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Items: 1 to 50 of 112

1.

Asparagine 905 of the mammalian phospholipid flippase ATP8A2 is essential for lipid substrate-induced activation of ATP8A2 dephosphorylation.

Mikkelsen SA, Mogensen LS, Vilsen B, Molday RS, Vestergaard AL, Andersen JP.

J Biol Chem. 2019 Apr 12;294(15):5970-5979. doi: 10.1074/jbc.RA118.007240. Epub 2019 Feb 13.

PMID:
30760526
2.

Functional consequences of the CAPOS mutation E818K of Na+,K+-ATPase.

Roenn CP, Li M, Schack VR, Forster IC, Holm R, Toustrup-Jensen MS, Andersen JP, Petrou S, Vilsen B.

J Biol Chem. 2019 Jan 4;294(1):269-280. doi: 10.1074/jbc.RA118.004591. Epub 2018 Nov 8.

PMID:
30409907
3.

Germline De Novo Mutations in ATP1A1 Cause Renal Hypomagnesemia, Refractory Seizures, and Intellectual Disability.

Schlingmann KP, Bandulik S, Mammen C, Tarailo-Graovac M, Holm R, Baumann M, König J, Lee JJY, Drögemöller B, Imminger K, Beck BB, Altmüller J, Thiele H, Waldegger S, Van't Hoff W, Kleta R, Warth R, van Karnebeek CDM, Vilsen B, Bockenhauer D, Konrad M.

Am J Hum Genet. 2018 Nov 1;103(5):808-816. doi: 10.1016/j.ajhg.2018.10.004.

4.

Disease mutations reveal residues critical to the interaction of P4-ATPases with lipid substrates.

Gantzel RH, Mogensen LS, Mikkelsen SA, Vilsen B, Molday RS, Vestergaard AL, Andersen JP.

Sci Rep. 2017 Sep 5;7(1):10418. doi: 10.1038/s41598-017-10741-z.

5.

The α2β2 isoform combination dominates the astrocytic Na+ /K+ -ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation.

Stoica A, Larsen BR, Assentoft M, Holm R, Holt LM, Vilhardt F, Vilsen B, Lykke-Hartmann K, Olsen ML, MacAulay N.

Glia. 2017 Nov;65(11):1777-1793. doi: 10.1002/glia.23194. Epub 2017 Aug 8.

PMID:
28787093
6.

Arginine substitution of a cysteine in transmembrane helix M8 converts Na+,K+-ATPase to an electroneutral pump similar to H+,K+-ATPase.

Holm R, Khandelwal J, Einholm AP, Andersen JP, Artigas P, Vilsen B.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):316-321. doi: 10.1073/pnas.1617951114. Epub 2016 Dec 27. Erratum in: Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1573.

7.

Neurological disease mutations of α3 Na+,K+-ATPase: Structural and functional perspectives and rescue of compromised function.

Holm R, Toustrup-Jensen MS, Einholm AP, Schack VR, Andersen JP, Vilsen B.

Biochim Biophys Acta. 2016 Nov;1857(11):1807-1828. doi: 10.1016/j.bbabio.2016.08.009. Epub 2016 Aug 28. Review.

8.

Glutamate transporter activity promotes enhanced Na+ /K+ -ATPase-mediated extracellular K+ management during neuronal activity.

Larsen BR, Holm R, Vilsen B, MacAulay N.

J Physiol. 2016 Nov 15;594(22):6627-6641. doi: 10.1113/JP272531. Epub 2016 Jun 29.

9.

Importance of a Potential Protein Kinase A Phosphorylation Site of Na+,K+-ATPase and Its Interaction Network for Na+ Binding.

Einholm AP, Nielsen HN, Holm R, Toustrup-Jensen MS, Vilsen B.

J Biol Chem. 2016 May 13;291(20):10934-47. doi: 10.1074/jbc.M115.701201. Epub 2016 Mar 24.

10.

Specific mutations in mammalian P4-ATPase ATP8A2 catalytic subunit entail differential glycosylation of the accessory CDC50A subunit.

Vestergaard AL, Mikkelsen SA, Coleman JA, Molday RS, Vilsen B, Andersen JP.

FEBS Lett. 2015 Dec 21;589(24 Pt B):3908-14. doi: 10.1016/j.febslet.2015.11.031. Epub 2015 Nov 22.

11.

Rescue of Na+ affinity in aspartate 928 mutants of Na+,K+-ATPase by secondary mutation of glutamate 314.

Holm R, Einholm AP, Andersen JP, Vilsen B.

J Biol Chem. 2015 Apr 10;290(15):9801-11. doi: 10.1074/jbc.M114.625509. Epub 2015 Feb 24.

12.

Distinct neurological disorders with ATP1A3 mutations.

Heinzen EL, Arzimanoglou A, Brashear A, Clapcote SJ, Gurrieri F, Goldstein DB, Jóhannesson SH, Mikati MA, Neville B, Nicole S, Ozelius LJ, Poulsen H, Schyns T, Sweadner KJ, van den Maagdenberg A, Vilsen B; ATP1A3 Working Group.

Lancet Neurol. 2014 May;13(5):503-14. doi: 10.1016/S1474-4422(14)70011-0. Review.

13.

Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2.

Vestergaard AL, Coleman JA, Lemmin T, Mikkelsen SA, Molday LL, Vilsen B, Molday RS, Dal Peraro M, Andersen JP.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1334-43. doi: 10.1073/pnas.1321165111. Epub 2014 Mar 24. Erratum in: Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16629.

14.

Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease.

Toustrup-Jensen MS, Einholm AP, Schack VR, Nielsen HN, Holm R, Sobrido MJ, Andersen JP, Clausen T, Vilsen B.

J Biol Chem. 2014 Feb 7;289(6):3186-97. doi: 10.1074/jbc.M113.543272. Epub 2013 Dec 19.

15.

Molecular cloning and characterization of porcine Na⁺/K⁺-ATPase isoforms α1, α2, α3 and the ATP1A3 promoter.

Henriksen C, Kjaer-Sorensen K, Einholm AP, Madsen LB, Momeni J, Bendixen C, Oxvig C, Vilsen B, Larsen K.

PLoS One. 2013 Nov 13;8(11):e79127. doi: 10.1371/journal.pone.0079127. eCollection 2013.

16.

Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state.

Kanai R, Ogawa H, Vilsen B, Cornelius F, Toyoshima C.

Nature. 2013 Oct 10;502(7470):201-6. doi: 10.1038/nature12578. Epub 2013 Oct 2.

PMID:
24089211
17.

Somatic ATP1A1, ATP2B3, and KCNJ5 mutations in aldosterone-producing adenomas.

Williams TA, Monticone S, Schack VR, Stindl J, Burrello J, Buffolo F, Annaratone L, Castellano I, Beuschlein F, Reincke M, Lucatello B, Ronconi V, Fallo F, Bernini G, Maccario M, Giacchetti G, Veglio F, Warth R, Vilsen B, Mulatero P.

Hypertension. 2014 Jan;63(1):188-95. doi: 10.1161/HYPERTENSIONAHA.113.01733. Epub 2013 Sep 30.

18.

Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension.

Beuschlein F, Boulkroun S, Osswald A, Wieland T, Nielsen HN, Lichtenauer UD, Penton D, Schack VR, Amar L, Fischer E, Walther A, Tauber P, Schwarzmayr T, Diener S, Graf E, Allolio B, Samson-Couterie B, Benecke A, Quinkler M, Fallo F, Plouin PF, Mantero F, Meitinger T, Mulatero P, Jeunemaitre X, Warth R, Vilsen B, Zennaro MC, Strom TM, Reincke M.

Nat Genet. 2013 Apr;45(4):440-4, 444e1-2. doi: 10.1038/ng.2550. Epub 2013 Feb 17.

PMID:
23416519
19.

Genetic suppression of agrin reduces mania-like behavior in Na+ , K+ -ATPase α3 mutant mice.

Kirshenbaum GS, Clapcote SJ, Petersen J, Vilsen B, Ralph MR, Roder JC.

Genes Brain Behav. 2012 Jun;11(4):436-43. doi: 10.1111/j.1601-183X.2012.00800.x. Epub 2012 May 11.

20.

Critical role of a transmembrane lysine in aminophospholipid transport by mammalian photoreceptor P4-ATPase ATP8A2.

Coleman JA, Vestergaard AL, Molday RS, Vilsen B, Andersen JP.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1449-54. doi: 10.1073/pnas.1108862109. Epub 2012 Jan 17.

21.

Inhibition of phosphorylation of na+,k+-ATPase by mutations causing familial hemiplegic migraine.

Schack VR, Holm R, Vilsen B.

J Biol Chem. 2012 Jan 13;287(3):2191-202. doi: 10.1074/jbc.M111.323022. Epub 2011 Nov 23.

22.

Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump.

Kirshenbaum GS, Clapcote SJ, Duffy S, Burgess CR, Petersen J, Jarowek KJ, Yücel YH, Cortez MA, Snead OC 3rd, Vilsen B, Peever JH, Ralph MR, Roder JC.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18144-9. doi: 10.1073/pnas.1108416108. Epub 2011 Oct 24. Erratum in: Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2174.

23.

Decreased neuronal Na+, K+ -ATPase activity in Atp1a3 heterozygous mice increases susceptibility to depression-like endophenotypes by chronic variable stress.

Kirshenbaum GS, Saltzman K, Rose B, Petersen J, Vilsen B, Roder JC.

Genes Brain Behav. 2011 Jul;10(5):542-50. doi: 10.1111/j.1601-183X.2011.00691.x. Epub 2011 Apr 13.

24.

A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps.

Morth JP, Pedersen BP, Buch-Pedersen MJ, Andersen JP, Vilsen B, Palmgren MG, Nissen P.

Nat Rev Mol Cell Biol. 2011 Jan;12(1):60-70. doi: 10.1038/nrm3031. Review.

PMID:
21179061
25.

The rapid-onset dystonia parkinsonism mutation D923N of the Na+, K+-ATPase alpha3 isoform disrupts Na+ interaction at the third Na+ site.

Einholm AP, Toustrup-Jensen MS, Holm R, Andersen JP, Vilsen B.

J Biol Chem. 2010 Aug 20;285(34):26245-54. doi: 10.1074/jbc.M110.123976. Epub 2010 Jun 24.

26.

Mutation I810N in the alpha3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS.

Clapcote SJ, Duffy S, Xie G, Kirshenbaum G, Bechard AR, Rodacker Schack V, Petersen J, Sinai L, Saab BJ, Lerch JP, Minassian BA, Ackerley CA, Sled JG, Cortez MA, Henderson JT, Vilsen B, Roder JC.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14085-90. doi: 10.1073/pnas.0904817106. Epub 2009 Aug 3.

27.

The C terminus of Na+,K+-ATPase controls Na+ affinity on both sides of the membrane through Arg935.

Toustrup-Jensen MS, Holm R, Einholm AP, Schack VR, Morth JP, Nissen P, Andersen JP, Vilsen B.

J Biol Chem. 2009 Jul 10;284(28):18715-25. doi: 10.1074/jbc.M109.015099. Epub 2009 May 5.

28.

P-type ATPases as drug targets: tools for medicine and science.

Yatime L, Buch-Pedersen MJ, Musgaard M, Morth JP, Lund Winther AM, Pedersen BP, Olesen C, Andersen JP, Vilsen B, Schiøtt B, Palmgren MG, Møller JV, Nissen P, Fedosova N.

Biochim Biophys Acta. 2009 Apr;1787(4):207-20. Review.

29.

A C-terminal mutation of ATP1A3 underscores the crucial role of sodium affinity in the pathophysiology of rapid-onset dystonia-parkinsonism.

Blanco-Arias P, Einholm AP, Mamsa H, Concheiro C, Gutiérrez-de-Terán H, Romero J, Toustrup-Jensen MS, Carracedo A, Jen JC, Vilsen B, Sobrido MJ.

Hum Mol Genet. 2009 Jul 1;18(13):2370-7. doi: 10.1093/hmg/ddp170. Epub 2009 Apr 7.

PMID:
19351654
30.

The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations.

Morth JP, Poulsen H, Toustrup-Jensen MS, Schack VR, Egebjerg J, Andersen JP, Vilsen B, Nissen P.

Philos Trans R Soc Lond B Biol Sci. 2009 Jan 27;364(1514):217-27. doi: 10.1098/rstb.2008.0201.

31.

Identification and function of a cytoplasmic K+ site of the Na+, K+ -ATPase.

Schack VR, Morth JP, Toustrup-Jensen MS, Anthonisen AN, Nissen P, Andersen JP, Vilsen B.

J Biol Chem. 2008 Oct 10;283(41):27982-90. doi: 10.1074/jbc.M803506200. Epub 2008 Jul 31.

32.

[The Na+,K+ pump continues to cause surprise].

Vilsen B.

Ugeskr Laeger. 2008 May 19;170(21):1821-3. Danish.

PMID:
18492448
33.

Crystal structure of D351A and P312A mutant forms of the mammalian sarcoplasmic reticulum Ca(2+) -ATPase reveals key events in phosphorylation and Ca(2+) release.

Marchand A, Winther AM, Holm PJ, Olesen C, Montigny C, Arnou B, Champeil P, Clausen JD, Vilsen B, Andersen JP, Nissen P, Jaxel C, Møller JV, le Maire M.

J Biol Chem. 2008 May 23;283(21):14867-82. doi: 10.1074/jbc.M710165200. Epub 2008 Mar 20.

34.

Crystal structure of the sodium-potassium pump.

Morth JP, Pedersen BP, Toustrup-Jensen MS, Sørensen TL, Petersen J, Andersen JP, Vilsen B, Nissen P.

Nature. 2007 Dec 13;450(7172):1043-9.

PMID:
18075585
35.

Roles of transmembrane segment M1 of Na+,K+-ATPase and Ca2-ATPase, the gatekeeper and the pivot.

Einholm AP, Andersen JP, Vilsen B.

J Bioenerg Biomembr. 2007 Dec;39(5-6):357-66. Review.

PMID:
18058007
36.

Importance of Leu99 in transmembrane segment M1 of the Na+, K+ -ATPase in the binding and occlusion of K+.

Einholm AP, Andersen JP, Vilsen B.

J Biol Chem. 2007 Aug 17;282(33):23854-66. Epub 2007 Jun 6.

37.

ATP-binding modes and functionally important interdomain bonds of sarcoplasmic reticulum Ca2+-ATPase revealed by mutation of glycine 438, glutamate 439, and arginine 678.

Clausen JD, McIntosh DB, Anthonisen AN, Woolley DG, Vilsen B, Andersen JP.

J Biol Chem. 2007 Jul 13;282(28):20686-97. Epub 2007 May 15.

38.
39.

Asparagine 706 and glutamate 183 at the catalytic site of sarcoplasmic reticulum Ca2+-ATPase play critical but distinct roles in E2 states.

Clausen JD, McIntosh DB, Woolley DG, Anthonisen AN, Vilsen B, Andersen JP.

J Biol Chem. 2006 Apr 7;281(14):9471-81. Epub 2006 Jan 30.

40.

Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses.

Dode L, Andersen JP, Vanoevelen J, Raeymaekers L, Missiaen L, Vilsen B, Wuytack F.

J Biol Chem. 2006 Feb 10;281(6):3182-9. Epub 2005 Dec 6.

41.

Functional comparison between secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and sarcoplasmic reticulum Ca2+-ATPase (SERCA) 1 isoforms by steady-state and transient kinetic analyses.

Dode L, Andersen JP, Raeymaekers L, Missiaen L, Vilsen B, Wuytack F.

J Biol Chem. 2005 Nov 25;280(47):39124-34. Epub 2005 Sep 28.

42.

Mutation of Gly-94 in transmembrane segment M1 of Na+,K+-ATPase interferes with Na+ and K+ binding in E2P conformation.

Einholm AP, Toustrup-Jensen M, Andersen JP, Vilsen B.

Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11254-9. Epub 2005 Jul 27.

43.

Interaction between the catalytic site and the A-M3 linker stabilizes E2/E2P conformational states of Na+,K+-ATPase.

Toustrup-Jensen M, Vilsen B.

J Biol Chem. 2005 Mar 18;280(11):10210-8. Epub 2004 Nov 30.

44.

Localization of a K+ -binding site involved in dephosphorylation of the sarcoplasmic reticulum Ca2+ -ATPase.

Sørensen TL, Clausen JD, Jensen AM, Vilsen B, Møller JV, Andersen JP, Nissen P.

J Biol Chem. 2004 Nov 5;279(45):46355-8. Epub 2004 Sep 21.

45.

Roles of conserved P domain residues and Mg2+ in ATP binding in the ground and Ca2+-activated states of sarcoplasmic reticulum Ca2+-ATPase.

McIntosh DB, Clausen JD, Woolley DG, MacLennan DH, Vilsen B, Andersen JP.

J Biol Chem. 2004 Jul 30;279(31):32515-23. Epub 2004 May 7.

46.

Glutamate-183 in the conserved TGES motif of domain A of sarcoplasmic reticulum Ca2+-ATPase assists in catalysis of E2/E2P partial reactions.

Clausen JD, Vilsen B, McIntosh DB, Einholm AP, Andersen JP.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2776-81. Epub 2004 Feb 17.

47.

Importance of transmembrane segment M1 of the sarcoplasmic reticulum Ca2+-ATPase in Ca2+ occlusion and phosphoenzyme processing.

Einholm AP, Vilsen B, Andersen JP.

J Biol Chem. 2004 Apr 16;279(16):15888-96. Epub 2004 Jan 30.

48.
50.

Functional consequences of charge reversals of acidic residues in M1 of the SR Ca-ATPase.

Einholm AP, Vilsen B, Andersen JP.

Ann N Y Acad Sci. 2003 Apr;986:310-1. No abstract available.

PMID:
12763833

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