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Spatial Regulation of Polo-Like Kinase Activity During Caenorhabditis elegans Meiosis by the Nucleoplasmic HAL-2/HAL-3 Complex.

Roelens B, Barroso C, Montoya A, Cutillas P, Zhang W, Woglar A, Girard C, Martinez-Perez E, Villeneuve AM.

Genetics. 2019 Sep;213(1):79-96. doi: 10.1534/genetics.119.302479. Epub 2019 Jul 25.


Dynamic Architecture of DNA Repair Complexes and the Synaptonemal Complex at Sites of Meiotic Recombination.

Woglar A, Villeneuve AM.

Cell. 2018 Jun 14;173(7):1678-1691.e16. doi: 10.1016/j.cell.2018.03.066. Epub 2018 May 10.


Interdependent and separable functions of Caenorhabditis elegans MRN-C complex members couple formation and repair of meiotic DSBs.

Girard C, Roelens B, Zawadzki KA, Villeneuve AM.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4443-E4452. doi: 10.1073/pnas.1719029115. Epub 2018 Apr 23. Erratum in: Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):334-336.


Time-Course Analysis of Early Meiotic Prophase Events Informs Mechanisms of Homolog Pairing and Synapsis in Caenorhabditis elegans.

Mlynarczyk-Evans S, Villeneuve AM.

Genetics. 2017 Sep;207(1):103-114. doi: 10.1534/genetics.117.204172. Epub 2017 Jul 14.


Meiotic recombination modulates the structure and dynamics of the synaptonemal complex during C. elegans meiosis.

Pattabiraman D, Roelens B, Woglar A, Villeneuve AM.

PLoS Genet. 2017 Mar 24;13(3):e1006670. doi: 10.1371/journal.pgen.1006670. eCollection 2017 Mar.


A streamlined tethered chromosome conformation capture protocol.

Gabdank I, Ramakrishnan S, Villeneuve AM, Fire AZ.

BMC Genomics. 2016 Apr 1;17:274. doi: 10.1186/s12864-016-2596-3.


Separable Roles for a Caenorhabditis elegans RMI1 Homolog in Promoting and Antagonizing Meiotic Crossovers Ensure Faithful Chromosome Inheritance.

Jagut M, Hamminger P, Woglar A, Millonigg S, Paulin L, Mikl M, Dello Stritto MR, Tang L, Habacher C, Tam A, Gallach M, von Haeseler A, Villeneuve AM, Jantsch V.

PLoS Biol. 2016 Mar 24;14(3):e1002412. doi: 10.1371/journal.pbio.1002412. eCollection 2016 Mar.


Manipulation of Karyotype in Caenorhabditis elegans Reveals Multiple Inputs Driving Pairwise Chromosome Synapsis During Meiosis.

Roelens B, Schvarzstein M, Villeneuve AM.

Genetics. 2015 Dec;201(4):1363-79. doi: 10.1534/genetics.115.182279. Epub 2015 Oct 23.


DNA helicase HIM-6/BLM both promotes MutSγ-dependent crossovers and antagonizes MutSγ-independent interhomolog associations during caenorhabditis elegans meiosis.

Schvarzstein M, Pattabiraman D, Libuda DE, Ramadugu A, Tam A, Martinez-Perez E, Roelens B, Zawadzki KA, Yokoo R, Rosu S, Severson AF, Meyer BJ, Nabeshima K, Villeneuve AM.

Genetics. 2014 Sep;198(1):193-207. doi: 10.1534/genetics.114.161513. Epub 2014 Jul 21.


Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites.

Holloway JK, Sun X, Yokoo R, Villeneuve AM, Cohen PE.

J Cell Biol. 2014 Jun 9;205(5):633-41. doi: 10.1083/jcb.201401122. Epub 2014 Jun 2.


Evidence that masking of synapsis imperfections counterbalances quality control to promote efficient meiosis.

Mlynarczyk-Evans S, Roelens B, Villeneuve AM.

PLoS Genet. 2013;9(12):e1003963. doi: 10.1371/journal.pgen.1003963. Epub 2013 Dec 5.


Meiotic chromosome structures constrain and respond to designation of crossover sites.

Libuda DE, Uzawa S, Meyer BJ, Villeneuve AM.

Nature. 2013 Oct 31;502(7473):703-6. doi: 10.1038/nature12577. Epub 2013 Oct 9.


Identification of DSB-1, a protein required for initiation of meiotic recombination in Caenorhabditis elegans, illuminates a crossover assurance checkpoint.

Stamper EL, Rodenbusch SE, Rosu S, Ahringer J, Villeneuve AM, Dernburg AF.

PLoS Genet. 2013;9(8):e1003679. doi: 10.1371/journal.pgen.1003679. Epub 2013 Aug 8.


The C. elegans DSB-2 protein reveals a regulatory network that controls competence for meiotic DSB formation and promotes crossover assurance.

Rosu S, Zawadzki KA, Stamper EL, Libuda DE, Reese AL, Dernburg AF, Villeneuve AM.

PLoS Genet. 2013;9(8):e1003674. doi: 10.1371/journal.pgen.1003674. Epub 2013 Aug 8.


Chromosome movements promoted by the mitochondrial protein SPD-3 are required for homology search during Caenorhabditis elegans meiosis.

Labrador L, Barroso C, Lightfoot J, Müller-Reichert T, Flibotte S, Taylor J, Moerman DG, Villeneuve AM, Martinez-Perez E.

PLoS Genet. 2013 May;9(5):e1003497. doi: 10.1371/journal.pgen.1003497. Epub 2013 May 9.


Assembly of the Synaptonemal Complex Is a Highly Temperature-Sensitive Process That Is Supported by PGL-1 During Caenorhabditis elegans Meiosis.

Bilgir C, Dombecki CR, Chen PF, Villeneuve AM, Nabeshima K.

G3 (Bethesda). 2013 Apr 9;3(4):585-595. doi: 10.1534/g3.112.005165.


Meiotic HORMA domain proteins prevent untimely centriole disengagement during Caenorhabditis elegans spermatocyte meiosis.

Schvarzstein M, Pattabiraman D, Bembenek JN, Villeneuve AM.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E898-907. doi: 10.1073/pnas.1213888110. Epub 2013 Feb 11.


Full-length synaptonemal complex grows continuously during meiotic prophase in budding yeast.

Voelkel-Meiman K, Moustafa SS, Lefrançois P, Villeneuve AM, MacQueen AJ.

PLoS Genet. 2012;8(10):e1002993. doi: 10.1371/journal.pgen.1002993. Epub 2012 Oct 11.


HAL-2 promotes homologous pairing during Caenorhabditis elegans meiosis by antagonizing inhibitory effects of synaptonemal complex precursors.

Zhang W, Miley N, Zastrow MS, MacQueen AJ, Sato A, Nabeshima K, Martinez-Perez E, Mlynarczyk-Evans S, Carlton PM, Villeneuve AM.

PLoS Genet. 2012;8(8):e1002880. doi: 10.1371/journal.pgen.1002880. Epub 2012 Aug 9.


COSA-1 reveals robust homeostasis and separable licensing and reinforcement steps governing meiotic crossovers.

Yokoo R, Zawadzki KA, Nabeshima K, Drake M, Arur S, Villeneuve AM.

Cell. 2012 Mar 30;149(1):75-87. doi: 10.1016/j.cell.2012.01.052.


Robust crossover assurance and regulated interhomolog access maintain meiotic crossover number.

Rosu S, Libuda DE, Villeneuve AM.

Science. 2011 Dec 2;334(6060):1286-9. doi: 10.1126/science.1212424.


Chromosome painting reveals asynaptic full alignment of homologs and HIM-8-dependent remodeling of X chromosome territories during Caenorhabditis elegans meiosis.

Nabeshima K, Mlynarczyk-Evans S, Villeneuve AM.

PLoS Genet. 2011 Aug;7(8):e1002231. doi: 10.1371/journal.pgen.1002231. Epub 2011 Aug 18.


Chromosome Organization, Mitosis, and Meiosis.

Albertson DG, Rose AM, Villeneuve AM.

In: Riddle DL, Blumenthal T, Meyer BJ, Priess JR, editors. C. elegans II. 2nd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1997. No abstract available. Chapter 3.


An asymmetric chromosome pair undergoes synaptic adjustment and crossover redistribution during Caenorhabditis elegans meiosis: implications for sex chromosome evolution.

Henzel JV, Nabeshima K, Schvarzstein M, Turner BE, Villeneuve AM, Hillers KJ.

Genetics. 2011 Mar;187(3):685-99. doi: 10.1534/genetics.110.124958. Epub 2011 Jan 6.


The synaptonemal complex shapes the crossover landscape through cooperative assembly, crossover promotion and crossover inhibition during Caenorhabditis elegans meiosis.

Hayashi M, Mlynarczyk-Evans S, Villeneuve AM.

Genetics. 2010 Sep;186(1):45-58. doi: 10.1534/genetics.110.115501. Epub 2010 Jun 30.


Coordinating cohesion, co-orientation, and congression during meiosis: lessons from holocentric chromosomes.

Schvarzstein M, Wignall SM, Villeneuve AM.

Genes Dev. 2010 Feb 1;24(3):219-28. doi: 10.1101/gad.1863610. Review.


Differential localization and independent acquisition of the H3K9me2 and H3K9me3 chromatin modifications in the Caenorhabditis elegans adult germ line.

Bessler JB, Andersen EC, Villeneuve AM.

PLoS Genet. 2010 Jan 22;6(1):e1000830. doi: 10.1371/journal.pgen.1000830.


A Caenorhabditis elegans RNA-directed RNA polymerase in sperm development and endogenous RNA interference.

Gent JI, Schvarzstein M, Villeneuve AM, Gu SG, Jantsch V, Fire AZ, Baudrimont A.

Genetics. 2009 Dec;183(4):1297-314. doi: 10.1534/genetics.109.109686. Epub 2009 Oct 5.


Analysis of meiotic recombination in Caenorhabditis elegans.

Hillers KJ, Villeneuve AM.

Methods Mol Biol. 2009;557:77-97. doi: 10.1007/978-1-59745-527-5_7. Review.


Lateral microtubule bundles promote chromosome alignment during acentrosomal oocyte meiosis.

Wignall SM, Villeneuve AM.

Nat Cell Biol. 2009 Jul;11(7):839-44. doi: 10.1038/ncb1891. Epub 2009 Jun 14.


Ensuring an exit strategy: RTEL1 restricts rogue recombination.

Villeneuve AM.

Cell. 2008 Oct 17;135(2):213-5. doi: 10.1016/j.cell.2008.10.003.


Crossovers trigger a remodeling of meiotic chromosome axis composition that is linked to two-step loss of sister chromatid cohesion.

Martinez-Perez E, Schvarzstein M, Barroso C, Lightfoot J, Dernburg AF, Villeneuve AM.

Genes Dev. 2008 Oct 15;22(20):2886-901. doi: 10.1101/gad.1694108.


Differential timing of S phases, X chromosome replication, and meiotic prophase in the C. elegans germ line.

Jaramillo-Lambert A, Ellefson M, Villeneuve AM, Engebrecht J.

Dev Biol. 2007 Aug 1;308(1):206-21. Epub 2007 May 25.


Synapsis-defective mutants reveal a correlation between chromosome conformation and the mode of double-strand break repair during Caenorhabditis elegans meiosis.

Smolikov S, Eizinger A, Hurlburt A, Rogers E, Villeneuve AM, Colaiácovo MP.

Genetics. 2007 Aug;176(4):2027-33. Epub 2007 Jun 11.


SYP-3 restricts synaptonemal complex assembly to bridge paired chromosome axes during meiosis in Caenorhabditis elegans.

Smolikov S, Eizinger A, Schild-Prufert K, Hurlburt A, McDonald K, Engebrecht J, Villeneuve AM, Colaiácovo MP.

Genetics. 2007 Aug;176(4):2015-25. Epub 2007 Jun 11.


A role for Caenorhabditis elegans chromatin-associated protein HIM-17 in the proliferation vs. meiotic entry decision.

Bessler JB, Reddy KC, Hayashi M, Hodgkin J, Villeneuve AM.

Genetics. 2007 Apr;175(4):2029-37. Epub 2007 Jan 21.


Chromosome sites play dual roles to establish homologous synapsis during meiosis in C. elegans.

MacQueen AJ, Phillips CM, Bhalla N, Weiser P, Villeneuve AM, Dernburg AF.

Cell. 2005 Dec 16;123(6):1037-50.


Methods for analyzing checkpoint responses in Caenorhabditis elegans.

Gartner A, MacQueen AJ, Villeneuve AM.

Methods Mol Biol. 2004;280:257-74.


Chromosome-wide control of meiotic crossing over in C. elegans.

Hillers KJ, Villeneuve AM.

Curr Biol. 2003 Sep 16;13(18):1641-7.


Synaptonemal complex assembly in C. elegans is dispensable for loading strand-exchange proteins but critical for proper completion of recombination.

Colaiácovo MP, MacQueen AJ, Martinez-Perez E, McDonald K, Adamo A, La Volpe A, Villeneuve AM.

Dev Cell. 2003 Sep;5(3):463-74.


A gene recommender algorithm to identify coexpressed genes in C. elegans.

Owen AB, Stuart J, Mach K, Villeneuve AM, Kim S.

Genome Res. 2003 Aug;13(8):1828-37.


A targeted RNAi screen for genes involved in chromosome morphogenesis and nuclear organization in the Caenorhabditis elegans germline.

Colaiácovo MP, Stanfield GM, Reddy KC, Reinke V, Kim SK, Villeneuve AM.

Genetics. 2002 Sep;162(1):113-28.


Synapsis-dependent and -independent mechanisms stabilize homolog pairing during meiotic prophase in C. elegans.

MacQueen AJ, Colaiácovo MP, McDonald K, Villeneuve AM.

Genes Dev. 2002 Sep 15;16(18):2428-42.

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