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Items: 1 to 50 of 250

1.

Prolonged Release and Functionality of Interleukin-10 Encapsulated within PLA-PEG Nanoparticles.

Duncan SA, Dixit S, Sahu R, Martin D, Baganizi DR, Nyairo E, Villinger F, Singh SR, Dennis VA.

Nanomaterials (Basel). 2019 Jul 26;9(8). pii: E1074. doi: 10.3390/nano9081074.

2.

Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques.

Calenda G, Frank I, Arrode-Brusés G, Pegu A, Wang K, Arthos J, Cicala C, Rogers KA, Shirreff L, Grasperge B, Blanchard JL, Maldonado S, Roberts K, Gettie A, Villinger F, Fauci AS, Mascola JR, Martinelli E.

PLoS Pathog. 2019 May 13;15(5):e1007776. doi: 10.1371/journal.ppat.1007776. eCollection 2019 May.

3.

Visualization of early events in mRNA vaccine delivery in non-human primates via PET-CT and near-infrared imaging.

Lindsay KE, Bhosle SM, Zurla C, Beyersdorf J, Rogers KA, Vanover D, Xiao P, Araínga M, Shirreff LM, Pitard B, Baumhof P, Villinger F, Santangelo PJ.

Nat Biomed Eng. 2019 May;3(5):371-380. doi: 10.1038/s41551-019-0378-3. Epub 2019 Apr 1.

PMID:
30936432
4.

Divergent HIV-1-Directed Immune Responses Generated by Systemic and Mucosal Immunization with Replicating Single-Cycle Adenoviruses in Rhesus Macaques.

Matchett WE, Anguiano-Zarate SS, Nehete PN, Shelton K, Nehete BP, Yang G, Dorta-Estremera S, Barnette P, Xiao P, Byrareddy SN, Villinger F, Hessell AJ, Haigwood NL, Sastry KJ, Barry MA.

J Virol. 2019 May 1;93(10). pii: e02016-18. doi: 10.1128/JVI.02016-18. Print 2019 May 15.

PMID:
30842321
5.

Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques.

Petitdemange C, Kasturi SP, Kozlowski PA, Nabi R, Quarnstrom CF, Reddy PBJ, Derdeyn CA, Spicer LM, Patel P, Legere T, Kovalenkov YO, Labranche CC, Villinger F, Tomai M, Vasilakos J, Haynes B, Kang CY, Gibbs JS, Yewdell JW, Barouch D, Wrammert J, Montefiori D, Hunter E, Amara RR, Masopust D, Pulendran B.

JCI Insight. 2019 Feb 21;4(4). pii: 126047. doi: 10.1172/jci.insight.126047. eCollection 2019 Feb 21.

6.

Adaptation of an R5 Simian-Human Immunodeficiency Virus Encoding an HIV Clade A Envelope with or without Ablation of Adaptive Host Immunity: Differential Selection of Viral Mutants.

Zhou M, Humbert M, Mukhtar MM, Scinto HB, Vyas HK, Lakhashe SK, Byrareddy SN, Maurer G, Thorat S, Owuor J, Lai Z, Chen Y, Griffiths A, Chenine AL, Gumber S, Villinger F, Montefiori D, Ruprecht RM.

J Virol. 2019 Apr 17;93(9). pii: e02267-18. doi: 10.1128/JVI.02267-18. Print 2019 May 1.

PMID:
30760566
7.

Immune Priming and Long-term Persistence of Memory B Cells After Inactivated Poliovirus Vaccine in Macaque Models: Support for at least 2 Doses.

Bhaumik SK, Kulkarni RR, Weldon WC, Silveira ELV, Ahmed H, Gunisetty S, Chandele A, Antia R, Verma H, Sutter R, Pallansch MA, Oberste MS, Villinger F, Orenstein W, Murali-Krishna K.

Clin Infect Dis. 2018 Oct 30;67(suppl_1):S66-S77. doi: 10.1093/cid/ciy634.

8.

Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaques.

Chand HS, Vazquez-Guillamet R, Royer C, Rudolph K, Mishra N, Singh SP, Hussain SS, Barrett E, Callen S, Byrareddy SN, Guillamet MCV, Abukhalaf J, Sheybani A, Exil V, Raizada V, Agarwal H, Nair M, Villinger F, Buch S, Sopori M.

J Clin Invest. 2018 Dec 3;128(12):5428-5433. doi: 10.1172/JCI121935. Epub 2018 Nov 5.

9.

Morphine Potentiates Dysbiotic Microbial and Metabolic Shifts in Acute SIV Infection.

Sindberg GM, Callen SE, Banerjee S, Meng J, Hale VL, Hegde R, Cheney PD, Villinger F, Roy S, Buch S.

J Neuroimmune Pharmacol. 2019 Jun;14(2):200-214. doi: 10.1007/s11481-018-9805-6. Epub 2018 Sep 21.

PMID:
30242614
10.

Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7.

Lertjuthaporn S, Cicala C, Van Ryk D, Liu M, Yolitz J, Wei D, Nawaz F, Doyle A, Horowitch B, Park C, Lu S, Lou Y, Wang S, Pan R, Jiang X, Villinger F, Byrareddy SN, Santangelo PJ, Morris L, Wibmer CK, Biris K, Mason RD, Gorman J, Hiatt J, Martinelli E, Roederer M, Fujikawa D, Gorini G, Franchini G, Arakelyan A, Ansari AA, Pattanapanyasat K, Kong XP, Fauci AS, Arthos J.

PLoS Pathog. 2018 Aug 28;14(8):e1007278. doi: 10.1371/journal.ppat.1007278. eCollection 2018 Aug.

11.

MAdCAM costimulation through Integrin-α4β7 promotes HIV replication.

Nawaz F, Goes LR, Ray JC, Olowojesiku R, Sajani A, Ansari AA, Perrone I, Hiatt J, Van Ryk D, Wei D, Waliszewski M, Soares MA, Jelicic K, Connors M, Migueles SA, Martinelli E, Villinger F, Cicala C, Fauci AS, Arthos J.

Mucosal Immunol. 2018 Sep;11(5):1342-1351. doi: 10.1038/s41385-018-0044-1. Epub 2018 Jun 6.

12.

Development of rectal enema as microbicide (DREAM): Preclinical progressive selection of a tenofovir prodrug enema.

Hoang T, Date AA, Ortiz JO, Young TW, Bensouda S, Xiao P, Marzinke M, Rohan L, Fuchs EJ, Hendrix C, Gumber S, Villinger F, Cone RA, Hanes J, Ensign LM.

Eur J Pharm Biopharm. 2019 May;138:23-29. doi: 10.1016/j.ejpb.2018.05.030. Epub 2018 May 24.

PMID:
29802984
13.

In vivo characterization of macrophage-tropic simian immunodeficiency virus molecular clones in rhesus macaques.

Gumber S, Amancha PK, Yen PJ, Villinger F, Gabuzda D, Byrareddy SN.

J Neurovirol. 2018 Aug;24(4):411-419. doi: 10.1007/s13365-018-0628-2. Epub 2018 Mar 28.

14.

The Role of Integrin α4β7 in HIV Pathogenesis and Treatment.

Arthos J, Cicala C, Nawaz F, Byrareddy SN, Villinger F, Santangelo PJ, Ansari AA, Fauci AS.

Curr HIV/AIDS Rep. 2018 Apr;15(2):127-135. doi: 10.1007/s11904-018-0382-3. Review.

15.

Early treatment of SIV+ macaques with an α4β7 mAb alters virus distribution and preserves CD4+ T cells in later stages of infection.

Santangelo PJ, Cicala C, Byrareddy SN, Ortiz KT, Little D, Lindsay KE, Gumber S, Hong JJ, Jelicic K, Rogers KA, Zurla C, Villinger F, Ansari AA, Fauci AS, Arthos J.

Mucosal Immunol. 2018 May;11(3):932-946. doi: 10.1038/mi.2017.112. Epub 2017 Dec 20.

16.

A tetravalent virus-like particle vaccine designed to display domain III of dengue envelope proteins induces multi-serotype neutralizing antibodies in mice and macaques which confer protection against antibody dependent enhancement in AG129 mice.

Ramasamy V, Arora U, Shukla R, Poddar A, Shanmugam RK, White LJ, Mattocks MM, Raut R, Perween A, Tyagi P, de Silva AM, Bhaumik SK, Kaja MK, Villinger F, Ahmed R, Johnston RE, Swaminathan S, Khanna N.

PLoS Negl Trop Dis. 2018 Jan 8;12(1):e0006191. doi: 10.1371/journal.pntd.0006191. eCollection 2018 Jan.

17.

FDC:TFH Interactions within Cervical Lymph Nodes of SIV-Infected Rhesus Macaques.

Dave RS, Sharma RK, Muir RR, Haddad E, Gumber S, Villinger F, Nehra AP, Khan ZK, Wigdahl B, Ansari AA, Byrareddy SN, Jain P.

J Neuroimmune Pharmacol. 2018 Jun;13(2):204-218. doi: 10.1007/s11481-017-9775-0. Epub 2017 Dec 29.

18.

IL-21 Therapy Controls Immune Activation and Maintains Antiviral CD8+ T Cell Responses in Acute Simian Immunodeficiency Virus Infection.

Méndez-Lagares G, Lu D, Merriam D, Baker CA, Villinger F, Van Rompay KKA, McCune JM, Hartigan-O'Connor DJ.

AIDS Res Hum Retroviruses. 2017 Nov;33(S1):S81-S92. doi: 10.1089/aid.2017.0160.

19.

Hypo-osmolar Formulation of Tenofovir (TFV) Enema Promotes Uptake and Metabolism of TFV in Tissues, Leading to Prevention of SHIV/SIV Infection.

Xiao P, Gumber S, Marzinke MA, Date AA, Hoang T, Hanes J, Ensign LM, Wang L, Rohan L, Fuchs EJ, Hendrix C, Villinger F.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01644-17. doi: 10.1128/AAC.01644-17. Print 2018 Jan.

20.

Depletion of Gut-Resident CCR5+ Cells for HIV Cure Strategies.

Merriam D, Chen C, Méndez-Lagares G, Rogers KA, Michaels AJ, Yan J, Casaz P, Reimann KA, Villinger F, Hartigan-O'Connor DJ.

AIDS Res Hum Retroviruses. 2017 Nov;33(S1):S70-S80. doi: 10.1089/aid.2017.0159.

21.

Early initiation of antiretroviral treatment postSIV infection does not resolve lymphoid tissue activation.

Hong JJ, Silveira ELDV, Amancha PK, Byrareddy SN, Gumber S, Chang KT, Ansari AA, Villinger F.

AIDS. 2017 Aug 24;31(13):1819-1824. doi: 10.1097/QAD.0000000000001576.

22.

Immune Cell Dynamics in Rhesus Macaques Infected with a Brazilian Strain of Zika Virus.

Silveira ELV, Rogers KA, Gumber S, Amancha P, Xiao P, Woollard SM, Byrareddy SN, Teixeira MM, Villinger F.

J Immunol. 2017 Aug 1;199(3):1003-1011. doi: 10.4049/jimmunol.1700256. Epub 2017 Jun 30.

23.

Comparison of the vaginal environment in rhesus and cynomolgus macaques pre- and post-lactobacillus colonization.

Daggett GJ Jr, Zhao C, Connor-Stroud F, Oviedo-Moreno P, Moon H, Cho MW, Moench T, Anderson DJ, Villinger F.

J Med Primatol. 2017 Oct;46(5):232-238. doi: 10.1111/jmp.12264. Epub 2017 May 9.

24.

Systemic and topical use of monoclonal antibodies to prevent the sexual transmission of HIV.

Anderson DJ, Politch JA, Zeitlin L, Hiatt A, Kadasia K, Mayer KH, Ruprecht RM, Villinger F, Whaley KJ.

AIDS. 2017 Jul 17;31(11):1505-1517. doi: 10.1097/QAD.0000000000001521. Review.

25.

Simian Immunodeficiency Virus Targeting of CXCR3+ CD4+ T Cells in Secondary Lymphoid Organs Is Associated with Robust CXCL10 Expression in Monocyte/Macrophage Subsets.

Fujino M, Sato H, Okamura T, Uda A, Takeda S, Ahmed N, Shichino S, Shiino T, Saito Y, Watanabe S, Sugimoto C, Kuroda MJ, Ato M, Nagai Y, Izumo S, Matsushima K, Miyazawa M, Ansari AA, Villinger F, Mori K.

J Virol. 2017 Jun 9;91(13). pii: e00439-17. doi: 10.1128/JVI.00439-17. Print 2017 Jul 1.

26.

Pharmacokinetics and Preliminary Safety of Pod-Intravaginal Rings Delivering the Monoclonal Antibody VRC01-N for HIV Prophylaxis in a Macaque Model.

Zhao C, Gunawardana M, Villinger F, Baum MM, Remedios-Chan M, Moench TR, Zeitlin L, Whaley KJ, Bohorov O, Smith TJ, Anderson DJ, Moss JA.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e02465-16. doi: 10.1128/AAC.02465-16. Print 2017 Jul.

27.

Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques.

Kasturi SP, Kozlowski PA, Nakaya HI, Burger MC, Russo P, Pham M, Kovalenkov Y, Silveira ELV, Havenar-Daughton C, Burton SL, Kilgore KM, Johnson MJ, Nabi R, Legere T, Sher ZJ, Chen X, Amara RR, Hunter E, Bosinger SE, Spearman P, Crotty S, Villinger F, Derdeyn CA, Wrammert J, Pulendran B.

J Virol. 2017 Jan 31;91(4). pii: e01844-16. doi: 10.1128/JVI.01844-16. Print 2017 Feb 15.

28.

The Dynamics of T and B Cells in Lymph Node during Chronic HIV Infection: TFH and HIV, Unhappy Dance Partners?

Hong JJ, Chang KT, Villinger F.

Front Immunol. 2016 Nov 22;7:522. eCollection 2016. Review.

29.

Reproducing SIVΔnef vaccine correlates of protection: trimeric gp41 antibody concentrated at mucosal front lines.

Voss JE, Macauley MS, Rogers KA, Villinger F, Duan L, Shang L, Fink EA, Andrabi R, Colantonio AD, Robinson JE, Johnson RP, Burton DR, Haase AT.

AIDS. 2016 Oct 23;30(16):2427-2438.

30.

Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy.

Byrareddy SN, Arthos J, Cicala C, Villinger F, Ortiz KT, Little D, Sidell N, Kane MA, Yu J, Jones JW, Santangelo PJ, Zurla C, McKinnon LR, Arnold KB, Woody CE, Walter L, Roos C, Noll A, Van Ryk D, Jelicic K, Cimbro R, Gumber S, Reid MD, Adsay V, Amancha PK, Mayne AE, Parslow TG, Fauci AS, Ansari AA.

Science. 2016 Oct 14;354(6309):197-202.

31.

Induction of Th1-Biased T Follicular Helper (Tfh) Cells in Lymphoid Tissues during Chronic Simian Immunodeficiency Virus Infection Defines Functionally Distinct Germinal Center Tfh Cells.

Velu V, Mylvaganam GH, Gangadhara S, Hong JJ, Iyer SS, Gumber S, Ibegbu CC, Villinger F, Amara RR.

J Immunol. 2016 Sep 1;197(5):1832-42. doi: 10.4049/jimmunol.1600143. Epub 2016 Aug 1.

32.

Characterization of dengue virus 2 growth in megakaryocyte-erythrocyte progenitor cells.

Clark KB, Hsiao HM, Bassit L, Crowe JE Jr, Schinazi RF, Perng GC, Villinger F.

Virology. 2016 Jun;493:162-72. doi: 10.1016/j.virol.2016.03.024. Epub 2016 Apr 6.

33.

Experimental transfusion-induced Babesia microti infection: dynamics of parasitemia and immune responses in a rhesus macaque model.

Gumber S, Nascimento FS, Rogers KA, Bishop HS, Rivera HN, Xayavong MV, Devare SG, Schochetman G, Amancha PK, Qvarnstrom Y, Wilkins PP, Villinger F.

Transfusion. 2016 Jun;56(6 Pt 2):1508-19. doi: 10.1111/trf.13521. Epub 2016 Feb 19.

34.

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals.

Konadu KA, Huang MB, Roth W, Armstrong W, Powell M, Villinger F, Bond V.

J Vis Exp. 2016 Jan 5;(107). doi: 10.3791/53495.

35.

Antiretroviral therapy induces a rapid increase in bone resorption that is positively associated with the magnitude of immune reconstitution in HIV infection.

Ofotokun I, Titanji K, Vunnava A, Roser-Page S, Vikulina T, Villinger F, Rogers K, Sheth AN, Lahiri CD, Lennox JL, Weitzmann MN.

AIDS. 2016 Jan 28;30(3):405-14. doi: 10.1097/QAD.0000000000000918.

36.

Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology.

Burghuber CK, Kwun J, Page EJ, Manook M, Gibby AC, Leopardi FV, Song M, Farris AB 3rd, Hong JJ, Villinger F, Adams AB, Iwakoshi NN, Knechtle SJ.

Am J Transplant. 2016 Jun;16(6):1726-38. doi: 10.1111/ajt.13688. Epub 2016 Mar 25.

37.

SIV/SHIV Infection Triggers Vascular Inflammation, Diminished Expression of Krüppel-like Factor 2 and Endothelial Dysfunction.

Panigrahi S, Freeman ML, Funderburg NT, Mudd JC, Younes SA, Sieg SF, Zidar DA, Paiardini M, Villinger F, Calabrese LH, Ransohoff RM, Jain MK, Lederman MM.

J Infect Dis. 2016 May 1;213(9):1419-27. doi: 10.1093/infdis/jiv749. Epub 2015 Dec 15.

38.

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques.

Micci L, Ryan ES, Fromentin R, Bosinger SE, Harper JL, He T, Paganini S, Easley KA, Chahroudi A, Benne C, Gumber S, McGary CS, Rogers KA, Deleage C, Lucero C, Byrareddy SN, Apetrei C, Estes JD, Lifson JD, Piatak M Jr, Chomont N, Villinger F, Silvestri G, Brenchley JM, Paiardini M.

J Clin Invest. 2015 Dec;125(12):4497-513. doi: 10.1172/JCI81400. Epub 2015 Nov 9.

39.

Hallmarks of HIV-1 pathogenesis are modulated by Nef's Secretion Modification Region.

Konadu KA, Anderson JS, Huang MB, Ali SA, Powell MD, Villinger F, Bond VC.

J AIDS Clin Res. 2015 Jul;6(7). pii: 476. Epub 2015 Jun 30.

40.

Phenotypic and Functional Characterization of Monoclonal Antibodies with Specificity for Rhesus Macaque CD200, CD200R and Mincle.

Byrareddy SN, Little D, Mayne AE, Villinger F, Ansari AA.

PLoS One. 2015 Oct 15;10(10):e0140689. doi: 10.1371/journal.pone.0140689. eCollection 2015.

41.

Codelivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CXCR5+ and CXCR5- CD4 T Cell Responses in Rhesus Macaques.

Iyer SS, Gangadhara S, Victor B, Gomez R, Basu R, Hong JJ, Labranche C, Montefiori DC, Villinger F, Moss B, Amara RR.

J Immunol. 2015 Aug 1;195(3):994-1005. doi: 10.4049/jimmunol.1500083. Epub 2015 Jun 26.

42.

Relationship of menstrual cycle and vaginal infection in female rhesus macaques challenged with repeated, low doses of SIVmac251.

Morris MR, Byrareddy SN, Villinger F, Henning TC, Butler K, Ansari AA, McNicholl JM, Kersh EN.

J Med Primatol. 2015 Oct;44(5):301-5. doi: 10.1111/jmp.12177. Epub 2015 Jun 5.

43.

Characterization and Implementation of a Diverse Simian Immunodeficiency Virus SIVsm Envelope Panel in the Assessment of Neutralizing Antibody Breadth Elicited in Rhesus Macaques by Multimodal Vaccines Expressing the SIVmac239 Envelope.

Kilgore KM, Murphy MK, Burton SL, Wetzel KS, Smith SA, Xiao P, Reddy S, Francella N, Sodora DL, Silvestri G, Cole KS, Villinger F, Robinson JE, Pulendran B, Hunter E, Collman RG, Amara RR, Derdeyn CA.

J Virol. 2015 Aug;89(16):8130-51. doi: 10.1128/JVI.01221-14. Epub 2015 May 27.

44.

Suppression of the Insulin Receptors in Adult Schistosoma japonicum Impacts on Parasite Growth and Development: Further Evidence of Vaccine Potential.

You H, Gobert GN, Cai P, Mou R, Nawaratna S, Fang G, Villinger F, McManus DP.

PLoS Negl Trop Dis. 2015 May 11;9(5):e0003730. doi: 10.1371/journal.pntd.0003730. eCollection 2015 May.

45.

Species-specific differences in the expression and regulation of α4β7 integrin in various nonhuman primates.

Byrareddy SN, Sidell N, Arthos J, Cicala C, Zhao C, Little DM, Dunbar P, Yang GX, Pierzchalski K, Kane MA, Mayne AE, Song B, Soares MA, Villinger F, Fauci AS, Ansari AA.

J Immunol. 2015 Jun 15;194(12):5968-79. doi: 10.4049/jimmunol.1402866. Epub 2015 May 6.

46.

Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: complete protection of rhesus monkeys from mucosal SHIV challenge.

Sholukh AM, Watkins JD, Vyas HK, Gupta S, Lakhashe SK, Thorat S, Zhou M, Hemashettar G, Bachler BC, Forthal DN, Villinger F, Sattentau QJ, Weiss RA, Agatic G, Corti D, Lanzavecchia A, Heeney JL, Ruprecht RM.

Vaccine. 2015 Apr 21;33(17):2086-95. doi: 10.1016/j.vaccine.2015.02.020. Epub 2015 Mar 11.

47.

Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy-treated macaques.

Santangelo PJ, Rogers KA, Zurla C, Blanchard EL, Gumber S, Strait K, Connor-Stroud F, Schuster DM, Amancha PK, Hong JJ, Byrareddy SN, Hoxie JA, Vidakovic B, Ansari AA, Hunter E, Villinger F.

Nat Methods. 2015 May;12(5):427-32. doi: 10.1038/nmeth.3320. Epub 2015 Mar 9.

48.

Up-regulation of Tim-3 on T cells during acute simian immunodeficiency virus infection and on antigen specific responders.

Amancha PK, Hong JJ, Ansari AA, Villinger F.

AIDS. 2015 Mar 13;29(5):531-6. doi: 10.1097/QAD.0000000000000589.

49.

Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model.

Kwun J, Page E, Hong JJ, Gibby A, Yoon J, Farris AB, Villinger F, Knechtle S.

Am J Transplant. 2015 Mar;15(3):815-22. doi: 10.1111/ajt.13045. Epub 2015 Feb 12.

50.

CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection.

Kwa S, Sadagopal S, Shen X, Hong JJ, Gangadhara S, Basu R, Victor B, Iyer SS, LaBranche CC, Montefiori DC, Tomaras GD, Villinger F, Moss B, Kozlowski PA, Amara RR.

J Virol. 2015 Apr;89(8):4690-5. doi: 10.1128/JVI.03527-14. Epub 2015 Feb 4.

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