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Items: 1 to 50 of 321

1.

A new approach to obtain pure and active proteins from Lactococcus lactis protein aggregates.

Gifre-Renom L, Cano-Garrido O, Fàbregas F, Roca-Pinilla R, Seras-Franzoso J, Ferrer-Miralles N, Villaverde A, Bach À, Devant M, Arís A, Garcia-Fruitós E.

Sci Rep. 2018 Sep 17;8(1):13917. doi: 10.1038/s41598-018-32213-8.

2.

Selective depletion of metastatic stem cells as therapy for human colorectal cancer.

Céspedes MV, Unzueta U, Aviñó A, Gallardo A, Álamo P, Sala R, Sánchez-Chardi A, Casanova I, Mangues MA, Lopez-Pousa A, Eritja R, Villaverde A, Vázquez E, Mangues R.

EMBO Mol Med. 2018 Oct;10(10). pii: e8772. doi: 10.15252/emmm.201708772.

3.

Protein Nanoparticles Made of Recombinant Viral Antigens: A Promising Biomaterial for Oral Delivery of Fish Prophylactics.

Thwaite R, Ji J, Torrealba D, Coll J, Sabés M, Villaverde A, Roher N.

Front Immunol. 2018 Jul 18;9:1652. doi: 10.3389/fimmu.2018.01652. eCollection 2018.

4.

Conformational Conversion during Controlled Oligomerization into Nonamylogenic Protein Nanoparticles.

Sánchez JM, Sánchez-García L, Pesarrodona M, Serna N, Sánchez-Chardi A, Unzueta U, Mangues R, Vázquez E, Villaverde A.

Biomacromolecules. 2018 Sep 10;19(9):3788-3797. doi: 10.1021/acs.biomac.8b00924. Epub 2018 Aug 13.

PMID:
30052033
5.

Suicidal ideation and suicide attempts in persons with gender dysphoria.

García-Vega E, Camero A, Fernández M, Villaverde A.

Psicothema. 2018 Aug;30(3):283-288. doi: 10.7334/psicothema2017.438.

PMID:
30009750
6.

Surface-Bound Gradient Deposition of Protein Nanoparticles for Cell Motility Studies.

Tatkiewicz WI, Seras-Franzoso J, Garcia-Fruitós E, Vazquez E, Kyvik AR, Guasch J, Villaverde A, Veciana J, Ratera I.

ACS Appl Mater Interfaces. 2018 Aug 1;10(30):25779-25786. doi: 10.1021/acsami.8b06821. Epub 2018 Jul 23.

PMID:
29989793
7.

Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin.

Díaz R, Pallarès V, Cano-Garrido O, Serna N, Sánchez-García L, Falgàs A, Pesarrodona M, Unzueta U, Sánchez-Chardi A, Sánchez JM, Casanova I, Vázquez E, Mangues R, Villaverde A.

Small. 2018 Jun;14(26):e1800665. doi: 10.1002/smll.201800665. Epub 2018 May 29.

PMID:
29845742
8.

Switching cell penetrating and CXCR4-binding activities of nanoscale-organized arginine-rich peptides.

Favaro MTP, Serna N, Sánchez-García L, Cubarsi R, Roldán M, Sánchez-Chardi A, Unzueta U, Mangues R, Ferrer-Miralles N, Azzoni AR, Vázquez E, Villaverde A.

Nanomedicine. 2018 Aug;14(6):1777-1786. doi: 10.1016/j.nano.2018.05.002. Epub 2018 May 16.

PMID:
29777875
9.

Release of targeted protein nanoparticles from functional bacterial amyloids: A death star-like approach.

Unzueta U, Cespedes MV, Sala R, Alamo P, Sánchez-Chardi A, Pesarrodona M, Sánchez-García L, Cano-Garrido O, Villaverde A, Vázquez E, Mangues R, Seras-Franzoso J.

J Control Release. 2018 Jun 10;279:29-39. doi: 10.1016/j.jconrel.2018.04.004. Epub 2018 Apr 8.

PMID:
29641987
10.

Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs.

Sánchez-García L, Serna N, Álamo P, Sala R, Céspedes MV, Roldan M, Sánchez-Chardi A, Unzueta U, Casanova I, Mangues R, Vázquez E, Villaverde A.

J Control Release. 2018 Mar 28;274:81-92. doi: 10.1016/j.jconrel.2018.01.031. Epub 2018 Jan 31.

PMID:
29408658
11.

Protein nanoparticles are nontoxic, tuneable cell stressors.

de Pinho Favaro MT, Sánchez-García L, Sánchez-Chardi A, Roldán M, Unzueta U, Serna N, Cano-Garrido O, Azzoni AR, Ferrer-Miralles N, Villaverde A, Vázquez E.

Nanomedicine (Lond). 2018 Feb;13(3):255-268. doi: 10.2217/nnm-2017-0294. Epub 2018 Jan 17.

PMID:
29338574
12.

Improving Biomaterials Imaging for Nanotechnology: Rapid Methods for Protein Localization at Ultrastructural Level.

Cano-Garrido O, Garcia-Fruitós E, Villaverde A, Sánchez-Chardi A.

Biotechnol J. 2018 Apr;13(4):e1700388. doi: 10.1002/biot.201700388. Epub 2018 Jan 24.

PMID:
29271611
13.

Use of photodynamic therapy in the treatment of bovine subclinical mastitis.

Moreira LH, de Souza JCP, de Lima CJ, Salgado MAC, Fernandes AB, Andreani DIK, Villaverde AB, Zângaro RA.

Photodiagnosis Photodyn Ther. 2018 Mar;21:246-251. doi: 10.1016/j.pdpdt.2017.12.009. Epub 2017 Dec 16.

PMID:
29258951
14.

Protein-Based Therapeutic Killing for Cancer Therapies.

Serna N, Sánchez-García L, Unzueta U, Díaz R, Vázquez E, Mangues R, Villaverde A.

Trends Biotechnol. 2018 Mar;36(3):318-335. doi: 10.1016/j.tibtech.2017.11.007. Epub 2017 Dec 12. Review.

PMID:
29246477
15.

Dynamical compensation and structural identifiability of biological models: Analysis, implications, and reconciliation.

Villaverde AF, Banga JR.

PLoS Comput Biol. 2017 Nov 29;13(11):e1005878. doi: 10.1371/journal.pcbi.1005878. eCollection 2017 Nov.

16.

Intracellular trafficking of a dynein-based nanoparticle designed for gene delivery.

Favaro MTP, Unzueta U, de Cabo M, Villaverde A, Ferrer-Miralles N, Azzoni AR.

Eur J Pharm Sci. 2018 Jan 15;112:71-78. doi: 10.1016/j.ejps.2017.11.002. Epub 2017 Nov 4.

PMID:
29113920
17.

Engineering multifunctional protein nanoparticles by in vitro disassembling and reassembling of heterologous building blocks.

Unzueta U, Serna N, Sánchez-García L, Roldán M, Sánchez-Chardi A, Mangues R, Villaverde A, Vázquez E.

Nanotechnology. 2017 Dec 15;28(50):505102. doi: 10.1088/1361-6528/aa963e.

PMID:
29072576
18.

A Study on the Macroscopic Morphometry of the Lesion Area on Diabetic Ulcers in Humans Treated with Photodynamic Therapy Using Two Methods of Measurement.

Carrinho PM, Andreani DIK, Morete VA, Iseri S, Navarro RS, Villaverde AB.

Photomed Laser Surg. 2018 Jan;36(1):44-50. doi: 10.1089/pho.2017.4305. Epub 2017 Oct 9.

PMID:
29023192
19.

PREMER: A Tool to Infer Biological Networks.

Villaverde AF, Becker K, Banga JR.

IEEE/ACM Trans Comput Biol Bioinform. 2018 Jul-Aug;15(4):1193-1202. doi: 10.1109/TCBB.2017.2758786. Epub 2017 Oct 4.

PMID:
28981423
20.

Protein-only, antimicrobial peptide-containing recombinant nanoparticles with inherent built-in antibacterial activity.

Serna N, Sánchez-García L, Sánchez-Chardi A, Unzueta U, Roldán M, Mangues R, Vázquez E, Villaverde A.

Acta Biomater. 2017 Sep 15;60:256-263. doi: 10.1016/j.actbio.2017.07.027. Epub 2017 Jul 19.

PMID:
28735028
21.

Application of phototherapy for the healing of the navels of neonatal dairy calves.

de Souza Faria ALB, Conrado LAL, Vanzela LS, Villaverde AB, Munin E.

Lasers Med Sci. 2017 Sep;32(7):1579-1586. doi: 10.1007/s10103-017-2283-x. Epub 2017 Jul 17.

PMID:
28717890
22.

Parameter identifiability analysis and visualization in large-scale kinetic models of biosystems.

Gábor A, Villaverde AF, Banga JR.

BMC Syst Biol. 2017 May 5;11(1):54. doi: 10.1186/s12918-017-0428-y.

23.

Intrinsic functional and architectonic heterogeneity of tumor-targeted protein nanoparticles.

Pesarrodona M, Crosas E, Cubarsi R, Sánchez-Chardi A, Saccardo P, Unzueta U, Rueda F, Sanchez-García L, Serna N, Mangues R, Ferrer-Miralles N, Vázquez E, Villaverde A.

Nanoscale. 2017 May 18;9(19):6427-6435. doi: 10.1039/c6nr09182b.

PMID:
28463351
24.

The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles.

Sánchez-García L, Serna N, Mattanovich M, Cazzanelli P, Sánchez-Chardi A, Conchillo-Solé O, Cortés F, Daura X, Unzueta U, Mangues R, Villaverde A, Vázquez E.

Chem Commun (Camb). 2017 Apr 20;53(33):4565-4568. doi: 10.1039/c6cc09900a.

PMID:
28322369
25.

Bacterial Inclusion Bodies: Discovering Their Better Half.

Rinas U, Garcia-Fruitós E, Corchero JL, Vázquez E, Seras-Franzoso J, Villaverde A.

Trends Biochem Sci. 2017 Sep;42(9):726-737. doi: 10.1016/j.tibs.2017.01.005. Epub 2017 Feb 27. Review.

PMID:
28254353
26.

Data-driven reverse engineering of signaling pathways using ensembles of dynamic models.

Henriques D, Villaverde AF, Rocha M, Saez-Rodriguez J, Banga JR.

PLoS Comput Biol. 2017 Feb 6;13(2):e1005379. doi: 10.1371/journal.pcbi.1005379. eCollection 2017 Feb.

27.

Fluorescence visualization efficacy for detecting oral lesions more prone to be dysplastic and potentially malignant disorders: a pilot study.

Simonato LE, Tomo S, Miyahara GI, Navarro RS, Villaverde AGJB.

Photodiagnosis Photodyn Ther. 2017 Mar;17:1-4. doi: 10.1016/j.pdpdt.2016.10.010. Epub 2016 Oct 29.

PMID:
27989864
28.

Engineering tumor cell targeting in nanoscale amyloidal materials.

Unzueta U, Seras-Franzoso J, Céspedes MV, Saccardo P, Cortés F, Rueda F, Garcia-Fruitós E, Ferrer-Miralles N, Mangues R, Vázquez E, Villaverde A.

Nanotechnology. 2017 Jan 6;28(1):015102. Epub 2016 Nov 28.

PMID:
27893441
29.

Structural Identifiability of Dynamic Systems Biology Models.

Villaverde AF, Barreiro A, Papachristodoulou A.

PLoS Comput Biol. 2016 Oct 28;12(10):e1005153. doi: 10.1371/journal.pcbi.1005153. eCollection 2016 Oct.

30.

On the relationship between sloppiness and identifiability.

Chis OT, Villaverde AF, Banga JR, Balsa-Canto E.

Math Biosci. 2016 Dec;282:147-161. doi: 10.1016/j.mbs.2016.10.009. Epub 2016 Oct 24.

PMID:
27789352
31.

Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs.

Céspedes MV, Fernández Y, Unzueta U, Mendoza R, Seras-Franzoso J, Sánchez-Chardi A, Álamo P, Toledo-Rubio V, Ferrer-Miralles N, Vázquez E, Schwartz S, Abasolo I, Corchero JL, Mangues R, Villaverde A.

Sci Rep. 2016 Oct 24;6:35765. doi: 10.1038/srep35765.

32.

Complex Particulate Biomaterials as Immunostimulant-Delivery Platforms.

Torrealba D, Seras-Franzoso J, Mamat U, Wilke K, Villaverde A, Roher N, Garcia-Fruitós E.

PLoS One. 2016 Oct 7;11(10):e0164073. doi: 10.1371/journal.pone.0164073. eCollection 2016.

33.

Functional inclusion bodies produced in the yeast Pichia pastoris.

Rueda F, Gasser B, Sánchez-Chardi A, Roldán M, Villegas S, Puxbaum V, Ferrer-Miralles N, Unzueta U, Vázquez E, Garcia-Fruitós E, Mattanovich D, Villaverde A.

Microb Cell Fact. 2016 Oct 1;15(1):166.

34.

Nanostructured recombinant cytokines: A highly stable alternative to short-lived prophylactics.

Torrealba D, Parra D, Seras-Franzoso J, Vallejos-Vidal E, Yero D, Gibert I, Villaverde A, Garcia-Fruitós E, Roher N.

Biomaterials. 2016 Nov;107:102-14. doi: 10.1016/j.biomaterials.2016.08.043. Epub 2016 Aug 27.

PMID:
27614162
35.

Highly Versatile Polyelectrolyte Complexes for Improving the Enzyme Replacement Therapy of Lysosomal Storage Disorders.

Giannotti MI, Abasolo I, Oliva M, Andrade F, García-Aranda N, Melgarejo M, Pulido D, Corchero JL, Fernández Y, Villaverde A, Royo M, García-Parajo MF, Sanz F, Schwartz S Jr.

ACS Appl Mater Interfaces. 2016 Oct 5;8(39):25741-25752. Epub 2016 Sep 22.

PMID:
27610822
36.

CXCR4(+)-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis.

Cano-Garrido O, Céspedes MV, Unzueta U, Saccardo P, Roldán M, Sánchez-Chardi A, Cubarsi R, Vázquez E, Mangues R, García-Fruitós E, Villaverde A.

Nanomedicine (Lond). 2016 Sep;11(18):2387-98. doi: 10.2217/nnm-2016-0200. Epub 2016 Aug 16.

37.

Functional protein-based nanomaterial produced in microorganisms recognized as safe: A new platform for biotechnology.

Cano-Garrido O, Sánchez-Chardi A, Parés S, Giró I, Tatkiewicz WI, Ferrer-Miralles N, Ratera I, Natalello A, Cubarsi R, Veciana J, Bach À, Villaverde A, Arís A, Garcia-Fruitós E.

Acta Biomater. 2016 Oct 1;43:230-239. doi: 10.1016/j.actbio.2016.07.038. Epub 2016 Jul 21.

PMID:
27452157
38.

Low intensity laser and LED therapies associated with lateral decubitus position and flexion exercises of the lower limbs in patients with lumbar disk herniation: clinical randomized trial.

de Carvalho ME, de Carvalho RM Jr, Marques AP, de Carvalho Lucio LM, de Oliveira AC, Neto OP, Villaverde AB, de Lima CJ.

Lasers Med Sci. 2016 Sep;31(7):1455-63. doi: 10.1007/s10103-016-2009-5. Epub 2016 Jul 5.

PMID:
27379776
39.

Functional recruitment for drug delivery through protein-based nanotechnologies.

Vazquez E, Mangues R, Villaverde A.

Nanomedicine (Lond). 2016 Jun;11(11):1333-6. doi: 10.2217/nnm-2016-0090. Epub 2016 May 12. No abstract available.

PMID:
27221076
40.

Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4+ colorectal cancer models.

Céspedes MV, Unzueta U, Álamo P, Gallardo A, Sala R, Casanova I, Pavón MA, Mangues MA, Trías M, López-Pousa A, Villaverde A, Vázquez E, Mangues R.

Nanomedicine. 2016 Oct;12(7):1987-1996. doi: 10.1016/j.nano.2016.04.003. Epub 2016 Apr 13.

PMID:
27085904
41.

Conformational and functional variants of CD44-targeted protein nanoparticles bio-produced in bacteria.

Pesarrodona M, Fernández Y, Foradada L, Sánchez-Chardi A, Conchillo-Solé O, Unzueta U, Xu Z, Roldán M, Villegas S, Ferrer-Miralles N, Schwartz S Jr, Rinas U, Daura X, Abasolo I, Vázquez E, Villaverde A.

Biofabrication. 2016 Apr 14;8(2):025001. doi: 10.1088/1758-5090/8/2/025001.

PMID:
27078873
42.

Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli.

Rueda F, Céspedes MV, Sánchez-Chardi A, Seras-Franzoso J, Pesarrodona M, Ferrer-Miralles N, Vázquez E, Rinas U, Unzueta U, Mamat U, Mangues R, García-Fruitós E, Villaverde A.

Microb Cell Fact. 2016 Apr 8;15:59. doi: 10.1186/s12934-016-0457-z.

43.

Quantitative Glycopeptide Changes in Rat Sperm During Epididymal Transit.

Villaverde AI, Hetherington L, Baker MA.

Biol Reprod. 2016 Apr;94(4):91. doi: 10.1095/biolreprod.115.134114. Epub 2016 Mar 9.

PMID:
26962120
44.

Cellular uptake and intracellular fate of protein releasing bacterial amyloids in mammalian cells.

Seras-Franzoso J, Sánchez-Chardi A, Garcia-Fruitós E, Vázquez E, Villaverde A.

Soft Matter. 2016 Apr 14;12(14):3451-60. doi: 10.1039/c5sm02930a. Epub 2016 Mar 9.

PMID:
26956912
45.

Rational engineering of single-chain polypeptides into protein-only, BBB-targeted nanoparticles.

Serna N, Céspedes MV, Saccardo P, Xu Z, Unzueta U, Álamo P, Pesarrodona M, Sánchez-Chardi A, Roldán M, Mangues R, Vázquez E, Villaverde A, Ferrer-Miralles N.

Nanomedicine. 2016 Jul;12(5):1241-51. doi: 10.1016/j.nano.2016.01.004. Epub 2016 Mar 4.

PMID:
26949165
46.

Targeting in Cancer Therapies.

Mangues R, Vázquez E, Villaverde A.

Med Sci (Basel). 2016 Mar 8;4(1). pii: E6. doi: 10.3390/medsci4010006.

47.

[Flexible endoscopic treatment for Zenker's diverticulum: preliminary results in a single center experience in a public hospital in Argentina.]

Carrica SA, Martinez H, Correa GJ, Yantorno M, Tufare F, Baldoni FT, Villaverde A, Chopita N.

Acta Gastroenterol Latinoam. 2016 Mar;46(1):22-29. Review. Spanish.

PMID:
29470880
48.

α-Galactosidase-A Loaded-Nanoliposomes with Enhanced Enzymatic Activity and Intracellular Penetration.

Cabrera I, Abasolo I, Corchero JL, Elizondo E, Gil PR, Moreno E, Faraudo J, Sala S, Bueno D, González-Mira E, Rivas M, Melgarejo M, Pulido D, Albericio F, Royo M, Villaverde A, García-Parajo MF, Schwartz S Jr, Ventosa N, Veciana J.

Adv Healthc Mater. 2016 Apr 6;5(7):829-40. doi: 10.1002/adhm.201500746. Epub 2016 Feb 18.

PMID:
26890358
49.

Recombinant pharmaceuticals from microbial cells: a 2015 update.

Sanchez-Garcia L, Martín L, Mangues R, Ferrer-Miralles N, Vázquez E, Villaverde A.

Microb Cell Fact. 2016 Feb 9;15:33. doi: 10.1186/s12934-016-0437-3. Review.

50.

Metabolic engineering with multi-objective optimization of kinetic models.

Villaverde AF, Bongard S, Mauch K, Balsa-Canto E, Banga JR.

J Biotechnol. 2016 Mar 20;222:1-8. doi: 10.1016/j.jbiotec.2016.01.005. Epub 2016 Jan 28.

PMID:
26826510

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