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Early Hyperbaric Oxygen Therapy Improves Survival in a Model of Severe Sepsis.

Halbach JL, Prieto JM, Wang AW, Hawisher D, Cauvi DM, Reyes T, Okerblom J, Ramirez-Sanchez I, Villarreal F, Patel HH, Bickler SW, Perdrizet GA, De Maio A.

Am J Physiol Regul Integr Comp Physiol. 2019 May 15. doi: 10.1152/ajpregu.00083.2019. [Epub ahead of print]


High flavonoid cocoa supplement ameliorates plasma oxidative stress and inflammation levels while improving mobility and quality of life in older subjects: a double blind randomized clinical trial.

Munguia L, Rubio-Gayosso I, Ramirez-Sanchez I, Ortiz A, Hidalgoa I, Gonzalez C, Meaney E, Villarreal F, Najera N, Ceballos G.

J Gerontol A Biol Sci Med Sci. 2019 May 6. pii: glz107. doi: 10.1093/gerona/glz107. [Epub ahead of print]


Effect of (-)-epicatechin on the modulation of progression markers of chronic renal damage in a 5/6 nephrectomy experimental model.

Montes-Rivera J, Arellano-Mendoza M, Nájera N, Del Valle-Mondragón L, Villarreal F, Rubio-Gayosso I, Perez-Duran J, Meaney E, Ceballos G.

Heliyon. 2019 Apr 16;5(4):e01512. doi: 10.1016/j.heliyon.2019.e01512. eCollection 2019 Apr.


Obesity and Cardiovascular Risk Improvement Using Cacao By-Products in a Diet-Induced Obesity Murine Model.

Hidalgo I, Ortiz A, Sanchez-Pardo M, Garduño-Siciliano L, Hernández-Ortega M, Villarreal F, Meaney E, Najera N, Ceballos GM.

J Med Food. 2019 Jun;22(6):567-577. doi: 10.1089/jmf.2018.0210. Epub 2019 Apr 25.


Structural and energetic basis for novel epicatechin derivatives acting as GPER agonists through the MMGBSA method.

Bello M, Méndez-Luna D, Sarmiento V, Correa Basurto J, Najera N, Villarreal F, Ceballos G.

J Steroid Biochem Mol Biol. 2019 May;189:176-186. doi: 10.1016/j.jsbmb.2019.03.006. Epub 2019 Mar 6.


Unmasking of oestrogen-dependent changes in left ventricular structure and function in aged female rats: a potential model for pre-heart failure with preserved ejection fraction.

Bustamante M, Garate-Carrillo A, R Ito B, Garcia R, Carson N, Ceballos G, Ramirez-Sanchez I, Omens J, Villarreal F.

J Physiol. 2019 Apr;597(7):1805-1817. doi: 10.1113/JP277479. Epub 2019 Feb 12.


Correction to: Mitochondrial H+-ATP synthase in human skeletal muscle: contribution to dyslipidaemia and insulin resistance.

Formentini L, Ryan AJ, Gálvez-Santisteban M, Carter L, Taub P, Lapek JD Jr, Gonzalez DJ, Villarreal F, Ciaraldi TP, Cuezva JM, Henry RR.

Diabetologia. 2018 Dec;61(12):2674. doi: 10.1007/s00125-018-4747-3.


(-)-Epicatechin induced reversal of endothelial cell aging and improved vascular function: underlying mechanisms.

Ramirez-Sanchez I, Mansour C, Navarrete-Yañez V, Ayala-Hernandez M, Guevara G, Castillo C, Loredo M, Bustamante M, Ceballos G, Villarreal FJ.

Food Funct. 2018 Sep 19;9(9):4802-4813. doi: 10.1039/c8fo00483h.


Dotette: Programmable, high-precision, plug-and-play droplet pipetting.

Fan J, Men Y, Hao Tseng K, Ding Y, Ding Y, Villarreal F, Tan C, Li B, Pan T.

Biomicrofluidics. 2018 May 21;12(3):034107. doi: 10.1063/1.5030629. eCollection 2018 May.


Pituitary estrogen receptor alpha is involved in luteinizing hormone pulsatility at mid-gestation in the South American plains vizcacha, Lagostomus maximus (Rodentia, Caviomorpha).

Proietto S, Yankelevich L, Villarreal FM, Inserra PIF, Charif SE, Schmidt AR, Cortasa SA, Corso MC, Di Giorgio NP, Lux-Lantos V, Vitullo AD, Halperin J, Dorfman VB.

Gen Comp Endocrinol. 2019 Mar 1;273:40-51. doi: 10.1016/j.ygcen.2018.04.001. Epub 2018 Apr 12.


Characterization of the cytotoxic effects of the combination of cisplatin and flavanol (-)-epicatechin on human lung cancer cell line A549. An isobolographic approach.

Varela-Castillo O, Cordero P, Gutiérrez-Iglesias G, Palma I, Rubio-Gayosso I, Meaney E, Ramirez-Sanchez I, Villarreal F, Ceballos G, Nájera N.

Exp Oncol. 2018 Mar;40(1):19-23.


Synthesis of novel (-)-epicatechin derivatives as potential endothelial GPER agonists: Evaluation of biological effects.

Sarmiento V, Ramirez-Sanchez I, Moreno-Ulloa A, Romero-Perez D, Chávez D, Ortiz M, Najera N, Correa-Basurto J, Villarreal F, Ceballos G.

Bioorg Med Chem Lett. 2018 Feb 15;28(4):658-663. doi: 10.1016/j.bmcl.2018.01.025. Epub 2018 Jan 24.


(-)-Epicatechin stimulates mitochondrial biogenesis and cell growth in C2C12 myotubes via the G-protein coupled estrogen receptor.

Moreno-Ulloa A, Miranda-Cervantes A, Licea-Navarro A, Mansour C, Beltrán-Partida E, Donis-Maturano L, Delgado De la Herrán HC, Villarreal F, Álvarez-Delgado C.

Eur J Pharmacol. 2018 Mar 5;822:95-107. doi: 10.1016/j.ejphar.2018.01.014. Epub 2018 Jan 20.


A pilot study on clinical pharmacokinetics and preclinical pharmacodynamics of (+)-epicatechin on cardiometabolic endpoints.

Moreno-Ulloa A, Nájera-García N, Hernández M, Ramírez-Sánchez I, Taub PR, Su Y, Beltrán-Partida E, Ceballos G, Dugar S, Schreiner G, Best BM, Ciaraldi TP, Henry RR, Villarreal F.

Food Funct. 2018 Jan 24;9(1):307-319. doi: 10.1039/c7fo01028a.


Dysregulation of mitochondrial function and biogenesis modulators in adipose tissue of obese children.

Zamora-Mendoza R, Rosas-Vargas H, Ramos-Cervantes MT, Garcia-Zuniga P, Perez-Lorenzana H, Mendoza-Lorenzo P, Perez-Ortiz AC, Estrada-Mena FJ, Miliar-Garcia A, Lara-Padilla E, Ceballos G, Rodriguez A, Villarreal F, Ramirez-Sanchez I.

Int J Obes (Lond). 2018 Apr;42(4):618-624. doi: 10.1038/ijo.2017.274. Epub 2017 Nov 21.


Synthetic microbial consortia enable rapid assembly of pure translation machinery.

Villarreal F, Contreras-Llano LE, Chavez M, Ding Y, Fan J, Pan T, Tan C.

Nat Chem Biol. 2018 Jan;14(1):29-35. doi: 10.1038/nchembio.2514. Epub 2017 Nov 13.


The cardioprotective effects of (-)-Epicatechin are mediated through arginase activity inhibition in a murine model of ischemia/reperfusion.

Ortiz-Vilchis P, Ortiz-Flores M, Pacheco M, Ramirez-Sanchez I, Moreno-Ulloa A, Vega L, Ortiz A, Villarreal F, Rubio-Gayosso I, Najera N, Meaney E, Ceballos G.

Eur J Pharmacol. 2018 Jan 5;818:335-342. doi: 10.1016/j.ejphar.2017.11.007. Epub 2017 Nov 7.


Effects of (-)-epicatechin on frontal cortex DAPC and dysbindin of the mdx mice.

Estrada-Mena FJ, Rodriguez A, Mendoza-Lorenzo P, Neri-Gomez T, Manjarrez-Gutierrez G, Perez-Ortiz AC, Ordonez-Razo R, Ceballos G, Villarreal F, Ramirez-Sanchez I.

Neurosci Lett. 2017 Sep 29;658:142-149. doi: 10.1016/j.neulet.2017.08.056.


Mitochondrial H+-ATP synthase in human skeletal muscle: contribution to dyslipidaemia and insulin resistance.

Formentini L, Ryan AJ, Gálvez-Santisteban M, Carter L, Taub P, Lapek JD Jr, Gonzalez DJ, Villarreal F, Ciaraldi TP, Cuezva JM, Henry RR.

Diabetologia. 2017 Oct;60(10):2052-2065. doi: 10.1007/s00125-017-4379-z. Epub 2017 Aug 2. Erratum in: Diabetologia. 2018 Oct 15;:.


Multi-dimensional studies of synthetic genetic promoters enabled by microfluidic impact printing.

Fan J, Villarreal F, Weyers B, Ding Y, Tseng KH, Li J, Li B, Tan C, Pan T.

Lab Chip. 2017 Jun 27;17(13):2198-2207. doi: 10.1039/c7lc00382j.


Browning effects of (-)-epicatechin on adipocytes and white adipose tissue.

Varela CE, Rodriguez A, Romero-Valdovinos M, Mendoza-Lorenzo P, Mansour C, Ceballos G, Villarreal F, Ramirez-Sanchez I.

Eur J Pharmacol. 2017 Sep 15;811:48-59. doi: 10.1016/j.ejphar.2017.05.051. Epub 2017 May 30.


Improved in vitro angiogenic behavior on anodized titanium dioxide nanotubes.

Beltrán-Partida E, Valdéz-Salas B, Moreno-Ulloa A, Escamilla A, Curiel MA, Rosales-Ibáñez R, Villarreal F, Bastidas DM, Bastidas JM.

J Nanobiotechnology. 2017 Jan 31;15(1):10. doi: 10.1186/s12951-017-0247-8.


Effects of a natural extract of Aronia Melanocarpa berry on endothelial cell nitric oxide production.

Varela CE, Fromentin E, Roller M, Villarreal F, Ramirez-Sanchez I.

J Food Biochem. 2016 Aug;40(4):404-410. Epub 2015 Dec 2.


A randomized, placebo-controlled, double-blind study on the effects of (-)-epicatechin on the triglyceride/HDLc ratio and cardiometabolic profile of subjects with hypertriglyceridemia: Unique in vitro effects.

Gutiérrez-Salmeán G, Meaney E, Lanaspa MA, Cicerchi C, Johnson RJ, Dugar S, Taub P, Ramírez-Sánchez I, Villarreal F, Schreiner G, Ceballos G.

Int J Cardiol. 2016 Nov 15;223:500-506. doi: 10.1016/j.ijcard.2016.08.158. Epub 2016 Aug 8.


Beneficial effects of dark chocolate on exercise capacity in sedentary subjects: underlying mechanisms. A double blind, randomized, placebo controlled trial.

Taub PR, Ramirez-Sanchez I, Patel M, Higginbotham E, Moreno-Ulloa A, Román-Pintos LM, Phillips P, Perkins G, Ceballos G, Villarreal F.

Food Funct. 2016 Sep 14;7(9):3686-93. doi: 10.1039/c6fo00611f. Epub 2016 Aug 5.


(-)-Epicatechin-induced recovery of mitochondria from simulated diabetes: Potential role of endothelial nitric oxide synthase.

Ramírez-Sánchez I, Rodríguez A, Moreno-Ulloa A, Ceballos G, Villarreal F.

Diab Vasc Dis Res. 2016 May;13(3):201-10. doi: 10.1177/1479164115620982. Epub 2016 Mar 18.


The effects of (-)-epicatechin on endothelial cells involve the G protein-coupled estrogen receptor (GPER).

Moreno-Ulloa A, Mendez-Luna D, Beltran-Partida E, Castillo C, Guevara G, Ramirez-Sanchez I, Correa-Basurto J, Ceballos G, Villarreal F.

Pharmacol Res. 2015 Oct;100:309-20. doi: 10.1016/j.phrs.2015.08.014. Epub 2015 Aug 21.


Population-specific plasma proteomes of marine and freshwater three-spined sticklebacks (Gasterosteus aculeatus).

Kültz D, Li J, Zhang X, Villarreal F, Pham T, Paguio D.

Proteomics. 2015 Dec;15(23-24):3980-92. doi: 10.1002/pmic.201500132. Epub 2015 Aug 24.


Functional characterization of mutants affected in the carbonic anhydrase domain of the respiratory complex I in Arabidopsis thaliana.

Soto D, Córdoba JP, Villarreal F, Bartoli C, Schmitz J, Maurino VG, Braun HP, Pagnussat GC, Zabaleta E.

Plant J. 2015 Sep;83(5):831-44. doi: 10.1111/tpj.12930. Epub 2015 Jul 25.


Direct Ionic Regulation of the Activity of Myo-Inositol Biosynthesis Enzymes in Mozambique Tilapia.

Villarreal FD, Kültz D.

PLoS One. 2015 Jun 11;10(6):e0123212. doi: 10.1371/journal.pone.0123212. eCollection 2015.


Improved Osteoblast and Chondrocyte Adhesion and Viability by Surface-Modified Ti6Al4V Alloy with Anodized TiO₂ Nanotubes Using a Super-Oxidative Solution.

Beltrán-Partida E, Moreno-Ulloa A, Valdez-Salas B, Velasquillo C, Carrillo M, Escamilla A, Valdez E, Villarreal F.

Materials (Basel). 2015 Mar 2;8(3):867-883. doi: 10.3390/ma8030867.


Pharmacokinetic, partial pharmacodynamic and initial safety analysis of (-)-epicatechin in healthy volunteers.

Barnett CF, Moreno-Ulloa A, Shiva S, Ramirez-Sanchez I, Taub PR, Su Y, Ceballos G, Dugar S, Schreiner G, Villarreal F.

Food Funct. 2015 Mar;6(3):824-33. doi: 10.1039/c4fo00596a.


Synthetic biology outside the cell: linking computational tools to cell-free systems.

Lewis DD, Villarreal FD, Wu F, Tan C.

Front Bioeng Biotechnol. 2014 Dec 9;2:66. doi: 10.3389/fbioe.2014.00066. eCollection 2014. Review.


The science of cocoa flavanols: bioavailability, emerging evidence, and proposed mechanisms.

Blumberg JB, Ding EL, Dixon R, Pasinetti GM, Villarreal F.

Adv Nutr. 2014 Sep;5(5):547-9.


(-)-Epicatechin improves mitochondrial-related protein levels and ameliorates oxidative stress in dystrophic δ-sarcoglycan null mouse striated muscle.

Ramirez-Sanchez I, De los Santos S, Gonzalez-Basurto S, Canto P, Mendoza-Lorenzo P, Palma-Flores C, Ceballos-Reyes G, Villarreal F, Zentella-Dehesa A, Coral-Vazquez R.

FEBS J. 2014 Dec;281(24):5567-80. doi: 10.1111/febs.13098. Epub 2014 Oct 30.


Co-administration of the flavanol (-)-epicatechin with doxycycline synergistically reduces infarct size in a model of ischemia reperfusion injury by inhibition of mitochondrial swelling.

Ortiz-Vilchis P, Yamazaki KG, Rubio-Gayosso I, Ramirez-Sanchez I, Calzada C, Romero-Perez D, Ortiz A, Meaney E, Taub P, Villarreal F, Ceballos G.

Eur J Pharmacol. 2014 Dec 5;744:76-82. doi: 10.1016/j.ejphar.2014.09.042. Epub 2014 Oct 2.


Regression of human papillomavirus intraepithelial lesions is induced by MVA E2 therapeutic vaccine.

Rosales R, López-Contreras M, Rosales C, Magallanes-Molina JR, Gonzalez-Vergara R, Arroyo-Cazarez JM, Ricardez-Arenas A, Del Follo-Valencia A, Padilla-Arriaga S, Guerrero MV, Pirez MA, Arellano-Fiore C, Villarreal F.

Hum Gene Ther. 2014 Dec;25(12):1035-49. doi: 10.1089/hum.2014.024.


Myocardial matrix metalloproteinase-2: inside out and upside down.

DeCoux A, Lindsey ML, Villarreal F, Garcia RA, Schulz R.

J Mol Cell Cardiol. 2014 Dec;77:64-72. doi: 10.1016/j.yjmcc.2014.09.016. Epub 2014 Sep 28. Review.


Recovery of Indicators of Mitochondrial Biogenesis, Oxidative Stress, and Aging With (-)-Epicatechin in Senile Mice.

Moreno-Ulloa A, Nogueira L, Rodriguez A, Barboza J, Hogan MC, Ceballos G, Villarreal F, Ramirez-Sanchez I.

J Gerontol A Biol Sci Med Sci. 2015 Nov;70(11):1370-8. doi: 10.1093/gerona/glu131. Epub 2014 Aug 20.


Intravenous (-)-epicatechin reduces myocardial ischemic injury by protecting mitochondrial function.

Yamazaki KG, Andreyev AY, Ortiz-Vilchis P, Petrosyan S, Divakaruni AS, Wiley SE, De La Fuente C, Perkins G, Ceballos G, Villarreal F, Murphy AN.

Int J Cardiol. 2014 Aug 1;175(2):297-306. doi: 10.1016/j.ijcard.2014.05.009. Epub 2014 May 15.


Cell membrane mediated (-)-epicatechin effects on upstream endothelial cell signaling: evidence for a surface receptor.

Moreno-Ulloa A, Romero-Perez D, Villarreal F, Ceballos G, Ramirez-Sanchez I.

Bioorg Med Chem Lett. 2014 Jun 15;24(12):2749-52. doi: 10.1016/j.bmcl.2014.04.038. Epub 2014 Apr 19.


Targeting matrix metalloproteinases in heart disease: lessons from endogenous inhibitors.

Spinale FG, Villarreal F.

Biochem Pharmacol. 2014 Jul 1;90(1):7-15. doi: 10.1016/j.bcp.2014.04.011. Epub 2014 Apr 26. Review.


Dynamic changes in myocardial matrix and relevance to disease: translational perspectives.

Li AH, Liu PP, Villarreal FJ, Garcia RA.

Circ Res. 2014 Feb 28;114(5):916-27. doi: 10.1161/CIRCRESAHA.114.302819. Review.


Role for high-glucose-induced protein O-GlcNAcylation in stimulating cardiac fibroblast collagen synthesis.

Aguilar H, Fricovsky E, Ihm S, Schimke M, Maya-Ramos L, Aroonsakool N, Ceballos G, Dillmann W, Villarreal F, Ramirez-Sanchez I.

Am J Physiol Cell Physiol. 2014 May 1;306(9):C794-804. doi: 10.1152/ajpcell.00251.2013. Epub 2014 Feb 19.


Sublethal effects of CuO nanoparticles on Mozambique tilapia (Oreochromis mossambicus) are modulated by environmental salinity.

Villarreal FD, Das GK, Abid A, Kennedy IM, Kültz D.

PLoS One. 2014 Feb 10;9(2):e88723. doi: 10.1371/journal.pone.0088723. eCollection 2014.


Effects of (-)-epicatechin on a diet-induced rat model of cardiometabolic risk factors.

Gutiérrez-Salmeán G, Ortiz-Vilchis P, Vacaseydel CM, Garduño-Siciliano L, Chamorro-Cevallos G, Meaney E, Villafaña S, Villarreal F, Ceballos G, Ramírez-Sánchez I.

Eur J Pharmacol. 2014 Apr 5;728:24-30. doi: 10.1016/j.ejphar.2014.01.053. Epub 2014 Jan 31.


Acute effects of an oral supplement of (-)-epicatechin on postprandial fat and carbohydrate metabolism in normal and overweight subjects.

Gutiérrez-Salmeán G, Ortiz-Vilchis P, Vacaseydel CM, Rubio-Gayosso I, Meaney E, Villarreal F, Ramírez-Sánchez I, Ceballos G.

Food Funct. 2014 Mar;5(3):521-7. doi: 10.1039/c3fo60416k.


Effects of (-)-epicatechin on molecular modulators of skeletal muscle growth and differentiation.

Gutierrez-Salmean G, Ciaraldi TP, Nogueira L, Barboza J, Taub PR, Hogan MC, Henry RR, Meaney E, Villarreal F, Ceballos G, Ramirez-Sanchez I.

J Nutr Biochem. 2014 Jan;25(1):91-4. doi: 10.1016/j.jnutbio.2013.09.007. Epub 2013 Oct 18.


Salinity-induced regulation of the myo-inositol biosynthesis pathway in tilapia gill epithelium.

Sacchi R, Li J, Villarreal F, Gardell AM, Kültz D.

J Exp Biol. 2013 Dec 15;216(Pt 24):4626-38. doi: 10.1242/jeb.093823. Epub 2013 Sep 26.


(-)-Epicatechin rich cocoa mediated modulation of oxidative stress regulators in skeletal muscle of heart failure and type 2 diabetes patients.

Ramirez-Sanchez I, Taub PR, Ciaraldi TP, Nogueira L, Coe T, Perkins G, Hogan M, Maisel AS, Henry RR, Ceballos G, Villarreal F.

Int J Cardiol. 2013 Oct 9;168(4):3982-3990. doi: 10.1016/j.ijcard.2013.06.089. Epub 2013 Jul 17.

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