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The Humoral Immune Response to BCG Vaccination.

Tanner R, Villarreal-Ramos B, Vordermeier HM, McShane H.

Front Immunol. 2019 Jun 11;10:1317. doi: 10.3389/fimmu.2019.01317. eCollection 2019. Review.


Transposon libraries identify novel Mycobacterium bovis BCG genes involved in the dynamic interactions required for BCG to persist during in vivo passage in cattle.

Mendum TA, Chandran A, Williams K, Vordermeier HM, Villarreal-Ramos B, Wu H, Singh A, Smith AA, Butler RE, Prasad A, Bharti N, Banerjee R, Kasibhatla SM, Bhatt A, Stewart GR, McFadden J.

BMC Genomics. 2019 May 28;20(1):431. doi: 10.1186/s12864-019-5791-1.


The expression of Indoleamine 2, 3-dioxygenase (IDO) is reduced in granulomas from BCG vaccinated cattle compared to granulomas from unvaccinated controls after experimental challenge with Mycobacterium bovis.

Garcia-Jimenez WL, Villarreal-Ramos B, Grainger D, Hewisnon RG, Vordermeier HM, Salguero FJ.

Vet Immunol Immunopathol. 2018 Sep;203:52-56. doi: 10.1016/j.vetimm.2018.08.002. Epub 2018 Aug 13.


Ag85A-specific CD4+ T cell lines derived after boosting BCG-vaccinated cattle with Ad5-85A possess both mycobacterial growth inhibition and anti-inflammatory properties.

Metcalfe HJ, Biffar L, Steinbach S, Guzman E, Connelley T, Morrison I, Vordermeier HM, Villarreal-Ramos B.

Vaccine. 2018 May 11;36(20):2850-2854. doi: 10.1016/j.vaccine.2018.03.068. Epub 2018 Apr 11.


Experimental infection of cattle with Mycobacterium tuberculosis isolates shows the attenuation of the human tubercle bacillus for cattle.

Villarreal-Ramos B, Berg S, Whelan A, Holbert S, Carreras F, Salguero FJ, Khatri BL, Malone K, Rue-Albrecht K, Shaughnessy R, Smyth A, Ameni G, Aseffa A, Sarradin P, Winter N, Vordermeier M, Gordon SV.

Sci Rep. 2018 Jan 17;8(1):894. doi: 10.1038/s41598-017-18575-5.


A mycobacterial growth inhibition assay (MGIA) for bovine TB vaccine development.

Pepponi I, Khatri B, Tanner R, Villarreal-Ramos B, Vordermeier M, McShane H.

Tuberculosis (Edinb). 2017 Sep;106:118-122. doi: 10.1016/ Epub 2017 Jul 22.


Tuberculin Skin Testing Boosts Interferon Gamma Responses to DIVA Reagents in Mycobacterium bovis-Infected Cattle.

Jones GJ, Coad M, Khatri B, Bezos J, Parlane NA, Buddle BM, Villarreal-Ramos B, Hewinson RG, Vordermeier HM.

Clin Vaccine Immunol. 2017 May 5;24(5). pii: e00551-16. doi: 10.1128/CVI.00551-16. Print 2017 May.


Frequency and phenotype of natural killer cells and natural killer cell subsets in bovine lymphoid compartments and blood.

Hamilton CA, Mahan S, Bell CR, Villarreal-Ramos B, Charleston B, Entrican G, Hope JC.

Immunology. 2017 May;151(1):89-97. doi: 10.1111/imm.12708. Epub 2017 Feb 7.


Differential Cell Composition and Cytokine Expression Within Lymph Node Granulomas from BCG-Vaccinated and Non-vaccinated Cattle Experimentally Infected with Mycobacterium bovis.

Salguero FJ, Gibson S, Garcia-Jimenez W, Gough J, Strickland TS, Vordermeier HM, Villarreal-Ramos B.

Transbound Emerg Dis. 2017 Dec;64(6):1734-1749. doi: 10.1111/tbed.12561. Epub 2016 Sep 11.


Protection associated with a TB vaccine is linked to increased frequency of Ag85A-specific CD4(+) T cells but no increase in avidity for Ag85A.

Metcalfe HJ, Steinbach S, Jones GJ, Connelley T, Morrison WI, Vordermeier M, Villarreal-Ramos B.

Vaccine. 2016 Aug 31;34(38):4520-4525. doi: 10.1016/j.vaccine.2016.07.055. Epub 2016 Aug 4.


Differential macrophage function in Brown Swiss and Holstein Friesian cattle.

Gibson AJ, Woodman S, Pennelegion C, Patterson R, Stuart E, Hosker N, Siviter P, Douglas C, Whitehouse J, Wilkinson W, Pegg SA, Villarreal-Ramos B, Werling D.

Vet Immunol Immunopathol. 2016 Nov 15;181:15-23. doi: 10.1016/j.vetimm.2016.02.018. Epub 2016 Feb 28.


Bovine Tuberculosis in Cattle: Vaccines, DIVA Tests, and Host Biomarker Discovery.

Vordermeier HM, Jones GJ, Buddle BM, Hewinson RG, Villarreal-Ramos B.

Annu Rev Anim Biosci. 2016;4:87-109. doi: 10.1146/annurev-animal-021815-111311. Review.


Phenotypic characterization of bovine memory cells responding to mycobacteria in IFNγ enzyme linked immunospot assays.

Blunt L, Hogarth PJ, Kaveh DA, Webb P, Villarreal-Ramos B, Vordermeier HM.

Vaccine. 2015 Dec 16;33(51):7276-7282. doi: 10.1016/j.vaccine.2015.10.113. Epub 2015 Nov 6.


Protection Induced by Simultaneous Subcutaneous and Endobronchial Vaccination with BCG/BCG and BCG/Adenovirus Expressing Antigen 85A against Mycobacterium bovis in Cattle.

Dean GS, Clifford D, Whelan AO, Tchilian EZ, Beverley PC, Salguero FJ, Xing Z, Vordermeier HM, Villarreal-Ramos B.

PLoS One. 2015 Nov 6;10(11):e0142270. doi: 10.1371/journal.pone.0142270. eCollection 2015.


Development of a BCG challenge model for the testing of vaccine candidates against tuberculosis in cattle.

Villarreal-Ramos B, Berg S, Chamberlain L, McShane H, Hewinson RG, Clifford D, Vordermeier M.

Vaccine. 2014 Sep 29;32(43):5645-9. doi: 10.1016/j.vaccine.2014.08.009. Epub 2014 Aug 17.


MicroRNA expression profiling of PPD-B stimulated PBMC from M. bovis-challenged unvaccinated and BCG vaccinated cattle.

Golby P, Villarreal-Ramos B, Dean G, Jones GJ, Vordermeier M.

Vaccine. 2014 Oct 7;32(44):5839-44. doi: 10.1016/j.vaccine.2014.07.034. Epub 2014 Aug 5.


Vaccination of domestic animals against tuberculosis: review of progress and contributions to the field of the TBSTEP project.

Vordermeier HM, Pérez de Val B, Buddle BM, Villarreal-Ramos B, Jones GJ, Hewinson RG, Domingo M.

Res Vet Sci. 2014 Oct;97 Suppl:S53-60. doi: 10.1016/j.rvsc.2014.04.015. Epub 2014 May 6. Review.


Evaluation of the single cervical skin test and interferon gamma responses to detect Mycobacterium bovis infected cattle in a herd co-infected with Mycobacterium avium subsp. paratuberculosis.

Seva J, Sanes JM, Ramis G, Mas A, Quereda JJ, Villarreal-Ramos B, Villar D, Pallares FJ.

Vet Microbiol. 2014 Jun 25;171(1-2):139-46. doi: 10.1016/j.vetmic.2014.03.035. Epub 2014 Apr 3.


Effect of dose and route of immunisation on the immune response induced in cattle by heterologous Bacille Calmette-Guerin priming and recombinant adenoviral vector boosting.

Dean G, Clifford D, Gilbert S, McShane H, Hewinson RG, Vordermeier HM, Villarreal-Ramos B.

Vet Immunol Immunopathol. 2014 Apr 15;158(3-4):208-13. doi: 10.1016/j.vetimm.2014.01.010. Epub 2014 Jan 28.


A multi-antigenic adenoviral-vectored vaccine improves BCG-induced protection of goats against pulmonary tuberculosis infection and prevents disease progression.

Pérez de Val B, Vidal E, Villarreal-Ramos B, Gilbert SC, Andaluz A, Moll X, Martín M, Nofrarías M, McShane H, Vordermeier HM, Domingo M.

PLoS One. 2013 Nov 21;8(11):e81317. doi: 10.1371/journal.pone.0081317. eCollection 2013.


Comparison of the immunogenicity and protection against bovine tuberculosis following immunization by BCG-priming and boosting with adenovirus or protein based vaccines.

Dean G, Whelan A, Clifford D, Salguero FJ, Xing Z, Gilbert S, McShane H, Hewinson RG, Vordermeier M, Villarreal-Ramos B.

Vaccine. 2014 Mar 5;32(11):1304-10. doi: 10.1016/j.vaccine.2013.11.045. Epub 2013 Nov 19.


Use of antigen-specific interleukin-2 to differentiate between cattle vaccinated with Mycobacterium bovis BCG and cattle infected with M. bovis.

Rhodes SG, McKinna LC, Steinbach S, Dean GS, Villarreal-Ramos B, Whelan AO, Pirson C, Jones GJ, Clifford D, Vordermeier HM.

Clin Vaccine Immunol. 2014 Jan;21(1):39-45. doi: 10.1128/CVI.00522-13. Epub 2013 Oct 30.


Global gene transcriptome analysis in vaccinated cattle revealed a dominant role of IL-22 for protection against bovine tuberculosis.

Bhuju S, Aranday-Cortes E, Villarreal-Ramos B, Xing Z, Singh M, Vordermeier HM.

PLoS Pathog. 2012 Dec;8(12):e1003077. doi: 10.1371/journal.ppat.1003077. Epub 2012 Dec 27.


Effects of vaccination against paratuberculosis on tuberculosis in goats: diagnostic interferences and cross-protection.

Pérez de Val B, Nofrarías M, López-Soria S, Garrido JM, Vordermeier HM, Villarreal-Ramos B, Martín M, Puentes E, Juste RA, Domingo M.

BMC Vet Res. 2012 Oct 16;8:191. doi: 10.1186/1746-6148-8-191.


Upregulation of IL-17A, CXCL9 and CXCL10 in early-stage granulomas induced by Mycobacterium bovis in cattle.

Aranday-Cortes E, Bull NC, Villarreal-Ramos B, Gough J, Hicks D, Ortiz-Peláez A, Vordermeier HM, Salguero FJ.

Transbound Emerg Dis. 2013 Dec;60(6):525-37. doi: 10.1111/j.1865-1682.2012.01370.x. Epub 2012 Aug 22.


Immunogenicity comparison of the intradermal or endobronchial boosting of BCG vaccinates with Ad5-85A.

Whelan A, Court P, Xing Z, Clifford D, Hogarth PJ, Vordermeier M, Villarreal-Ramos B.

Vaccine. 2012 Sep 28;30(44):6294-300. doi: 10.1016/j.vaccine.2012.07.086. Epub 2012 Aug 10.


Goats primed with Mycobacterium bovis BCG and boosted with a recombinant adenovirus expressing Ag85A show enhanced protection against tuberculosis.

Pérez de Val B, Villarreal-Ramos B, Nofrarías M, López-Soria S, Romera N, Singh M, Abad FX, Xing Z, Vordermeier HM, Domingo M.

Clin Vaccine Immunol. 2012 Sep;19(9):1339-47. doi: 10.1128/CVI.00275-12. Epub 2012 Jul 3.


Duration of immunity against Mycobacterium bovis following neonatal vaccination with bacillus Calmette-Guérin Danish: significant protection against infection at 12, but not 24, months.

Thom ML, McAulay M, Vordermeier HM, Clifford D, Hewinson RG, Villarreal-Ramos B, Hope JC.

Clin Vaccine Immunol. 2012 Aug;19(8):1254-60. doi: 10.1128/CVI.00301-12. Epub 2012 Jun 20.


Transcriptional profiling of disease-induced host responses in bovine tuberculosis and the identification of potential diagnostic biomarkers.

Aranday-Cortes E, Hogarth PJ, Kaveh DA, Whelan AO, Villarreal-Ramos B, Lalvani A, Vordermeier HM.

PLoS One. 2012;7(2):e30626. doi: 10.1371/journal.pone.0030626. Epub 2012 Feb 16.


Development of an antibody to bovine IL-2 reveals multifunctional CD4 T(EM) cells in cattle naturally infected with bovine tuberculosis.

Whelan AO, Villarreal-Ramos B, Vordermeier HM, Hogarth PJ.

PLoS One. 2011;6(12):e29194. doi: 10.1371/journal.pone.0029194. Epub 2011 Dec 22.


Yeast-surface expressed BVDV E2 protein induces a Th1/Th2 response in naïve T cells.

Patterson R, Nerren J, Kogut M, Court P, Villarreal-Ramos B, Seyfert HM, Dalby P, Werling D.

Dev Comp Immunol. 2012 May;37(1):107-14. doi: 10.1016/j.dci.2011.10.009. Epub 2011 Oct 31.


Experimental model of tuberculosis in the domestic goat after endobronchial infection with Mycobacterium caprae.

de Val Pérez B, López-Soria S, Nofrarías M, Martín M, Vordermeier HM, Villarreal-Ramos B, Romera N, Escobar M, Solanes D, Cardona PJ, Domingo M.

Clin Vaccine Immunol. 2011 Nov;18(11):1872-81. doi: 10.1128/CVI.05323-11. Epub 2011 Aug 31.


Identification of surrogates and correlates of protection in protective immunity against Mycobacterium bovis infection induced in neonatal calves by vaccination with M. bovis BCG Pasteur and M. bovis BCG Danish.

Hope JC, Thom ML, McAulay M, Mead E, Vordermeier HM, Clifford D, Hewinson RG, Villarreal-Ramos B.

Clin Vaccine Immunol. 2011 Mar;18(3):373-9. doi: 10.1128/CVI.00543-10. Epub 2011 Jan 12.


Characterization of age-related changes in bovine CD8+ T-cells.

Hogg AE, Parsons K, Taylor G, Worth A, Beverley P, Howard CJ, Villarreal-Ramos B.

Vet Immunol Immunopathol. 2011 Mar 15;140(1-2):47-54. doi: 10.1016/j.vetimm.2010.11.012. Epub 2010 Nov 19.


Differential distribution of WC1(+) gammadelta TCR(+) T lymphocyte subsets within lymphoid tissues of the head and respiratory tract and effects of intranasal M. bovis BCG vaccination.

Price S, Davies M, Villarreal-Ramos B, Hope J.

Vet Immunol Immunopathol. 2010 Jul;136(1-2):133-7. doi: 10.1016/j.vetimm.2010.02.010. Epub 2010 Feb 21.


Towards improved understanding of protective mechanisms induced by the BCG vaccine.

Villarreal-Ramos B.

Expert Rev Vaccines. 2009 Nov;8(11):1531-4. doi: 10.1586/erv.09.109. Review.


Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis.

Vordermeier HM, Villarreal-Ramos B, Cockle PJ, McAulay M, Rhodes SG, Thacker T, Gilbert SC, McShane H, Hill AV, Xing Z, Hewinson RG.

Infect Immun. 2009 Aug;77(8):3364-73. doi: 10.1128/IAI.00287-09. Epub 2009 Jun 1. Erratum in: Infect Immun. 2011 May;79(5):2134.


The antigen-specific memory CD8+ T-cell response induced by BCG in cattle resides in the CD8+gamma/deltaTCR-CD45RO+ T-cell population.

Hogg AE, Worth A, Beverley P, Howard CJ, Villarreal-Ramos B.

Vaccine. 2009 Jan 7;27(2):270-9. doi: 10.1016/j.vaccine.2008.10.053. Epub 2008 Nov 7.


Consequence of prior exposure to environmental mycobacteria on BCG vaccination and diagnosis of tuberculosis infection.

Thom M, Howard C, Villarreal-Ramos B, Mead E, Vordermeier M, Hope J.

Tuberculosis (Edinb). 2008 Jul;88(4):324-34. doi: 10.1016/ Epub 2008 Mar 7.


Mycobacterium bovis BCG vaccination induces memory CD4+ T cells characterized by effector biomarker expression and anti-mycobacterial activity.

Endsley JJ, Hogg A, Shell LJ, McAulay M, Coffey T, Howard C, Capinos Scherer CF, Waters WR, Nonnecke B, Estes DM, Villarreal-Ramos B.

Vaccine. 2007 Dec 5;25(50):8384-94. Epub 2007 Oct 23.


Bovine TB and the development of new vaccines.

Hope JC, Villarreal-Ramos B.

Comp Immunol Microbiol Infect Dis. 2008 Mar;31(2-3):77-100. Epub 2007 Aug 30. Review.


Systemic translocation of Salmonella enterica serovar Dublin in cattle occurs predominantly via efferent lymphatics in a cell-free niche and requires type III secretion system 1 (T3SS-1) but not T3SS-2.

Pullinger GD, Paulin SM, Charleston B, Watson PR, Bowen AJ, Dziva F, Morgan E, Villarreal-Ramos B, Wallis TS, Stevens MP.

Infect Immun. 2007 Nov;75(11):5191-9. Epub 2007 Aug 27.


Bio-control by wildlife vaccination: a unique set of opportunities and challenges.

Villarreal-Ramos B.

Vet J. 2007 Nov;174(3):454-5. Epub 2007 Mar 6. No abstract available.


Influence of the nature of the antigen on the boosting of responses to mycobacteria in M. bovis-BCG vaccinated cattle.

Villarreal-Ramos B, Reed S, McAulay M, Prentice H, Coffey T, Charleston BC, Howard CJ.

Vaccine. 2006 Nov 17;24(47-48):6850-8. Epub 2006 Jul 5.


The effect of tuberculin testing on the development of cell-mediated immune responses during Mycobacterium bovis infection.

Thom ML, Hope JC, McAulay M, Villarreal-Ramos B, Coffey TJ, Stephens S, Vordermeier HM, Howard CJ.

Vet Immunol Immunopathol. 2006 Nov 15;114(1-2):25-36. Epub 2006 Aug 14.


Cytokine expression profiles of bovine lymph nodes: effects of Mycobacterium bovis infection and bacille Calmette-Guérin vaccination.

Widdison S, Schreuder LJ, Villarreal-Ramos B, Howard CJ, Watson M, Coffey TJ.

Clin Exp Immunol. 2006 May;144(2):281-9.


Bone marrow immunosuppression in Salmonella-infected mice is prolonged following influenza virus infection.

Hyland L, Villarreal-Ramos B, Clarke B, Baaten B, Hou S.

Exp Hematol. 2005 Dec;33(12):1477-85.


Exposure to Mycobacterium avium induces low-level protection from Mycobacterium bovis infection but compromises diagnosis of disease in cattle.

Hope JC, Thom ML, Villarreal-Ramos B, Vordermeier HM, Hewinson RG, Howard CJ.

Clin Exp Immunol. 2005 Sep;141(3):432-9. Erratum in: Clin Exp Immunol. 2005 Dec;142(3):595.


Vaccination of neonatal calves with Mycobacterium bovis BCG induces protection against intranasal challenge with virulent M. bovis.

Hope JC, Thom ML, Villarreal-Ramos B, Vordermeier HM, Hewinson RG, Howard CJ.

Clin Exp Immunol. 2005 Jan;139(1):48-56. Erratum in: Clin Exp Immunol. 2005 Apr;140(1):192.


The effect of repeated tuberculin skin testing of cattle on immune responses and disease following experimental infection with Mycobacterium bovis.

Thom M, Morgan JH, Hope JC, Villarreal-Ramos B, Martin M, Howard CJ.

Vet Immunol Immunopathol. 2004 Dec 28;102(4):399-412.


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