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Items: 1 to 50 of 78

1.

Heparan Sulfate Proteoglycan Synthesis Is Dysregulated in Human Osteoarthritic Cartilage.

Chanalaris A, Clarke H, Guimond SE, Vincent TL, Turnbull JE, Troeberg L.

Am J Pathol. 2018 Dec 14. pii: S0002-9440(18)30512-1. doi: 10.1016/j.ajpath.2018.11.011. [Epub ahead of print]

PMID:
30553836
2.

Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia.

Urtishak KA, Wang LS, Culjkovic-Kraljacic B, Davenport JW, Porazzi P, Vincent TL, Teachey DT, Tasian SK, Moore JS, Seif AE, Jin S, Barrett JS, Robinson BW, Chen IL, Harvey RC, Carroll MP, Carroll AJ, Heerema NA, Devidas M, Dreyer ZE, Hilden JM, Hunger SP, Willman CL, Borden KLB, Felix CA.

Oncogene. 2018 Nov 26. doi: 10.1038/s41388-018-0567-7. [Epub ahead of print]

PMID:
30478448
3.

Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management.

Marshall M, Watt FE, Vincent TL, Dziedzic K.

Nat Rev Rheumatol. 2018 Nov;14(11):641-656. doi: 10.1038/s41584-018-0095-4. Review.

PMID:
30305701
4.

Studying Osteoarthritis Pathogenesis in Mice.

Blease A, Das Neves Borges P, Curtinha M, Javaheri B, von Loga IS, Parisi I, Zarebska J, Pitsillides A, Vincent TL, Potter PK.

Curr Protoc Mouse Biol. 2018 Dec;8(4):e50. doi: 10.1002/cpmo.50. Epub 2018 Sep 21.

PMID:
30240153
5.

Connective tissue growth factor contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβ.

Tang X, Muhammad H, McLean C, Miotla-Zarebska J, Fleming J, Didangelos A, Önnerfjord P, Leask A, Saklatvala J, Vincent TL.

Ann Rheum Dis. 2018 Sep;77(9):1372-1380. doi: 10.1136/annrheumdis-2018-212964. Epub 2018 Jun 20.

6.

Mechanoadaptation: articular cartilage through thick and thin.

Vincent TL, Wann AKT.

J Physiol. 2018 Jun 19. doi: 10.1113/JP275451. [Epub ahead of print]

PMID:
29917242
7.

Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant.

Shepherd C, Zhu D, Skelton AJ, Combe J, Threadgold H, Zhu L, Vincent TL, Stuart P, Reynard LN, Loughlin J.

Arthritis Rheumatol. 2018 Oct;70(10):1577-1587. doi: 10.1002/art.40545. Epub 2018 Aug 23.

8.

MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia.

Evensen NA, Madhusoodhan PP, Meyer J, Saliba J, Chowdhury A, Araten DJ, Nersting J, Bhatla T, Vincent TL, Teachey D, Hunger SP, Yang J, Schmiegelow K, Carroll WL.

Haematologica. 2018 May;103(5):830-839. doi: 10.3324/haematol.2017.176362. Epub 2018 Feb 15.

9.

Preclinical efficacy of daratumumab in T-cell acute lymphoblastic leukemia.

Bride KL, Vincent TL, Im SY, Aplenc R, Barrett DM, Carroll WL, Carson R, Dai Y, Devidas M, Dunsmore KP, Fuller T, Glisovic-Aplenc T, Horton TM, Hunger SP, Loh ML, Maude SL, Raetz EA, Winter SS, Grupp SA, Hermiston ML, Wood BL, Teachey DT.

Blood. 2018 Mar 1;131(9):995-999. doi: 10.1182/blood-2017-07-794214. Epub 2018 Jan 5.

PMID:
29305553
10.

FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression.

Ikpegbu E, Basta L, Clements DN, Fleming R, Vincent TL, Buttle DJ, Pitsillides AA, Staines KA, Farquharson C.

J Cell Physiol. 2018 Jul;233(7):5334-5347. doi: 10.1002/jcp.26345. Epub 2018 Jan 23.

11.

Application of autofluorescence robotic histology for quantitative evaluation of the 3-dimensional morphology of murine articular cartilage.

Das Neves Borges P, Vincent TL, Marenzana M.

Microsc Res Tech. 2017 Dec;80(12):1351-1360. doi: 10.1002/jemt.22948. Epub 2017 Sep 30.

12.

Unlimited niche packing in a Lotka-Volterra competition game.

Cressman R, Halloway A, McNickle GG, Apaloo J, Brown JS, Vincent TL.

Theor Popul Biol. 2017 Aug;116:1-17. doi: 10.1016/j.tpb.2017.04.003. Epub 2017 May 8.

PMID:
28495494
13.

Automated assessment of bone changes in cross-sectional micro-CT studies of murine experimental osteoarthritis.

Das Neves Borges P, Vincent TL, Marenzana M.

PLoS One. 2017 Mar 23;12(3):e0174294. doi: 10.1371/journal.pone.0174294. eCollection 2017.

14.

Gα11 mutation in mice causes hypocalcemia rectifiable by calcilytic therapy.

Gorvin CM, Hannan FM, Howles SA, Babinsky VN, Piret SE, Rogers A, Freidin AJ, Stewart M, Paudyal A, Hough TA, Nesbit MA, Wells S, Vincent TL, Brown SD, Cox RD, Thakker RV.

JCI Insight. 2017 Feb 9;2(3):e91103. doi: 10.1172/jci.insight.91103.

15.

Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation.

Frank DB, Peng T, Zepp JA, Snitow M, Vincent TL, Penkala IJ, Cui Z, Herriges MJ, Morley MP, Zhou S, Lu MM, Morrisey EE.

Cell Rep. 2016 Nov 22;17(9):2312-2325. doi: 10.1016/j.celrep.2016.11.001.

16.

CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy.

Miotla Zarebska J, Chanalaris A, Driscoll C, Burleigh A, Miller RE, Malfait AM, Stott B, Vincent TL.

Osteoarthritis Cartilage. 2017 Mar;25(3):406-412. doi: 10.1016/j.joca.2016.10.008. Epub 2016 Oct 13.

17.

Potent efficacy of combined PI3K/mTOR and JAK or ABL inhibition in murine xenograft models of Ph-like acute lymphoblastic leukemia.

Tasian SK, Teachey DT, Li Y, Shen F, Harvey RC, Chen IM, Ryan T, Vincent TL, Willman CL, Perl AE, Hunger SP, Loh ML, Carroll M, Grupp SA.

Blood. 2017 Jan 12;129(2):177-187. doi: 10.1182/blood-2016-05-707653. Epub 2016 Oct 24.

18.
19.

Progression to COPD in smokers with normal spirometry/low DLCO using different methods to determine normal levels.

Harvey BG, Strulovici-Barel Y, Kaner RJ, Sanders A, Vincent TL, Mezey JG, Crystal RG.

Eur Respir J. 2016 Jun;47(6):1888-9. doi: 10.1183/13993003.00435-2016. No abstract available.

20.

Cellular ageing mechanisms in osteoarthritis.

Sacitharan PK, Vincent TL.

Mamm Genome. 2016 Aug;27(7-8):421-9. doi: 10.1007/s00335-016-9641-z. Epub 2016 May 23. Review.

21.

Pulmonary Abnormalities in Young, Light-Use Waterpipe (Hookah) Smokers.

Strulovici-Barel Y, Shaykhiev R, Salit J, Deeb RS, Krause A, Kaner RJ, Vincent TL, Agosto-Perez F, Wang G, Hollmann C, Shanmugam V, Almulla AM, Sattar H, Mahmoud M, Mezey JG, Gross SS, Staudt MR, Walters MS, Crystal RG.

Am J Respir Crit Care Med. 2016 Sep 1;194(5):587-95. doi: 10.1164/rccm.201512-2470OC.

22.

Acute Molecular Changes in Synovial Fluid Following Human Knee Injury: Association With Early Clinical Outcomes.

Watt FE, Paterson E, Freidin A, Kenny M, Judge A, Saklatvala J, Williams A, Vincent TL.

Arthritis Rheumatol. 2016 Sep;68(9):2129-40. doi: 10.1002/art.39677.

23.

Quantitative phosphotyrosine profiling of patient-derived xenografts identifies therapeutic targets in pediatric leukemia.

Dolai S, Sia KC, Robbins AK, Zhong L, Heatley SL, Vincent TL, Hochgräfe F, Sutton R, Kurmasheva RT, Revesz T, White DL, Houghton PJ, Smith MA, Teachey DT, Daly RJ, Raftery MJ, Lock RB.

Cancer Res. 2016 May;76(9):2766-2777. doi: 10.1158/0008-5472.CAN-15-2786. Epub 2016 Mar 9.

24.

Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations.

Rodriguez-Flores JL, Fakhro K, Agosto-Perez F, Ramstetter MD, Arbiza L, Vincent TL, Robay A, Malek JA, Suhre K, Chouchane L, Badii R, Al-Nabet Al-Marri A, Abi Khalil C, Zirie M, Jayyousi A, Salit J, Keinan A, Clark AG, Crystal RG, Mezey JG.

Genome Res. 2016 Feb;26(2):151-62. doi: 10.1101/gr.191478.115. Epub 2016 Jan 4.

25.

In vivo optical imaging of early osteoarthritis using an antibody specific to damaged arthritic cartilage.

Lim NH, Vincent TL, Nissim A.

Arthritis Res Ther. 2015 Dec 25;17:376. doi: 10.1186/s13075-015-0898-5.

26.

The microRNA-29 family in cartilage homeostasis and osteoarthritis.

Le LT, Swingler TE, Crowe N, Vincent TL, Barter MJ, Donell ST, Delany AM, Dalmay T, Young DA, Clark IM.

J Mol Med (Berl). 2016 May;94(5):583-96. doi: 10.1007/s00109-015-1374-z. Epub 2015 Dec 19.

27.

Brief Report: JNK-2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis.

Ismail HM, Miotla-Zarebska J, Troeberg L, Tang X, Stott B, Yamamoto K, Nagase H, Fosang AJ, Vincent TL, Saklatvala J.

Arthritis Rheumatol. 2016 May;68(5):1165-71. doi: 10.1002/art.39547.

28.

Nociceptive Sensitizers Are Regulated in Damaged Joint Tissues, Including Articular Cartilage, When Osteoarthritic Mice Display Pain Behavior.

Driscoll C, Chanalaris A, Knights C, Ismail H, Sacitharan PK, Gentry C, Bevan S, Vincent TL.

Arthritis Rheumatol. 2016 Apr;68(4):857-67. doi: 10.1002/art.39523.

29.

Risk of COPD with obstruction in active smokers with normal spirometry and reduced diffusion capacity.

Harvey BG, Strulovici-Barel Y, Kaner RJ, Sanders A, Vincent TL, Mezey JG, Crystal RG.

Eur Respir J. 2015 Dec;46(6):1589-1597. doi: 10.1183/13993003.02377-2014. Epub 2015 Nov 5.

30.

Divergent and convergent evolution in metastases suggest treatment strategies based on specific metastatic sites.

Cunningham JJ, Brown JS, Vincent TL, Gatenby RA.

Evol Med Public Health. 2015 Mar 20;2015(1):76-87. doi: 10.1093/emph/eov006.

31.

Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes.

Ismail HM, Yamamoto K, Vincent TL, Nagase H, Troeberg L, Saklatvala J.

Arthritis Rheumatol. 2015 Jul;67(7):1826-36. doi: 10.1002/art.39099.

32.

Osteoarthritis.

Glyn-Jones S, Palmer AJ, Agricola R, Price AJ, Vincent TL, Weinans H, Carr AJ.

Lancet. 2015 Jul 25;386(9991):376-87. doi: 10.1016/S0140-6736(14)60802-3. Epub 2015 Mar 4. Review.

PMID:
25748615
33.

Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis.

Gardiner MD, Vincent TL, Driscoll C, Burleigh A, Bou-Gharios G, Saklatvala J, Nagase H, Chanalaris A.

Osteoarthritis Cartilage. 2015 Apr;23(4):616-28. doi: 10.1016/j.joca.2014.12.014. Epub 2014 Dec 26.

34.

Rapid, automated imaging of mouse articular cartilage by microCT for early detection of osteoarthritis and finite element modelling of joint mechanics.

Das Neves Borges P, Forte AE, Vincent TL, Dini D, Marenzana M.

Osteoarthritis Cartilage. 2014 Oct;22(10):1419-28. doi: 10.1016/j.joca.2014.07.014.

35.

Targeting of viral interleukin-10 with an antibody fragment specific to damaged arthritic cartilage improves its therapeutic potency.

Hughes C, Sette A, Seed M, D'Acquisto F, Manzo A, Vincent TL, Lim NH, Nissim A.

Arthritis Res Ther. 2014 Jul 16;16(4):R151. doi: 10.1186/ar4613.

36.

Night-time immobilization of the distal interphalangeal joint reduces pain and extension deformity in hand osteoarthritis.

Watt FE, Kennedy DL, Carlisle KE, Freidin AJ, Szydlo RM, Honeyfield L, Satchithananda K, Vincent TL.

Rheumatology (Oxford). 2014 Jun;53(6):1142-9. doi: 10.1093/rheumatology/ket455. Epub 2014 Feb 8.

37.

Smoking dysregulates the human airway basal cell transcriptome at COPD risk locus 19q13.2.

Ryan DM, Vincent TL, Salit J, Walters MS, Agosto-Perez F, Shaykhiev R, Strulovici-Barel Y, Downey RJ, Buro-Auriemma LJ, Staudt MR, Hackett NR, Mezey JG, Crystal RG.

PLoS One. 2014 Feb 3;9(2):e88051. doi: 10.1371/journal.pone.0088051. eCollection 2014.

38.

Synchrotron- and laboratory-based X-ray phase-contrast imaging for imaging mouse articular cartilage in the absence of radiopaque contrast agents.

Marenzana M, Hagen CK, Borges PD, Endrizzi M, Szafraniec MB, Vincent TL, Rigon L, Arfelli F, Menk RH, Olivo A.

Philos Trans A Math Phys Eng Sci. 2014 Jan 27;372(2010):20130127. doi: 10.1098/rsta.2013.0127. Print 2014 Mar 6.

39.

High correlation of the response of upper and lower lobe small airway epithelium to smoking.

Harvey BG, Strulovici-Barel Y, Vincent TL, Mezey JG, Raviram R, Gordon C, Salit J, Tilley AE, Chung A, Sanders A, Crystal RG.

PLoS One. 2013 Sep 9;8(9):e72669. doi: 10.1371/journal.pone.0072669. eCollection 2013.

40.

Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo.

Davidson RK, Jupp O, de Ferrars R, Kay CD, Culley KL, Norton R, Driscoll C, Vincent TL, Donell ST, Bao Y, Clark IM.

Arthritis Rheum. 2013 Dec;65(12):3130-40. doi: 10.1002/art.38133.

41.

A late presentation of Loeys-Dietz syndrome: joint hypermobility is not always benign.

Mehta P, Holder SE, Fisher B, Vincent TL.

Rheumatology (Oxford). 2014 Mar;53(3):574-6. doi: 10.1093/rheumatology/ket138. Epub 2013 Aug 25. No abstract available.

PMID:
23980202
42.

Prediction and analysis of higher-order coiled-coils: insights from proteins of the extracellular matrix, tenascins and thrombospondins.

Vincent TL, Woolfson DN, Adams JC.

Int J Biochem Cell Biol. 2013 Nov;45(11):2392-401. doi: 10.1016/j.biocel.2013.07.011. Epub 2013 Jul 24.

PMID:
23891848
43.

Fibroblast growth factor 2 drives changes in gene expression following injury to murine cartilage in vitro and in vivo.

Chong KW, Chanalaris A, Burleigh A, Jin H, Watt FE, Saklatvala J, Vincent TL.

Arthritis Rheum. 2013 Sep;65(9):2346-55. doi: 10.1002/art.38039.

44.

A basis set of de novo coiled-coil peptide oligomers for rational protein design and synthetic biology.

Fletcher JM, Boyle AL, Bruning M, Bartlett GJ, Vincent TL, Zaccai NR, Armstrong CT, Bromley EH, Booth PJ, Brady RL, Thomson AR, Woolfson DN.

ACS Synth Biol. 2012 Jun 15;1(6):240-50. doi: 10.1021/sb300028q. Epub 2012 May 14.

PMID:
23651206
45.

Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis (HERO): study protocol for a randomized controlled trial.

Kingsbury SR, Tharmanathan P, Adamson J, Arden NK, Birrell F, Cockayne S, Dickson J, Doherty M, Dziedzic KS, Grainger A, Hewitt CE, O'Neill TW, Scott DL, Vincent TL, Wakefield RJ, Watt FE, Torgerson DJ, Conaghan PG.

Trials. 2013 Mar 2;14:64. doi: 10.1186/1745-6215-14-64.

46.

Targeting mechanotransduction pathways in osteoarthritis: a focus on the pericellular matrix.

Vincent TL.

Curr Opin Pharmacol. 2013 Jun;13(3):449-54. doi: 10.1016/j.coph.2013.01.010. Epub 2013 Feb 18. Review.

PMID:
23428386
47.

LOGICOIL--multi-state prediction of coiled-coil oligomeric state.

Vincent TL, Green PJ, Woolfson DN.

Bioinformatics. 2013 Jan 1;29(1):69-76. doi: 10.1093/bioinformatics/bts648. Epub 2012 Nov 4.

PMID:
23129295
48.

Src and fibroblast growth factor 2 independently regulate signaling and gene expression induced by experimental injury to intact articular cartilage.

Watt FE, Ismail HM, Didangelos A, Peirce M, Vincent TL, Wait R, Saklatvala J.

Arthritis Rheum. 2013 Feb;65(2):397-407. doi: 10.1002/art.37765.

49.

Explaining the fibroblast growth factor paradox in osteoarthritis: lessons from conditional knockout mice.

Vincent TL.

Arthritis Rheum. 2012 Dec;64(12):3835-8. doi: 10.1002/art.34648. No abstract available.

50.

Mapping pathogenesis of arthritis through small animal models.

Vincent TL, Williams RO, Maciewicz R, Silman A, Garside P; Arthritis Research UK animal models working group.

Rheumatology (Oxford). 2012 Nov;51(11):1931-41. doi: 10.1093/rheumatology/kes035. Epub 2012 Mar 16. Review.

PMID:
22427408

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