641746
14.

Corrigendum: Critical exponents and scaling invariance in the absence of a critical point.

Saratz N, Zanin DA, Ramsperger U, Cannas SA, Pescia D, Vindigni A.

Nat Commun. 2017 Jan 17;8:14372. doi: 10.1038/ncomms14372. No abstract available.

15.

Thirty per cent contrast in secondary-electron imaging by scanning field-emission microscopy.

Zanin DA, De Pietro LG, Peter Q, Kostanyan A, Cabrera H, Vindigni A, Bähler T, Pescia D, Ramsperger U.

Proc Math Phys Eng Sci. 2016 Nov;472(2195):20160475.

16.

Combining electron microscopy with single molecule DNA fiber approaches to study DNA replication dynamics.

Vindigni A, Lopes M.

Biophys Chem. 2017 Jun;225:3-9. doi: 10.1016/j.bpc.2016.11.014. Epub 2016 Dec 3. Review.

17.

Critical exponents and scaling invariance in the absence of a critical point.

Saratz N, Zanin DA, Ramsperger U, Cannas S, Pescia D, Vindigni A.

Nat Commun. 2016 Dec 5;7:13611. doi: 10.1038/ncomms13611.

18.

The Architectural Chromatin Factor High Mobility Group A1 Enhances DNA Ligase IV Activity Influencing DNA Repair.

Pellarin I, Arnoldo L, Costantini S, Pegoraro S, Ros G, Penzo C, Triolo G, Demarchi F, Sgarra R, Vindigni A, Manfioletti G.

PLoS One. 2016 Oct 10;11(10):e0164258. doi: 10.1371/journal.pone.0164258. eCollection 2016.

19.

Topoisomerase IIβ mediates the resistance of glioblastoma stem cells to replication stress-inducing drugs.

Kenig S, Faoro V, Bourkoula E, Podergajs N, Ius T, Vindigni M, Skrap M, Lah T, Cesselli D, Storici P, Vindigni A.

Cancer Cell Int. 2016 Jul 26;16:58. doi: 10.1186/s12935-016-0339-9. eCollection 2016.

20.

Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors.

Yamamoto K, Wang J, Sprinzen L, Xu J, Haddock CJ, Li C, Lee BJ, Loredan DG, Jiang W, Vindigni A, Wang D, Rabadan R, Zha S.

Elife. 2016 Jun 15;5. pii: e14709. doi: 10.7554/eLife.14709.

21.

Structural and biochemical characterization of an RNA/DNA binding motif in the N-terminal domain of RecQ4 helicases.

Marino F, Mojumdar A, Zucchelli C, Bhardwaj A, Buratti E, Vindigni A, Musco G, Onesti S.

Sci Rep. 2016 Feb 18;6:21501. doi: 10.1038/srep21501.

22.

Replication stress: getting back on track.

Berti M, Vindigni A.

Nat Struct Mol Biol. 2016 Feb;23(2):103-9. Review.

23.

Fourier transform infrared microspectroscopy reveals biochemical changes associated with glioma stem cell differentiation.

Kenig S, Bedolla DE, Birarda G, Faoro V, Mitri E, Vindigni A, Storici P, Vaccari L.

Biophys Chem. 2015 Dec;207:90-6. doi: 10.1016/j.bpc.2015.09.005. Epub 2015 Sep 25.

PMID:
26426146
24.

Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures.

Pike AC, Gomathinayagam S, Swuec P, Berti M, Zhang Y, Schnecke C, Marino F, von Delft F, Renault L, Costa A, Gileadi O, Vindigni A.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4286-91. doi: 10.1073/pnas.1417594112. Epub 2015 Mar 23.

25.

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells.

Zellweger R, Dalcher D, Mutreja K, Berti M, Schmid JA, Herrador R, Vindigni A, Lopes M.

J Cell Biol. 2015 Mar 2;208(5):563-79. doi: 10.1083/jcb.201406099.

26.

DNA2 drives processing and restart of reversed replication forks in human cells.

Thangavel S, Berti M, Levikova M, Pinto C, Gomathinayagam S, Vujanovic M, Zellweger R, Moore H, Lee EH, Hendrickson EA, Cejka P, Stewart S, Lopes M, Vindigni A.

J Cell Biol. 2015 Mar 2;208(5):545-62. doi: 10.1083/jcb.201406100.

27.

Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion.

Li XL, Lu X, Parvathaneni S, Bilke S, Zhang H, Thangavel S, Vindigni A, Hara T, Zhu Y, Meltzer PS, Lal A, Sharma S.

Cell Cycle. 2014;13(15):2431-45. doi: 10.4161/cc.29419.

28.

Scaling theory of electric-field-assisted tunnelling.

Michaels TC, Cabrera H, Zanin DA, De Pietro L, Ramsperger U, Vindigni A, Pescia D.

Proc Math Phys Eng Sci. 2014 Jul 8;470(2167):20140014.

29.

Discovery of ML216, a Small Molecule Inhibitor of Bloom (BLM) Helicase.

Rosenthal AS, Dexheimer TS, Nguyen G, Gileadi O, Vindigni A, Simeonov A, Jadhav A, Hickson I, Maloney DJ.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Apr 15 [updated 2013 Feb 28].

30.

The two faces of DNA repair: disease and therapy.

Vindigni A, Gonzalo S.

Mo Med. 2013 Jul-Aug;110(4):314-9.

31.

Bioinformatic analysis of RecQ4 helicases reveals the presence of a RQC domain and a Zn knuckle.

Marino F, Vindigni A, Onesti S.

Biophys Chem. 2013 Jul-Aug;177-178:34-9. doi: 10.1016/j.bpc.2013.02.009. Epub 2013 Mar 20.

PMID:
23624328
32.

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition.

Berti M, Ray Chaudhuri A, Thangavel S, Gomathinayagam S, Kenig S, Vujanovic M, Odreman F, Glatter T, Graziano S, Mendoza-Maldonado R, Marino F, Lucic B, Biasin V, Gstaiger M, Aebersold R, Sidorova JM, Monnat RJ Jr, Lopes M, Vindigni A.

Nat Struct Mol Biol. 2013 Mar;20(3):347-54. doi: 10.1038/nsmb.2501. Epub 2013 Feb 10.

33.

In Vitro Enzyme Comparative Kinetics: Unwinding of Surface-Bound DNA Nanostructures by RecQ and RecQ1.

Parisse P, Vindigni A, Scoles G, Casalis L.

J Phys Chem Lett. 2012 Dec 6;3(23):3532-7. doi: 10.1021/jz3018682. Epub 2012 Nov 19.

PMID:
26290984
34.

The α2 helix in the DNA ligase IV BRCT-1 domain is required for targeted degradation of ligase IV during adenovirus infection.

Gilson T, Greer AE, Vindigni A, Ketner G, Hanakahi LA.

Virology. 2012 Jul 5;428(2):128-35. doi: 10.1016/j.virol.2012.03.006. Epub 2012 Apr 24.

35.

Proteomic analysis of gastric cancer and immunoblot validation of potential biomarkers.

Kočevar N, Odreman F, Vindigni A, Grazio SF, Komel R.

World J Gastroenterol. 2012 Mar 21;18(11):1216-28. doi: 10.3748/wjg.v18.i11.1216.

36.

The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation.

Mendoza-Maldonado R, Faoro V, Bajpai S, Berti M, Odreman F, Vindigni M, Ius T, Ghasemian A, Bonin S, Skrap M, Stanta G, Vindigni A.

Mol Cancer. 2011 Jul 13;10:83. doi: 10.1186/1476-4598-10-83.

37.

A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation.

Lucic B, Zhang Y, King O, Mendoza-Maldonado R, Berti M, Niesen FH, Burgess-Brown NA, Pike AC, Cooper CD, Gileadi O, Vindigni A.

Nucleic Acids Res. 2011 Mar;39(5):1703-17. doi: 10.1093/nar/gkq1031. Epub 2010 Nov 8.

38.

Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication.

Xu D, Muniandy P, Leo E, Yin J, Thangavel S, Shen X, Ii M, Agama K, Guo R, Fox D 3rd, Meetei AR, Wilson L, Nguyen H, Weng NP, Brill SJ, Li L, Vindigni A, Pommier Y, Seidman M, Wang W.

EMBO J. 2010 Sep 15;29(18):3140-55. doi: 10.1038/emboj.2010.186. Epub 2010 Aug 13.

39.

Probing the structural basis of RecQ helicase function.

Vindigni A, Marino F, Gileadi O.

Biophys Chem. 2010 Jul;149(3):67-77. doi: 10.1016/j.bpc.2010.03.012. Epub 2010 Mar 20. Review.

PMID:
20392558
40.

Experimental phase diagram of perpendicularly magnetized ultrathin ferromagnetic films.

Saratz N, Lichtenberger A, Portmann O, Ramsperger U, Vindigni A, Pescia D.

Phys Rev Lett. 2010 Feb 19;104(7):077203. Epub 2010 Feb 19.

PMID:
20366912
41.

Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation.

Thangavel S, Mendoza-Maldonado R, Tissino E, Sidorova JM, Yin J, Wang W, Monnat RJ Jr, Falaschi A, Vindigni A.

Mol Cell Biol. 2010 Mar;30(6):1382-96. doi: 10.1128/MCB.01290-09. Epub 2010 Jan 11.

42.

RecQ helicases: multiple structures for multiple functions?

Vindigni A, Hickson ID.

HFSP J. 2009 Jun;3(3):153-64. doi: 10.2976/1.3079540. Epub 2009 Mar 18.

43.

Selection rules for single-chain-magnet behaviour in non-collinear Ising systems.

Vindigni A, Pini MG.

J Phys Condens Matter. 2009 Jun 10;21(23):236007. doi: 10.1088/0953-8984/21/23/236007. Epub 2009 May 13.

PMID:
21825604
44.

An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63.

Smith E, Dejsuphong D, Balestrini A, Hampel M, Lenz C, Takeda S, Vindigni A, Costanzo V.

Nat Cell Biol. 2009 Mar;11(3):278-85. doi: 10.1038/ncb1835. Epub 2009 Feb 1.

PMID:
19182792
45.

Structure of the human RECQ1 helicase reveals a putative strand-separation pin.

Pike AC, Shrestha B, Popuri V, Burgess-Brown N, Muzzolini L, Costantini S, Vindigni A, Gileadi O.

Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1039-44. doi: 10.1073/pnas.0806908106. Epub 2009 Jan 16.

46.

[Major emergency management in ship collusion].

Mazzei S, Famà F, Vindigni A, Villari SA, Gioffrè Florio MA.

Ann Ital Chir. 2008 Sep-Oct;79(5):321-5. Italian.

PMID:
19149359
47.

An unusual presentation of secondary involvement of B-cell chronic lymphocytic leukemia. A case report.

Famà F, Barresi V, Giuffrè G, Todaro P, Mazzei S, Vindigni A, Gioffrè-Florio M.

Tumori. 2008 Jul-Aug;94(4):617-20.

PMID:
18822706
48.

Werner protein cooperates with the XRCC4-DNA ligase IV complex in end-processing.

Kusumoto R, Dawut L, Marchetti C, Wan Lee J, Vindigni A, Ramsden D, Bohr VA.

Biochemistry. 2008 Jul 15;47(28):7548-56. doi: 10.1021/bi702325t. Epub 2008 Jun 18.

49.

A proteomic approach for evaluating the cell response to a novel histone deacetylase inhibitor in colon cancer cells.

Milli A, Cecconi D, Campostrini N, Timperio AM, Zolla L, Righetti SC, Zunino F, Perego P, Benedetti V, Gatti L, Odreman F, Vindigni A, Righetti PG.

Biochim Biophys Acta. 2008 Nov;1784(11):1702-10. doi: 10.1016/j.bbapap.2008.04.022. Epub 2008 May 4.

PMID:
18503786
50.

The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities.

Popuri V, Bachrati CZ, Muzzolini L, Mosedale G, Costantini S, Giacomini E, Hickson ID, Vindigni A.

J Biol Chem. 2008 Jun 27;283(26):17766-76. doi: 10.1074/jbc.M709749200. Epub 2008 Apr 30.

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