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Should TPMT genotype and activity be used to monitor 6-mercaptopurine treatment in children with acute lymphoblastic leukaemia?

Fakhoury M, Andreu-Gallien J, Mahr A, Medard Y, Azougagh S, Vilmer E, Jacqz-Aigrain E.

J Clin Pharm Ther. 2007 Dec;32(6):633-9.


The prognostic significance of CDKN2A, CDKN2B and MTAP inactivation in B-lineage acute lymphoblastic leukemia of childhood. Results of the EORTC studies 58881 and 58951.

Mirebeau D, Acquaviva C, Suciu S, Bertin R, Dastugue N, Robert A, Boutard P, Méchinaud F, Plouvier E, Otten J, Vilmer E, Cavé H; EORTC-CLG.

Haematologica. 2006 Jul;91(7):881-5.


Efficacy and safety of rituximab in B-cell post-transplantation lymphoproliferative disorders: results of a prospective multicenter phase 2 study.

Choquet S, Leblond V, Herbrecht R, Socié G, Stoppa AM, Vandenberghe P, Fischer A, Morschhauser F, Salles G, Feremans W, Vilmer E, Peraldi MN, Lang P, Lebranchu Y, Oksenhendler E, Garnier JL, Lamy T, Jaccard A, Ferrant A, Offner F, Hermine O, Moreau A, Fafi-Kremer S, Morand P, Chatenoud L, Berriot-Varoqueaux N, Bergougnoux L, Milpied N.

Blood. 2006 Apr 15;107(8):3053-7. Epub 2005 Oct 27.


Results of 58872 and 58921 trials in acute myeloblastic leukemia and relative value of chemotherapy vs allogeneic bone marrow transplantation in first complete remission: the EORTC Children Leukemia Group report.

Entz-Werle N, Suciu S, van der Werff ten Bosch J, Vilmer E, Bertrand Y, Benoit Y, Margueritte G, Plouvier E, Boutard P, Vandecruys E, Ferster A, Lutz P, Uyttebroeck A, Hoyoux C, Thyss A, Rialland X, Norton L, Pages MP, Philippe N, Otten J, Behar C; EORTC Children Leukemia Group.

Leukemia. 2005 Dec;19(12):2072-81.


Improvement in bone mineral density and body composition in survivors of childhood acute lymphoblastic leukemia: a 1-year prospective study.

Marinovic D, Dorgeret S, Lescoeur B, Alberti C, Noel M, Czernichow P, Sebag G, Vilmer E, Léger J.

Pediatrics. 2005 Jul;116(1):e102-8.


Listing of common HLA alleles and haplotypes based on the study of 356 families residing in the Paris, France, area: implications for unrelated hematopoietic stem cell donor selection.

Pedron B, Yakouben K, Adjaoud D, Auvrignon A, Landman J, Guerin V, Leverger G, Vilmer E, Sterkers G.

Hum Immunol. 2005 Jun;66(6):721-31. Epub 2005 Mar 18.


Late thyroid toxicity in 153 long-term survivors of allogeneic bone marrow transplantation for acute lymphoblastic leukaemia.

Berger C, Le-Gallo B, Donadieu J, Richard O, Devergie A, Galambrun C, Bordigoni P, Vilmer E, Plouvier E, Perel Y, Michel G, Stephan JL.

Bone Marrow Transplant. 2005 May;35(10):991-5.


Value of intravenous 6-mercaptopurine during continuation treatment in childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma: final results of a randomized phase III trial (58881) of the EORTC CLG.

van der Werff Ten Bosch J, Suciu S, Thyss A, Bertrand Y, Norton L, Mazingue F, Uyttebroeck A, Lutz P, Robert A, Boutard P, Ferster A, Plouvier E, Maes P, Munzer M, Plantaz D, Dresse MF, Philippet P, Sirvent N, Waterkeyn C, Vilmer E, Philippe N, Otten J.

Leukemia. 2005 May;19(5):721-6.


No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities.

Moorman AV, Raimondi SC, Pui CH, Baruchel A, Biondi A, Carroll AJ, Forestier E, Gaynon PS, Harbott J, Harms DO, Heerema N, Pieters R, Schrappe M, Silverman LB, Vilmer E, Harrison CJ; Ponte di Legno Working Group.

Leukemia. 2005 Apr;19(4):557-63.


Analysis of risk factors for myelodysplasias, leukemias and death from infection among patients with congenital neutropenia. Experience of the French Severe Chronic Neutropenia Study Group.

Donadieu J, Leblanc T, Bader Meunier B, Barkaoui M, Fenneteau O, Bertrand Y, Maier-Redelsperger M, Micheau M, Stephan JL, Phillipe N, Bordigoni P, Babin-Boilletot A, Bensaid P, Manel AM, Vilmer E, Thuret I, Blanche S, Gluckman E, Fischer A, Mechinaud F, Joly B, Lamy T, Hermine O, Cassinat B, Bellanné-Chantelot C, Chomienne C; French Severe Chronic Neutropenia Study Group.

Haematologica. 2005 Jan;90(1):45-53.


Autoimmune lymphoproliferative syndrome with somatic Fas mutations.

Holzelova E, Vonarbourg C, Stolzenberg MC, Arkwright PD, Selz F, Prieur AM, Blanche S, Bartunkova J, Vilmer E, Fischer A, Le Deist F, Rieux-Laucat F.

N Engl J Med. 2004 Sep 30;351(14):1409-18.


Acute childhood leukaemia and environmental exposure to potential sources of benzene and other hydrocarbons; a case-control study.

Steffen C, Auclerc MF, Auvrignon A, Baruchel A, Kebaili K, Lambilliotte A, Leverger G, Sommelet D, Vilmer E, Hémon D, Clavel J.

Occup Environ Med. 2004 Sep;61(9):773-8.


Incidence of childhood leukaemia and non-Hodgkin's lymphoma in France: National Registry of Childhood Leukaemia and Lymphoma, 1990-1999.

Clavel J, Goubin A, Auclerc MF, Auvrignon A, Waterkeyn C, Patte C, Baruchel A, Leverger G, Nelken B, Philippe N, Sommelet D, Vilmer E, Bellec S, Perrillat-Menegaux F, Hémon D.

Eur J Cancer Prev. 2004 Apr;13(2):97-103.


Outcome of childhood acute promyelocytic leukemia with all-trans-retinoic acid and chemotherapy.

de Botton S, Coiteux V, Chevret S, Rayon C, Vilmer E, Sanz M, de La Serna J, Philippe N, Baruchel A, Leverger G, Robert A, San Miguel J, Conde E, Sotto JJ, Bordessoule D, Fegueux N, Fey M, Parry A, Chomienne C, Degos L, Fenaux P.

J Clin Oncol. 2004 Apr 15;22(8):1404-12.


Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

Feldmann J, Callebaut I, Raposo G, Certain S, Bacq D, Dumont C, Lambert N, Ouachée-Chardin M, Chedeville G, Tamary H, Minard-Colin V, Vilmer E, Blanche S, Le Deist F, Fischer A, de Saint Basile G.

Cell. 2003 Nov 14;115(4):461-73.


Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951.

Cavé H, Suciu S, Preudhomme C, Poppe B, Robert A, Uyttebroeck A, Malet M, Boutard P, Benoit Y, Mauvieux L, Lutz P, Méchinaud F, Grardel N, Mazingue F, Dupont M, Margueritte G, Pages MP, Bertrand Y, Plouvier E, Brunie G, Bastard C, Plantaz D, Vande Velde I, Hagemeijer A, Speleman F, Lessard M, Otten J, Vilmer E, Dastugue N; EORTC-CLG.

Blood. 2004 Jan 15;103(2):442-50. Epub 2003 Sep 22.


Hematopoietic stem cell transplantation in patients with severe Langerhans cell histiocytosis and hematological dysfunction: experience of the French Langerhans Cell Study Group.

Akkari V, Donadieu J, Piguet C, Bordigoni P, Michel G, Blanche S, Casanova JL, Thomas C, Vilmer E, Fischer A, Bertrand Y; French Langerhans Cell Study Group.

Bone Marrow Transplant. 2003 Jun;31(12):1097-103.


Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements.

Pui CH, Chessells JM, Camitta B, Baruchel A, Biondi A, Boyett JM, Carroll A, Eden OB, Evans WE, Gadner H, Harbott J, Harms DO, Harrison CJ, Harrison PL, Heerema N, Janka-Schaub G, Kamps W, Masera G, Pullen J, Raimondi SC, Richards S, Riehm H, Sallan S, Sather H, Shuster J, Silverman LB, Valsecchi MG, Vilmer E, Zhou Y, Gaynon PS, Schrappe M.

Leukemia. 2003 Apr;17(4):700-6. Review.


Common genomic HLA haplotypes contributing to successful donor search in unrelated hematopoietic transplantation.

Pedron B, Duval M, Elbou OM, Moskwa M, Jambou M, Vilmer E, Sterkers G.

Bone Marrow Transplant. 2003 Mar;31(6):423-7.


CDKN2A, CDKN2B, and MTAP gene dosage permits precise characterization of mono- and bi-allelic 9p21 deletions in childhood acute lymphoblastic leukemia.

Bertin R, Acquaviva C, Mirebeau D, Guidal-Giroux C, Vilmer E, Cavé H.

Genes Chromosomes Cancer. 2003 May;37(1):44-57.


Family history of autoimmune thyroid disease and childhood acute leukemia.

Perillat-Menegaux F, Clavel J, Auclerc MF, Baruchel A, Leverger G, Nelken B, Philippe N, Sommelet D, Vilmer E, Hémon D.

Cancer Epidemiol Biomarkers Prev. 2003 Jan;12(1):60-3.


Severe autoimmune hemolytic anemia caused by a warm IgA autoantibody directed against the third loop of band 3 (RBC anion-exchange protein 1).

Janvier D, Sellami F, Missud F, Fenneteau O, Vilmer E, Cartron J, Rohrlich P.

Transfusion. 2002 Dec;42(12):1547-52.


Cerebellar herniation after intrathecal chemotherapy including cytosine arabinoside in a boy with T acute lymphoblastic leukemia.

Legrand F, Dorgeret S, Saizou C, Duval M, Vilmer E.

Leukemia. 2002 Dec;16(12):2454-5. No abstract available.


Immune reconstitution after haematopoietic transplantation with two different doses of pre-graft antithymocyte globulin.

Duval M, Pédron B, Rohrlich P, Legrand F, Faye A, Lescoeur B, Bensaid P, Larchee R, Sterkers G, Vilmer E.

Bone Marrow Transplant. 2002 Oct;30(7):421-6.


Early multitherapy including a protease inhibitor for human immunodeficiency virus type 1-infected infants.

Faye A, Bertone C, Teglas JP, Chaix ML, Douard D, Firtion G, Thuret I, Dollfus C, Monpoux F, Floch C, Nicolas J, Vilmer E, Rouzioux C, Mayaux MJ, Blanche S; French Perinatal Study.

Pediatr Infect Dis J. 2002 Jun;21(6):518-25.


Immune reconstitution without graft-versus-host disease after haemopoietic stem-cell transplantation: a phase 1/2 study.

André-Schmutz I, Le Deist F, Hacein-Bey-Abina S, Vitetta E, Schindler J, Chedeville G, Vilmer E, Fischer A, Cavazzana-Calvo M.

Lancet. 2002 Jul 13;360(9327):130-7.


Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region.

Pui CH, Gaynon PS, Boyett JM, Chessells JM, Baruchel A, Kamps W, Silverman LB, Biondi A, Harms DO, Vilmer E, Schrappe M, Camitta B.

Lancet. 2002 Jun 1;359(9321):1909-15.


Breast-feeding, fetal loss and childhood acute leukaemia.

Perrillat F, Clavel J, Jaussent I, Baruchel A, Leverger G, Nelken B, Philippe N, Schaison G, Sommelet D, Vilmer E, Hémon D.

Eur J Pediatr. 2002 Apr;161(4):235-7. No abstract available.


Day-care, early common infections and childhood acute leukaemia: a multicentre French case-control study.

Perrillat F, Clavel J, Auclerc MF, Baruchel A, Leverger G, Nelken B, Philippe N, Schaison G, Sommelet D, Vilmer E, Hémon D.

Br J Cancer. 2002 Apr 8;86(7):1064-9.


[Acute lymphoblastic leukemia].

Vilmer E, Dhedin N.

Rev Prat. 2002 Jan 15;52(2):213-7. French. No abstract available.


Hydroxyurea corrects the dysregulated L-selectin expression and increased H(2)O(2) production of polymorphonuclear neutrophils from patients with sickle cell anemia.

Benkerrou M, Delarche C, Brahimi L, Fay M, Vilmer E, Elion J, Gougerot-Pocidalo MA, Elbim C.

Blood. 2002 Apr 1;99(7):2297-303.


The Children Leukemia Group: 30 years of research and achievements.

Otten J, Philippe N, Suciu S, Béhar C, Babin-Boilletot A, Thyss A, Ferster A, Vilmer E; EORTC Children Leukemia Group.

Eur J Cancer. 2002 Mar;38 Suppl 4:S44-9.


Family cancer history and risk of childhood acute leukemia (France).

Perrillat F, Clavel J, Jaussent I, Baruchel A, Leverger G, Nelken B, Philippe N, Schaison G, Sommelet D, Vilmer E, Bonaïti-Pellié C, Hémon D.

Cancer Causes Control. 2001 Dec;12(10):935-41.


Molecular analysis of nonrandom 8q12 deletions in acute lymphoblastic leukemia: identification of two candidate genes.

Bardet V, Couque N, Cattolico L, Hetet G, Devaux I, Duprat S, Gressin L, Vilmer E, Cavé H, Grandchamp B.

Genes Chromosomes Cancer. 2002 Feb;33(2):178-87.


Chimaeric anti-CD20 monoclonal antibody (rituximab) in post-transplant B-lymphoproliferative disorder following stem cell transplantation in children.

Faye A, Quartier P, Reguerre Y, Lutz P, Carret AS, Dehée A, Rohrlich P, Peuchmaur M, Matthieu-Boué A, Fischer A, Vilmer E.

Br J Haematol. 2001 Oct;115(1):112-8.


Quantification of busulfan in plasma by liquid chromatography-ion spray mass spectrometry. Application to pharmacokinetic studies in children.

Quernin MH, Duval M, Litalien C, Vilmer E, Aigrain EJ.

J Chromatogr B Biomed Sci Appl. 2001 Nov 5;763(1-2):61-9.


Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine.

Dervieux T, Médard Y, Verpillat P, Guigonis V, Duval M, Lescoeur B, Suciu S, Vilmer E, Jacqz-Aigrain E.

Leukemia. 2001 Nov;15(11):1706-12.


[T-cell-depleted HLA non-identical bone marrow transplantation in the child: prevention of graft-versus-host reaction by administration of donor T lymphocytes alloreactive against the recipient].

Cavazzana-Calvo M, André-Schmutz I, Hacein-Bey S, Schindler J, Vitetta H, Dupuis S, Quartier P, Chedeville G, Vilmer E, Casanova JL, Buffet R, Caillat-Zucman S, Radford I, Le Deist F, Fischer A.

J Soc Biol. 2001;195(1):65-8. French.


Quantification of TEL-AML1 transcript for minimal residual disease assessment in childhood acute lymphoblastic leukaemia.

Drunat S, Olivi M, Brunie G, Grandchamp B, Vilmer E, Bièche I, Cavé H.

Br J Haematol. 2001 Aug;114(2):281-9.


[Neonatal screening for sickle cell anemia: evaluation of a five-year experience in an area of northern Paris].

Ducrocq R, Benkerrou M, Brahimi L, Belloy M, Briard ML, Vilmer E, Elion J.

Arch Pediatr. 2001 May;8(5):474-80. French.


Early diagnosis of adenovirus infection and treatment with cidofovir after bone marrow transplantation in children.

Legrand F, Berrebi D, Houhou N, Freymuth F, Faye A, Duval M, Mougenot JF, Peuchmaur M, Vilmer E.

Bone Marrow Transplant. 2001 Mar;27(6):621-6.


Value of high-dose cytarabine during interval therapy of a Berlin-Frankfurt-Munster-based protocol in increased-risk children with acute lymphoblastic leukemia and lymphoblastic lymphoma: results of the European Organization for Research and Treatment of Cancer 58881 randomized phase III trial.

Millot F, Suciu S, Philippe N, Benoit Y, Mazingue F, Uyttebroeck A, Lutz P, Mechinaud F, Robert A, Boutard P, Marguerite G, Ferster A, Plouvier E, Rialland X, Behard C, Plantaz D, Dresse MF, Philippet P, Norton L, Thyss A, Dastugue N, Waterkeyn C, Vilmer E, Otten J; Children's Leukemia Cooperative Group of the European Organiztaion for Research and Treatment of Cancer.

J Clin Oncol. 2001 Apr 1;19(7):1935-42.


Characterization of the B*5002-Cw*0602-DRB1*0406-DQB1*0402 Haplotype: impact on the unrelated-bone marrow donor search strategy.

Ansart-Pirenne H, Dufossé F, Duval M, Cracco P, Jambou M, Pédron B, Vilmer E, Sterkers G.

Tissue Antigens. 2001 Feb;57(2):163-6.


Deletion of chromosomal region 13q14.3 in childhood acute lymphoblastic leukemia.

Cavé H, Avet-Loiseau H, Devaux I, Rondeau G, Boutard P, Lebrun E, Méchinaud F, Vilmer E, Grandchamp B.

Leukemia. 2001 Mar;15(3):371-6.


Long-term results of three randomized trials (58831, 58832, 58881) in childhood acute lymphoblastic leukemia: a CLCG-EORTC report. Children Leukemia Cooperative Group.

Vilmer E, Suciu S, Ferster A, Bertrand Y, Cavé H, Thyss A, Benoit Y, Dastugue N, Fournier M, Souillet G, Manel AM, Robert A, Nelken B, Millot F, Lutz P, Rialland X, Mechinaud F, Boutard P, Behar C, Chantraine JM, Plouvier E, Laureys G, Brock P, Uyttebroeck A, Margueritte G, Plantaz D, Norton L, Francotte N, Gyselinck J, Waterkeyn C, Solbu G, Philippe N, Otten J.

Leukemia. 2000 Dec;14(12):2257-66.


Long-term results of large prospective trials in childhood acute lymphoblastic leukemia.

Schrappe M, Camitta B, Pui CH, Eden T, Gaynon P, Gustafsson G, Janka-Schaub GE, Kamps W, Masera G, Sallan S, Tsuchida M, Vilmer E.

Leukemia. 2000 Dec;14(12):2193-4. No abstract available.

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