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Items: 1 to 50 of 184

1.

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model.

Erlich Z, Shlomovitz I, Edry-Botzer L, Cohen H, Frank D, Wang H, Lew AM, Lawlor KE, Zhan Y, Vince JE, Gerlic M.

Nat Immunol. 2019 Apr;20(4):397-406. doi: 10.1038/s41590-019-0313-5. Epub 2019 Feb 11.

PMID:
30742078
2.

Activated MLKL attenuates autophagy following its translocation to intracellular membranes.

Frank D, Vaux DL, Murphy JM, Vince JE, Lindqvist LM.

J Cell Sci. 2019 Feb 28;132(5). pii: jcs220996. doi: 10.1242/jcs.220996.

PMID:
30709919
3.

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.

Vince JE, De Nardo D, Gao W, Vince AJ, Hall C, McArthur K, Simpson D, Vijayaraj S, Lindqvist LM, Bouillet P, Rizzacasa MA, Man SM, Silke J, Masters SL, Lessene G, Huang DCS, Gray DHD, Kile BT, Shao F, Lawlor KE.

Cell Rep. 2018 Nov 27;25(9):2339-2353.e4. doi: 10.1016/j.celrep.2018.10.103.

4.

Simplified management protocol for term neonates after prolonged rupture of membranes in a setting with high rates of neonatal sepsis and mortality: a quality improvement study.

Olita'a D, Barnabas R, Vali Boma G, Pameh W, Vince J, Duke T.

Arch Dis Child. 2019 Feb;104(2):115-120. doi: 10.1136/archdischild-2018-315826. Epub 2018 Nov 24.

5.

Pyroptosis versus necroptosis: similarities, differences, and crosstalk.

Frank D, Vince JE.

Cell Death Differ. 2019 Jan;26(1):99-114. doi: 10.1038/s41418-018-0212-6. Epub 2018 Oct 19.

PMID:
30341423
6.

Ion Man: GSDMD Punches Pores to Knock Out cGAS.

Feltham R, Vince JE.

Immunity. 2018 Sep 18;49(3):379-381. doi: 10.1016/j.immuni.2018.08.026.

PMID:
30231975
7.

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development.

Anderton H, Bandala-Sanchez E, Simpson DS, Rickard JA, Ng AP, Di Rago L, Hall C, Vince JE, Silke J, Liccardi G, Feltham R.

Cell Death Differ. 2019 May;26(5):877-889. doi: 10.1038/s41418-018-0166-8. Epub 2018 Sep 5.

PMID:
30185824
8.

The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils.

D'Cruz AA, Speir M, Bliss-Moreau M, Dietrich S, Wang S, Chen AA, Gavillet M, Al-Obeidi A, Lawlor KE, Vince JE, Kelliher MA, Hakem R, Pasparakis M, Williams DA, Ericsson M, Croker BA.

Sci Signal. 2018 Sep 4;11(546). pii: eaao1716. doi: 10.1126/scisignal.aao1716.

9.

Antibiotic use in the management of children with the common cold at a provincial hospital in Papua New Guinea: a point-prevalence study.

Zamunu A, Pameh W, Ripa P, Vince J, Duke T.

Paediatr Int Child Health. 2018 Nov;38(4):261-265. doi: 10.1080/20469047.2018.1489628. Epub 2018 Aug 6.

PMID:
30079842
10.

Cutting Edge: Blockade of Inhibitor of Apoptosis Proteins Sensitizes Neutrophils to TNF- but Not Lipopolysaccharide-Mediated Cell Death and IL-1β Secretion.

Chen KW, Lawlor KE, von Pein JB, Boucher D, Gerlic M, Croker BA, Bezbradica JS, Vince JE, Schroder K.

J Immunol. 2018 May 15;200(10):3341-3346. doi: 10.4049/jimmunol.1701620. Epub 2018 Apr 16.

11.

Safety, Effectiveness and Feasibility of Outpatient Management of Children with Pneumonia with Chest Indrawing at Port Moresby General Hospital, Papua New Guinea.

Morre R, Sobi K, Pameh W, Ripa P, Vince JD, Duke T.

J Trop Pediatr. 2019 Feb 1;65(1):71-77. doi: 10.1093/tropej/fmy013.

12.

Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications.

Sharma A, Tate M, Mathew G, Vince JE, Ritchie RH, de Haan JB.

Front Physiol. 2018 Feb 20;9:114. doi: 10.3389/fphys.2018.00114. eCollection 2018. Review.

13.

CD52 inhibits Toll-like receptor activation of NF-κB and triggers apoptosis to suppress inflammation.

Rashidi M, Bandala-Sanchez E, Lawlor KE, Zhang Y, Neale AM, Vijayaraj SL, O'Donoghue R, Wentworth JM, Adams TE, Vince JE, Harrison LC.

Cell Death Differ. 2018 Feb;25(2):392-405. doi: 10.1038/cdd.2017.173. Epub 2017 Dec 15.

14.

Simultaneous Detection of Cellular Viability and Interleukin-1β Secretion from Single Cells by ELISpot.

Conos SA, Lindqvist LM, Vince JE.

Methods Mol Biol. 2018;1714:229-236. doi: 10.1007/978-1-4939-7519-8_15.

PMID:
29177866
15.

Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8.

Sagulenko V, Vitak N, Vajjhala PR, Vince JE, Stacey KJ.

J Mol Biol. 2018 Jan 19;430(2):238-247. doi: 10.1016/j.jmb.2017.10.028. Epub 2017 Oct 31.

PMID:
29100888
16.

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

Feltham RL, Moulin M, Vince JE, Mace PD, Wong WW, Anderton H, Day CL, Vaux DL, Silke J.

J Biol Chem. 2017 Aug 25;292(34):14310. doi: 10.1074/jbc.A109.087635. No abstract available.

17.

XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.

Lawlor KE, Feltham R, Yabal M, Conos SA, Chen KW, Ziehe S, Graß C, Zhan Y, Nguyen TA, Hall C, Vince AJ, Chatfield SM, D'Silva DB, Pang KC, Schroder K, Silke J, Vaux DL, Jost PJ, Vince JE.

Cell Rep. 2017 Jul 18;20(3):668-682. doi: 10.1016/j.celrep.2017.06.073.

18.

Hybrid governance of aquaculture: Opportunities and challenges.

Vince J, Haward M.

J Environ Manage. 2017 Oct 1;201:138-144. doi: 10.1016/j.jenvman.2017.06.039. Epub 2017 Jun 24.

PMID:
28654801
19.

Posttranslational Modification as a Critical Determinant of Cytoplasmic Innate Immune Recognition.

Baker PJ, De Nardo D, Moghaddas F, Tran LS, Bachem A, Nguyen T, Hayman T, Tye H, Vince JE, Bedoui S, Ferrero RL, Masters SL.

Physiol Rev. 2017 Jul 1;97(3):1165-1209. doi: 10.1152/physrev.00026.2016. Review.

20.

Evaluation of Xpert MTB/RIF assay in children with presumed pulmonary tuberculosis in Papua New Guinea.

Kasa Tom S, Welch H, Kilalang C, Tefuarani N, Vince J, Lavu E, Johnson K, Magaye R, Duke T.

Paediatr Int Child Health. 2018 May;38(2):97-105. doi: 10.1080/20469047.2017.1319898. Epub 2017 May 11.

PMID:
28490246
21.

Legionella pneumophila Strain 130b Evades Macrophage Cell Death Independent of the Effector SidF in the Absence of Flagellin.

Speir M, Vogrin A, Seidi A, Abraham G, Hunot S, Han Q, Dorn GW 2nd, Masters SL, Flavell RA, Vince JE, Naderer T.

Front Cell Infect Microbiol. 2017 Feb 16;7:35. doi: 10.3389/fcimb.2017.00035. eCollection 2017.

22.

IAPs and Cell Death.

Silke J, Vince J.

Curr Top Microbiol Immunol. 2017;403:95-117. doi: 10.1007/82_2016_507. Review.

PMID:
28204973
23.

Caspase-8: not so silently deadly.

Feltham R, Vince JE, Lawlor KE.

Clin Transl Immunology. 2017 Jan 6;6(1):e124. doi: 10.1038/cti.2016.83. eCollection 2017 Jan. Review.

24.

Necroptotic death signaling: evolution, mechanisms and disease relevance.

Vince JE.

Immunol Cell Biol. 2017 Feb;95(2):129-130. doi: 10.1038/icb.2016.119. No abstract available.

PMID:
28194028
25.

Erratum: EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation.

Pearson JS, Giogha C, Mühlen S, Nachbur U, Pham CL, Zhang Y, Hildebrand JM, Oates CV, Lung TW, Ingle D, Dagley LF, Bankovacki A, Petrie EJ, Schroeder GN, Crepin VF, Frankel G, Masters SL, Vince J, Murphy JM, Sunde M, Webb AI, Silke J, Hartland EL.

Nat Microbiol. 2017 Feb 13;2:17024. doi: 10.1038/nmicrobiol.2017.24. No abstract available.

26.

Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways.

Tanzer MC, Khan N, Rickard JA, Etemadi N, Lalaoui N, Spall SK, Hildebrand JM, Segal D, Miasari M, Chau D, Wong WL, McKinlay M, Chunduru SK, Benetatos CA, Condon SM, Vince JE, Herold MJ, Silke J.

Cell Death Differ. 2017 Mar;24(3):481-491. doi: 10.1038/cdd.2016.147. Epub 2017 Jan 20.

27.

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

Conos SA, Chen KW, De Nardo D, Hara H, Whitehead L, Núñez G, Masters SL, Murphy JM, Schroder K, Vaux DL, Lawlor KE, Lindqvist LM, Vince JE.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E961-E969. doi: 10.1073/pnas.1613305114. Epub 2017 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5762-E5763.

28.

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation.

Pearson JS, Giogha C, Mühlen S, Nachbur U, Pham CL, Zhang Y, Hildebrand JM, Oates CV, Lung TW, Ingle D, Dagley LF, Bankovacki A, Petrie EJ, Schroeder GN, Crepin VF, Frankel G, Masters SL, Vince J, Murphy JM, Sunde M, Webb AI, Silke J, Hartland EL.

Nat Microbiol. 2017 Jan 13;2:16258. doi: 10.1038/nmicrobiol.2016.258. Erratum in: Nat Microbiol. 2017 Feb 13;2:17024.

29.

Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins.

Goodall KJ, Finch-Edmondson ML, van Vuuren J, Yeoh GC, Gentle IE, Vince JE, Ekert PG, Vaux DL, Callus BA.

PLoS One. 2016 Nov 2;11(11):e0164003. doi: 10.1371/journal.pone.0164003. eCollection 2016.

30.

Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion.

Conos SA, Lawlor KE, Vaux DL, Vince JE, Lindqvist LM.

Cell Death Differ. 2016 Nov 1;23(11):1827-1838. doi: 10.1038/cdd.2016.69. Epub 2016 Jul 15.

31.

Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis.

Speir M, Lawlor KE, Glaser SP, Abraham G, Chow S, Vogrin A, Schulze KE, Schuelein R, O'Reilly LA, Mason K, Hartland EL, Lithgow T, Strasser A, Lessene G, Huang DC, Vince JE, Naderer T.

Nat Microbiol. 2016 Feb 24;1:15034. doi: 10.1038/nmicrobiol.2015.34.

PMID:
27572165
32.

The intersection of cell death and inflammasome activation.

Vince JE, Silke J.

Cell Mol Life Sci. 2016 Jun;73(11-12):2349-67. doi: 10.1007/s00018-016-2205-2. Epub 2016 Apr 11. Review.

PMID:
27066895
33.

Evolutionary divergence of the necroptosis effector MLKL.

Tanzer MC, Matti I, Hildebrand JM, Young SN, Wardak A, Tripaydonis A, Petrie EJ, Mildenhall AL, Vaux DL, Vince JE, Czabotar PE, Silke J, Murphy JM.

Cell Death Differ. 2016 Jul;23(7):1185-97. doi: 10.1038/cdd.2015.169. Epub 2016 Feb 12.

34.

New insights into the regulation of innate immunity by caspase-8.

Sagulenko V, Lawlor KE, Vince JE.

Arthritis Res Ther. 2016 Jan 13;18:4. doi: 10.1186/s13075-015-0910-0.

35.

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.

Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee MK, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW, DiRago L, Cengia L, Lane RM, Metcalf D, Vince JE, Harrison LC, Kallies A, Kile BT, Croker BA, Febbraio MA, Masters SL.

Cell Metab. 2016 Jan 12;23(1):155-64. doi: 10.1016/j.cmet.2015.09.024. Epub 2015 Oct 22.

36.

Response to Heard et al.

Moulin M, Voss AK, Thomas T, Wong WW, Cook WD, Koentgen F, Vince J, Silke J, Vaux DL.

EMBO J. 2015 Oct 1;34(19):2396-7. doi: 10.15252/embj.201592761. No abstract available.

37.

When Beauty Is Skin Deep: Regulation of the Wound Response by Caspase-8, RIPK3, and the Inflammasome.

Vince JE.

J Invest Dermatol. 2015 Aug;135(8):1936-1939. doi: 10.1038/jid.2015.185.

38.

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production.

Nachbur U, Stafford CA, Bankovacki A, Zhan Y, Lindqvist LM, Fiil BK, Khakham Y, Ko HJ, Sandow JJ, Falk H, Holien JK, Chau D, Hildebrand J, Vince JE, Sharp PP, Webb AI, Jackman KA, Mühlen S, Kennedy CL, Lowes KN, Murphy JM, Gyrd-Hansen M, Parker MW, Hartland EL, Lew AM, Huang DC, Lessene G, Silke J.

Nat Commun. 2015 Mar 17;6:6442. doi: 10.1038/ncomms7442.

PMID:
25778803
39.

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.

Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE.

Nat Commun. 2015 Feb 18;6:6282. doi: 10.1038/ncomms7282.

40.

Millennium Development Goals: progress in Oceania.

Vince JD.

Arch Dis Child. 2015 Feb;100 Suppl 1:S63-5. doi: 10.1136/archdischild-2013-305618. No abstract available.

PMID:
25613974
41.

Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.

Murphy JM, Vince JE.

F1000Res. 2015 Nov 19;4. pii: F1000 Faculty Rev-1297. doi: 10.12688/f1000research.7046.1. eCollection 2015. Review.

42.

Risk factors for malnutrition in children at Port Moresby General Hospital, Papua New Guinea: a case-control study.

Olita'a D, Vince J, Ripa P, Tefuarani N.

J Trop Pediatr. 2014 Dec;60(6):442-8. doi: 10.1093/tropej/fmu049. Epub 2014 Sep 17.

PMID:
25233854
43.

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming.

Allam R, Lawlor KE, Yu EC, Mildenhall AL, Moujalled DM, Lewis RS, Ke F, Mason KD, White MJ, Stacey KJ, Strasser A, O'Reilly LA, Alexander W, Kile BT, Vaux DL, Vince JE.

EMBO Rep. 2014 Sep;15(9):982-90. doi: 10.15252/embr.201438463. Epub 2014 Jul 2.

44.

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

Rickard JA, O'Donnell JA, Evans JM, Lalaoui N, Poh AR, Rogers T, Vince JE, Lawlor KE, Ninnis RL, Anderton H, Hall C, Spall SK, Phesse TJ, Abud HE, Cengia LH, Corbin J, Mifsud S, Di Rago L, Metcalf D, Ernst M, Dewson G, Roberts AW, Alexander WS, Murphy JM, Ekert PG, Masters SL, Vaux DL, Croker BA, Gerlic M, Silke J.

Cell. 2014 May 22;157(5):1175-88. doi: 10.1016/j.cell.2014.04.019. Epub 2014 May 8.

45.

Integrated package approach in delivering interventions during immunisation campaigns in a complex environment in Papua New Guinea: a case study.

Vince JD, Datta SS, Toikilik S, Lagani W.

Vaccine. 2014 Aug 6;32(36):4614-9. doi: 10.1016/j.vaccine.2014.04.056. Epub 2014 Apr 30. Review.

PMID:
24795224
46.

Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies.

Condon SM, Mitsuuchi Y, Deng Y, LaPorte MG, Rippin SR, Haimowitz T, Alexander MD, Kumar PT, Hendi MS, Lee YH, Benetatos CA, Yu G, Kapoor GS, Neiman E, Seipel ME, Burns JM, Graham MA, McKinlay MA, Li X, Wang J, Shi Y, Feltham R, Bettjeman B, Cumming MH, Vince JE, Khan N, Silke J, Day CL, Chunduru SK.

J Med Chem. 2014 May 8;57(9):3666-77. doi: 10.1021/jm500176w. Epub 2014 Apr 15.

PMID:
24684347
47.

The pathogen Candida albicans hijacks pyroptosis for escape from macrophages.

Uwamahoro N, Verma-Gaur J, Shen HH, Qu Y, Lewis R, Lu J, Bambery K, Masters SL, Vince JE, Naderer T, Traven A.

MBio. 2014 Mar 25;5(2):e00003-14. doi: 10.1128/mBio.00003-14.

48.

Adolf Saweri (28 Jul 1941 - 11 Nov 2012).

Vince JD.

P N G Med J. 2014 Mar-Dec;57(1-4):105. No abstract available.

PMID:
26930895
49.

More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling.

Khan N, Lawlor KE, Murphy JM, Vince JE.

Curr Opin Immunol. 2014 Feb;26:76-89. doi: 10.1016/j.coi.2013.10.017. Epub 2013 Nov 30. Review.

PMID:
24556404
50.

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner.

Wong WW, Vince JE, Lalaoui N, Lawlor KE, Chau D, Bankovacki A, Anderton H, Metcalf D, O'Reilly L, Jost PJ, Murphy JM, Alexander WS, Strasser A, Vaux DL, Silke J.

Blood. 2014 Apr 17;123(16):2562-72. doi: 10.1182/blood-2013-06-510743. Epub 2014 Feb 4.

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