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Items: 1 to 50 of 94

1.

Progression of Alzheimer's disease and effect of scFv-h3D6 immunotherapy in the 3xTg-AD mouse model: An in vivo longitudinal study using Magnetic Resonance Imaging and Spectroscopy.

Güell-Bosch J, Lope-Piedrafita S, Esquerda-Canals G, Montoliu-Gaya L, Villegas S.

NMR Biomed. 2020 Feb 17:e4263. doi: 10.1002/nbm.4263. [Epub ahead of print]

PMID:
32067292
2.

Low-density lipoprotein aggregation is inhibited by apolipoprotein J-derived mimetic peptide D-[113-122]apoJ.

Rivas-Urbina A, Rull A, Montoliu-Gaya L, Pérez-Cuellar M, Ordóñez-Llanos J, Villegas S, Sánchez-Quesada JL.

Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Feb;1865(2):158541. doi: 10.1016/j.bbalip.2019.158541. Epub 2019 Oct 28.

PMID:
31672573
3.

Using Drosophila Models and Tools to Understand the Mechanisms of Novel Human Cancer Driver Gene Function.

Villegas SN, Ferres-Marco D, Domínguez M.

Adv Exp Med Biol. 2019;1167:15-35. doi: 10.1007/978-3-030-23629-8_2. Review.

PMID:
31520347
4.

Papillary Renal Cell Carcinomas Rewire Glutathione Metabolism and Are Deficient in Both Anabolic Glucose Synthesis and Oxidative Phosphorylation.

Al Ahmad A, Paffrath V, Clima R, Busch JF, Rabien A, Kilic E, Villegas S, Timmermann B, Attimonelli M, Jung K, Meierhofer D.

Cancers (Basel). 2019 Sep 3;11(9). pii: E1298. doi: 10.3390/cancers11091298.

5.

Treatment with scFv-h3D6 Prevented Neuronal Loss and Improved Spatial Memory in Young 3xTg-AD Mice by Reducing the Intracellular Amyloid-β Burden.

Esquerda-Canals G, Roda AR, Martí-Clúa J, Montoliu-Gaya L, Rivera-Hernández G, Villegas S.

J Alzheimers Dis. 2019;70(4):1069-1091. doi: 10.3233/JAD-190484.

PMID:
31306135
6.

Pharmacokinetic parameters and mechanism of action of an efficient anti-Aβ single chain antibody fragment.

Esquerda-Canals G, Martí-Clúa J, Villegas S.

PLoS One. 2019 May 31;14(5):e0217793. doi: 10.1371/journal.pone.0217793. eCollection 2019.

7.

Molecular basis for the protective effects of low-density lipoprotein receptor-related protein 1 (LRP1)-derived peptides against LDL aggregation.

Benitez-Amaro A, Pallara C, Nasarre L, Rivas-Urbina A, Benitez S, Vea A, Bornachea O, de Gonzalo-Calvo D, Serra-Mir G, Villegas S, Prades R, Sanchez-Quesada JL, Chiva C, Sabido E, Tarragó T, Llorente-Cortés V.

Biochim Biophys Acta Biomembr. 2019 Jul 1;1861(7):1302-1316. doi: 10.1016/j.bbamem.2019.05.003. Epub 2019 May 8.

PMID:
31077676
8.

Intraoperative awareness and experience with a ketamine-based anaesthesia package to support emergency and essential surgery when no anaesthetist is available.

Villegas S, Suarez S, Owuor J, Wuyke GM, Nelson BD, Imbamba J, Rogo D, Rogo K, Burke TF.

Afr J Emerg Med. 2019;9(Suppl):S56-S60. doi: 10.1016/j.afjem.2018.07.003. Epub 2018 Jul 26.

9.

One hundred years of Drosophila cancer research: no longer in solitude.

Villegas SN.

Dis Model Mech. 2019 Apr 1;12(4). pii: dmm039032. doi: 10.1242/dmm.039032. Review.

10.

The Role of Apolipoprotein E Isoforms in Alzheimer's Disease.

Roda AR, Montoliu-Gaya L, Villegas S.

J Alzheimers Dis. 2019;68(2):459-471. doi: 10.3233/JAD-180740. Review.

PMID:
30775980
11.

The power of culture and context on Hispanic/Latina teen pregnancy and birth in Oklahoma: provider and parental perspectives.

Alzate MM, Villegas S, Salihu HM.

Soc Work Health Care. 2018 Nov-Dec;57(10):890-905. doi: 10.1080/00981389.2018.1514351. Epub 2018 Sep 5.

PMID:
30183573
12.

Differential effects of apoE and apoJ mimetic peptides on the action of an anti-Aβ scFv in 3xTg-AD mice.

Montoliu-Gaya L, Güell-Bosch J, Esquerda-Canals G, Roda AR, Serra-Mir G, Lope-Piedrafita S, Sánchez-Quesada JL, Villegas S.

Biochem Pharmacol. 2018 Sep;155:380-392. doi: 10.1016/j.bcp.2018.07.012. Epub 2018 Jul 17.

PMID:
30026023
13.

Aβ-oligomer uptake and the resulting inflammatory response in adult human astrocytes are precluded by an anti-Aβ single chain variable fragment in combination with an apoE mimetic peptide.

Montoliu-Gaya L, Mulder SD, Herrebout MAC, Baayen JC, Villegas S, Veerhuis R.

Mol Cell Neurosci. 2018 Jun;89:49-59. doi: 10.1016/j.mcn.2018.03.015. Epub 2018 Apr 3.

14.

Long-term efficacy and safety after corneal collagen crosslinking in pediatric patients: Three-year follow-up.

Henriquez MA, Villegas S, Rincon M, Maldonado C, Izquierdo L Jr.

Eur J Ophthalmol. 2018 Jul;28(4):415-418. doi: 10.1177/1120672118760149. Epub 2018 Mar 22.

PMID:
29564931
15.

PI3K/Akt Cooperates with Oncogenic Notch by Inducing Nitric Oxide-Dependent Inflammation.

Villegas SN, Gombos R, García-López L, Gutiérrez-Pérez I, García-Castillo J, Vallejo DM, Da Ros VG, Ballesta-Illán E, Mihály J, Dominguez M.

Cell Rep. 2018 Mar 6;22(10):2541-2549. doi: 10.1016/j.celrep.2018.02.049.

16.

Expression of Cyclin D1 protein in residual tumor after neoadjuvant chemotherapy for breast cancer.

Villegas SL, Darb-Esfahani S, von Minckwitz G, Huober J, Weber K, Marmé F, Furlanetto J, Schem C, Pfitzner BM, Lederer B, Engels K, Kümmel S, Müller V, Mehta K, Denkert C, Loibl S.

Breast Cancer Res Treat. 2018 Feb;168(1):179-187. doi: 10.1007/s10549-017-4581-1. Epub 2017 Nov 25.

PMID:
29177689
17.

Effects of an Aβ-antibody fragment on Aβ aggregation and astrocytic uptake are modulated by apolipoprotein E and J mimetic peptides.

Montoliu-Gaya L, Mulder SD, Veerhuis R, Villegas S.

PLoS One. 2017 Nov 20;12(11):e0188191. doi: 10.1371/journal.pone.0188191. eCollection 2017.

18.

Reproductive ecology of the carnivorous plant Pinguicula moranensis (Lentibulariaceae).

Villegas SG, Alcalá RE.

Plant Biol (Stuttg). 2018 Mar;20(2):205-212. doi: 10.1111/plb.12652. Epub 2017 Nov 28.

PMID:
29083079
19.

Production of an anti-Aβ antibody fragment in Pichia pastoris and in vitro and in vivo validation of its therapeutic effect.

Montoliu-Gaya L, Esquerda-Canals G, Bronsoms S, Villegas S.

PLoS One. 2017 Aug 3;12(8):e0181480. doi: 10.1371/journal.pone.0181480. eCollection 2017.

20.

Towards the improvement in stability of an anti-Aβ single-chain variable fragment, scFv-h3D6, as a way to enhance its therapeutic potential.

Montoliu-Gaya L, Murciano-Calles J, Martinez JC, Villegas S.

Amyloid. 2017 Sep;24(3):167-175. doi: 10.1080/13506129.2017.1348347. Epub 2017 Jul 12.

PMID:
28699800
21.

An Intracellular Amyloid-β/AβPP Epitope Correlates with Neurodegeneration in those Neuronal Populations Early Involved in Alzheimer's Disease.

Esquerda-Canals G, Martí-Clúa J, Roda AR, Villegas S.

J Alzheimers Dis. 2017;59(3):1079-1096. doi: 10.3233/JAD-170218.

PMID:
28697564
22.

Understanding the contribution of disulfide bridges to the folding and misfolding of an anti-Aβ scFv.

Montoliu-Gaya L, Martínez JC, Villegas S.

Protein Sci. 2017 Jun;26(6):1138-1149. doi: 10.1002/pro.3164. Epub 2017 Apr 11.

23.

Mouse Models of Alzheimer's Disease.

Esquerda-Canals G, Montoliu-Gaya L, Güell-Bosch J, Villegas S.

J Alzheimers Dis. 2017;57(4):1171-1183. doi: 10.3233/JAD-170045. Review.

PMID:
28304309
24.

Assessment of palliative care services in western Kenya.

Zubairi H, Tulshian P, Villegas S, Nelson BD, Ouma K, Burke TF.

Ann Palliat Med. 2017 Apr;6(2):153-158. doi: 10.21037/apm.2017.01.02. Epub 2017 Jan 19.

25.

Functional inclusion bodies produced in the yeast Pichia pastoris.

Rueda F, Gasser B, Sánchez-Chardi A, Roldán M, Villegas S, Puxbaum V, Ferrer-Miralles N, Unzueta U, Vázquez E, Garcia-Fruitós E, Mattanovich D, Villaverde A.

Microb Cell Fact. 2016 Oct 1;15(1):166.

26.

The chondroitin sulfate/dermatan sulfate 4-O-endosulfatase from marine bacterium Vibrio sp FC509 is a dimeric species: Biophysical characterization of an endosulfatase.

Neira JL, Medina-Carmona E, Hernández-Cifre JG, Montoliu-Gaya L, Cámara-Artigás A, Seffouh I, Gonnet F, Daniel R, Villegas S, de la Torre JG, Pey AL, Li F.

Biochimie. 2016 Dec;131:85-95. doi: 10.1016/j.biochi.2016.09.015. Epub 2016 Oct 1.

PMID:
27687161
27.

Aβ-Immunotherapeutic strategies: a wide range of approaches for Alzheimer's disease treatment.

Montoliu-Gaya L, Villegas S.

Expert Rev Mol Med. 2016 Jun 30;18:e13. doi: 10.1017/erm.2016.11. Review.

PMID:
27357999
28.

Aβ immunotherapy for Alzheimer's disease: where are we?

Güell-Bosch J, Montoliu-Gaya L, Esquerda-Canals G, Villegas S.

Neurodegener Dis Manag. 2016 Jun;6(3):179-81. doi: 10.2217/nmt-2016-0006. Epub 2016 May 27. No abstract available.

29.
30.

Conformational and functional variants of CD44-targeted protein nanoparticles bio-produced in bacteria.

Pesarrodona M, Fernández Y, Foradada L, Sánchez-Chardi A, Conchillo-Solé O, Unzueta U, Xu Z, Roldán M, Villegas S, Ferrer-Miralles N, Schwartz S Jr, Rinas U, Daura X, Abasolo I, Vázquez E, Villaverde A.

Biofabrication. 2016 Apr 14;8(2):025001. doi: 10.1088/1758-5090/8/2/025001.

PMID:
27078873
31.

Differentiation of Mouse Embryonic Stem Cells into Ventral Foregut Precursors.

Rothová M, Hölzenspies JJ, Livigni A, Villegas SN, Brickman JM.

Curr Protoc Stem Cell Biol. 2016 Feb 3;36:1G.3.1-1G.3.12. doi: 10.1002/9780470151808.sc01g03s36. Review.

PMID:
26840225
32.

Common features in the unfolding and misfolding of PDZ domains and beyond: the modulatory effect of domain swapping and extra-elements.

Murciano-Calles J, Güell-Bosch J, Villegas S, Martinez JC.

Sci Rep. 2016 Jan 12;6:19242. doi: 10.1038/srep19242.

33.

3% Hypertonic Saline Versus Normal Saline in Inpatient Bronchiolitis: A Randomized Controlled Trial.

Silver AH, Esteban-Cruciani N, Azzarone G, Douglas LC, Lee DS, Liewehr S, Nazif JM, Agalliu I, Villegas S, Rhim HJ, Rinke ML, O'Connor K.

Pediatrics. 2015 Dec;136(6):1036-43. doi: 10.1542/peds.2015-1037. Epub 2015 Nov 9.

34.

Protein structures in Alzheimer's disease: The basis for rationale therapeutic design.

Montoliu-Gaya L, Villegas S.

Arch Biochem Biophys. 2015 Dec 15;588:1-14. doi: 10.1016/j.abb.2015.10.005. Epub 2015 Oct 22. Review.

PMID:
26475676
35.

Mutations can cause light chains to be too stable or too unstable to form amyloid fibrils.

Marin-Argany M, Güell-Bosch J, Blancas-Mejía LM, Villegas S, Ramirez-Alvarado M.

Protein Sci. 2015 Nov;24(11):1829-40. doi: 10.1002/pro.2790. Epub 2015 Sep 7.

36.

Modulation by geraniol of gene expression involved in lipid metabolism leading to a reduction of serum-cholesterol and triglyceride levels.

Galle M, Kladniew BR, Castro MA, Villegas SM, Lacunza E, Polo M, de Bravo MG, Crespo R.

Phytomedicine. 2015 Jul 15;22(7-8):696-704. doi: 10.1016/j.phymed.2015.04.005. Epub 2015 May 22.

PMID:
26141755
37.

Study of the scientific production on leishmaniasis in Latin America.

Perilla-Gonzalez Y, Gomez-Suta D, Delgado-Osorio N, Hurtado-Hurtado N, Baquero-Rodriguez JD, Lopez-Isaza AF, Lagos-Grisales GJ, Villegas S, Rodriguez-Morales AJ.

Recent Pat Antiinfect Drug Discov. 2014;9(3):216-22.

PMID:
25858270
38.

Scientific research in malaria: bibliometric assessment of the Latin-American contributions.

Munoz-Urbano M, Lopez-Isaza AF, Hurtado-Hurtado N, Gomez-Suta D, Murillo-Abadia J, Delgado-Osorio N, Lagos-Grisales GJ, Villegas S, Medina-Morales DA, Rodriguez-Morales AJ.

Recent Pat Antiinfect Drug Discov. 2014;9(3):209-15.

PMID:
25858269
39.

Bibliometric assessment of the Latin-American contributions in dengue.

Vera-Polania F, Perilla-Gonzalez Y, Martinez-Pulgarin DF, Baquero-Rodriguez JD, Munoz-Urbano M, Lagos-Gallego M, Lagos-Grisales GJ, Villegas S, Rodriguez-Morales AJ.

Recent Pat Antiinfect Drug Discov. 2014;9(3):195-201.

PMID:
25858260
40.

[Rh alloimmunization in pregnant women, a look to diagnosis and therapeutic approach].

Lambertino JR, Villegas SM.

Ginecol Obstet Mex. 2014 Nov;82(11):744-54. Review. Spanish.

PMID:
25826956
41.

Bacteraemia and antibiotic-resistant pathogens in community acquired pneumonia: risk and prognosis.

Torres A, Cillóniz C, Ferrer M, Gabarrús A, Polverino E, Villegas S, Marco F, Mensa J, Menéndez R, Niederman M.

Eur Respir J. 2015 May;45(5):1353-63. doi: 10.1183/09031936.00152514. Epub 2015 Jan 22.

42.

Clusterin/apolipoprotein J binds to aggregated LDL in human plasma and plays a protective role against LDL aggregation.

Martínez-Bujidos M, Rull A, González-Cura B, Pérez-Cuéllar M, Montoliu-Gaya L, Villegas S, Ordóñez-Llanos J, Sánchez-Quesada JL.

FASEB J. 2015 May;29(5):1688-700. doi: 10.1096/fj.14-264036. Epub 2014 Dec 30.

PMID:
25550461
43.

[Alzheimer's disease: New therapeutic strategies].

Villegas S.

Med Clin (Barc). 2015 Jul 20;145(2):76-83. doi: 10.1016/j.medcli.2014.05.023. Epub 2014 Sep 20. Review. Spanish.

PMID:
25245784
44.

Assessment of children exposed to adult pulmonary tuberculosis in Cali, Colombia.

Villegas SL, Ferro BE, Rojas CM, Perez-Velez CM.

Paediatr Int Child Health. 2014 Aug;34(3):170-7. doi: 10.1179/2046905514Y.0000000128. Epub 2014 Jun 17.

PMID:
24939365
45.

Suppression by geraniol of the growth of A549 human lung adenocarcinoma cells and inhibition of the mevalonate pathway in culture and in vivo: potential use in cancer chemotherapy.

Galle M, Crespo R, Kladniew BR, Villegas SM, Polo M, de Bravo MG.

Nutr Cancer. 2014;66(5):888-95. doi: 10.1080/01635581.2014.916320. Epub 2014 May 29.

PMID:
24875281
46.

The impact of extra-domain structures and post-translational modifications in the folding/misfolding behaviour of the third PDZ domain of MAGUK neuronal protein PSD-95.

Murciano-Calles J, Marin-Argany M, Cobos ES, Villegas S, Martinez JC.

PLoS One. 2014 May 20;9(5):e98124. doi: 10.1371/journal.pone.0098124. eCollection 2014.

47.

CKD-EPI and cockcroft-gault equations identify similar candidates for neoadjuvant chemotherapy in muscle-invasive bladder cancer.

Pal SK, Ruel N, Villegas S, Chang M, DeWalt K, Wilson TG, Vogelzang NJ, Yuh BE.

PLoS One. 2014 Apr 10;9(4):e94471. doi: 10.1371/journal.pone.0094471. eCollection 2014.

48.

Community-acquired lung respiratory infections in HIV-infected patients: microbial aetiology and outcome.

Cilloniz C, Torres A, Polverino E, Gabarrus A, Amaro R, Moreno E, Villegas S, Ortega M, Mensa J, Marcos MA, Moreno A, Miro JM.

Eur Respir J. 2014 Jun;43(6):1698-708. doi: 10.1183/09031936.00155813. Epub 2014 Feb 13.

49.

PI3K/Akt1 signalling specifies foregut precursors by generating regionalized extra-cellular matrix.

Villegas SN, Rothová M, Barrios-Llerena ME, Pulina M, Hadjantonakis AK, Le Bihan T, Astrof S, Brickman JM.

Elife. 2013 Dec 24;2:e00806. doi: 10.7554/eLife.00806.

50.

A thermodynamic study of the third PDZ domain of MAGUK neuronal protein PSD-95 reveals a complex three-state folding behavior.

Murciano-Calles J, Martinez JC, Marin-Argany M, Villegas S, Cobos ES.

Biophys Chem. 2014 Jan;185:1-7. doi: 10.1016/j.bpc.2013.10.005. Epub 2013 Nov 2.

PMID:
24295614

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