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Items: 1 to 50 of 91

1.

TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.

Laboucarié T, Detilleux D, Rodriguez-Mias RA, Faux C, Romeo Y, Franz-Wachtel M, Krug K, Maček B, Villén J, Petersen J, Helmlinger D.

EMBO Rep. 2017 Dec;18(12):2197-2218. doi: 10.15252/embr.201744942. Epub 2017 Oct 27.

PMID:
29079657
2.

The phosphatidic acid-binding, polybasic domain is responsible for the differences in the phosphoregulation of lipins 1 and 3.

Boroda S, Takkellapati S, Lawrence RT, Entwisle SW, Pearson JM, Granade ME, Mullins GR, Eaton JM, Villén J, Harris TE.

J Biol Chem. 2017 Dec 15;292(50):20481-20493. doi: 10.1074/jbc.M117.786574. Epub 2017 Oct 5.

PMID:
28982975
3.

Determinants and Regulation of Protein Turnover in Yeast.

Martin-Perez M, Villén J.

Cell Syst. 2017 Sep 27;5(3):283-294.e5. doi: 10.1016/j.cels.2017.08.008. Epub 2017 Sep 13.

PMID:
28918244
4.

An atlas of human kinase regulation.

Ochoa D, Jonikas M, Lawrence RT, El Debs B, Selkrig J, Typas A, Villén J, Santos SD, Beltrao P.

Mol Syst Biol. 2016 Dec 1;12(12):888. doi: 10.15252/msb.20167295.

5.

Evolution of protein phosphorylation across 18 fungal species.

Studer RA, Rodriguez-Mias RA, Haas KM, Hsu JI, Viéitez C, Solé C, Swaney DL, Stanford LB, Liachko I, Böttcher R, Dunham MJ, de Nadal E, Posas F, Beltrao P, Villén J.

Science. 2016 Oct 14;354(6309):229-232.

PMID:
27738172
6.

Altered CSNK1E, FABP4 and NEFH protein levels in the dorsolateral prefrontal cortex in schizophrenia.

Pinacho R, Villalmanzo N, Meana JJ, Ferrer I, Berengueras A, Haro JM, Villén J, Ramos B.

Schizophr Res. 2016 Nov;177(1-3):88-97. doi: 10.1016/j.schres.2016.04.050. Epub 2016 May 25.

PMID:
27236410
7.

Plug-and-play analysis of the human phosphoproteome by targeted high-resolution mass spectrometry.

Lawrence RT, Searle BC, Llovet A, Villén J.

Nat Methods. 2016 May;13(5):431-4. doi: 10.1038/nmeth.3811. Epub 2016 Mar 28.

8.

Proteomic Analysis of Protein Posttranslational Modifications by Mass Spectrometry.

Swaney DL, Villén J.

Cold Spring Harb Protoc. 2016 Mar 1;2016(3):pdb.top077743. doi: 10.1101/pdb.top077743.

PMID:
26933252
9.

Enrichment of Modified Peptides via Immunoaffinity Precipitation with Modification-Specific Antibodies.

Swaney DL, Villén J.

Cold Spring Harb Protoc. 2016 Mar 1;2016(3):pdb.prot088013. doi: 10.1101/pdb.prot088013.

PMID:
26933248
10.

Enrichment of Phosphopeptides via Immobilized Metal Affinity Chromatography.

Swaney DL, Villén J.

Cold Spring Harb Protoc. 2016 Mar 1;2016(3):pdb.prot088005. doi: 10.1101/pdb.prot088005.

PMID:
26933247
11.

Phosphorylation of ubiquitin at Ser65 affects its polymerization, targets, and proteome-wide turnover.

Swaney DL, Rodríguez-Mias RA, Villén J.

EMBO Rep. 2015 Sep;16(9):1131-44. doi: 10.15252/embr.201540298. Epub 2015 Jul 3.

12.

The Proteomic Landscape of Triple-Negative Breast Cancer.

Lawrence RT, Perez EM, Hernández D, Miller CP, Haas KM, Irie HY, Lee SI, Blau CA, Villén J.

Cell Rep. 2015 May 12;11(6):990. doi: 10.1016/j.celrep.2015.04.059. Epub 2015 May 12. No abstract available.

13.

The proteomic landscape of triple-negative breast cancer.

Lawrence RT, Perez EM, Hernández D, Miller CP, Haas KM, Irie HY, Lee SI, Blau CA, Villén J.

Cell Rep. 2015 Apr 28;11(4):630-44. doi: 10.1016/j.celrep.2015.03.050. Epub 2015 Apr 16. Erratum in: Cell Rep. 2015 May 12;11(6):990.

14.

Analysis of polycyclic aromatic hydrocarbons in aqueous samples by large volume injection gas chromatography-mass spectrometry using the through oven transfer adsorption desorption interface.

Aragón Á, Toledano RM, Vázquez A, Villén J, Cortés JM.

Talanta. 2015 Jul 1;139:1-5. doi: 10.1016/j.talanta.2015.02.028. Epub 2015 Feb 25.

PMID:
25882400
15.

Feasibility of protein turnover studies in prototroph Saccharomyces cerevisiae strains.

Martin-Perez M, Villén J.

Anal Chem. 2015 Apr 7;87(7):4008-14. doi: 10.1021/acs.analchem.5b00264. Epub 2015 Mar 26.

16.

Development of an analytical method for the determination of the misuse in sports of boldenone through the analysis of urine by on-line coupling liquid chromatography-gas chromatography-combustion-isotope ratio mass spectrometry.

Toledano RM, Díaz-Plaza EM, Cortes JM, Aragón A, Vázquez AM, Villén J, Muñoz-Guerra J.

J Chromatogr A. 2014 Nov 28;1370:171-8. doi: 10.1016/j.chroma.2014.10.049. Epub 2014 Oct 24.

PMID:
25454142
17.

mRNA destabilization is the dominant effect of mammalian microRNAs by the time substantial repression ensues.

Eichhorn SW, Guo H, McGeary SE, Rodriguez-Mias RA, Shin C, Baek D, Hsu SH, Ghoshal K, Villén J, Bartel DP.

Mol Cell. 2014 Oct 2;56(1):104-15. doi: 10.1016/j.molcel.2014.08.028. Epub 2014 Sep 25.

18.

Drafts of the human proteome.

Lawrence RT, Villén J.

Nat Biotechnol. 2014 Aug;32(8):752-3. doi: 10.1038/nbt.2982. No abstract available.

PMID:
25101745
19.

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.

Chow JD, Lawrence RT, Healy ME, Dominy JE, Liao JA, Breen DS, Byrne FL, Kenwood BM, Lackner C, Okutsu S, Mas VR, Caldwell SH, Tomsig JL, Cooney GJ, Puigserver PB, Turner N, James DE, Villén J, Hoehn KL.

Mol Metab. 2014 Mar 12;3(4):419-31. doi: 10.1016/j.molmet.2014.02.004. eCollection 2014 Jul.

20.

Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond switch mechanism independent of phosphorylation.

Eaton JM, Takkellapati S, Lawrence RT, McQueeney KE, Boroda S, Mullins GR, Sherwood SG, Finck BN, Villén J, Harris TE.

J Biol Chem. 2014 Jun 27;289(26):18055-66. doi: 10.1074/jbc.M114.547604. Epub 2014 May 8.

21.

A practical recipe to survey phosphoproteomes.

Edelman WC, Haas KM, Hsu JI, Lawrence RT, Villén J.

Methods Mol Biol. 2014;1156:389-405. doi: 10.1007/978-1-4939-0685-7_26.

PMID:
24792003
22.

Large volume injection in gas chromatography using the through oven transfer adsorption desorption interface operating under vacuum.

Aragón Á, Toledano RM, Gea S, Cortés JM, Vázquez AM, Villén J.

Talanta. 2014 Jun;123:39-44. doi: 10.1016/j.talanta.2014.01.064. Epub 2014 Feb 4.

PMID:
24725862
23.

Use of nitrogen to remove solvent from through oven transfer adsorption desorption interface during analysis of polycyclic aromatic hydrocarbons by large volume injection in gas chromatography.

Áragón A, Toledano RM, Cortés JM, Vázquez AM, Villén J.

J Chromatogr A. 2014 Apr 25;1339:224-8. doi: 10.1016/j.chroma.2014.03.005. Epub 2014 Mar 10.

PMID:
24657145
24.

E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis.

Pruneda JN, Smith FD, Daurie A, Swaney DL, Villén J, Scott JD, Stadnyk AW, Le Trong I, Stenkamp RE, Klevit RE, Rohde JR, Brzovic PS.

EMBO J. 2014 Mar 3;33(5):437-49. doi: 10.1002/embj.201386386. Epub 2014 Jan 20.

25.

Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.

Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.

Nat Methods. 2013 Jul;10(7):676-82. doi: 10.1038/nmeth.2519. Epub 2013 Jun 9.

26.

Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor β (TGFβ) signaling is essential for testicular aging and regulating testis size.

Oldknow KJ, Seebacher J, Goswami T, Villen J, Pitsillides AA, O'Shaughnessy PJ, Gygi SP, Schneyer AL, Mukherjee A.

Endocrinology. 2013 Mar;154(3):1310-20. doi: 10.1210/en.2012-1886. Epub 2013 Feb 13.

27.

Affinity-based probes based on type II kinase inhibitors.

Ranjitkar P, Perera BG, Swaney DL, Hari SB, Larson ET, Krishnamurty R, Merritt EA, Villén J, Maly DJ.

J Am Chem Soc. 2012 Nov 21;134(46):19017-25. doi: 10.1021/ja306035v. Epub 2012 Nov 6. Erratum in: J Am Chem Soc. 2013 Jan 16;135(2):948. Swaney, Daniel L [corrected to Swaney, Danielle L].

28.

On-line derivatization with on-line coupled normal phase liquid chromatography-gas chromatography using the through oven transfer adsorption desorption interface: application to the analysis of total sterols in edible oils.

Toledano RM, Cortés JM, Andini JC, Vázquez A, Villén J.

J Chromatogr A. 2012 Sep 21;1256:191-6. doi: 10.1016/j.chroma.2012.07.057. Epub 2012 Jul 25.

PMID:
22885052
29.

Analysis of free and esterified sterols in edible oils by online reversed phase liquid chromatography-gas chromatography (RPLC-GC) using the through oven transfer adsorption desorption (TOTAD) interface.

Toledano RM, Cortés JM, Rubio-Moraga Á, Villén J, Vázquez A.

Food Chem. 2012 Nov 15;135(2):610-5. doi: 10.1016/j.foodchem.2012.04.097. Epub 2012 Apr 30.

PMID:
22868136
30.

Analysis of steroids in human urine by on line liquid chromatography-gas chromatography-mass spectrometry using the Through Oven Transfer Adsorption Desorption interface and a fraction collector.

Toledano RM, Díaz-Plaza EM, Cortés JM, Blázquez I, Vázquez A, Villén J, Muñoz-Guerra J.

Anal Chim Acta. 2012 Sep 5;741:78-85. doi: 10.1016/j.aca.2012.06.050. Epub 2012 Jul 8.

PMID:
22840707
31.

Systematic functional prioritization of protein posttranslational modifications.

Beltrao P, Albanèse V, Kenner LR, Swaney DL, Burlingame A, Villén J, Lim WA, Fraser JS, Frydman J, Krogan NJ.

Cell. 2012 Jul 20;150(2):413-25. doi: 10.1016/j.cell.2012.05.036.

32.

The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.

Chen S, Ma J, Wu F, Xiong LJ, Ma H, Xu W, Lv R, Li X, Villen J, Gygi SP, Liu XS, Shi Y.

Genes Dev. 2012 Jun 15;26(12):1364-75. doi: 10.1101/gad.186056.111.

33.

Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis.

Banko MR, Allen JJ, Schaffer BE, Wilker EW, Tsou P, White JL, Villén J, Wang B, Kim SR, Sakamoto K, Gygi SP, Cantley LC, Yaffe MB, Shokat KM, Brunet A.

Mol Cell. 2011 Dec 23;44(6):878-92. doi: 10.1016/j.molcel.2011.11.005. Epub 2011 Dec 1.

34.

Angiogenin-induced tRNA fragments inhibit translation initiation.

Ivanov P, Emara MM, Villen J, Gygi SP, Anderson P.

Mol Cell. 2011 Aug 19;43(4):613-23. doi: 10.1016/j.molcel.2011.06.022.

35.

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.

Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villén J, Kubica N, Hoffman GR, Cantley LC, Gygi SP, Blenis J.

Science. 2011 Jun 10;332(6035):1322-6. doi: 10.1126/science.1199484.

36.

Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.

Helmlinger D, Marguerat S, Villén J, Swaney DL, Gygi SP, Bähler J, Winston F.

EMBO J. 2011 Jun 3;30(14):2843-52. doi: 10.1038/emboj.2011.181.

37.

Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease.

Arboleda-Velasquez JF, Manent J, Lee JH, Tikka S, Ospina C, Vanderburg CR, Frosch MP, Rodríguez-Falcón M, Villen J, Gygi S, Lopera F, Kalimo H, Moskowitz MA, Ayata C, Louvi A, Artavanis-Tsakonas S.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):E128-35. doi: 10.1073/pnas.1101964108. Epub 2011 May 9.

38.

Survey of activated FLT3 signaling in leukemia.

Gu TL, Nardone J, Wang Y, Loriaux M, Villén J, Beausoleil S, Tucker M, Kornhauser J, Ren J, MacNeill J, Gygi SP, Druker BJ, Heinrich MC, Rush J, Polakiewicz RD.

PLoS One. 2011 Apr 28;6(4):e19169. doi: 10.1371/journal.pone.0019169.

39.

Analysis of wax esters in edible oils by automated on-line coupling liquid chromatography-gas chromatography using the through oven transfer adsorption desorption (TOTAD) interface.

Aragón A, Cortés JM, Toledano RM, Villén J, Vázquez A.

J Chromatogr A. 2011 Jul 29;1218(30):4960-5. doi: 10.1016/j.chroma.2010.12.042. Epub 2010 Dec 21.

PMID:
21256496
40.

A tissue-specific atlas of mouse protein phosphorylation and expression.

Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villén J, Haas W, Sowa ME, Gygi SP.

Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001.

41.

The gammaTuRC revisited: a comparative analysis of interphase and mitotic human gammaTuRC redefines the set of core components and identifies the novel subunit GCP8.

Teixidó-Travesa N, Villén J, Lacasa C, Bertran MT, Archinti M, Gygi SP, Caelles C, Roig J, Lüders J.

Mol Biol Cell. 2010 Nov 15;21(22):3963-72. doi: 10.1091/mbc.E10-05-0408. Epub 2010 Sep 22.

42.

Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases.

Moritz A, Li Y, Guo A, Villén J, Wang Y, MacNeill J, Kornhauser J, Sprott K, Zhou J, Possemato A, Ren JM, Hornbeck P, Cantley LC, Gygi SP, Rush J, Comb MJ.

Sci Signal. 2010 Aug 24;3(136):ra64. doi: 10.1126/scisignal.2000998.

43.

Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).

Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK, Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, Mizuno K, Ma'ayan A, Gygi SP, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15299-304. doi: 10.1073/pnas.1008461107. Epub 2010 Aug 4. Erratum in: Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13464.

44.

Large volume injection of water in gas chromatography–mass spectrometry using the Through Oven Transfer Adsorption Desorption interface: Application to multiresidue analysis of pesticides.

Toledano RM, Cortés JM, Andini JC, Villén J, Vázquez A.

J Chromatogr A. 2010 Jul 9;1217(28):4738-42. doi: 10.1016/j.chroma.2010.05.011.

PMID:
20605155
45.

Sensitive multiplexed analysis of kinase activities and activity-based kinase identification.

Kubota K, Anjum R, Yu Y, Kunz RC, Andersen JN, Kraus M, Keilhack H, Nagashima K, Krauss S, Paweletz C, Hendrickson RC, Feldman AS, Wu CL, Rush J, Villén J, Gygi SP.

Nat Biotechnol. 2009 Oct;27(10):933-40. doi: 10.1038/nbt.1566. Epub 2009 Oct 4.

46.

Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.

Holt LJ, Tuch BB, Villén J, Johnson AD, Gygi SP, Morgan DO.

Science. 2009 Sep 25;325(5948):1682-6. doi: 10.1126/science.1172867.

47.

A site-specific, multiplexed kinase activity assay using stable-isotope dilution and high-resolution mass spectrometry.

Yu Y, Anjum R, Kubota K, Rush J, Villen J, Gygi SP.

Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11606-11. doi: 10.1073/pnas.0905165106. Epub 2009 Jun 29.

48.

Regulation of neuronal cell death by MST1-FOXO1 signaling.

Yuan Z, Lehtinen MK, Merlo P, Villén J, Gygi S, Bonni A.

J Biol Chem. 2009 Apr 24;284(17):11285-92. doi: 10.1074/jbc.M900461200. Epub 2009 Feb 16.

49.

The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.

Helmlinger D, Marguerat S, Villén J, Gygi SP, Bähler J, Winston F.

Genes Dev. 2008 Nov 15;22(22):3184-95. doi: 10.1101/gad.1719908.

50.

Evaluation of the utility of neutral-loss-dependent MS3 strategies in large-scale phosphorylation analysis.

Villén J, Beausoleil SA, Gygi SP.

Proteomics. 2008 Nov;8(21):4444-52. doi: 10.1002/pmic.200800283.

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