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Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma.

Best SA, Ding S, Kersbergen A, Dong X, Song JY, Xie Y, Reljic B, Li K, Vince JE, Rathi V, Wright GM, Ritchie ME, Sutherland KD.

Nat Commun. 2019 Sep 13;10(1):4190. doi: 10.1038/s41467-019-12164-y.


The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release.

Rashidi M, Simpson DS, Hempel A, Frank D, Petrie E, Vince A, Feltham R, Murphy J, Chatfield SM, Salvesen GS, Murphy JM, Wicks IP, Vince JE.

J Immunol. 2019 Aug 1;203(3):736-748. doi: 10.4049/jimmunol.1900228. Epub 2019 Jun 17.


Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model.

Erlich Z, Shlomovitz I, Edry-Botzer L, Cohen H, Frank D, Wang H, Lew AM, Lawlor KE, Zhan Y, Vince JE, Gerlic M.

Nat Immunol. 2019 Apr;20(4):397-406. doi: 10.1038/s41590-019-0313-5. Epub 2019 Feb 11.


Activated MLKL attenuates autophagy following its translocation to intracellular membranes.

Frank D, Vaux DL, Murphy JM, Vince JE, Lindqvist LM.

J Cell Sci. 2019 Feb 28;132(5). pii: jcs220996. doi: 10.1242/jcs.220996.


The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.

Vince JE, De Nardo D, Gao W, Vince AJ, Hall C, McArthur K, Simpson D, Vijayaraj S, Lindqvist LM, Bouillet P, Rizzacasa MA, Man SM, Silke J, Masters SL, Lessene G, Huang DCS, Gray DHD, Kile BT, Shao F, Lawlor KE.

Cell Rep. 2018 Nov 27;25(9):2339-2353.e4. doi: 10.1016/j.celrep.2018.10.103.


Pyroptosis versus necroptosis: similarities, differences, and crosstalk.

Frank D, Vince JE.

Cell Death Differ. 2019 Jan;26(1):99-114. doi: 10.1038/s41418-018-0212-6. Epub 2018 Oct 19. Review.


Ion Man: GSDMD Punches Pores to Knock Out cGAS.

Feltham R, Vince JE.

Immunity. 2018 Sep 18;49(3):379-381. doi: 10.1016/j.immuni.2018.08.026.


RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development.

Anderton H, Bandala-Sanchez E, Simpson DS, Rickard JA, Ng AP, Di Rago L, Hall C, Vince JE, Silke J, Liccardi G, Feltham R.

Cell Death Differ. 2019 May;26(5):877-889. doi: 10.1038/s41418-018-0166-8. Epub 2018 Sep 5.


The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils.

D'Cruz AA, Speir M, Bliss-Moreau M, Dietrich S, Wang S, Chen AA, Gavillet M, Al-Obeidi A, Lawlor KE, Vince JE, Kelliher MA, Hakem R, Pasparakis M, Williams DA, Ericsson M, Croker BA.

Sci Signal. 2018 Sep 4;11(546). pii: eaao1716. doi: 10.1126/scisignal.aao1716.


Cutting Edge: Blockade of Inhibitor of Apoptosis Proteins Sensitizes Neutrophils to TNF- but Not Lipopolysaccharide-Mediated Cell Death and IL-1β Secretion.

Chen KW, Lawlor KE, von Pein JB, Boucher D, Gerlic M, Croker BA, Bezbradica JS, Vince JE, Schroder K.

J Immunol. 2018 May 15;200(10):3341-3346. doi: 10.4049/jimmunol.1701620. Epub 2018 Apr 16.


Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications.

Sharma A, Tate M, Mathew G, Vince JE, Ritchie RH, de Haan JB.

Front Physiol. 2018 Feb 20;9:114. doi: 10.3389/fphys.2018.00114. eCollection 2018. Review.


CD52 inhibits Toll-like receptor activation of NF-κB and triggers apoptosis to suppress inflammation.

Rashidi M, Bandala-Sanchez E, Lawlor KE, Zhang Y, Neale AM, Vijayaraj SL, O'Donoghue R, Wentworth JM, Adams TE, Vince JE, Harrison LC.

Cell Death Differ. 2018 Feb;25(2):392-405. doi: 10.1038/cdd.2017.173. Epub 2017 Dec 15.


Simultaneous Detection of Cellular Viability and Interleukin-1β Secretion from Single Cells by ELISpot.

Conos SA, Lindqvist LM, Vince JE.

Methods Mol Biol. 2018;1714:229-236. doi: 10.1007/978-1-4939-7519-8_15.


Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8.

Sagulenko V, Vitak N, Vajjhala PR, Vince JE, Stacey KJ.

J Mol Biol. 2018 Jan 19;430(2):238-247. doi: 10.1016/j.jmb.2017.10.028. Epub 2017 Oct 31.


Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

Feltham RL, Moulin M, Vince JE, Mace PD, Wong WW, Anderton H, Day CL, Vaux DL, Silke J.

J Biol Chem. 2017 Aug 25;292(34):14310. doi: 10.1074/jbc.A109.087635. No abstract available.


XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.

Lawlor KE, Feltham R, Yabal M, Conos SA, Chen KW, Ziehe S, Graß C, Zhan Y, Nguyen TA, Hall C, Vince AJ, Chatfield SM, D'Silva DB, Pang KC, Schroder K, Silke J, Vaux DL, Jost PJ, Vince JE.

Cell Rep. 2017 Jul 18;20(3):668-682. doi: 10.1016/j.celrep.2017.06.073.


Posttranslational Modification as a Critical Determinant of Cytoplasmic Innate Immune Recognition.

Baker PJ, De Nardo D, Moghaddas F, Tran LS, Bachem A, Nguyen T, Hayman T, Tye H, Vince JE, Bedoui S, Ferrero RL, Masters SL.

Physiol Rev. 2017 Jul 1;97(3):1165-1209. doi: 10.1152/physrev.00026.2016. Review.


Legionella pneumophila Strain 130b Evades Macrophage Cell Death Independent of the Effector SidF in the Absence of Flagellin.

Speir M, Vogrin A, Seidi A, Abraham G, Hunot S, Han Q, Dorn GW 2nd, Masters SL, Flavell RA, Vince JE, Naderer T.

Front Cell Infect Microbiol. 2017 Feb 16;7:35. doi: 10.3389/fcimb.2017.00035. eCollection 2017.


Caspase-8: not so silently deadly.

Feltham R, Vince JE, Lawlor KE.

Clin Transl Immunology. 2017 Jan 6;6(1):e124. doi: 10.1038/cti.2016.83. eCollection 2017 Jan. Review.


Necroptotic death signaling: evolution, mechanisms and disease relevance.

Vince JE.

Immunol Cell Biol. 2017 Feb;95(2):129-130. doi: 10.1038/icb.2016.119. No abstract available.


Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways.

Tanzer MC, Khan N, Rickard JA, Etemadi N, Lalaoui N, Spall SK, Hildebrand JM, Segal D, Miasari M, Chau D, Wong WL, McKinlay M, Chunduru SK, Benetatos CA, Condon SM, Vince JE, Herold MJ, Silke J.

Cell Death Differ. 2017 Mar;24(3):481-491. doi: 10.1038/cdd.2016.147. Epub 2017 Jan 20.


Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

Conos SA, Chen KW, De Nardo D, Hara H, Whitehead L, Núñez G, Masters SL, Murphy JM, Schroder K, Vaux DL, Lawlor KE, Lindqvist LM, Vince JE.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E961-E969. doi: 10.1073/pnas.1613305114. Epub 2017 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5762-E5763.


Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins.

Goodall KJ, Finch-Edmondson ML, van Vuuren J, Yeoh GC, Gentle IE, Vince JE, Ekert PG, Vaux DL, Callus BA.

PLoS One. 2016 Nov 2;11(11):e0164003. doi: 10.1371/journal.pone.0164003. eCollection 2016.


Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion.

Conos SA, Lawlor KE, Vaux DL, Vince JE, Lindqvist LM.

Cell Death Differ. 2016 Nov 1;23(11):1827-1838. doi: 10.1038/cdd.2016.69. Epub 2016 Jul 15.


Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis.

Speir M, Lawlor KE, Glaser SP, Abraham G, Chow S, Vogrin A, Schulze KE, Schuelein R, O'Reilly LA, Mason K, Hartland EL, Lithgow T, Strasser A, Lessene G, Huang DC, Vince JE, Naderer T.

Nat Microbiol. 2016 Feb 24;1:15034. doi: 10.1038/nmicrobiol.2015.34.


The intersection of cell death and inflammasome activation.

Vince JE, Silke J.

Cell Mol Life Sci. 2016 Jun;73(11-12):2349-67. doi: 10.1007/s00018-016-2205-2. Epub 2016 Apr 11. Review.


Evolutionary divergence of the necroptosis effector MLKL.

Tanzer MC, Matti I, Hildebrand JM, Young SN, Wardak A, Tripaydonis A, Petrie EJ, Mildenhall AL, Vaux DL, Vince JE, Czabotar PE, Silke J, Murphy JM.

Cell Death Differ. 2016 Jul;23(7):1185-97. doi: 10.1038/cdd.2015.169. Epub 2016 Feb 12.


New insights into the regulation of innate immunity by caspase-8.

Sagulenko V, Lawlor KE, Vince JE.

Arthritis Res Ther. 2016 Jan 13;18:4. doi: 10.1186/s13075-015-0910-0.


IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.

Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee MK, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW, DiRago L, Cengia L, Lane RM, Metcalf D, Vince JE, Harrison LC, Kallies A, Kile BT, Croker BA, Febbraio MA, Masters SL.

Cell Metab. 2016 Jan 12;23(1):155-64. doi: 10.1016/j.cmet.2015.09.024. Epub 2015 Oct 22.


When Beauty Is Skin Deep: Regulation of the Wound Response by Caspase-8, RIPK3, and the Inflammasome.

Vince JE.

J Invest Dermatol. 2015 Aug;135(8):1936-1939. doi: 10.1038/jid.2015.185.


A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production.

Nachbur U, Stafford CA, Bankovacki A, Zhan Y, Lindqvist LM, Fiil BK, Khakham Y, Ko HJ, Sandow JJ, Falk H, Holien JK, Chau D, Hildebrand J, Vince JE, Sharp PP, Webb AI, Jackman KA, Mühlen S, Kennedy CL, Lowes KN, Murphy JM, Gyrd-Hansen M, Parker MW, Hartland EL, Lew AM, Huang DC, Lessene G, Silke J.

Nat Commun. 2015 Mar 17;6:6442. doi: 10.1038/ncomms7442.


RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.

Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE.

Nat Commun. 2015 Feb 18;6:6282. doi: 10.1038/ncomms7282.


Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.

Murphy JM, Vince JE.

F1000Res. 2015 Nov 19;4. pii: F1000 Faculty Rev-1297. doi: 10.12688/f1000research.7046.1. eCollection 2015. Review.


Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming.

Allam R, Lawlor KE, Yu EC, Mildenhall AL, Moujalled DM, Lewis RS, Ke F, Mason KD, White MJ, Stacey KJ, Strasser A, O'Reilly LA, Alexander W, Kile BT, Vaux DL, Vince JE.

EMBO Rep. 2014 Sep;15(9):982-90. doi: 10.15252/embr.201438463. Epub 2014 Jul 2.


RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

Rickard JA, O'Donnell JA, Evans JM, Lalaoui N, Poh AR, Rogers T, Vince JE, Lawlor KE, Ninnis RL, Anderton H, Hall C, Spall SK, Phesse TJ, Abud HE, Cengia LH, Corbin J, Mifsud S, Di Rago L, Metcalf D, Ernst M, Dewson G, Roberts AW, Alexander WS, Murphy JM, Ekert PG, Masters SL, Vaux DL, Croker BA, Gerlic M, Silke J.

Cell. 2014 May 22;157(5):1175-88. doi: 10.1016/j.cell.2014.04.019. Epub 2014 May 8.


Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies.

Condon SM, Mitsuuchi Y, Deng Y, LaPorte MG, Rippin SR, Haimowitz T, Alexander MD, Kumar PT, Hendi MS, Lee YH, Benetatos CA, Yu G, Kapoor GS, Neiman E, Seipel ME, Burns JM, Graham MA, McKinlay MA, Li X, Wang J, Shi Y, Feltham R, Bettjeman B, Cumming MH, Vince JE, Khan N, Silke J, Day CL, Chunduru SK.

J Med Chem. 2014 May 8;57(9):3666-77. doi: 10.1021/jm500176w. Epub 2014 Apr 15.


The pathogen Candida albicans hijacks pyroptosis for escape from macrophages.

Uwamahoro N, Verma-Gaur J, Shen HH, Qu Y, Lewis R, Lu J, Bambery K, Masters SL, Vince JE, Naderer T, Traven A.

mBio. 2014 Mar 25;5(2):e00003-14. doi: 10.1128/mBio.00003-14.


More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling.

Khan N, Lawlor KE, Murphy JM, Vince JE.

Curr Opin Immunol. 2014 Feb;26:76-89. doi: 10.1016/j.coi.2013.10.017. Epub 2013 Nov 30. Review.


cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner.

Wong WW, Vince JE, Lalaoui N, Lawlor KE, Chau D, Bankovacki A, Anderton H, Metcalf D, O'Reilly L, Jost PJ, Murphy JM, Alexander WS, Strasser A, Vaux DL, Silke J.

Blood. 2014 Apr 17;123(16):2562-72. doi: 10.1182/blood-2013-06-510743. Epub 2014 Feb 4.


Programmed cell death in Legionella infection.

Speir M, Vince JE, Naderer T.

Future Microbiol. 2014;9(1):107-18. doi: 10.2217/fmb.13.139. Review.


Ambiguities in NLRP3 inflammasome regulation: is there a role for mitochondria?

Lawlor KE, Vince JE.

Biochim Biophys Acta. 2014 Apr;1840(4):1433-40. doi: 10.1016/j.bbagen.2013.08.014. Epub 2013 Aug 27. Review.


AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC.

Sagulenko V, Thygesen SJ, Sester DP, Idris A, Cridland JA, Vajjhala PR, Roberts TL, Schroder K, Vince JE, Hill JM, Silke J, Stacey KJ.

Cell Death Differ. 2013 Sep;20(9):1149-60. doi: 10.1038/cdd.2013.37. Epub 2013 May 3.


Bcl-2 overexpression ameliorates immune complex-mediated arthritis by altering FcγRIIb expression and monocyte homeostasis.

Lawlor KE, van Nieuwenhuijze A, Parker KL, Drake SF, Campbell IK, Smith SD, Vince JE, Strasser A, Wicks IP.

J Leukoc Biol. 2013 Apr;93(4):585-97. doi: 10.1189/jlb.0412190. Epub 2013 Jan 22. Erratum in: J Leukoc Biol. 2013 Dec;94(6):1345. J Leukoc Biol. 2013 Dec;94(6):1345.


TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1.

Moujalled DM, Cook WD, Okamoto T, Murphy J, Lawlor KE, Vince JE, Vaux DL.

Cell Death Dis. 2013 Jan 17;4:e465. doi: 10.1038/cddis.2012.201.


Is BID required for NOD signalling?

Nachbur U, Vince JE, O'Reilly LA, Strasser A, Silke J.

Nature. 2012 Aug 23;488(7412):E4-6; discussion E6-8. doi: 10.1038/nature11366. No abstract available. Erratum in: Nature. 2012 Nov 29;491(7426):784.


Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

Vince JE, Wong WW, Gentle I, Lawlor KE, Allam R, O'Reilly L, Mason K, Gross O, Ma S, Guarda G, Anderton H, Castillo R, Häcker G, Silke J, Tschopp J.

Immunity. 2012 Feb 24;36(2):215-27. doi: 10.1016/j.immuni.2012.01.012.


IAPs, TNF, inflammation and Jürg Tschopp; a personal perspective.

Silke J, Vince JE.

Cell Death Differ. 2012 Jan;19(1):1-4. doi: 10.1038/cdd.2011.166. No abstract available.


The NLRP3 inflammasome in health and disease: the good, the bad and the ugly.

Menu P, Vince JE.

Clin Exp Immunol. 2011 Oct;166(1):1-15. doi: 10.1111/j.1365-2249.2011.04440.x. Epub 2011 Jul 15. Review.


Lysosomal degradation of Leishmania hexose and inositol transporters is regulated in a stage-, nutrient- and ubiquitin-dependent manner.

Vince JE, Tull D, Landfear S, McConville MJ.

Int J Parasitol. 2011 Jun;41(7):791-800. doi: 10.1016/j.ijpara.2011.02.003. Epub 2011 Apr 9.


IRF-3 partners Bax in a viral-induced dance macabre.

Vince JE, Tschopp J.

EMBO J. 2010 May 19;29(10):1627-8. doi: 10.1038/emboj.2010.79. No abstract available.

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